中国组织工程研究

肠道类器官：组织/器官生物学、疾病建模和临床应用前沿趋势的文献计量学分析

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赵乾威 ¹, , 孙光源 ¹,

中国组织工程研究 | 大数据分析 2026,30(1): 238-247

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中国组织工程研究 |大数据分析 2026 , 30 (1) : 238 -247

肠道类器官：组织/器官生物学、疾病建模和临床应用前沿趋势的文献计量学分析

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赵乾威¹,, 孙光源¹,

作者信息

^1.北北方学院附属第一医院创伤急救外科，河北省张家口市 075061

^2.北北方学院附属第一医院创伤急救外科，河北省张家口市 075061

Intestinal organoids: a bibliometric analysis of the latest trends in tissue/organ biology, disease modeling, and clinical applications

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出版时间: 2026-01-08 doi: 10.12307/2026.542

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背景：肠道类器官在组织/器官生物学、疾病建模和临床应用方面具有极高的吸引力，近年来已经成为生物医学研究的前沿热点之一。然而，这一新兴领域至今尚未进行文献计量学的总结。目的：总结肠道类器官的研究趋势，基于文献计量学探索肠道类器官的热点与前沿进展。方法：从Web of Science核心合集中检索2006-01-01/2024-11-06发表的肠道类器官相关文献，运用CiteSpace、VOSviewer和Office软件对检索到文献的年发文量、国家、机构、作者、期刊、引文和关键词等内容进行文献计量与可视化分析。结果与结论：共检索到2 135篇文献，经严格筛选后，1 577篇文献纳入最终分析。2006-2024年，全球肠道类器官领域发文量呈逐年上升趋势，分子生物学、遗传学、免疫学以及临床医学是肠道类器官研究的主流学科，美国在肠道类器官领域的发文量最多，且与中国、荷兰、德国等国家合作较为密切；荷兰乌得勒支大学是发文量最多的机构，《International Journal of Molecular Sciences》是刊载肠道类器官文献最多的期刊；共被引频次最高的文章是“Replication of human noroviruses in stem cell-derived human enteroids”；人肠道类器官、干细胞龛、类器官疗法的潜力等是肠道类器官领域的前沿与热点。类器官结合生物工程和材料技术、肠道类器官芯片技术等是未来研究的重点。该研究采用文献计量学和可视化方法对肠道类器官的研究进行了全面阐述，将帮助学者更好地了解肠道类器官的动态演变，并为未来的研究指明方向。

关键词

类器官 / 肠道类器官 / 肠道干细胞 / 文献计量学 / CiteSpace / VOSviewer / 工程化类器官

Abstract

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BACKGROUND: Intestinal organoids are highly attractive in tissue/organ biology, disease modeling, and clinical applications, and have become one of the frontiers of biomedical research in recent years. However, this emerging field has not yet been summarized by bibliometrics. OBJECTIVE: To summarize the research trends of intestinal organoids and explore the hot topics and frontier advances of intestinal organoids based on bibliometrics. METHODS: Relevant literature on intestinal organoids was retrieved from the Web of Science Core Collection database, spanning the period from January 1, 2006 to November 6, 2024. CiteSpace, VOSviewer, and Office software was utilized to conduct bibliometric and visual analyses of the retrieved literature, focusing on annual publication volume, countries, institutions, authors, journals, citations, and keywords. RESULTS AND CONCLUSION: A total of 2 135 articles were retrieved, and after rigorous screening, 1 577 articles were included in the final analysis. From 2006 to 2024, there was a steady increase in global publications in the field of intestinal organoids. Molecular biology, genetics, immunology, and clinical medicine emerged as the mainstream disciplines in intestinal organoid research. The United States had the highest number of publications in the field of intestinal organoids and maintained close collaborations with countries such as China, the Netherlands, and Germany. Utrecht University in the Netherlands was the most prolific institution, while the International Journal of Molecular Sciences was the journal with the highest number of publications in the area of intestinal organoids. The article “Replication of human noroviruses in stem cell-derived human enteroids” had the highest co-citation frequency. Human intestinal organoids, stem cell niches, and the potential of organoid therapy are the frontiers and hotspots in the domain of intestinal organoids. The integration of organoids with bioengineering and material technology, as well as intestinal organoid-on-a-chip technology, represent future research priorities in this field. This article provides a comprehensive overview of intestinal organoid research using bibliometric and visualization methods. This paper will help scholars to better understand the dynamic evolution of intestinal organoids and provide guidance for future research.

Key words

organoids / intestinal organoids / intestinal stem cell / bibliometrics / CiteSpace / VOSviewer / engineered organoids

引用本文

赵乾威, 孙光源. 肠道类器官：组织/器官生物学、疾病建模和临床应用前沿趋势的文献计量学分析. 中国组织工程研究, 2026 , 30 (1) : 238 -247 . DOI: 10.12307/2026.542

. Intestinal organoids: a bibliometric analysis of the latest trends in tissue/organ biology, disease modeling, and clinical applications[J]. Chinese Journal of Tissue Engineering Research, 2026 , 30 (1) : 238 -247 . DOI: 10.12307/2026.542

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张家口市重点研发项目计划

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2026年第30卷第1期

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doi: 10.12307/2026.542

首发时间：2025-05-30
出版时间：2026-01-08

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录用日期：2025-04-26

基金

张家口市重点研发项目计划

作者信息

^1.北北方学院附属第一医院创伤急救外科，河北省张家口市 075061

^2.北北方学院附属第一医院创伤急救外科，河北省张家口市 075061

通讯作者:

孙光源: 孙光源，硕士，副主任医师，河北北方学院附属第一医院创伤急救外科，河北省张家口市 075061

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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