Article(id=1320388802737193592, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, articleNumber=null, orderNo=null, doi=10.11876/mimt202506004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734822209, onlineDateStr=2026-10-23, pubDate=1765296000000, pubDateStr=2025-12-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734822209, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734822209, creator=13701087609, updateTime=1792734822209, updator=13701087609, issue=Issue{id=1320388792901554957, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='6', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1765296000000', pubDateStr='2025-12-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734819865, creator='13701087609', updateTime=1792746371372, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437243483902178, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437243483902179, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388792901554957, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=20, endPage=25, ext={EN=ArticleExt(id=1320388802909160058, articleId=1320388802737193592, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Analysis of regional brain activity changes in Parkinson's disease patients with excessive daytime sleepiness by MRI, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the alteration of brain regional homogeneity (ReHo) in Parkinson's disease (PD) patients with excessive daytime sleepiness (EDS) by resting-state functional MRI.
Methods Total of 56 PD patients and age, gender and education level-matched 25 healthy controls underwent clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI). Patients were further divided into PD with EDS (n=27) and PD without EDS (n=29), according to the Epworth sleepiness scale (ESS). The data was processed by DPABI based on MATLAB. ANCOVA and post hoc two-sample t-tests were performed to examine between-groups differences of ReHo. Correlation analyses were performed between ReHo values of the regions showing group differences and ESS scores respectively.
Results Compared to the HC group, the ReHo values of the left superior temporal gyrus, left pallidum and left caudate in the PD with EDS group were decreased, while the right angular and right superior frontal gyrus were increased (P<0.05, FDR corrected). Compared to the PD without EDS group, the ReHo values of the left superior temporal gyrus in the PD with EDS group were decreased, while the left thalamus and left middle occipital gyrus were increased (P<0.05, FDR corrected). Additionally, ReHo values of the left superior temporal gyrus in the PD with EDS group differing brain regions was negatively correlated with ESS scores (r=-0.45, P<0.05).
Conclusion There are abnormal brain activities of the basal ganglia region and dorsal attention network in PD with EDS, it is helpful to exlpain the neurophysiological mechanisms of PD with EDS.
, authors=Yongfeng Jia, Xinxin Miao, Peixian Ji, Jianwei Wang, Min Wang, Jun Liu
*, authorsList=Yongfeng Jia, Xinxin Miao, Peixian Ji, Jianwei Wang, Min Wang, Jun Liu, authorCompany=null, correspAuthors=Jun Liu, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320388803290841723, articleId=1320388802737193592, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=帕金森病伴日间过度嗜睡患者静息状态下局部脑功能改变的磁共振研究, columnId=1320381058969883180, journalTitle=现代仪器与医疗, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨帕金森病（Parkinson's disease，PD）伴日间过度嗜睡（excessive daytime sleepiness，EDS）的患者静息状态下局部脑功能的改变。
方法 收集56例PD患者和25例年龄、性别、教育程度相匹配的健康对照者的静息态功能磁共振（resting-state functional MRI，rs-fMRI）图像，根据Epworth嗜睡量表（Epworth sleepiness scale，ESS）评分将PD患者分为PD伴EDS（PD-EDS）27例和PD不伴EDS（PD-nonEDS）29例。采用基于MATLAB的DPABI软件进行数据处理，运用协方差分析和Post-Hoc t检验观察组间局部一致性（regional homogeneity，ReHo）的差异，并提取差异脑区的ReHo值，利用Pearson相关分析计算其与ESS评分的相关性。
结果 PD-EDS组、PD-nonEDS组及HC组的ReHo值有显著性差异，组间Post-Hoc t检验显示，与HC组比较，PD-EDS组的左侧颞上回、左侧苍白球、左侧尾状核ReHo值减低，右侧角回、右侧额上回ReHo值升高（P<0.05，FDR校正）；与PD-nonEDS组比较，PD-EDS组的左侧颞上回ReHo值减低，左侧丘脑、左侧枕中回ReHo值升高（P<0.05，FDR校正）。Pearson相关分析结果显示PD-EDS组差异脑区左侧颞上回的ReHo值与ESS评分呈负相关，相关系数为-0.45（P<0.05）。
结论 PD-EDS患者静息态脑功能活动ReHo异常改变的脑区主要集中在基底节区及背侧注意网络相关脑区，提示EDS的发生可能与这些脑区功能活动局部一致性异常有关，有助于进一步探知PD伴发EDS的神经病理机制。
, authors=贾永锋, 苗新欣, 姬佩弦, 王建伟, 王敏, 刘俊
*, authorsList=贾永锋, 苗新欣, 姬佩弦, 王建伟, 王敏, 刘俊, authorCompany=null, correspAuthors=刘俊, authorNote=
贾永锋，男，硕士研究生，住院医师，研究方向：中枢神经系统影像诊断
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刘俊，男，本科，副主任技师，研究方向：医学影像处理
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2025年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=1LFrh8xPorWYxPL4U60YXQ==, magXml=5nIgCKPrtQLDCTNcXPGthw==, pdfUrl=null, pdf=zytZAgFvyGuQ9UcmHFGdvw==, pdfFileSize=1977617, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=29CJLM05ur3D0/jSonotyg==, mapNumber=null, fund=null)}, authors=[Author(id=1320388803580248704, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388802737193592, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320388803676717698, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388802737193592, authorId=1320388803580248704, language=EN, stringName=Yongfeng Jia, firstName=Yongfeng, middleName=null, lastName=Jia, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320388803743826563, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388802737193592, authorId=1320388803580248704, language=CN, stringName=贾永锋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学第一附属医院放射科，南京 210029, bio={"content":"
贾永锋，男，硕士研究生，住院医师，研究方向：中枢神经系统影像诊断
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