现代仪器与医疗

时域干涉刺激在意识障碍中的机制研究与临床证据综述

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茆梓恒 ¹ , 李晨曦 ¹ , 杨心怡 ² , 张艳正 ¹ , 陈树耿 ³^,^*

现代仪器与医疗 | 探索脑机接口与神经调控技术的应用 2026,32(4): 45-51

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现代仪器与医疗 |探索脑机接口与神经调控技术的应用 2026 , 32 (4) : 45 -51

时域干涉刺激在意识障碍中的机制研究与临床证据综述

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茆梓恒¹, 李晨曦¹, 杨心怡², 张艳正¹, 陈树耿³^,^*

作者信息

^1.上海市誉华康复医院康复医学科，上海　201700

^2.上海中医药大学康复医学院，上海　201203

^3.复旦大学附属华山医院康复医学科，上海　200040

通讯作者:

陈树耿，男，博士研究生，主管治疗师，研究方向：脑机接口与神经康复

作者简介:

茆梓恒，男，本科，初级康复师，研究方向：意识障碍康复与神经调控

Mechanisms and clinical evidence of temporal interference stimulation in disorders of consciousness: a review

Ziheng Mao¹, Chenxi Li¹, Xinyi Yang², Yanzheng Zhang¹, Shugeng Chen³^,^*

Affiliations

^1.Department of Rehabilitation Medicine, Shanghai Yuhua Rehabilitation Hospital, Shanghai 201700, China

^2.School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

^3.Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China

出版时间: 2026-08-10 doi: 10.11876/mimt202604006

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摘要

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目的

系统综述时域干涉刺激（temporal interference stimulation，TI）的神经调控机制及其在意识障碍（disorders of consciousness，DOC）中的应用潜力，为其临床转化提供理论依据。

方法

检索PubMed、EBSCOhost及Google Scholar数据库中近年相关文献，围绕TI的物理学原理、神经电生理机制及其在动物实验与临床研究中的应用进展进行归纳分析，并对相关研究进行定性整合。

结果

现有研究表明，TI可通过高频电流干涉产生低频包络信号，实现对深部脑结构的选择性调控，其主要作用机制包括调节丘脑-皮层网络、影响神经振荡活动及调控神经递质系统。动物实验及初步人体研究证实，TI已在健康人中实现对深部脑区的非侵入性调控，但在DOC患者中的临床疗效尚待正在进行的临床试验验证。目前相关证据仍主要来源于动物实验及小样本研究，缺乏统一刺激参数及高质量临床试验证据。

结论

TI可实现对深部脑区的非侵入性调控，针对DOC患者的促醒康复具有潜在的研究价值，但其临床疗效及安全性仍需通过大规模随机对照研究进一步验证。

关键词

时域干涉刺激 / 意识障碍 / 神经调控 / 丘脑-皮层网络 / 微小意识状态

Abstract

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Objective

To systematically review the mechanisms of temporal interference stimulation (TI) and summarize its current research progress in disorders of consciousness (DOC).

Methods

A comprehensive literature search was conducted in PubMed, EBSCOhost, and Google Scholar to identify studies related to TI stimulation. Both animal experiments and human studies were included. The neurophysiological mechanisms and clinical evidence of TI were analyzed through a narrative review and qualitative synthesis.

Results

Current evidence suggests that TI can selectively modulate deep brain structures by generating amplitude-modulated electric fields within brain tissue. Its neuromodulatory effects are primarily associated with the regulation of thalamocortical networks, neural oscillatory activity, and neurotransmitter systems. Animal experiments and preliminary human studies have indicated that TI can achieve non-invasive modulation of deep brain regions in healthy individuals; however, its clinical efficacy in patients with (DOC) remains to be validated by ongoing clinical trials. At present, the available evidence is still mainly derived from animal experiments and small-sample studies, and standardized stimulation parameters as well as high-quality clinical trial evidence are lacking.

Conclusion

As an emerging non-invasive deep brain neuromodulation technique, TI has been demonstrated to enable non-invasive modulation of deep brain regions in healthy individuals and may have potential research value for arousal-promoting rehabilitation in patients with DOC. Nevertheless, its clinical efficacy and safety require further validation through large-scale randomized controlled trials.

Key words

Temporal interference stimulation / Disorders of consciousness / Neuromodulation / Thalamocortical network / Minimally conscious state

引用本文

茆梓恒, 李晨曦, 杨心怡, 张艳正, 陈树耿. 时域干涉刺激在意识障碍中的机制研究与临床证据综述. 现代仪器与医疗, 2026 , 32 (4) : 45 -51 . DOI: 10.11876/mimt202604006

Ziheng Mao, Chenxi Li, Xinyi Yang, Yanzheng Zhang, Shugeng Chen. Mechanisms and clinical evidence of temporal interference stimulation in disorders of consciousness: a review[J]. Modern Instruments & Medical Treatment, 2026 , 32 (4) : 45 -51 . DOI: 10.11876/mimt202604006

基金

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上海市养老科技专项(24YL1900202)
国家自然科学基金资助项目(82202798)
上海扬帆专项(22YF1404200)

参考文献

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文献

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参考文献引证文献

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2026年第32卷第4期

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文章信息

doi: 10.11876/mimt202604006

接收时间：2026-04-29
首发时间：2026-10-23
出版时间：2026-08-10

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收稿日期：2026-04-29

基金

上海市养老科技专项(24YL1900202)

国家自然科学基金资助项目(82202798)

上海扬帆专项(22YF1404200)

作者信息

^1.上海市誉华康复医院康复医学科，上海　201700

^2.上海中医药大学康复医学院，上海　201203

^3.复旦大学附属华山医院康复医学科，上海　200040

通讯作者:

陈树耿，男，博士研究生，主管治疗师，研究方向：脑机接口与神经康复

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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