现代仪器与医疗

神经调控技术在中央型颈脊髓损伤后上肢及手功能康复中的应用进展

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谢娜 ¹^,² , 刘楠 ²^,^*

现代仪器与医疗 | 探索脑机接口与神经调控技术的应用 2026,32(4): 52-60

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现代仪器与医疗 |探索脑机接口与神经调控技术的应用 2026 , 32 (4) : 52 -60

神经调控技术在中央型颈脊髓损伤后上肢及手功能康复中的应用进展

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谢娜¹^,², 刘楠²^,^*

作者信息

^1.北京大学国际医院康复医学科，北京　102200

^2.北京大学第三医院康复医学科，北京　100080

通讯作者:

刘楠，男，博士研究生，主任医师，研究方向：脊髓损伤康复，神经康复，肌骨康复

作者简介:

谢娜，女，在读博士研究生，主治医师，研究方向：神经康复，肿瘤康复

The application progress of neural regulation technology in the rehabilitation of upper limb and hand functions after traumatic central cord syndrome

Na Xie¹^,², Nan Liu²^,^*

Affiliations

^1.Department of Rehabilitation Medicine, Peking University International Hospital, Beijing 102200, China

^2.Department of Rehabilitation Medicine, Peking University Third Hospital, Beijing 100080, China

出版时间: 2026-08-10 doi: 10.11876/mimt202604007

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摘要

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创伤性中央脊髓综合征（traumatic central cord syndrome，TCCS），又称中央型颈脊髓损伤，是临床最常见的不完全性颈脊髓损伤亚型，该病以单侧或双侧上肢、手部运动功能重度障碍为核心特征，下肢功能受累相对较轻，常伴随感觉异常、膀胱功能障碍等症状，严重损害患者的日常生活活动能力，极大降低其社会参与水平。神经调控技术是一类新型无创或微创神经康复干预手段，可通过磁场、恒定电场、电刺激等物理干预方式调控中枢及外周神经可塑性、调节皮质脊髓束兴奋性，为TCCS患者上肢及手功能的精准康复提供了全新的治疗思路与技术路径。本文聚焦重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）、经颅直流电刺激（transcranial direct current stimulation，tDCS）、脊髓电刺激（spinal cord stimulation，SCS）及外周神经电刺激（peripheral nerve stimulation，PNS），综述其在TCCS后上肢及手功能康复中的最新研究进展，深入探讨各技术的作用机制、临床证据及优化策略、安全性和未来发展方向，重点探讨多模式联合干预策略的协同效应和临床应用场景，总结现阶段相关研究的局限性，并展望未来研究发展方向，旨在为TCCS患者个体化、精准化康复方案的优化制定提供理论依据，助力改善TCCS患者康复预后与生活质量。

关键词

神经调控技术 / 中央型颈脊髓损伤 / 上肢功能 / 手功能障碍 / 康复

Abstract

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Traumatic central cord syndrome (TCCS), also known as central cervical spinal cord injury, is the most common subtype of incomplete cervical spinal cord injury. It is characterized by severe motor dysfunction in the unilateral or bilateral upper extremities and hands, with relatively mild impairment of lower extremity function, often accompanied by paresthesia and bladder dysfunction. These symptoms seriously impair patients' activities of daily living and greatly reduce their level of social participation. As a novel type of non-invasive or minimally invasive rehabilitation intervention, neuromodulation techniques regulate central and peripheral neuroplasticity as well as corticospinal tract excitability through physical factors such as magnetic fields, constant electric fields, and electrical stimulation, providing a new therapeutic approach for the precise rehabilitation of upper limb and hand function in TCCS patients. This paper focuses on repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), spinal cord stimulation (SCS), and peripheral nerve stimulation (PNS), and reviews the latest research progress of these techniques in the rehabilitation of upper limb and hand function after TCCS. It deeply explores the mechanism of action, clinical evidence, optimization strategies, safety, and future development directions of each technique, and focuses on the synergistic effect and clinical application scenarios of multimodal combined intervention strategies. In addition, it summarizes the limitations of current research and prospects future research directions, aiming to provide a theoretical basis for the formulation and optimization of individualized and precise rehabilitation protocols for TCCS patients and improve their rehabilitation prognosis and quality of life.

Key words

Neural regulation technology / Traumatic central cord syndrome / Upper limb function / Hand function disorder / Rehabilitation

引用本文

谢娜, 刘楠. 神经调控技术在中央型颈脊髓损伤后上肢及手功能康复中的应用进展. 现代仪器与医疗, 2026 , 32 (4) : 52 -60 . DOI: 10.11876/mimt202604007

Na Xie, Nan Liu. The application progress of neural regulation technology in the rehabilitation of upper limb and hand functions after traumatic central cord syndrome[J]. Modern Instruments & Medical Treatment, 2026 , 32 (4) : 52 -60 . DOI: 10.11876/mimt202604007

基金

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国家自然科学基金面上项目(82472596)

参考文献

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2026年第32卷第4期

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doi: 10.11876/mimt202604007

接收时间：2026-07-01
首发时间：2026-10-23
出版时间：2026-08-10

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收稿日期：2026-07-01

基金

国家自然科学基金面上项目(82472596)

作者信息

^1.北京大学国际医院康复医学科，北京　102200

^2.北京大学第三医院康复医学科，北京　100080

通讯作者:

刘楠，男，博士研究生，主任医师，研究方向：脊髓损伤康复，神经康复，肌骨康复

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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