Article(id=1321500878708781319, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_IcKiw5z9, orderNo=null, doi=10.12307/2026.539, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1745337600000, acceptedDateStr=2025-04-23, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792999961782, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792999961782, creator=admin, updateTime=1792999961782, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=10, endPage=20, ext={EN=ArticleExt(id=1321500881506382089, articleId=1321500878708781319, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Senescence of human bone marrow mesenchymal stromal cells with increasing age is not dependent on the mediation of endogenous retroviruses, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: Aging of human body may be due to the senescence and depletion of various stem cells in the body. Bone marrow mesenchymal stromal cells have important physiological functions and have shown certain therapeutic effects on various diseases. It is of great significance to study the senescence and mechanism of bone marrow mesenchymal stromal cells. OBJECTIVE: To investigate whether human bone marrow mesenchymal stromal cells exhibit senescence phenotypes with increasing donor age, and further determine whether endogenous retrovirus drives the senescence of bone marrow mesenchymal stromal cells, offering a novel reference for the investigation of stem cell senescence mechanism. METHODS: The senescence of bone marrow mesenchymal stromal cells at different ages was characterized by flow cytometry, β-galactosidase staining, qPCR, western blotting, and EdU fluorescence imaging. Bone marrow mesenchymal stromal cells and cell culture supernatant were collected from donors of different ages. The content of human endogenous retrovirus was detected by qPCR. Furthermore, highly sensitive droplet digital PCR was used to detect the expression of endogenous retrovirus-like particles in the cell culture supernatant. The content of endogenous retrovirus in bone marrow plasma samples of different ages was detected by ELISA. RESULTS AND CONCLUSION: Bone marrow mesenchymal stromal cells exhibited obvious senescence with increasing age, including significant morphological changes, increased proportion of β-galactosidase positive cells, increased expression of senescence markers P16 and P21 protein, decreased expression of LMNB1 protein, and reduced cell proliferation ability. There was no significant difference in the content of endogenous retrovirus in bone marrow mesenchymal stromal cells at different ages, almost no endogenous retrovirus-like particles in the cell culture supernatant. There was no significant difference in endogenous retrovirus-like particles detected in bone marrow plasma samples at different ages. These findings indicate that human bone marrow mesenchymal stromal cells have normal physiological senescence with increasing age, but the mechanism of senescence is not mediated by abnormal activation of endogenous retroviruses, which may have a more complex driving mechanism., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321500881401524488, articleId=1321500878708781319, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=人骨髓间充质干细胞增龄衰老不依赖于内源性反转录病毒的介导, columnId=null, journalTitle=中国组织工程研究, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=背景：人体增龄衰老可能是由于体内各种干细胞的衰老和耗竭。骨髓间充质干细胞具有重要的生理功能并对多种疾病展现出一定的疗效，研究骨髓间充质干细胞的衰老及机制具有重要意义。 目的：探讨人骨髓间充质干细胞是否伴随供者年龄的增加而呈现衰老表型，并进一步检测内源性反转录病毒是否驱动骨髓间充质干细胞的增龄衰老，为干细胞衰老机制研究提供新参考。 方法：采用流式细胞术、β-半乳糖苷酶染色、qPCR、免疫印迹法及EdU荧光成像对不同年龄段的骨髓间充质干细胞进行衰老表征研究。收集不同年龄段供者的骨髓间充质干细胞及细胞培养上清，通过qPCR法检测人内源性反转录病毒的含量，进一步采用高灵敏的液滴式数字PCR检测细胞培养上清中内源性反转录病毒颗粒的表达，并用ELISA检测不同年龄段骨髓血浆样本中的内源性反转录病毒含量。 结果与结论：骨髓间充质干细胞具有明显的增龄衰老，包括显著的形态学改变、β-半乳糖苷酶染色阳性细胞比例升高、衰老标志物P16和P21蛋白表达升高，LMNB1蛋白表达下降，细胞增殖能力减弱。不同年龄段骨髓间充质干细胞中的内源性反转录病毒含量无显著性差异，培养上清中几乎不存在内源性反转录病毒颗粒，不同年龄段骨髓血浆样本中内源性反转录病毒无显著性差异。结果表明，人骨髓间充质干细胞具有正常生理性增龄衰老，但不是通过内源性反转录病毒的异常激活介导的，可能具有更加复杂的驱动机制。