现代仪器与医疗

基于专利分析的环境响应智能膜发展态势研究

PDF下载

郭美圆 , 刘键 , 桑元

现代仪器与医疗 | 综述 2026,32(3): 124-132

收起

现代仪器与医疗 |综述 2026 , 32 (3) : 124 -132

基于专利分析的环境响应智能膜发展态势研究

全屏

[Author(id=1320381209222431462, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381209335677672, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209222431462, language=EN, stringName=Meiyuan Guo, firstName=Meiyuan, middleName=null, lastName=Guo, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381209448923881, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209222431462, language=CN, stringName=郭美圆, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家知识产权局专利局专利审查协作河南中心，郑州　450000, bio={"content":"

郭美圆，女，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查；

"}, bioImg=null, bioContent=

郭美圆，女，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查；

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1320381209151128290, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, xref=null, ext=[AuthorCompanyExt(id=1320381209155322595, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China), AuthorCompanyExt(id=1320381209163711204, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家知识产权局专利局专利审查协作河南中心，郑州　450000)])]), Author(id=1320381209511838443, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381209595724525, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209511838443, language=EN, stringName=Jian Liu, firstName=Jian, middleName=null, lastName=Liu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381209667027694, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209511838443, language=CN, stringName=刘键, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家知识产权局专利局专利审查协作河南中心，郑州　450000, bio={"content":"

刘键，男，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查

"}, bioImg=null, bioContent=

刘键，男，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1320381209151128290, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, xref=null, ext=[AuthorCompanyExt(id=1320381209155322595, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China), AuthorCompanyExt(id=1320381209163711204, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家知识产权局专利局专利审查协作河南中心，郑州　450000)])]), Author(id=1320381209734136560, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381209805439730, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209734136560, language=EN, stringName=Yuan Sang, firstName=Yuan, middleName=null, lastName=Sang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381211457995507, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, authorId=1320381209734136560, language=CN, stringName=桑元, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家知识产权局专利局专利审查协作河南中心，郑州　450000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1320381209151128290, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, xref=null, ext=[AuthorCompanyExt(id=1320381209155322595, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China), AuthorCompanyExt(id=1320381209163711204, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381208568120031, companyId=1320381209151128290, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家知识产权局专利局专利审查协作河南中心，郑州　450000)])])]

郭美圆, 刘键, 桑元

作者信息

国家知识产权局专利局专利审查协作河南中心，郑州　450000

作者简介:

郭美圆，女，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查；

刘键，男，硕士研究生，知识产权师，研究方向：半透膜，气体分离，混合专利审查

Research on the development trend of environment-responsive smart membranes based on patent analysis

Meiyuan Guo, Jian Liu, Yuan Sang

Affiliations

Patent Examination Cooperation (Henan) Center of the Patent Office, CNIPA, Zhengzhou 450000, China

出版时间: 2026-06-10 doi: 10.11876/mimt202603018

文章导航

摘要

收起

环境响应智能膜由多孔膜基材和能感应外界环境刺激的聚合物功能开关两部分构成，通过外界环境的刺激改变智能膜自身的物理化学性质，从而实现分离性能或其他性能的主动调控。环境响应智能膜因其独特的性质在多个领域得到广泛应用，是当前的研究热点。本文采用定量与定性相结合的研究方法，分析了智能膜技术专利申请量变化趋势、主要来源国分布、主要申请人排名、各技术分支申请量对比情况，并进一步对重点技术进行了详细分析，包括：温度响应的低临界溶解温度（lower critical solution temperature，LCST）相变特性；分子识别的印迹与涂覆技术；光响应的光致动器、光致变色和光刺激催化3类方向；pH响应的接枝共混与响应灵敏度提升。研究表明，中国是环境响应智能膜的主要申请来源国，主要申请人为高校，企业申请量占比较低，温度响应、分子识别、光响应和pH响应智能膜是重点研发方向。未来应重点发展生物刺激响应膜与仿生设计膜，持续优化温度和pH响应膜性能、拓展光响应膜应用、推动分子识别膜功能转化，并通过产学研协同加速产业转化。

关键词

智能膜 / 环境响应 / 专利分析

Abstract

收起

Environment-responsive smart membranes consist of two components: a porous membrane substrate and a polymeric functional switch that senses external environmental stimuli. Through external environmental stimuli, the physical and chemical properties of the smart membrane are altered, thereby enabling active regulation of separation performance or other functionalities. Due to their unique properties, environment-responsive smart membranes have been widely applied in various fields and are currently a research hotspot. This paper adopts a combination of quantitative and qualitative research methods to analyze the changing trend in patent applications, the distribution of major source countries, the ranking of major applicants, and the comparison of application volumes across different technical branches in the field of smart membrane technology. Furthermore, it provides a detailed analysis of key technologies, including the LCST phase transition characteristics of temperature-responsive membranes, imprinting and coating techniques for molecularly responsive membranes, three directions of light-responsive membranes—photoactuators, photochromism, photocatalysis, as well as graft blending and response sensitivity enhancement for pH-responsive membranes. The research shows that China is the major source country for environment-responsive smart membrane patent applications, with universities being the main applicants and enterprises accounting for a relatively low share. Temperature-responsive, molecularly responsive, light-responsive, and pH-responsive smart membranes are the key research and development directions. To this end, future efforts should focus on developing bio-stimuli-responsive membranes and biomimetic membranes, continuously optimizing the performance of temperature and pH-responsive membranes, expanding the applications of light-responsive membranes, promoting the functional transformation of molecularly responsive membranes, and accelerating industrial transformation through industry-university-research collaboration.

