Article(id=1320388875428671921, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388863101612371, articleNumber=null, orderNo=null, doi=10.11876/mimt202502004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792734839540, onlineDateStr=2026-10-23, pubDate=1744214400000, pubDateStr=2025-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792734839540, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792734839540, creator=13701087609, updateTime=1792734839540, updator=13701087609, issue=Issue{id=1320388863101612371, tenantId=1146029695717560320, journalId=1319373289681944729, year='2025', volume='31', issue='2', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1744214400000', pubDateStr='2025-04-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792734836602, creator='13701087609', updateTime=1792746450319, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320437574611620097, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388863101612371, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320437574611620098, tenantId=1146029695717560320, journalId=1319373289681944729, issueId=1320388863101612371, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=19, endPage=23, ext={EN=ArticleExt(id=1320388875613221298, articleId=1320388875428671921, tenantId=1146029695717560320, journalId=1319373289681944729, language=EN, title=Application of magnetic resonance imaging sequences in a small animal model of cerebral small vessel hemorrhage, columnId=null, journalTitle=Modern Instruments & Medical Treatment, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective The aim of this study is to provide technical support and reference basis for the research on the mechanism of cerebral small vessel hemorrhage and treatment methods through small animal Magnetic Resonance Imaging (MRI) sequences. This will facilitate in - depth exploration of the nature of the disease, optimization of treatment strategies, and promotion of the development of new treatment methods.
Methods In this study, 5 C57 mice overexpressing the mutant sites of PIK3CA and MAP3K3 (p.I441M) were taken as the research objects. Imaging was carried out using different sequences of 7.0T small - animal nuclear magnetic resonance, such as T1WI, T2WI, SWI, DTI, and ASL. Parameter setting and image acquisition were performed, and the scanning results were statistically analyzed in terms of indicators such as the number of lesions, lesion area, and signal - to - noise ratio.
Results SWI shows excellent performance in the detection of the number, size, and signal - to - noise ratio of lesions (P<0.05). T2WI shows lesions more clearly than T1WI (P<0.05). DTI and ASL provide micro - structure and blood perfusion information respectively.
Conclusion The comprehensive application of multiple sequences is helpful for a comprehensive assessment of pathological characteristics
, authors=Zhanjing Wang, Jingdong Bi, Wenqi Wu, Jianfeng Lei
*, authorsList=Zhanjing Wang, Jingdong Bi, Wenqi Wu, Jianfeng Lei, authorCompany=null, correspAuthors=Jianfeng Lei, authorNote=null, correspAuthorsNote=null, copyrightStatement=
All copyrights in 2025 belong to the sponsor of the journal.Not content published by the journal may be reproduced or abridged without authorization., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320388875940377011, articleId=1320388875428671921, tenantId=1146029695717560320, journalId=1319373289681944729, language=CN, title=小动物脑部小血管出血病灶模型的核磁序列扫描应用探索, columnId=1320381056239387017, journalTitle=现代仪器与医疗, columnName=医学工程, runingTitle=null, highlight=null, articleAbstract=