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2030916229985292289/excel/pdfs/398bdd9762ef46ab9e5ec85d4163aabc.pdf?response-content-disposition=attachment%3B%20filename%3D%22%E4%BA%BA%E9%AA%A8%E9%AB%93%E9%97%B4%E5%85%85%E8%B4%A8%E5%B9%B2%E7%BB%86%E8%83%9E%E5%A2%9E%E9%BE%84%E8%A1%B0%E8%80%81%E4%B8%8D%E4%BE%9D%E8%B5%96%E4%BA%8E%E5%86%85%E6%BA%90%E6%80%A7%E5%8F%8D%E8%BD%AC%E5%BD%95%E7%97%85%E6%AF%92%E7%9A%84%E4%BB%8B%E5%AF%BC.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261026T073148Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261026%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=783670d897b57d4dfc65177408d9cbe64301c1974cce56a6ab14b2c772b9775b, pdf=bIMQ8Ki1+12REMzMxA04lg==, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, 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tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, language=EN, orderNo=5, keyword=endogenous retrovirus), Keyword(id=1321500883385430312, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, language=EN, orderNo=6, keyword=endogenous retrovirus-like particle), Keyword(id=1321500883494482217, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, language=EN, orderNo=7, keyword=droplet digital PCR)], refs=[Reference(id=1321500883775500587, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=GOODELL MA, RANDO TA. Stem cells and healthy aging. Science. 2015; 350(6265):1199-1204., articleTitle=null, refAbstract=null), Reference(id=1321500883779694892, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=曾晨叶,花瑞,王钊.衰老细胞清除策略与CAR细胞疗法在抗衰老治疗中的应用[J].中国生物化学与分子生物学报,2024,40(9):1197-1204., articleTitle=null, refAbstract=null), Reference(id=1321500883779694893, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=武泽明,刘晓倩,刘光慧.内源性逆转录病毒复活作为衰老的新型生物标志物和驱动力[J].科学通报,2024,69(Z2):4163-4165., articleTitle=null, refAbstract=null), Reference(id=1321500883779694894, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=DENG J, OUYANG P, LI W, et al. Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway. Int J Mol Sci. 2021;22(21):11356., articleTitle=null, refAbstract=null), Reference(id=1321500883779694895, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=SYKOVÁ E, RYCHMACH P, DRAHORÁDOVÁ I, et al. Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial. Cell Transplant. 2017;26(4):647-658., articleTitle=null, refAbstract=null), Reference(id=1321500883779694896, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=XU Y, CHANG L, CHEN Y, et al. USP26 Combats Age-Related Declines in Self-Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis. Adv Sci (Weinh). 2024;11(44):e2406428., articleTitle=null, refAbstract=null), Reference(id=1321500883779694897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=吴美燕.FOXK1与FHL2在大肠癌的增殖、EMT、侵袭和转移中的相互作用[D].广州:南方医科大学,2017., articleTitle=null, refAbstract=null), Reference(id=1321500883779694898, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=XIAO X, XU M, YU H, et al. Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal Transduct Target Ther. 2021;6(1):354., articleTitle=null, refAbstract=null), Reference(id=1321500883779694899, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO Y, HE J, QIU T, et al. Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases. Stem Cell Res Ther. 2022;13(1):201., articleTitle=null, refAbstract=null), Reference(id=1321500883779694900, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=HERNANDEZ-SEGURA A, NEHME J, DEMARIA M. Hallmarks of Cellular Senescence. Trends Cell Biol. 2018;28(6):436-453., articleTitle=null, refAbstract=null), Reference(id=1321500883779694901, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=ACHA B, CORROZA J, SÁNCHEZ-RUIZ DE GORDOA J, et al. Association of Blood-Based DNA Methylation Markers With Late-Onset Alzheimer Disease: A Potential Diagnostic Approach. Neurology. 2023;101(23):e2434-e2447., articleTitle=null, refAbstract=null), Reference(id=1321500883779694902, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=ÁLVAREZ-SATTA M, BERNA-ERRO A, CARRASCO-GARCIA E, et al. Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models. Aging (Albany NY). 