Article(id=1320381097280647452, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381076653060187, articleNumber=null, orderNo=null, doi=10.11876/mimt202602016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792732985085, onlineDateStr=2026-10-23, pubDate=1775750400000, pubDateStr=2026-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792732985085, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792732985085, creator=13701087609, updateTime=1792732985085, updator=13701087609, issue=Issue{id=1320381076653060187, tenantId=1146029695717560320, journalId=1319373289681944729, year='2026', volume='32', issue='2', pageStart='1', pageEnd='120', issueExtLink='null', onlineDate='null', pubDate='1775750400000', pubDateStr='2026-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792732980168, creator='13701087609', updateTime=1792746330832, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437073467789517, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381076653060187, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437073467789518, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320381076653060187, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=96, endPage=103, ext={EN=ArticleExt(id=1320381099096781085, articleId=1320381097280647452, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Research progress of Gamma rhythmic stimulation for the treatment of Alzheimer's disease, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=

With the intensification of population aging, Alzheimer's disease (AD), as the main type of dementia, has attracted increasing attention due to its high incidence and heavy disease burden. The pathogenesis of AD remains unclear, and existing drug therapies still face significant limitations in terms of efficacy, accessibility, and economic burden. Therefore, non-pharmacological interventions have become a research hotspot. Gamma rhythm, a neural oscillation at 30~100 Hz in the brain, is closely related to cognitive function, and its attenuation is an important feature of cognitive impairment in AD. Gamma rhythmic stimulation enhances brain gamma oscillations through neural entrainment, showing great potential in AD intervention. This study systematically retrieved relevant literature from China National Knowledge Infrastructure database and Web of Science Core Collection from January 1, 2015 to June 30, 2025. It reviewed the researches of gamma rhythmic stimulation in the treatment of AD. The results show that gamma rhythmic stimulation exerts neuroprotective and cognitive-improving effects through multiple pathways, such as reducing amyloid β-protein (Aβ) deposition and tau hyperphosphorylation. Among them, audiovisual combined multimodal stimulation has entered phase III clinical trials, with good safety and compliance in home-based interventions. However, several key issues remain to be addressed in this field, including inconsistent stimulation parameters, incompletely clarified mechanisms, insufficient reproducibility of clinical effects, and lack of a standardized verification system. In the future, it is necessary to establish a neural entrainment verification standard based on electroencephalography/quantitative electroencephalography (EEG/qEEG), standardize stimulation parameters, develop precise and wearable closed-loop devices, promote multimodal synergistic interventions, and deepen research on molecular and circuit mechanisms. These efforts will accelerate the translational application of gamma rhythmic stimulation from basic research to standardized clinical practice for AD.

, authors=Geng Zhu, Xiaoli Wang, Yuqing Zhou, Yicheng Cao, Zhihui Liu, Huaichao Shang^*, authorsList=Geng Zhu, Xiaoli Wang, Yuqing Zhou, Yicheng Cao, Zhihui Liu, Huaichao Shang, authorCompany=null, correspAuthors=Huaichao Shang, authorNote=null, correspAuthorsNote=null, copyrightStatement=All copyrights in 2026 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320381099440714015, articleId=1320381097280647452, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=Gamma节律刺激在阿尔茨海默病治疗中的应用研究进展, columnId=1320381099210027294, journalTitle=现代仪器与医疗, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

随着人口老龄化加剧，阿尔茨海默病（Alzheimer's disease，AD）作为痴呆的主要类型，因其高发病率与所造成的沉重社会负担而备受关注。AD发病机制尚未完全明确，现有药物治疗在疗效、可及性和经济负担等方面仍存在显著局限，非药物干预成为当前研究热点。Gamma节律作为大脑30~100 Hz神经振荡，与认知功能密切相关，其减弱是AD认知障碍的重要特征。Gamma节律刺激通过神经夹带效应增强大脑Gamma神经振荡，在AD干预中展现出巨大潜力。本文系统检索中国知网和Web of Science（WOS）核心数据库2015年1月1日至2025年6月30日的相关文献，围绕Gamma节律刺激治疗AD的研究进展进行综述。结果表明，Gamma节律刺激可通过减少β-淀粉样蛋白（amyloid β-protein，Aβ）沉积与tau蛋白过度磷酸化等多种途径发挥神经保护与认知改善作用，其中视听联合多模态刺激已进入Ⅲ期临床试验，居家干预安全性与依从性良好。但该领域仍存在参数不统一、机制未完全明确、临床效应可重复性不足、缺乏标准化验证体系等问题。未来需建立基于脑电图（electroencephalography，EEG）/定量脑电图（quantitative electroencephalography，qEEG）的神经夹带验证标准，规范刺激参数，研发精准可穿戴闭环设备，推进多模态协同干预，并深化分子与环路机制研究，以加速Gamma节律刺激从基础研究向AD临床规范化应用转化。

, authors=朱耿, 王晓理, 周雨晴, 曹熠程, 刘智慧, 商怀超^*, authorsList=朱耿, 王晓理, 周雨晴, 曹熠程, 刘智慧, 商怀超, authorCompany=null, correspAuthors=商怀超, authorNote=, correspAuthorsNote=, copyrightStatement=2026年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=+huHtE7RXexDvB6WpnwcFw==, magXml=uN9p2Ad/Xy8rAxcXqNC42g==, pdfUrl=null, pdf=T80EqFhJojMHngLYJOsWRw==, pdfFileSize=1582484, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=r+G5dDwbCB+uFWhBDU/MnQ==, mapNumber=null, fund=null)}, authors=[Author(id=1320381099763675428, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381097280647452, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320381099839172902, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381097280647452, authorId=1320381099763675428, language=EN, stringName=Geng Zhu, firstName=Geng, middleName=null, lastName=Zhu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=School of Medical Institute, Shanghai University of Medicine & Health Science, Shanghai 201318, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320381099897893159, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320381097280647452, authorId=1320381099763675428, language=CN, stringName=朱耿, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海健康医学院医疗器械学院，上海　201318, bio={"content":"

朱耿，女，博士研究生，讲师，研究方向：主要从事脑疾病在神经网络水平的机制及相关治疗方面的研究

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朱耿，女，博士研究生，讲师，研究方向：主要从事脑疾病在神经网络水平的机制及相关治疗方面的研究

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