目的 本研究的目标是通过小动物磁共振成像（Magnetic Resonance Imaging，MRI）序列，为脑小血管出血机制研究和治疗手段提供技术支持与参考依据，利于深入探究该疾病本质与优化治疗策略，促进新治疗方法的研发。
方法 本研究以5只海绵状血管瘤小鼠模型（利用腺相关病毒作为载体，同时过表达突变鼠的PIK3CA和MAP3K3（p.I441M）突变位点）为研究对象，利用7.0T小动物核磁不同序列T1加权成像（T1-Weighted Imaging，T1WI）、T2加权成像（T2-Weighted Imaging，T2WI）、磁敏感加权成像（Susceptibilityweighted Imaging，SWI）、弥散张量成像（Diffusion Tensor Imaging，DTI）和动脉自旋标记成像（Arterial Spin Labeling，ASL）等成像，实行参数设定、图像采集，并从病灶数量、病灶面积、信噪比等指标对扫描结果进行数据统计分析。
结果 SWI在病灶数量、面积及信噪比检测上更加敏感（P<0.01），T2WI较T1WI对病灶显示更清晰（P<0.01）。DTI和ASL分别提供微观结构与血流灌注信息。
, authors=王战京, 毕京东, 武文琦, 雷建锋
*, authorsList=王战京, 毕京东, 武文琦, 雷建锋, authorCompany=null, correspAuthors=雷建锋, authorNote=
王战京，男，硕士研究生，主管技师，研究方向：医学影像技术，小动物磁共振成像技术，小动物CT成像技术；
毕京东，男，硕士研究生，技师，研究方向：医学影像技术，小动物磁共振成像技术
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雷建锋，男，硕士研究生，副主任技师，研究方向：医学影像技术，小动物磁共振成像技术，小动物CT/PET成像技术
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2025年版权归本刊主办单位所有未经本刊书面许可, 不得转载、摘编本刊所有文章内容。, copyrightOwner=中国科学器材公司, extLink=null, articleAbsUrl=null, sourceXml=/ffZeYbXpc6L8GtOI8X7zg==, magXml=jIkEI7ZxP53A7kqHE7r5eA==, pdfUrl=null, pdf=J4XnISYN7ovGVaJ5yXkxaA==, pdfFileSize=2030400, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=P7ViAQ4qIcnEaLm6TKWeIQ==, mapNumber=null, fund=null)}, authors=[Author(id=1320388876343030201, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1320388876435304891, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, authorId=1320388876343030201, language=EN, stringName=Zhanjing Wang, firstName=Zhanjing, middleName=null, lastName=Wang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Core Facility Center, Capital Medical University, Beijing 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1320388876514996668, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, authorId=1320388876343030201, language=CN, stringName=王战京, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学中心实验室，北京 100069, bio={"content":"
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核磁共振GRE-T2*WI对脑内微出血的诊断[J]. 影像研究与医学应用, 2020, 4(14): 224-225., articleTitle=null, refAbstract=null), Reference(id=1320388880520557017, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=冯庆智. 核磁SWI序列在颅内微量出血鉴别诊断应用中相关研究[J]. 中国医学工程, 2015, 23(10): 154-158., articleTitle=null, refAbstract=null), Reference(id=1320388880587665882, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=庄卫东, 路慧敏, 葛新然, 等. 3.0T核磁SWI扫描在外伤性脑轴索损伤及微出血的应用[J]. 临床医药文献电子杂志, 2018, 5(43): 10., articleTitle=null, refAbstract=null), Reference(id=1320388880667357659, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=尹秀玲, 李绍林, 姜天娇, 等. 核磁共振SWI对高血压脑内微出血的检测分析[J]. 中国疗养医学, 2014(6): 490-492., articleTitle=null, refAbstract=null), Reference(id=1320388880742855132, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=柏园, 谭彧, 龚毅, 等. 脑微出血与老年抑郁综合征的相关性研究[J]. 江西医药, 2024, 59(1): 101-104., articleTitle=null, refAbstract=null), Reference(id=1320388880814158301, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=董衍军. 核磁共振成像检查在抗栓治疗发生脑微出血时的价值[J]. 中国保健营养(中旬刊), 2012(11): 341., articleTitle=null, refAbstract=null), Reference(id=1320388880902238686, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=买买提明·马合木提, 迪力夏提·依明, 潘家洁, 等. MR磁敏感加权成像检测高血压脑微出血的价值研究[J]. 中国医学装备, 2023, 20(3): 69-73., articleTitle=null, refAbstract=null), Reference(id=1320388880990319071, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=黄钻明, 王开福, 徐谢生, 等. 3.0T磁敏感加权成像在腔隙性脑梗塞中微出血的应用研究[J]. 中国医疗器械信息, 2023, 29(14): 10-12., articleTitle=null, refAbstract=null), Reference(id=1320388881078399456, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=翟志坚, 尚伟, 张颖, 等. 3.0T头颅MRI检查对脑微出血检出率的影响[J]. 临床研究, 2021, 29(2): 132-133., articleTitle=null, refAbstract=null), Reference(id=1320388881153896929, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=徐劲, 张驰, 马慧, 等. 