2020;12(10):9982-9999., articleTitle=null, refAbstract=null), Reference(id=1321500883779694903, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=KANG X, CHEN L, YANG S, et al. Zuogui Wan slowed senescence of bone marrow mesenchymal stem cells by suppressing Wnt/β-catenin signaling. J Ethnopharmacol. 2022;294:115323., articleTitle=null, refAbstract=null), Reference(id=1321500883779694904, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=王留娣,刘威,谢园园,等.三种人胎盘组织来源间充质干细胞的生物学特性[J].中国组织工程研究,2019,23(9):1377-1383., articleTitle=null, refAbstract=null), Reference(id=1321500883779694905, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=LÓPEZ-OTÍN C, BLASCO MA, PARTRIDGE L, et al. The hallmarks of aging. Cell. 2013;153(6):1194-1217., articleTitle=null, refAbstract=null), Reference(id=1321500883779694906, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=BARTEK J, FALCK J, LUKAS J. CHK2 kinase--a busy messenger. Nat Rev Mol Cell Biol. 2001;2(12):877-886., articleTitle=null, refAbstract=null), Reference(id=1321500883779694907, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=BRUNET A, GOODELL MA, RANDO TA. Ageing and rejuvenation of tissue stem cells and their niches. Nat Rev Mol Cell Biol. 2023;24(1):45-62., articleTitle=null, refAbstract=null), Reference(id=1321500883779694908, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=HU M, XING L, ZHANG L, et al. NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation. Aging Cell. 2022; 21(2):e13551., articleTitle=null, refAbstract=null), Reference(id=1321500883779694909, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG H, XU R, LI B, et al. LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance. Cell Death Differ. 2022;29(2):351-365., articleTitle=null, refAbstract=null), Reference(id=1321500883779694910, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG D, LIN J, WANG Y, et al. Effects of resveratrol on aging of mesenchymal stem cells and its mechanism. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019;48(6):617-624., articleTitle=null, refAbstract=null), Reference(id=1321500883779694911, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=SU X, ZHANG H, LEI F, et al. Epigenetic therapy attenuates oxidative stress in BMSCs during ageing. J Cell Mol Med. 2022;26(2):375-384., articleTitle=null, refAbstract=null), Reference(id=1321500883779694912, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHOU S, GREENBERGER JS, EPPERLY MW, et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008;7(3):335-343., articleTitle=null, refAbstract=null), Reference(id=1321500883779694913, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=张保虎,刘晓倩,武泽明,等.内源性逆转录病毒在人类健康及衰老中的作用和机制研究[J].中国基础科学,2024,26(1):14-21., articleTitle=null, refAbstract=null), Reference(id=1321500883783889197, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=KREBS AS, LIU HF, ZHOU Y, et al. Molecular architecture and conservation of an immature human endogenous retrovirus. Nat Commun. 2023;14(1):5149., articleTitle=null, refAbstract=null), Reference(id=1321500883783889198, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN MS, LEE RT, GARBERN JC. Senescence mechanisms and targets in the heart. Cardiovasc Res. 2022;118(5):1173-1187., articleTitle=null, refAbstract=null), Reference(id=1321500883783889199, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=BANIMOHAMAD-SHOTORBANI B, KAHROBA H, SADEGHZADEH H, et al. DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability. Ageing Res Rev. 2020;62:101125., articleTitle=null, refAbstract=null), Reference(id=1321500883783889200, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=MADSEN SD, RUSSELL KC, TUCKER HA, et al. Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2017;8(1):201., articleTitle=null, refAbstract=null), Reference(id=1321500883783889201, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Y, LI W, GUO Y, et al. Mitochondria Transplantation to Bone Marrow Stromal Cells Promotes Angiogenesis During Bone Repair. Adv Sci (Weinh). 