Article(id=1321501055590970316, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_NEkYkoJV, orderNo=null, doi=10.12307/2026.508, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1741104000000, acceptedDateStr=2025-03-05, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793000003954, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793000003954, creator=admin, updateTime=1793000003954, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=145, endPage=152, ext={EN=ArticleExt(id=1321501058166272974, articleId=1321501055590970316, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Regulation of lysosome function by stem cells in treatment of lysosomal storage diseases, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=null, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: Lysosomal storage diseases, as a group of rare genetic metabolic disorders, exhibit complex pathogenesis often leading to dysfunction of cells, tissues, and organs. Current therapeutic approaches have certain limitations. Stem cell transplantation, as an emerging treatment method, offers new options for patients with lysosomal storage diseases. OBJECTIVE: To review the mechanisms of action of stem cells in regulating lysosomes for the treatment of lysosomal storage diseases and explore the feasibility of traditional Chinese medicine in treating such diseases, providing new insights for the treatment of lysosomal storage diseases with stem cells. METHODS: Relevant literature from 2010 to 2024 was searched in CNKI and PubMed databases using keywords “stem cells, lysosomal storage disease, lysosome” in English and Chinese. Ultimately, 78 articles were included for review and analysis. RESULTS AND CONCLUSION: (1) Stem cells treat lysosomal storage diseases by regulating lysosomes primarily through three aspects: regulating stem cell differentiation and replacement, improving intercellular communication and the microenvironment, and enhancing lysosomal enzyme expression through gene editing. (2) Stem cells have achieved significant effects in the treatment of some lysosomal storage diseases, such as Niemann-Pick disease, mucopolysaccharidoses, Gaucher disease, and metachromatic leukodystrophy. (3) The procedure for stem cell transplantation needs further optimization. Adverse reactions post-transplantation urgently need to be addressed, and the efficiency and safety of gene-modified stem cells also need to be further improved. In the future, more research on the treatment of lysosomal storage diseases with traditional Chinese medicine is required to reveal the relevant mechanisms for the treatment of lysosomal storage diseases with traditional Chinese medicine., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321501058078192589, articleId=1321501055590970316, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=干细胞调控溶酶体功能治疗溶酶体贮积症, columnId=null, journalTitle=中国组织工程研究, columnName=null, runingTitle=null, highlight=null, articleAbstract=背景：溶酶体贮积症是一组罕见的遗传代谢疾病，发病机制复杂，常导致细胞、组织及器官功能障碍，目前的治疗方法具有一定局限性。干细胞移植作为一种新兴的治疗方法，为溶酶体贮积症患者提供了新的选择。 目的：综述干细胞调控溶酶体治疗溶酶体贮积症的作用机制，探讨中医药治疗此类疾病的可行性，为干细胞及中医药治疗溶酶体贮积症提供新的思路。 方法：以“stem cells，lysosomal storage disease，lysosome” 为英文检索词，以“干细胞，溶酶体贮积症，溶酶体”为中文检索词，检索中国知网、PubMed数据库2010-2024年的相关文献，最终纳入78篇文献进行综述分析。 结果与结论：①干细胞调控溶酶体治疗溶酶体贮积症，主要是通过调控干细胞分化与替代、改善细胞间通讯与微环境、基因编辑增强溶酶体酶表达3个方面发挥作用；②干细胞在部分溶酶体贮积症如尼曼匹克病、黏多糖贮积症、戈谢病及异染性脑白质营养不良的治疗中取得了明显效果；③干细胞移植的程序需要进一步优化，移植后的不良反应亟待解决，基因修饰干细胞的效率和安全性也需要进一步提高，未来还需要更多中医药治疗溶酶体贮积症的相关研究，揭示中医药治疗溶酶体贮积症的相关机制。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, 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transplantation), Keyword(id=1321501061601407981, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321501055590970316, language=EN, orderNo=5, keyword=traditional Chinese medicine), Keyword(id=1321501061685294062, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321501055590970316, language=EN, orderNo=6, keyword=Chinese herbal medicine), Keyword(id=1321501061748208623, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321501055590970316, language=EN, orderNo=7, keyword=compound prescription), Keyword(id=1321501061836289008, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321501055590970316, language=EN, orderNo=8, keyword=research progress)], refs=[Reference(id=1321501062310245366, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321501055590970316, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, 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