Article(id=1320388812107268796, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, articleNumber=null, orderNo=null, doi=10.11876/mimt202506009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734824444, onlineDateStr=2026-10-23, pubDate=1765296000000, pubDateStr=2025-12-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734824444, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734824444, creator=13701087609, updateTime=1792734824444, updator=13701087609, issue=Issue{id=1320388792901554957, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='6', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1765296000000', pubDateStr='2025-12-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734819865, creator='13701087609', updateTime=1792746371372, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437243483902178, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437243483902179, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=53, endPage=58, ext={EN=ArticleExt(id=1320388812296012478, articleId=1320388812107268796, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Analysis of marginal expansion in intensity-modulated radiotherapy for lung cancer based on CBCT images, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To obtain the target center positioning errors and the maximum tumor displacement positioning errors within the target volume for lung cancer patients during radiotherapy through cone-beam computed tomography (CBCT) image registration, and to determine two corresponding expansion margin respectively. To explore the influence of these two expansion margins on radiotherapy planning and treatment delivery for lung cancer patients, thereby improving the accuracy of clinical target volume to planning target volume (CTV-PTV) margin delineation.
Methods A retrospective analysis was conducted on CBCT images from 40 lung cancer patients who underwent itensity-modulated radiation therapy (IMRT) in the Radiotherapy Department of Southern Hospital, Southern Medical University, between March and September 2024. Displacement data were collected using two registration methods: target center registration and maximum tumor displacement registration within the target volume. The expansion margins for both registration methods were calculated based on the classic formula for MPTV (margin of planning target volume) expansion.
Results A total of 227 CBCT scans from the 40 lung cancer patients were analyzed. Statistics showed that under the target center registration method, the positioning errors in the anterior-posterior (AP), head-foot (HF), and left-right (LR) directions were (-0.019±0.218) cm, (0.028±0.239) cm, and (0.022±0.217) cm, respectively. Under the maximum tumor displacement registration method, the positioning errors in the AP, HF, and LR directions were (-0.017±0.205) cm, (0.038±0.290) cm, and (0.025±0.241) cm, respectively. The intra-class correlation coefficient (ICC) method confirmed a high consistency between the two datasets. Using the classic formula, the calculated expansion margins for the target center registration method in the AP, HF, and LR directions were 0.373 cm, 0.477 cm, and 0.466 cm, respectively. For the maximum tumor displacement registration method, the corresponding margins were 0.429 cm, 0.602 cm, and 0.506 cm.
Conclusion The target center registration and maximum tumor displacement registration within the target volume were performed using CBCT images of lung cancer patients, two sets of positioning errors and expansion margins were obtained. The ICC consistency test demonstrated good agreement between the two datasets. These results can serve as a theoretical basis for determining CTV-PTV margins in lung cancer radiotherapy and possess practical clinical application value.
, authors=Xiqu Ye, Xinyu Li
*, authorsList=Xiqu Ye, Xinyu Li, authorCompany=null, correspAuthors=Xinyu Li, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320388812862243519, articleId=1320388812107268796, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=基于CBCT图像的肺癌调强放射治疗外扩边界分析, columnId=1320381058969883180, journalTitle=现代仪器与医疗, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 通过锥形束计算机断层扫描（cone-beam computed tomography，CBCT）图像配准获取肺癌患者在放射治疗过程中靶区中心摆位误差和靶区内肿瘤最大位移摆位误差，分别得出两个外扩边界，探讨两个外扩边界对肺癌患者放射治疗计划与治疗过程的影响，提升临床靶区-计划靶区（clinical target volume-planning target volume，CTV-PTV）外扩的精确性。
方法 回顾性分析2024年3月—9月期间在南方医科大学南方医院放疗科行调强放射治疗（intensity-modulated radiotherapy，IMRT）的共40例肺癌患者的CBCT图像，用靶区中心配准和靶区内肿瘤最大位移配准两种方法收集位移量数据，根据外扩边界经典公式计算出两种配准方式下的外扩边界（margin of planning target volume，MPTV）。
结果 40例肺癌患者共227次CBCT扫描，统计得出在靶区中心配准方式下前后、头脚、左右方向的摆位误差分别为（-0.019±0.218）cm、（0.028±0.239）cm、（0.022±0.217）cm；靶区内肿瘤最大位移配准方式下前后、头脚、左右方向的摆位误差分别为（-0.017±0.205）cm、（0.038±0.290）cm、（0.025±0.241）cm。利用组内相关系数法（intra-class correlation coefficient，ICC）验证得出两组数据一致性高。利用经典公式计算出靶区中心配准方式在前后、头脚、左右方向的外扩边界分别为0.373 cm、0.477 cm、0.466 cm；靶区内肿瘤最大位移配准方式在前后、头脚、左右方向的外扩边界分别为0.429 cm、0.602 cm、0.506 cm。
结论 通过肺癌患者CBCT图像进行靶区中心配准和靶区内肿瘤最大位移配准，得出两组摆位误差和外扩边界，并通过ICC一致性检验证明两组数据具有一致性，此结果可作为肺癌患者CTV-PTV外扩边界的理论依据，具有实际的临床应用价值。
, authors=叶锡渠, 李新宇
*, authorsList=叶锡渠, 李新宇, authorCompany=null, correspAuthors=李新宇, authorNote=
叶锡渠，男，本科，助理工程师，研究方向：各专科误差分析、体位固定模具制作和加速器日常操作维护
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李新宇，男，硕士研究生，工程师，研究方向：肿瘤放射治疗前沿技术及其临床应用
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2025年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=Tt3/LBUcntj8v5q5YWlElA==, magXml=BI0SWadmskplCzZo+AFGoA==, pdfUrl=null, pdf=aNzmrnZk4SB+RTqYkwBV6Q==, pdfFileSize=2207741, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=3yjwG8vibbEMlz9CsxdpjQ==, mapNumber=null, fund=null)}, authors=[Author(id=1320388813147456196, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388812107268796, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320388813252313798, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388812107268796, authorId=1320388813147456196, language=EN, stringName=Xiqu Ye, firstName=Xiqu, middleName=null, lastName=Ye, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320388813315228359, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388812107268796, authorId=1320388813147456196, language=CN, stringName=叶锡渠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南方医科大学南方医院放疗科，广州 510515, bio={"content":"
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