Article(id=1320381280697565560, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, articleNumber=null, orderNo=null, doi=10.11876/mimt202604012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1779724800000, receivedDateStr=2026-05-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792733028816, onlineDateStr=2026-10-23, pubDate=1786291200000, pubDateStr=2026-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792733028816, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792733028816, creator=13701087609, updateTime=1792733028816, updator=13701087609, issue=Issue{id=1320381141954187504, tenantId=1146029695717560320, journalId=1319373289681944729, year='2026', volume='32', issue='4', pageStart='1', pageEnd='138', issueExtLink='null', onlineDate='null', pubDate='1786291200000', pubDateStr='2026-08-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792732995736, creator='13701087609', updateTime=1792746079001, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320436017232987019, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320436017232987020, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381141954187504, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=92, endPage=99, ext={EN=ArticleExt(id=1320381280852754809, articleId=1320381280697565560, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=The qualitative diagnostic value of superb microvascular imaging combined with contrast-enhanced ultrasound for liver space occupying lesions, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the qualitative diagnostic value of superb microvascular imaging (SMI) combined with contrast-enhanced ultrasound (CEUS) for liver space occupying lesions.
Method The clinical data of 115 patients with liver space occupying lesions who were admitted to our hospital from January 2023 to December 2025 were retrospectively collected. All patients underwent SMI and CEUS examinations, with surgical or puncture pathology results as the gold standard. The qualitative diagnostic results of SMI and CEUS alone and in combination for liver mass lesions were calculated, including the sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and consistency K value. The diagnostic accuracy of SMI and CEUS alone and in combination for different subgroups of liver mass lesions was analyzed. Based on the conventional ultrasound characteristics of different liver occupying lesions, a regression model was constructed and validated using Bootstrap self sampling, Hosmer-Lemeshow goodness of fit test, and decision curve.
Results In 115 patients with liver mass lesions, 48 were diagnosed with malignant lesions and 67 with benign lesions based on surgical or puncture pathology results. The pathological results of surgery or puncture were the gold standard, and the detection rates of SMI, CEUS alone, and in combination for malignant liver lesions were 75.00%, 70.83%, and 95.83%, respectively. The sensitivity, accuracy, and negative predictive value of SMI combined with CEUS were higher than those of SMI and CEUS alone, and the K value was the highest, at 0.757, with statistical significance differences (P<0.05). In the subgroup of lesions ≤ 3 cm, the accuracy of SMI and CEUS diagnosis alone was lower than that of combined diagnosis; in the subgroup of hepatocellular carcinoma, the accuracy of CEUS diagnosis alone was lower than that of combined diagnosis, all with statistical significant differences (P<0.05). The proportion of internal high echo, posterior echo attenuation, irregular morphology, and unclear boundaries in the malignant group was higher than that in the benign group (P<0.05). The results of Logistic regression analysis showed that SMI combined with CEUS diagnosis, internal echo, posterior echo, morphology, and boundary were all influencing factors of malignant liver lesions (P<0.05). Based on this, a regression model was constructed, and the internal validation results showed that the consistency index of the model was 0.955 (95% CI: 0.940~0.962). The fit between the internal calibration curve and the ideal curve was well reflected. The Hosmer-Lemeshow goodness of fit test results showed that the predicted outcome of the model was basically consistent with the actual situation (χ2=4.162, P=0.526). According to the decision curve evaluation, the model had a high net return rate within the threshold probability range of 0.01~0.09 and 0.33~0.93, with a maximum net return rate of 0.414.
Conclusion SMI combined with CEUS has high qualitative diagnostic value for liver space occupying lesions and can assist clinical decision-making.
, authors=Xin Sun, Ziping Lyu, Jinlan Xu, authorsList=Xin Sun, Ziping Lyu, Jinlan Xu, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2026 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320381281217659258, articleId=1320381280697565560, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=超微血管成像联合超声造影对肝脏占位病变的定性诊断价值, columnId=1320381058969883180, journalTitle=现代仪器与医疗, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨超微血管成像（superb microvascular imaging，SMI）联合超声造影（contrast-enhanced ultrasound，CEUS）对肝脏占位病变的定性诊断价值。
方法 回顾性收集2023年1月至2025年12月我院收治的115例肝脏占位病变患者的临床资料。所有患者均接受SMI、CEUS检查，以手术或穿刺病理结果为金标准，计算SMI、CEUS单独及联合对肝脏占位病变的定性诊断结果，包括敏感度、特异度、准确率、阳性预测值、阴性预测值、一致性K值，并分析二者单独及联合对不同亚组肝脏占位病变的诊断准确率，以及不同肝脏占位病变的常规超声特征，基于此构建回归模型，并采用Bootstrap自抽样法、Hosmer-Lemeshow拟合优度检验以及决策曲线对构建的模型进行验证。
结果 115例肝脏占位病变患者中，经手术或穿刺病理结果诊断为恶性病变48例，良性病变67例。以手术或穿刺病理结果为金标准，SMI、CEUS单独及联合对肝脏占位恶性病变的检出率分别为75.00%、70.83%、95.83%。SMI联合CEUS的敏感度、准确率、阴性预测值均高于SMI、CEUS单独诊断，且K值最高，为0.757，差异有统计学意义（P<0.05）。在病灶≤3 cm亚组中，SMI与CEUS单独诊断的准确率均低于联合诊断，在肝细胞癌亚组中，CEUS单独诊断的准确率低于联合诊断，差异均有统计学意义（P<0.05）。恶性组的内部高回声、后方回声衰减、形态不规则、边界不清晰占比均高于良性组（P<0.05）。Logistic回归分析结果显示，SMI联合CEUS诊断结果、内部回声、后方回声、形态、边界均是肝脏占位恶性病变的影响因素（P<0.05）。基于此构建回归模型，内部验证结果显示模型的一致性指数为0.955（95% CI：0.940~0.962），内部校正曲线与理想曲线的拟合反映良好，Hosmer-Lemeshow拟合优度检验结果显示，模型预测结局发生情况与实际情况基本一致（χ2=4.162，P=0.526）。经决策曲线评估，该模型在0.01~0.09、0.33~0.93阈值概率范围内具有较高的净收益率，最大净收益率为0.414。
结论 SMI联合CEUS对肝脏占位病变的定性诊断价值较高，可协助临床决策。
, authors=孙昕, 吕子平, 徐金兰, authorsList=孙昕, 吕子平, 徐金兰, authorCompany=null, correspAuthors=null, authorNote=
孙昕，女，本科，主治医师，研究方向：主要从事介入超声方面的相关研究
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2026年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=uuIMi293b8YHrKzAbTneSw==, magXml=fcZW4g7ifmQF/LQTcHQUgQ==, pdfUrl=null, pdf=JqFYv0l81AoMvEA54CAArw==, pdfFileSize=2474115, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=1ah/8QfMniQbXl8QCjHWfg==, mapNumber=null, fund=null)}, authors=[Author(id=1320381281662255487, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381280697565560, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381281737752961, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381280697565560, authorId=1320381281662255487, language=EN, stringName=Xin Sun, firstName=Xin, middleName=null, lastName=Sun, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Ultrasound Medicine, People's Hospital of Jinchang, Jinchang 710061, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381281796473218, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381280697565560, authorId=1320381281662255487, language=CN, stringName=孙昕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=金昌市人民医院超声医学科，金昌 710061, bio={"content":"
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