现代仪器与医疗

激光诱导击穿光谱结合主成分分析在生物医学领域的应用研究

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马越 ¹ , 邓美慧 ² , 陈建军 ¹^,^*

现代仪器与医疗 | 综述 2025,31(3): 89-96

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现代仪器与医疗 |综述 2025 , 31 (3) : 89 -96

激光诱导击穿光谱结合主成分分析在生物医学领域的应用研究

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马越¹, 邓美慧², 陈建军¹^,^*

作者信息

^1.新疆医科大学医学工程技术学院，乌鲁木齐　830000

^2.新疆四七四医院，乌鲁木齐　830011

通讯作者:

陈建军，男，博士研究生，教授，研究方向：生物信息处理

作者简介:

马越，男，硕士研究生，研究方向：生物信息处理

Research on the application of laser-induced breakdown spectroscopy combined with principal component analysis in the field of biomedicine

Yue Ma¹, Meihui Deng², Jianjun Chen¹^,^*

Affiliations

^1.School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830000, China

^2.Xinjiang 474 Hospital, Urumqi 830011, China

出版时间: 2025-06-10 doi: 10.11876/mimt202503016

文章导航

摘要

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激光诱导击穿光谱（laser-induced breakdown spectroscopy，LIBS）技术是一种通过脉冲激光聚焦样品产生等离子体，进而对等离子体发射光谱进行分析从而得到物质成分和含量的原子发射光谱技术，因该技术具备原位检测、低样品前处理需求、多元素同步检测等优点，在生物医学领域展现出了巨大的潜力。主成分分析（principal component analysis，PCA）作为经典降维技术，在保留LIBS光谱数据主要特征的同时，消除了光谱数据中的冗余变量，能显著提升模型的分类效率。本文回顾了近年来LIBS技术结合PCA算法在生物医学领域应用中的研究状况和最新进展，重点归纳了此类技术和方法在疾病诊断、药物分析和法医学及其他医学相关领域的应用，从优化算法、开发便携式设备及推动多技术融合等角度为未来发展提出了建议，以期为实现精准医疗和实时监测提供参考，为医学研究和临床应用提供支持。

关键词

激光诱导击穿光谱 / 主成分分析 / 生物医学应用 / 元素分析

Abstract

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Laser-induced breakdown spectroscopy (LIBS) is an atomic emission spectroscopy technique that generates plasma by focusing pulsed laser on a sample and then analyzes the emitted light spectrum to obtain the composition and content of the substance. Due to its advantages such as in-situ detection, low sample pretreatment requirements, and simultaneous detection of multiple elements, it has shown great potential in the biomedical field. Principal component analysis (PCA), as a classic dimensionality reduction technique, retains the main features of LIBS spectral data while eliminating redundant variables in the spectral data, significantly improving the classification efficiency of the model. This paper reviews the research status and latest progress of LIBS technology combined with PCA in biomedical applications in recent years. It focuses on summarizing the application of such technologies and methods in disease diagnosis, drug analysis, forensic science and other related fields. It provides suggestions for future development from the perspectives of algorithm optimization, development of portable devices, and promotion of multi-technology integration, providing a reference for achieving precise medical treatment and real-time monitoring, and offering support for medical research and clinical applications.

Key words

Laser-induced breakdown spectroscopy / Principal component analysis / Biomedical applications / Elemental analysis

引用本文

马越, 邓美慧, 陈建军. 激光诱导击穿光谱结合主成分分析在生物医学领域的应用研究. 现代仪器与医疗, 2025 , 31 (3) : 89 -96 . DOI: 10.11876/mimt202503016

Yue Ma, Meihui Deng, Jianjun Chen. Research on the application of laser-induced breakdown spectroscopy combined with principal component analysis in the field of biomedicine[J]. Modern Instruments & Medical Treatment, 2025 , 31 (3) : 89 -96 . DOI: 10.11876/mimt202503016

基金

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国家自然科学基金项目(31760269)
新疆维吾尔自治区“天山青年计划”培养项目(2018Q021)

参考文献

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参考文献引证文献

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2025年第31卷第3期

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文章信息

doi: 10.11876/mimt202503016

首发时间：2026-10-23
出版时间：2025-06-10

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基金

国家自然科学基金项目(31760269)

新疆维吾尔自治区“天山青年计划”培养项目(2018Q021)

作者信息

^1.新疆医科大学医学工程技术学院，乌鲁木齐　830000

^2.新疆四七四医院，乌鲁木齐　830011

通讯作者:

陈建军，男，博士研究生，教授，研究方向：生物信息处理

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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