现代仪器与医疗

低功率HIFU联合中频乳腺治疗仪治疗重症哺乳期乳腺炎的疗效研究

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闫丽娅 ¹ , 章超伟 ² , 赵洋 ³^,^*

现代仪器与医疗 | 临床研究 2026,32(4): 124-129

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现代仪器与医疗 |临床研究 2026 , 32 (4) : 124 -129

低功率HIFU联合中频乳腺治疗仪治疗重症哺乳期乳腺炎的疗效研究

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闫丽娅¹, 章超伟², 赵洋³^,^*

作者信息

^1.河北省直属机关第一门诊部，石家庄　050000

^2.张家口市第一医院健康管理科，张家口　075000

^3.石家庄市第四医院，石家庄　050000

通讯作者:

赵洋，男，本科，主治医师，研究方向：乳腺外科

作者简介:

闫丽娅，女，硕士研究生，副主任医师，研究方向：中西医结合外科

Efficacy of low-power HIFU combined with medium-frequency breast therapy device in treating severe mastitis during lactation

Liya Yan¹, Chaowei Zhang², Yang Zhao³^,^*

Affiliations

^1.The First Outpatient Department of the Direct Organs of Hebei Province, Shijiazhuang 050000, China

^2.Health Management Department of Zhangjiakou First Hospital, Zhangjiakou 075000, China

^3.The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China

出版时间: 2026-08-10 doi: 10.11876/mimt202604017

文章导航

摘要

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目的

探讨低功率高强度聚焦超声（high-intensity focused ultrasound，HIFU）联合中频乳腺治疗仪治疗重症哺乳期乳腺炎的临床疗效及其对患者免疫功能的影响。

方法

采用前瞻性随机对照研究设计，纳入2021年1月至2024年1月河北省直属机关第一门诊部和石家庄市第四医院收治的208例重症哺乳期乳腺炎患者，按治疗方式分为联合治疗组（104例）和对照组（104例），对照组采用常规治疗；联合治疗组在常规治疗基础上，加用低功率HIFU和中频乳腺治疗仪联合治疗。比较两组患者的退热时间、乳汁通畅率、疼痛程度[视觉模拟评分法（visual analogue scale，VAS）评分]及NK细胞活性、炎症因子水平。

结果

联合治疗组退热时间为（2.89±1.25）d，显著短于对照组的（5.21±1.58）d（P<0.001）；乳汁通畅率达94.23%，明显高于对照组的76.92%（P<0.001）；治疗后VAS评分降至（2.02±0.32）分，显著低于对照组的（3.56±1.17）分（P<0.001）；治疗后NK细胞活性显著升高（P<0.001），且明显高于对照组（P<0.001），血清IL-6、TNF-α水平均显著降低（P<0.001），且均明显低于对照组（P<0.001）。

结论

低功率HIFU联合中频乳腺治疗仪可显著提高重症哺乳期乳腺炎治疗效果，改善患者临床症状，其机制可能与调节机体免疫功能、降低炎症反应有关。

关键词

乳腺炎 / 低功率HIFU / 中频乳腺治疗仪 / 免疫功能 / NK细胞

Abstract

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Objective

To investigate the clinical efficacy of low-power high-intensity focused ultrasound (HIFU) combined with medium-frequency breast therapy device in the treatment of severe lactational mastitis and its impact on immune function.

Methods

A retrospective randomized controlled study was conducted, including 208 patients with severe lactational mastitis admitted from January 2021 to January 2024. Patients were divided into combined treatment group (104 cases, low-power HIFU + medium-frequency breast therapy device) and control group (104 cases, conventional treatment). The fever clearance time, milk flow rate, visual analogue scale (VAS) pain score, and peripheral blood NK cell activity and inflammatory factor levels were compared between the two groups.

Results

The fever clearance time in the combined treatment group was (2.89±1.25) days, significantly shorter than (5.21±1.58) days in the control group (P<0.001). The milk flow rate was 94.23%, significantly higher than 76.92% in the control group (P<0.001). The VAS pain score after treatment decreased to (2.02±0.32) points, significantly lower than (3.56±1.17) points in the control group (P<0.001). The activity of NK cells significantly increased (P<0.001), and was significantly higher than that of the control group (P<0.001). The levels of serum IL-6 and TNF-α significantly decreased (P<0.001), and were significantly lower than those of the control group (P<0.001).

Conclusion

Low-power HIFU combined with medium-frequency breast therapy device can significantly shorten the course of severe lactational mastitis and improve clinical symptoms. The mechanism may be related to regulating immune function and reducing inflammatory response.

Key words

Mastitis / Low-power HIFU / Medium-frequency breast therapy device / Immune function / NK cells

引用本文

闫丽娅, 章超伟, 赵洋. 低功率HIFU联合中频乳腺治疗仪治疗重症哺乳期乳腺炎的疗效研究. 现代仪器与医疗, 2026 , 32 (4) : 124 -129 . DOI: 10.11876/mimt202604017

Liya Yan, Chaowei Zhang, Yang Zhao. Efficacy of low-power HIFU combined with medium-frequency breast therapy device in treating severe mastitis during lactation[J]. Modern Instruments & Medical Treatment, 2026 , 32 (4) : 124 -129 . DOI: 10.11876/mimt202604017

基金

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河北省中医药管理局2026年度中医药类科学研究课题计划(2026404)

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2026年第32卷第4期

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文章信息

doi: 10.11876/mimt202604017

接收时间：2026-04-22
首发时间：2026-10-23
出版时间：2026-08-10

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收稿日期：2026-04-22

基金

河北省中医药管理局2026年度中医药类科学研究课题计划(2026404)

作者信息

^1.河北省直属机关第一门诊部，石家庄　050000

^2.张家口市第一医院健康管理科，张家口　075000

^3.石家庄市第四医院，石家庄　050000

通讯作者:

赵洋，男，本科，主治医师，研究方向：乳腺外科

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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