Article(id=1320381124120006726, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381108315870143, articleNumber=null, orderNo=null, doi=10.11876/mimt202603017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769616000000, receivedDateStr=2026-01-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792732991485, onlineDateStr=2026-10-23, pubDate=1781020800000, pubDateStr=2026-06-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792732991485, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792732991485, creator=13701087609, updateTime=1792732991485, updator=13701087609, issue=Issue{id=1320381108315870143, tenantId=1146029695717560320, journalId=1319373289681944729, year='2026', volume='32', issue='3', pageStart='1', pageEnd='132', issueExtLink='null', onlineDate='null', pubDate='1781020800000', pubDateStr='2026-06-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792732987716, creator='13701087609', updateTime=1792746098645, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320436099600728986, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381108315870143, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320436099600728987, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381108315870143, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=115, endPage=123, ext={EN=ArticleExt(id=1320381124329721927, articleId=1320381124120006726, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Application of super-resolution microscopic technology in cancer diagnosis and treatment, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Super-resolution microscopy (SRM) technology exhibits enormous application potential in the early diagnosis and treatment of cancer, owing to its capability of achieving ultra-high-resolution imaging of cellular structures or small-molecule substances at the nanoscale and even single-molecule level. This article systematically introduces the imaging principles of several mainstream SRM technologies, summarizes the commonly used fluorescent probe types of different technologies and the characteristics and specific application scenarios of each probe. Then, it outlines the application cases of SRM in early cancer diagnosis by observing diagnostic targets related to carbohydrates, membrane proteins, and exosomes. This demonstrates its core application value in identifying molecular distribution, monitoring structural changes, and revealing early cancer characteristics. It further introduces the advantages and specific applications of SRM in treating cancer through monitoring the endocytosis of nanomedicines, enhancing the efficacy of photodynamic therapy, and clarifying the mechanism of drug resistance. Finally, it discusses and analyzes the current shortcomings of SRM in imaging speed, probe stability, and clinical applicability, and looks forward to future research directions, aiming to promote the further application of SRM in cancer precision diagnosis and treatment.

, authors=Minghui Zhang^1a, Fuyan Liu^{1a, *}, Xinlei Song², Xuchen Wang^1a, Haojie Zheng^1a, Xiaofeng Zhang^{1a, b}, authorsList=Minghui Zhang, Fuyan Liu, Xinlei Song, Xuchen Wang, Haojie Zheng, Xiaofeng Zhang, authorCompany=null, correspAuthors=Fuyan Liu, authorNote=null, correspAuthorsNote=null, copyrightStatement=All copyrights in 2026 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320381126129078344, articleId=1320381124120006726, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=超分辨显微镜技术在癌症诊断与治疗中的应用, columnId=1320381099210027294, journalTitle=现代仪器与医疗, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

超分辨显微镜（super-resolution microscopy，SRM）技术因其可以在纳米尺度甚至单分子水平上对细胞结构或小分子物质进行超高分辨率成像，在癌症的早期诊断和治疗中展现出巨大的应用潜力。本文系统介绍了几种主流SRM技术的成像原理，梳理总结了不同技术常用的荧光探针类型及各类探针的特性和具体适用场景，归纳了SRM通过观察与碳水化合物、膜蛋白和外泌体相关的诊断靶点，对癌症进行早期诊断的应用案例，体现了其在识别分子分布、监测结构变化和揭示早期癌变特征等方面的核心应用价值。同时，介绍了SRM通过监测纳米药物入胞、提升光动力疗法疗效和阐明耐药机制等手段对癌症进行治疗的优势及具体应用，最后，讨论分析了当前SRM在成像速度、探针稳定性、临床适用性等方面的不足，并对未来的研究方向进行了展望，旨在推动SRM在癌症精准诊疗中的进一步应用。

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张明慧，女，硕士研究生，研究方向：蛋白类药物

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