2024;11(39):e2403201., articleTitle=null, refAbstract=null), Reference(id=1321500883783889202, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=张天喆.人多能性干细胞中内源性逆转录病毒元件调控宿主基因表达的研究[D].武汉:武汉大学,2023., articleTitle=null, refAbstract=null), Reference(id=1321500883783889203, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=LI G, ZHU Q, WANG B, et al. Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation. Adv Sci (Weinh). 2021;8(18):e2100964., articleTitle=null, refAbstract=null), Reference(id=1321500883783889204, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=KRITSILIS M, V RIZOU S, KOUTSOUDAKI PN, et al. Ageing, Cellular Senescence and Neurodegenerative Disease. Int J Mol Sci. 2018;19(10):2937., articleTitle=null, refAbstract=null), Reference(id=1321500883783889205, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=BLACKBURN EH, EPEL ES, LIN J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science (New York, NY). 2015;350(6265):1193-1198., articleTitle=null, refAbstract=null), Reference(id=1321500883783889206, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=LI DX, MA Z, SZOJKA AR, et al. Non-hypertrophic chondrogenesis of mesenchymal stem cells through mechano-hypoxia programing. J Tissue Eng. 2023;14:20417314231172574., articleTitle=null, refAbstract=null), Reference(id=1321500883783889207, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=GARCIA-MONTOJO M, FATHI S, NORATO G, et al. Inhibition of HERV-K (HML-2) in amyotrophic lateral sclerosis patients on antiretroviral therapy. J Neurol Sci. 2021;423:117358., articleTitle=null, refAbstract=null), Reference(id=1321500883783889208, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=王慧慧,吴情,赵玉梅.基于RNA测序的SHED体外连续扩增后差异表达基因的研究[J].口腔颌面外科杂志,2023,33(4):211-218., articleTitle=null, refAbstract=null), Reference(id=1321500883783889209, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=REN R, OCAMPO A, LIU GH, et al. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017;26(3):460-474., articleTitle=null, refAbstract=null), Reference(id=1321500883783889210, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=VOLKOVA MV, SHEN N, POLYANSKAYA A, et al. Tissue-Oxygen-Adaptation of Bone Marrow-Derived Mesenchymal Stromal Cells Enhances Their Immunomodulatory and Pro-Angiogenic Capacity, Resulting in Accelerated Healing of Chemical Burns. Int J Mol Sci. 2023;24(4):4102., articleTitle=null, refAbstract=null), Reference(id=1321500883783889211, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=STOLZING A, JONES E, MCGONAGLE D, et al. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008;129(3):163-173., articleTitle=null, refAbstract=null), Reference(id=1321500883783889212, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=DEMBNY P, NEWMAN AG, SINGH M, et al. Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI Insight. 2020;5(7):e131093., articleTitle=null, refAbstract=null), Reference(id=1321500883783889213, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=WEI FL, ZHAI Y, WANG TF, et al. Stem cell-homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling. Sci Adv. 2024;10(44):eadq6700., articleTitle=null, refAbstract=null), Reference(id=1321500883783889214, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=MATTEUCCI C, BALESTRIERI E, ARGAW-DENBOBA A, et al. Human endogenous retroviruses role in cancer cell stemness. Semin Cancer Biol. 2018;53:17-30., articleTitle=null, refAbstract=null), Reference(id=1321500883783889215, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=KIP E, PARR-BROWNLIE LC. Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease. Ageing Res Rev. 2022;78:101618., articleTitle=null, refAbstract=null), Reference(id=1321500883783889216, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=VASILEIOU PVS, EVANGELOU K, VLASIS K, et al. Mitochondrial Homeostasis and Cellular Senescence. Cells. 