脑微出血与脑卒中相关性的临床研究[J]. 中风与神经疾病杂志, 2014, 31(3): 219-221., articleTitle=null, refAbstract=null), Reference(id=1320388881216811490, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=张盼盼, 牛智领, 闫斌, 等. 磁敏感加权成像在急性脑梗死合并脑微出血诊断中的价值[J]. 临床心身疾病杂志, 2020, 26(4): 152-154, 185., articleTitle=null, refAbstract=null), Reference(id=1320388881292308963, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=王本国, 林棉, 杨楠, 等. 不同脑血管病患者脑微出血的患病率及其危险因素分析[J]. 中国神经精神疾病杂志, 2011, 37(5): 303-306., articleTitle=null, refAbstract=null), Reference(id=1320388881372000740, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=邹亚芬. 脑微出血的临床意义[J]. 中风与神经疾病杂志, 2010, 27(3): 284-285., articleTitle=null, refAbstract=null), Reference(id=1320388881443303909, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=杨淞然, 华平, 苏蔼欣, 等. 脑内微出血的严重程度分级及重度MB的危险因素分析[J]. 中山大学学报(医学科学版), 2007, 28(z1): 215-217., articleTitle=null, refAbstract=null), Reference(id=1320388881514607078, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=吴阿玲. 脑微出血与复发性缺血性卒中[D]. 大连: 大连医科大学, 2019., articleTitle=null, refAbstract=null), Reference(id=1320388881581715943, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=葛凯, 阳俊, 罗曦. 磁共振成像对脑小血管病脑微出血灶和认知相关性分析[J]. 健康必读, 2018(15): 234., articleTitle=null, refAbstract=null), Reference(id=1320388883242660328, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=滕振杰. 急性缺血性卒中患者脑微出血相关因素分析及与认知功能的临床研究[D]. 石家庄: 河北医科大学, 2017., articleTitle=null, refAbstract=null), Reference(id=1320388883305574889, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=金文晶. 磁敏感加权成像对高血压大鼠模型脑微出血的实验研究[D]. 南昌: 南昌大学, 2014., articleTitle=null, refAbstract=null), Reference(id=1320388883393655274, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=滕振杰, 董艳红, 李玲, 等. 脑微出血与急性缺血性卒中的临床关系分析[J]. 中国神经免疫学和神经病学杂志, 2016, 23(5): 312-316, 321., articleTitle=null, refAbstract=null), Reference(id=1320388883477541355, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=李立新, 黄海峰, 陈婵清. 磁敏感加权成像(SWI)在高血压患者脑微出血的价值研究[J]. 现代医用影像学, 2020, 29(6): 1035-1038., articleTitle=null, refAbstract=null), Reference(id=1320388883548844524, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=冯萌萌, 王媛, 刘霄翊, 等. 基于定量磁化率成像评估的脑小血管病患者灰质核团铁沉积情况及其与认知功能的相关性分析[J]. 中国脑血管病杂志, 2024, 21(9): 595-602., articleTitle=null, refAbstract=null), Reference(id=1320388883615953389, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=张方乐, 郭永杰, 陈冲, 等. 核磁共振中磁敏感加权成像扫描技术在脊髓损伤诊断及神经功能评价中的作用[J]. 四川解剖学杂志, 2024, 32(4): 7-9, 21., articleTitle=null, refAbstract=null), Reference(id=1320388883708228078, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=李明, 陈克敏, 潘自来, 等. CT及MRI预测急性缺血性脑梗死出血性转化的价值研究进展[J]. 诊断学理论与实践, 2024, 23(1): 83-89., articleTitle=null, refAbstract=null), Reference(id=1320388883787919855, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=卢丹丹, 王佩, 李蒙蒙, 等. 核磁负担评分与轻型脑卒中早期神经功能恶化的相关性[J]. 医学研究与教育, 2023, 40(4): 19-24., articleTitle=null, refAbstract=null), Reference(id=1320388883871805936, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=程昭昭. 基于MRI和体液生物标志物探究脑小血管病特征在阿尔茨海默病中的病理作用及临床诊断价值[D]. 济南: 山东大学, 2023., articleTitle=null, refAbstract=null), Reference(id=1320388883968274929, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=王玉青. 多模MRI指导下脑梗死患者溶栓后早期抗栓的安全性研究[D]. 唐山: 华北理工大学, 2022., articleTitle=null, refAbstract=null), Reference(id=1320388884043772402, tenantId=1146029695717560320, journalId=1319373289681944729, articleId=1320388875428671921, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=李扬. 大鼠轻度颅脑爆炸冲击伤的多模态影像学实验研究[D]. 重庆: 陆军军医大学, 2022., articleTitle=null, refAbstract=null), Reference(id=1320388884131852787, tenantId=1146029695717560320, 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