Article(id=1321500943603053089, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_T6lDhMxG, orderNo=null, doi=10.12307/2025.982, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1737993600000, acceptedDateStr=2025-01-28, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792999977254, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792999977254, creator=admin, updateTime=1792999977254, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=68, endPage=77, ext={EN=ArticleExt(id=1321500980450013741, articleId=1321500943603053089, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Scaffold-free three-dimensional human umbilical cord mesenchymal stem cell secretome repairs mouse skin injury, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=工程化脐带脐血干细胞, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: The mesenchymal stem cell secretome contains bioactive substances, cytokines, and growth factors. Three-dimensional cell culture can regulate the secretion of these components, potentially enhancing the ability to promote injury repair. OBJECTIVE: To investigate the repair effect of three-dimensional cultured human umbilical cord mesenchymal stem cell secretome on skin injuries in mice. METHODS: Human umbilical cord mesenchymal stem cells were cultured in conventional two-dimensional culture dishes and 96-well U-bottom cell culture plates, from which their secretory components were subsequently collected. The expression of skin damage repair related secretory factors in umbilical cord mesenchymal stem cells was analyzed using RT-qPCR. The protein expression level of skin damage repair related factors in umbilical cord mesenchymal stem cell secretome was detected using enzyme-linked immunosorbent assay. The potential of human umbilical cord mesenchymal stem cell secretome to repair vascular injuries was evaluated using an immortalized human umbilical vein endothelial cell migration model. A mouse skin injury model was established, and the human umbilical cord mesenchymal stem cell secretome was injected subcutaneously. Repair effects on skin injury were assessed through wound healing rates and histopathological analysis. RESULTS AND CONCLUSION: (1) After three days of cultivation, human umbilical cord mesenchymal stem cells cultured in two dimensions exhibited a fibroblast-like, swirling growth pattern, whereas three-dimensional culture led to the formation of uniform microspheres. (2) Compared with two-dimensional culture, three-dimensional culture significantly increased the mRNA expression of transforming growth factor β and basic fibroblast growth factor in human umbilical cord mesenchymal stem cells. (3) Compared with two-dimensional culture, three-dimensional cultured human umbilical cord mesenchymal stem cell secretome significantly enhanced the protein expression of vascular endothelial growth factor, interleukin-10, and granulocyte-macrophage colony-stimulating factor in the human umbilical cord mesenchymal stem cell secretome. (4) Compared with two-dimensional culture, three-dimensional cultured human umbilical cord mesenchymal stem cell secretome significantly promoted the migration of immortalized human umbilical cord mesenchymal stem cells. (5) Compared with the untreated control group and the two-dimensional cultured human umbilical cord mesenchymal stem cell secretome, the three-dimensional cultured human umbilical cord mesenchymal stem cell secretome can significantly accelerate the skin wound healing rate and wound skin structure remodeling in mice. These results indicate that three-dimensional culture can enhance the expression of paracrine factors of human umbilical cord mesenchymal stem cells, and their secretome can significantly promote the repair of mouse skin damage., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321500978545799722, articleId=1321500943603053089, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=无支架三维人脐带间充质干细胞分泌组修复小鼠皮肤损伤, columnId=null, journalTitle=中国组织工程研究, columnName=工程化脐带脐血干细胞, runingTitle=null, highlight=null, articleAbstract=背景：间充质干细胞分泌组中含有生物活性物质、细胞因子及生长因子等，三维细胞培养可调控间充质干细胞内含物的分泌，有望提升损伤修复的潜能。 目的：探讨三维培养人脐带间充质干细胞分泌组对小鼠皮肤损伤的修复效果。 方法：用常规二维培养皿和96孔U底细胞培养板培养人脐带间充质干细胞，收集其分泌组分，RT-qPCR检测人脐带间充质干细胞中皮肤损伤修复相关分泌因子基因表达水平，酶联免疫吸附实验检测人脐带间充质干细胞分泌组中皮肤损伤修复相关因子的蛋白表达水平；使用永生化人脐静脉内皮细胞迁移模型检测人脐带间充质干细胞分泌组的血管损伤修复潜能。建立小鼠皮肤损伤模型，经皮下注射人脐带间充质干细胞分泌组，通过伤口愈合率和组织病理学分析验证皮肤损伤的修复效果。 结果与结论：①培养3 d后，二维培养的人脐带间充质干细胞呈成纤维细胞样漩涡状生长，三维培养的人脐带间充质干细胞为均一微球体；②与二维培养相比，三维培养的人脐带间充质干细胞中转化生长因子β、碱性成纤维细胞生长因子mRNA表达水平显著升高；③与二维培养相比，三维培养的人脐带间充质干细胞分泌组中血管内皮细胞生长因子、白细胞介素10、粒细胞巨噬细胞集落刺激因子蛋白表达水平显著升高；④与二维培养相比，三维培养的人脐带间充质干细胞分泌组可显著促进永生化人脐静脉内皮细胞的迁移；⑤与未处理对照组和二维培养的人脐带间充质干细胞分泌组相比，三维培养的人脐带间充质干细胞分泌组可显著加快小鼠皮肤伤口愈合速率和伤口皮肤结构重塑。研究结果表明：三维培养可提高人脐带间充质干细胞的旁分泌因子表达，其分泌组可显著促进小鼠皮肤损伤修复。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, 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Cells. 2022;11(19):3089., articleTitle=null, refAbstract=null), Reference(id=1321500987756491383, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500943603053089, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG X, WANG Q, YIN P, et al. Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function. 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