2019;8(7):686., articleTitle=null, refAbstract=null), Reference(id=1321500883783889217, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG Q, ZOU Y, WEI X, et al. PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis. Biochim Biophys Acta Mol Basis Dis. 2023;1869(7):166795., articleTitle=null, refAbstract=null), Reference(id=1321500883783889218, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=GUO J, HUANG X, DOU L, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022;7(1):391., articleTitle=null, refAbstract=null), Reference(id=1321500883783889219, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=KONG X, LI R, CHEN M, et al. Endogenous retrovirus HERVH-derived lncRNA UCA1 controls human trophoblast development. Proc Natl Acad Sci U S A. 2024;121(12):e2318176121., articleTitle=null, refAbstract=null), Reference(id=1321500883783889220, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=null, journalName=null, refType=null, unstructuredReference=LI X, LUO X, HE Y, et al. Micronano Titanium Accelerates Mesenchymal Stem Cells Aging through the Activation of Senescence-Associated Secretory Phenotype. ACS Nano. 2023;17(22):22885-22900., articleTitle=null, refAbstract=null), Reference(id=1321500883783889221, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG JH, HAYANO M, GRIFFIN PT, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023;186(2):305-326.e27., articleTitle=null, refAbstract=null), Reference(id=1321500883783889222, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=null, journalName=null, refType=null, unstructuredReference=王龙,蒋航,陈图南,等.TAS102选择性抑制ATRX缺失胶质瘤细胞的实验研究[J].第三军医大学学报,2019,41(24):2393-2400., articleTitle=null, refAbstract=null), Reference(id=1321500883783889223, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=null, journalName=null, refType=null, unstructuredReference=EHLHARDT S, SEIFERT M, SCHNEIDER J, et al. Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia. J Rheumatol. 2006;33(1):16-23., articleTitle=null, refAbstract=null), Reference(id=1321500883783889224, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=null, journalName=null, refType=null, unstructuredReference=汪子铃.人参皂苷Rg1调控Keap1-NRF2-ARE通路延缓骨髓间充质干细胞衰老的机制研究[D].重庆:重庆医科大学,2021., articleTitle=null, refAbstract=null), Reference(id=1321500883783889225, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=null, journalName=null, refType=null, unstructuredReference=袁雅红,赵珊珊,王小莉,等.HIV P55-gag蛋白促进骨髓间充质干细胞的老化[J].生物医学工程研究,2017,36(1):52-56+61., articleTitle=null, refAbstract=null), Reference(id=1321500883788083502, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=null, journalName=null, refType=null, unstructuredReference=SHEN J, TSAI YT, DIMARCO NM, et al. Transplantation of mesenchymal stem cells from young donors delays aging in mice. Sci Rep. 2011;1:67., articleTitle=null, refAbstract=null), Reference(id=1321500883788083503, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=null, journalName=null, refType=null, unstructuredReference=GRAJEK S, POPIEL M, GIL L, et al. Influence of bone marrow stem cells on left ventricle perfusion and ejection fraction in patients with acute myocardial infarction of anterior wall: randomized clinical trial: Impact of bone marrow stem cell intracoronary infusion on improvement of microcirculation. Eur Heart J. 2010;31(6):691-702., articleTitle=null, refAbstract=null), Reference(id=1321500883788083504, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=null, journalName=null, refType=null, unstructuredReference=DOPKINS N, NIXON DF. Activation of human endogenous retroviruses and its physiological consequences. Nat Rev Mol Cell Biol. 2024;25(3):212-222., articleTitle=null, refAbstract=null), Reference(id=1321500883788083505, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[56], rfOrder=55, authorNames=null, journalName=null, refType=null, unstructuredReference=纪佳男.抑制抗氧化通路与ATR抑制剂在癌细胞中的协同致死作用及其机理研究[D].长春:吉林大学,2022., articleTitle=null, refAbstract=null), Reference(id=1321500883788083506, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU X, LIU Z, WU Z, et al. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023;186(2):287-304.e26., articleTitle=null, refAbstract=null), Reference(id=1321500883788083507, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=null, journalName=null, refType=null, unstructuredReference=LI CJ, XIAO Y, SUN YC, et al. Senescent immune cells release grancalcin to promote skeletal aging. Cell Metab. 