Key words

Smart membrane / Environmental response / Patent analysis

引用本文

郭美圆, 刘键, 桑元. 基于专利分析的环境响应智能膜发展态势研究. 现代仪器与医疗, 2026 , 32 (3) : 124 -132 . DOI: 10.11876/mimt202603018

Meiyuan Guo, Jian Liu, Yuan Sang. Research on the development trend of environment-responsive smart membranes based on patent analysis[J]. Modern Instruments & Medical Treatment, 2026 , 32 (3) : 124 -132 . DOI: 10.11876/mimt202603018

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

[1]

罗鹏, 冯弘宬, 肖晓勤, 等. 环境响应型智能膜的制备研究进展[J]. 广东化工, 2018, 45(14): 142-144.

[2]

Li Y, Zhao J, Zhang J, et al. Smart and solvent-switchable graphene-based membrane for graded molecular sieving[J]. Nature Communications, 2025, 16: 5363.

[3]

Yan H, Kou Y, Zhang S, et al. Flexible erythritol-based spatiotemporal phase change films with multiple energy responses for wearable thermal management[J]. Chemical Engineering Journal, 2025, 522: 167630.

[4]

Hefnawy A, Aziz Aljar M A, Abd-Rabboh H S M, et al. Functionalized asymmetric PVC membrane with molecularly imprinted beads for potentiometric sensing of tetrabromobisphenol A (TBBPA)[J]. Environmental Science: Nano, 2025, 12(12): 5281-5295.

[5]

杨彪, 杨万泰. 光接枝制备功能性核孔膜[J]. 膜科学与技术, 2003, 23(4): 38-44.

[6]

Allen A L, Tan K J, Fu H, et al. Solute- and temperature-responsive “smart” grafts and supported membranes formed by covalent layer-by-layer assembly[J]. Langmuir, 2012, 28(11): 5237-5242.

[7]

Xing H, Hwang K, Lu Y. Recent developments of liposomes as nanocarriers for theranostic applications[J]. Theranostics, 2016, 6(9): 1336-1352.

[8]

胡志民. 功能化脂质体的构建及其抑制变形链球菌生物膜的应用研究&临床病例报告[D]. 武汉: 武汉大学, 2023.

[9]

Dash M, Chiellini F, Ottenbrite R M, et al. Chitosan: a versatile semi-synthetic polymer in biomedical applications[J]. Progress in Polymer Science, 2011, 36(8): 981-1014.

[10]

Tan H, Marra K G. Injectable, biodegradable hydrogels for tissue engineering applications[J]. Materials, 2010, 3(3): 1746-1767.

[11]

Hosseini M, Dadashi-Noshahr K, Islami M, et al. A novel silk/PES hybrid nanofibrous scaffold promotes the in vitro proliferation and differentiation of adipose-derived mesenchymal stem cells into insulin producing cells[J]. Polymers for Advanced Technologies, 2020, 31(8): 1857-1864.

[12]

Rashki S, Asgarpour K, Tarrahimofrad H, et al. Chitosan-based nanoparticles against bacterial infections[J]. Carbohydrate Polymers, 2021, 251: 117108.

[13]

Assaad E, Maire M, Lerouge S. Injectable thermosensitive chitosan hydrogels with controlled gelation kinetics and enhanced mechanical resistance[J]. Carbohydrate Polymers, 2015, 130: 87-96.

[14]

Guo L, Liang Z, Yang L, et al. The role of natural polymers in bone tissue engineering[J]. Journal of Controlled Release, 2021, 338: 571-582.

[15]

Qi Y, Wang H, Wei K, et al. A review of structure construction of silk fibroin biomaterials from single structures to multi-level structures[J]. International Journal of Molecular Sciences, 2017, 18(3): 237.

[16]

Zhang Z H, Han Z, Zeng X A, et al. Enhancing mechanical properties of chitosan films via modification with vanillin[J]. International Journal of Biological Macromolecules, 2015, 81: 638-643.

2026年第32卷第3期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.11876/mimt202603018

接收时间：2025-11-20
首发时间：2026-10-23
出版时间：2026-06-10

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2025-11-20

基金

作者信息

国家知识产权局专利局专利审查协作河南中心，郑州　450000

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/xdyqyyl/CN/10.11876/mimt202603018

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT