现代仪器与医疗

5.0 T磁共振T2-MX3D-FS与3D-TOF-MRA融合序列在识别原发性三叉神经痛责任血管中的应用价值

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王宇晗 ¹^,² , 陈昊 ² , 刘梦秋 ² , 陈国澳 ¹^,² , 孙思琦 ¹^,² , 刘影 ¹^,²^,^*

现代仪器与医疗 | 临床研究 2026,32(2): 50-56

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现代仪器与医疗 |临床研究 2026 , 32 (2) : 50 -56

5.0 T磁共振T2-MX3D-FS与3D-TOF-MRA融合序列在识别原发性三叉神经痛责任血管中的应用价值

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王宇晗¹^,², 陈昊², 刘梦秋², 陈国澳¹^,², 孙思琦¹^,², 刘影¹^,²^,^*

作者信息

^1.皖南医科大学研究生学院，芜湖　241002

^2.中国科学技术大学附属第一医院（安徽省立医院）影像科，合肥　230036

通讯作者:

刘影，女，博士研究生，主任医师，研究方向：神经影像

作者简介:

王宇晗，男，本科，研究方向：颅脑磁共振成像

Application value of 5.0 T MRI T2-MX3D-FS and 3D-TOF-MRA fusion sequence in identifying responsible vessels in primary trigeminal neuralgia

Yuhan Wang¹^,², Hao Chen², Mengqiu Liu², Guoao Chen¹^,², Siqi Sun¹^,², Ying Liu¹^,²^,^*

Affiliations

^1.Graduate School of Wannan Medical University, Wuhu 241002, China

^2.Department of Radiology, the First Affiliated Hospital of USTC (Anhui Provincial Hospital), Hefei 230036, China

出版时间: 2026-04-10 doi: 10.11876/mimt202602008

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摘要

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目的

探讨5.0 T超高场强磁共振三维快速自旋回波T2加权压脂成像（T2-weighted 3D fast spin echo with fat suppression，T2-MX3D-FS）与三维时间飞跃法磁共振血管成像（three dimensional time of flight magnetic resonance angiography，3D-TOF-MRA）序列图像融合的新方法在识别原发性三叉神经痛（primary trigeminal neuralgia，PTN）责任血管中的应用价值，为临床确定神经血管压迫（neurovascular compression，NVC）提供更精准的影像诊断依据。

方法

回顾性分析2024年9月至2025年8月在中国科学技术大学附属第一医院诊断为PTN并行微血管减压术（microvascular decompression，MVD）的26例患者的临床及影像资料。所有患者术前均采用联影uMR Jupiter 5.0 T超导磁共振成像系统进行T2-MX3D-FS序列及3D-TOF-MRA序列扫描，并将原始图像传输至后处理工作站进行图像融合分析。以MVD术中所见责任血管作为判断的“金标准”，评估T2-MX3D-FS序列、3D-TOF-MRA序列以及二者融合序列判断NVC的能力和识别责任血管的准确性。

结果

26例患者中，有24例患者可见明确的NVC，MVD术中共发现责任血管39条。T2-MX3D-FS序列、3D-TOF-MRA序列与融合序列正确判断有无NVC的准确率分别为84.62%（22/26）、65.38%（17/26）及100%（26/26）。融合序列对判断NVC的准确率最高，高于任一单一序列，三种序列间的比较差异具有统计学意义（P=0.003 0）。T2-MX3D-FS序列、3D-TOF-MRA序列与融合序列正确识别责任血管的准确率为58.97%（23/39）、48.72%（19/39）及89.74%（35/39）。融合序列对责任血管的定性准确率显著高于单一序列，3种序列间比较差异具有统计学意义（P=0.000 2）。

结论

5.0 T超高场强磁共振凭借其极高的信噪比和空间分辨率，能够更清晰地显示三叉神经与周围微小血管的解剖关系。T2-MX3D-FS序列与3D-TOF-MRA序列在显示神经和血管方面具有互补性，将二者进行图像融合能显著提高对PTN责任血管的检出率、定性的准确性，为术前精准评估NVC的责任血管、制定个体化MVD手术方案提供了更为可靠的影像学依据，具有重要的临床转化价值及应用前景。

关键词

5.0 T磁共振 / 三叉神经痛 / 融合序列 / 责任血管 / 神经血管压迫 / T2-MX3D-FS / 3D-TOF-MRA

Abstract

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Objective

To investigate the application value of a novel image fusion method based on T2-weighted 3D fast spin echo with fat suppression (T2-MX3D-FS) and three dimensional time of flight magnetic resonance angiography (3D-TOF-MRA) sequences from 5.0 T ultra-high field magnetic resonance imaging in identifying the responsible vessels of primary trigeminal neuralgia (PTN), so as to provide more accurate imaging diagnostic evidence for the clinical confirmation of neurovascular compression (NVC).

