Article(id=1320381323752096465, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, articleNumber=null, orderNo=null, doi=10.11876/mimt202604015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773590400000, receivedDateStr=2026-03-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792733039080, onlineDateStr=2026-10-23, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792733039080, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792733039080, creator=13701087609, updateTime=1792733039080, updator=13701087609, issue=Issue{id=1320381141954187504, tenantId=1146029695717560320, journalId=1319373289681944729, year='2026', volume='32', issue='4', pageStart='1', pageEnd='138', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792732995736, creator='13701087609', updateTime=1792746079001, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320436017232987019, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320436017232987020, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=113, endPage=117, ext={EN=ArticleExt(id=1320381325446595282, articleId=1320381323752096465, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Application effect of endoscopic OTSC anastomosis clip hemostasis therapy on patients with acute non-variceal upper gastrointestinal bleeding, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the application effect of endoscopic over-the-scope clip (OTSC) anastomosis clip hemostasis therapy in patients with acute non-variceal upper gastrointestinal bleeding (ANVUGIB).
Methods A total of 302 patients with ANVUGIB admitted to our hospital from October 2023 to August 2025 were selected as the research subjects. They were randomly divided into the control group and the observation group, with 151 cases in each group. The control group received endoscopic metal titanium clip hemostasis, while the observation group received endoscopic OTSC anastomosis clip hemostasis therapy. The hemostasis effect, stress response, inflammatory indicators, and adverse reactions were compared between the two groups.
Results The hemostasis time of the observation group was (4.12±1.08) min, which was shorter than that of the control group [(10.33±2.61) min]. The immediate hemostasis rate was 98.01% (148/151), which was higher than that of the control group [90.07% (136/151)], and the rebleeding rate within 7 days was 1.32% (2/151), which was lower than that of the control group [6.62% (10/151)], and the differences were statistically significant (P<0.05). After treatment, the cortisol (Cor) of the observation group was (282.62±39.66) nmol/L, interleukin-6 (IL-6) was (18.12±3.25) pg/mL, tumor necrosis factor-α (TNF-α) was (22.46±4.81) pg/mL, and C-reactive protein (CRP) was (5.12±1.26) mg/L, which were lower than those of the control group [(308.96±45.18) nmol/L, (27.11±3.94) pg/mL, (31.05±5.78) pg/mL, and (8.45±1.44) mg/L], and the differences were statistically significant (P<0.05); the incidence of adverse reactions in the observation group was 2.65% (4/151), which was lower than that of the control group [7.95% (12/151)], and the difference was statistically significant (P<0.05).
Conclusion Endoscopic OTSC anastomosis clip hemostasis therapy for ANVUGIB has a definite hemostatic effect, can relieve stress response, reduce inflammatory levels, and has good safety.
, authors=Zhuanmin Wu, Junhong Yang, Shuxiu Yang, authorsList=Zhuanmin Wu, Junhong Yang, Shuxiu Yang, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2026 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320381325782139603, articleId=1320381323752096465, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=内镜下OTSC吻合夹止血疗法在急性非静脉曲张性上消化道出血患者中的应用效果研究, columnId=1320381058969883180, journalTitle=现代仪器与医疗, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨内镜下覆盖式夹闭装置（over-the-scope clip，OTSC）吻合夹止血疗法在急性非静脉曲张性上消化道出血（acute non-variceal upper gastrointestinal bleeding，ANVUGIB）患者中的应用效果。
方法 选取我院2023年10月至2025年8月收治的302例ANVUGIB患者作为研究对象，按随机数字表法分为对照组和观察组，每组均纳入151例。对照组实施内镜下金属钛夹止血治疗，观察组实施内镜下OTSC吻合夹止血治疗。对比两组止血效果、应激反应、炎症指标、不良反应。
结果 观察组止血时间为（4.12±1.08）min，短于对照组的（10.33±2.61）min，即时止血率为98.01%（148/151），高于对照组的90.07%（136/151），7 d内再出血率为1.32%（2/151），低于对照组的6.62%（10/151），差异均有统计学意义（P<0.05）；治疗后，观察组皮质醇（cortisol，Cor）为（282.62±39.66）nmol/L、白细胞介素-6（interleukin-6，IL-6）为（18.12±3.25）pg/mL、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）为（22.46±4.81）pg/mL、C反应蛋白（C-reactive protein，CRP）为（5.12±1.26）mg/L，低于对照组的（308.96±45.18）nmol/L、（27.11±3.94）pg/mL、（31.05±5.78）pg/mL、（8.45±1.44）mg/L，差异均有统计学意义（P<0.05）；观察组不良反应发生率为2.65%（4/151），低于对照组的7.95%（12/151），差异有统计学意义（P<0.05）。
结论 内镜下OTSC吻合夹止血疗法治疗ANVUGIB，止血效果确切，能够缓解应激反应，降低炎症水平，且安全性良好。
, authors=吴转民, 杨军红, 杨书秀, authorsList=吴转民, 杨军红, 杨书秀, authorCompany=null, correspAuthors=null, authorNote=
吴转民，女，本科，主治医师，研究方向：消化内科疾病的诊治
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2026年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=/Rh4J0rW3ttOJbzdD5wWmg==, magXml=Q6eAPMDHQ3+ZFOUZjsbVfg==, pdfUrl=null, pdf=iC2qUeoa8L8dYe3i/xRWUQ==, pdfFileSize=1777983, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=IpO1BlDrp2mbpLZAymnddw==, mapNumber=null, fund=null)}, authors=[Author(id=1320381326428062424, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381323752096465, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381326528725722, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381323752096465, authorId=1320381326428062424, language=EN, stringName=Zhuanmin Wu, firstName=Zhuanmin, middleName=null, lastName=Wu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gastroenterology, Baiyin Central Hospital, Baiyin 730900, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381326595834587, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381323752096465, authorId=1320381326428062424, language=CN, stringName=吴转民, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=白银市中心医院消化科，白银 730900, bio={"content":"
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