现代仪器与医疗

基于平面回波成像读出方式的5 T超高场多延迟动脉自旋标记灌注成像研究

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范培琳 ¹ , 李钟惠 ¹ , 韩华璐 ² , 范晓媛 ¹ , 刘思敏 ² , 陈硕 ² , 有慧 ¹ , 冯逢 ¹^,^*

现代仪器与医疗 | 5.0 T超高场磁共振成像专栏 2025,31(6): 7-12

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现代仪器与医疗 |5.0 T超高场磁共振成像专栏 2025 , 31 (6) : 7 -12

基于平面回波成像读出方式的5 T超高场多延迟动脉自旋标记灌注成像研究

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范培琳¹, 李钟惠¹, 韩华璐², 范晓媛¹, 刘思敏², 陈硕², 有慧¹, 冯逢¹^,^*

作者信息

^1.中国医学科学院北京协和医院放射科，北京　100730

^2.上海联影医疗科技股份有限公司，上海　201807

通讯作者:

冯逢，女，博士研究生，主任医师，研究方向：中枢神经系统磁共振成像

作者简介:

范培琳，女，硕士研究生，技师，研究方向：中枢神经系统磁共振成像技术

Multi-delay arterial spin labeling perfusion imaging at 5 T ultra-high field based on echo-planar imaging readout

Peilin Fan¹, Zhonghui Li¹, Hualu Han², Xiaoyuan Fan¹, Simin Liu², Shuo Chen², Hui You¹, Feng Feng¹^,^*

Affiliations

^1.Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

^2.Shanghai United Imaging Medical Technology Co., Ltd., Shanghai 201807, China

出版时间: 2025-12-10 doi: 10.11876/mimt202506002

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摘要

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目的

在5 T超高场MRI平台上，建立多延迟准连续式动脉自旋标记（multi-delay pseudocontinuous arterial spin labeling，MD pCASL）扫描方案，比较三维回波平面成像（three-dimensional echo-planar imaging，3D-EPI）与三维梯度和自旋回波（three-dimensional gradient and spin echo，3D-GRASE）两种读出序列在脑灌注成像的图像质量上的差异以及定量结果的相关性，探讨3D-EPI在超高场高分辨率MD pCASL中的应用价值。

方法

纳入10名健康志愿者，均在5 T MRI系统上接受MD pCASL扫描，延迟时间设为500～3 000 ms。分别采用3D-EPI与3D-GRASE读出序列，空间分辨率一致。通过FMRIB软件库中的BASIL工具计算脑血流量（cerebral blood flow，CBF）和动脉传输时间（arterial transit time，ATT），并使用模糊质量指标（blur quality metric，BQM）及主观评分评价图像质量。

结果

两种序列均成功获得可用的灌注图像。定性与定量图像质量分析表明，3D-EPI在层面方向模糊度方面（BQM）显著低于3D-GRASE（0.23±0.02 vs. 0.35±0.02），主观评分亦显著更高[10.00（8.00，11.00）分vs. 4.00（4.00，4.00）分]，说明3D-EPI的解剖保真度优于3D-GRASE；同时3D-EPI总扫描时间较短（4 min13 s vs. 5 min18 s）。定量结果显示，两种序列在全脑及灰白质分区的CBF与ATT值上相关性较显著。

结论

在5 T超高场MD pCASL成像中，3D-EPI相较于3D-GRASE显著改善图像结构清晰度并缩短扫描时间，同时保持CBF与ATT定量结果的一致性。3D-EPI有望成为超高场高分辨率ASL成像更优的读出选择，为小病灶检测及复杂血流动力学分析提供可靠支持。

关键词

动脉自旋标记 / 超高场磁共振 / 3D-EPI / 3D-GRASE / 脑灌注成像

Abstract

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Objective

To establish a multi-delay pseudocontinuous arterial spin labeling (MD pCASL) protocol on a 5 T ultra-high-field MRI system and to compare the performance of three-dimensional echo-planar imaging (3D-EPI) and three-dimensional gradient and spin echo (3D-GRASE) readout sequences in cerebral perfusion imaging. The study also aims to assess the potential of 3D-EPI for high-resolution MD pCASL at ultra-high field strength.

Methods

Ten healthy volunteers underwent MD pCASL examinations on a 5 T MRI system with post-labeling delays ranging from 500 to 3,000 ms. Both 3D-EPI and 3D-GRASE sequences were acquired using the same spatial resolution. Cerebral blood flow (CBF) and arterial transit time (ATT) were calculated using the BASIL toolbox in the FMRIB Software Library. Image quality was evaluated using the blur quality metric (BQM) and subjective scoring.

Results

Both sequences produced perfusion images of acceptable quality. Quantitative and qualitative assessments showed that 3D-EPI had significantly lower through-plane blurring than 3D-GRASE (BQM: 0.23±0.02 vs. 0.35±0.02). The subjective scores were also higher for 3D-EPI [3D-GRASE: 4.00 (4.00, 4.00); 3D-EPI: 10.00 (8.00, 11.00)], indicating better anatomical clarity. In addition, 3D-EPI achieved a shorter scan time (4 min 13 s vs. 5 min 18 s). CBF and ATT values derived from the two sequences showed strong correlations across the whole brain and within gray and white matter.

Conclusion

In 5 T MD pCASL imaging, 3D-EPI provides improved structural sharpness and reduced scan time compared with 3D-GRASE, while maintaining good agreement in CBF and ATT quantification. These results suggest that 3D-EPI is a promising readout option for high-resolution ASL at ultra-high field and may enhance the detection of small lesions and the evaluation of complex hemodynamic features.

Key words

Arterial spin labeling / Ultrahigh-field MRI / 3D-EPI / 3D-GRASE / Cerebral perfusion imaging

引用本文

范培琳, 李钟惠, 韩华璐, 范晓媛, 刘思敏, 陈硕, 有慧, 冯逢. 基于平面回波成像读出方式的5 T超高场多延迟动脉自旋标记灌注成像研究. 现代仪器与医疗, 2025 , 31 (6) : 7 -12 . DOI: 10.11876/mimt202506002

Peilin Fan, Zhonghui Li, Hualu Han, Xiaoyuan Fan, Simin Liu, Shuo Chen, Hui You, Feng Feng. Multi-delay arterial spin labeling perfusion imaging at 5 T ultra-high field based on echo-planar imaging readout[J]. Modern Instruments & Medical Treatment, 2025 , 31 (6) : 7 -12 . DOI: 10.11876/mimt202506002

基金

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国家自然科学基金面上项目(82371946; 82071899)

参考文献

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文献

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2025年第31卷第6期

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文章信息

doi: 10.11876/mimt202506002

首发时间：2026-10-23
出版时间：2025-12-10

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基金

国家自然科学基金面上项目(82371946; 82071899)

作者信息

^1.中国医学科学院北京协和医院放射科，北京　100730

^2.上海联影医疗科技股份有限公司，上海　201807

通讯作者:

冯逢，女，博士研究生，主任医师，研究方向：中枢神经系统磁共振成像

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
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				栓菌属 Trametes	5	2.39

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