Methods

A retrospective analysis was performed on the clinical and imaging data of 26 patients who were diagnosed with PTN and underwent microvascular decompression (MVD) at the First Affiliated Hospital of University of Science and Technology of China from September 2024 to August 2025. All patients underwent preoperative T2-MX3D-FS and 3D-TOF-MRA sequence scanning using a United Imaging uMR Jupiter 5.0 T superconducting MRI system, and the original images were transmitted to a post-processing workstation for image fusion analysis. Taking the responsible vessels identified during MVD as the diagnostic gold standard, we evaluated the ability of the T2-MX3D-FS sequence, 3D-TOF-MRA sequence, and the fusion sequence of the two to detect NVC, as well as their accuracy in identifying the responsible vessels.

Results

Among the 26 patients, definite NVC was observed in 24 patients, and a total of 39 responsible vessels were identified during MVD. The accuracy of the T2-MX3D-FS sequence, 3D-TOF-MRA sequence, and fusion sequence in correctly determining the presence or absence of NVC was 84.62% (22/26), 65.38% (17/26), and 100% (26/26), respectively. The fusion sequence had the highest accuracy for NVC detection, which was higher than that of any single sequence. The difference among the three sequences was statistically significant (P=0.003 0). The accuracy of the T2-MX3D-FS sequence, 3D-TOF-MRA sequence, and fusion sequence in correctly identifying responsible vessels was 58.97% (23/39), 48.72% (19/39), and 89.74% (35/39), respectively. The qualitative accuracy of the fusion sequence for responsible vessels was significantly higher than that of the single sequences, the difference among the three sequences was statistically significant (P=0.000 2).

Conclusion

5.0 T ultra-high-field MRI, by virtue of its extremely high signal-to-noise ratio and spatial resolution, allows for clearer visualization of the anatomical relationship between the trigeminal nerve and surrounding microvessels. The T2-MX3D-FS and 3D-TOF-MRA sequences complement each other in displaying nerves and blood vessels. Image fusion of these two sequences significantly improves the detection rate and characterization accuracy of the responsible vessels in PTN, providing a more reliable imaging basis for the precise preoperative assessment of NVC and the formulation of individualized MVD surgical plans, demonstrating significant clinical translational value and promising application prospects.

Key words

5.0 T MRI / Trigeminal neuralgia / Fusion sequence / Responsible vessel / Neurovascular compression / T2-MX3D-FS / 3D-TOF-MRA

引用本文

王宇晗, 陈昊, 刘梦秋, 陈国澳, 孙思琦, 刘影. 5.0 T磁共振T2-MX3D-FS与3D-TOF-MRA融合序列在识别原发性三叉神经痛责任血管中的应用价值. 现代仪器与医疗, 2026 , 32 (2) : 50 -56 . DOI: 10.11876/mimt202602008

Yuhan Wang, Hao Chen, Mengqiu Liu, Guoao Chen, Siqi Sun, Ying Liu. Application value of 5.0 T MRI T2-MX3D-FS and 3D-TOF-MRA fusion sequence in identifying responsible vessels in primary trigeminal neuralgia[J]. Modern Instruments & Medical Treatment, 2026 , 32 (2) : 50 -56 . DOI: 10.11876/mimt202602008

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2026年第32卷第2期

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doi: 10.11876/mimt202602008

首发时间：2026-10-23
出版时间：2026-04-10

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作者信息

^1.皖南医科大学研究生学院，芜湖　241002

^2.中国科学技术大学附属第一医院（安徽省立医院）影像科，合肥　230036

通讯作者:

刘影，女，博士研究生，主任医师，研究方向：神经影像

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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