现代仪器与医疗

术中手持式内窥OCT的研究进展与临床应用

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胡津源 ¹^,² , 杨建文 ¹^,² , 何益 ¹^,²^,^*

现代仪器与医疗 | 生物应用 2025,31(4): 91-100

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现代仪器与医疗 |生物应用 2025 , 31 (4) : 91 -100

术中手持式内窥OCT的研究进展与临床应用

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胡津源¹^,², 杨建文¹^,², 何益¹^,²^,^*

作者信息

^1.中国科学技术大学生物医学工程学院（苏州），生命科学与医学部，合肥　230026

^2.中国科学院苏州生物医学工程技术研究所，江苏省医用光学重点实验室，苏州　215163

通讯作者:

何益，男，博士研究生，研究员，研究方向：眼科光学、生物光子学、基于智能计算的精准医疗等

作者简介:

胡津源，男，在读博士研究生，研究方向：眼科内窥OCT、手术导航显微镜

Research progress and clinical application of intraoperative handheld endoscopic OCT

Jinyuan Hu¹^,², Jianwen Yang¹^,², Yi He¹^,²^,^*

Affiliations

^1.School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China

^2.Jiangsu Province Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China

出版时间: 2025-08-10 doi: 10.11876/mimt202504010

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摘要

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术中手持式内窥光学相干断层扫描（handheld endoscopic optical coherence tomography，HHOCT）通过融合光纤通讯与内窥镜技术，基于低相干干涉原理，利用亚毫米级微型化手持探针及MEMS驱动、光纤振动等灵活扫描机制，克服了传统OCT穿透深度的限制，能在血液、组织液等浑浊介质中获取视网膜分层、血管内膜等微米级高分辨率结构图像，其临床应用广泛覆盖眼科的玻璃体视网膜手术实时导航、心脏科的血管吻合评估、神经外科的深部脑组织成像及乳腺肿瘤切除中的切缘显微评估等领域，通过侧向或前向扫描探头及OCT手术钳等集成式手术器械实现操作与成像同步、消除视野盲区。当前技术在狭窄腔道适应性、多模态信息融合上存在挑战，未来将聚焦亚毫米级可弯曲探头研发、AI辅助病灶识别、机器人协同导航及低成本一次性器件普及，推动其向智能化手术导航系统演进。本文简述了HHOCT的发展现状，对其在系统结构优化、临床应用等方面的代表性工作进行了综述，并对其未来发展进行了展望。

关键词

光学相干断层扫描 / 内窥OCT / 内窥探头 / 术中成像 / 微型化

Abstract

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Optical coherence tomography (OCT) is a key technology for high-resolution biomedical imaging. Intraoperative handheld endoscopic OCT combines optical fiber communication with endoscopic technology. Based on the principle of low coherence interference, it uses a submillimeter miniaturized handheld probe (diameter≤1 mm) and flexible scanning mechanisms such as MEMS actuation and fiber vibration. Overcoming the penetration depth limitation of traditional OCT, it can obtain micron-level high-resolution structural images such as retinal stratification and vascular intima in turbid media such as blood and tissue fluid. Its clinical application widely covers ophthalmology (real-time navigation of vitreoretinal surgery), cardiology (vascular anastomosis evaluation), neurosurgery (deep brain tissue imaging) and breast tumor resection (microscopic margin assessment), etc. Through the integrated surgical instruments such as lateral or forward scanning probes and OCT surgical forceps, the operation and imaging can be synchronized and the blind area of the visual field can be eliminated. The current technology has challenges in narrow lumen adaptability and multimodal information fusion. The future development will focus on the development of submillimeter flexible probes, artificial intelligence-assisted lesion recognition, robot collaborative navigation, and the popularization of low-cost disposable devices, so as to promote its evolution to an intelligent surgical navigation system. This article briefly describes the current development status of intraoperative handheld endoscopic OCT, reviews its representative works in terms of system structure optimization and clinical application, and presents an outlook for its future development.

Key words

Optical coherence tomography / Endoscopic OCT / Endoscopic probe / Intraoperative imaging / Miniaturization

引用本文

胡津源, 杨建文, 何益. 术中手持式内窥OCT的研究进展与临床应用. 现代仪器与医疗, 2025 , 31 (4) : 91 -100 . DOI: 10.11876/mimt202504010

Jinyuan Hu, Jianwen Yang, Yi He. Research progress and clinical application of intraoperative handheld endoscopic OCT[J]. Modern Instruments & Medical Treatment, 2025 , 31 (4) : 91 -100 . DOI: 10.11876/mimt202504010

基金

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江苏省自然科学基金杰出青年基金项目(BK20240024)
中国科学院青年创新促进会优秀会员(Y2023087)
国家自然科学基金面上项目(62075235)
国家重点研发计划项目(2021YFF0700700)
中国科学院战略性先导科技专项(XDB1020000)

参考文献

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2025年第31卷第4期

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文章信息

doi: 10.11876/mimt202504010

首发时间：2026-10-23
出版时间：2025-08-10

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出版历史

基金

江苏省自然科学基金杰出青年基金项目(BK20240024)

中国科学院青年创新促进会优秀会员(Y2023087)

国家自然科学基金面上项目(62075235)

国家重点研发计划项目(2021YFF0700700)

中国科学院战略性先导科技专项(XDB1020000)

作者信息

^1.中国科学技术大学生物医学工程学院（苏州），生命科学与医学部，合肥　230026

^2.中国科学院苏州生物医学工程技术研究所，江苏省医用光学重点实验室，苏州　215163

通讯作者:

何益，男，博士研究生，研究员，研究方向：眼科光学、生物光子学、基于智能计算的精准医疗等

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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