2021;33(10):1957-1973.e6., articleTitle=null, refAbstract=null), Reference(id=1321500883788083508, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=null, journalName=null, refType=null, unstructuredReference=FREIJE JM, LÓPEZ-OTÍN C. Reprogramming aging and progeria. Curr Opin Cell Biol. 2012;24(6):757-764., articleTitle=null, refAbstract=null), Reference(id=1321500883788083509, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=null, journalName=null, refType=null, unstructuredReference=PACKHAM DK, FRASER IR, KERR PG, et al. Allogeneic Mesenchymal Precursor Cells (MPC) in Diabetic Nephropathy: A Randomized, Placebo-controlled, Dose Escalation Study. EBioMedicine. 2016;12:263-269., articleTitle=null, refAbstract=null), Reference(id=1321500883788083510, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[61], rfOrder=60, authorNames=null, journalName=null, refType=null, unstructuredReference=LI H, DAI H, LI J. Immunomodulatory properties of mesenchymal stromal/stem cells: The link with metabolism. J Adv Res. 2023;45:15-29., articleTitle=null, refAbstract=null), Reference(id=1321500883788083511, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[62], rfOrder=61, authorNames=null, journalName=null, refType=null, unstructuredReference=MOUSTOGIANNIS A, PHILIPPOU A, TASO O, et al. The Effects of Muscle Cell Aging on Myogenesis. Int J Mol Sci. 2021;22(7):3721., articleTitle=null, refAbstract=null), Reference(id=1321500883788083512, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[63], rfOrder=62, authorNames=null, journalName=null, refType=null, unstructuredReference=张宇宁.HK1通过与TERT结合抑制端粒酶活性调控肺腺癌细胞细胞衰老[D].长春:吉林大学,2023., articleTitle=null, refAbstract=null), Reference(id=1321500883788083513, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[64], rfOrder=63, authorNames=null, journalName=null, refType=null, unstructuredReference=IVANOVSKI S, HAN P, PETERS OA, et al. The Therapeutic Use of Dental Mesenchymal Stem Cells in Human Clinical Trials. J Dent Res. 2024;103(12): 1173-1184., articleTitle=null, refAbstract=null), Reference(id=1321500883788083514, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[65], rfOrder=64, authorNames=null, journalName=null, refType=null, unstructuredReference=LI C, WEI GJ, XU L, et al. The involvement of senescence induced by the telomere shortness in the decline of osteogenic differentiation in BMSCs. Eur Rev Med Pharmacol Sci. 2017;21(5):1117-1124., articleTitle=null, refAbstract=null), Reference(id=1321500883788083515, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[66], rfOrder=65, authorNames=null, journalName=null, refType=null, unstructuredReference=MANI C, REDDY PH, PALLE K. DNA repair fidelity in stem cell maintenance, health, and disease. Biochim Biophys Acta Mol Basis Dis. 2020;1866(4):165444., articleTitle=null, refAbstract=null), Reference(id=1321500883788083516, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[67], rfOrder=66, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU F, YUAN Y, BAI L, et al. LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss. Redox Biol. 2021;43:101963., articleTitle=null, refAbstract=null), Reference(id=1321500883788083517, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[68], rfOrder=67, authorNames=null, journalName=null, refType=null, unstructuredReference=张晓雯,徐康彦,王帮华,等.蝙蝠葛碱对恶性胶质瘤U87细胞的抑制及分子机制研究[J].湖北科技学院学报(医学版),2022,36(6):476-480., articleTitle=null, refAbstract=null), Reference(id=1321500883788083518, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[69], rfOrder=68, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Y, GAO T, WANG B. Application of mesenchymal stem cells for anti-senescence and clinical challenges. Stem Cell Res Ther. 2023;14(1):260., articleTitle=null, refAbstract=null), Reference(id=1321500883788083519, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[70], rfOrder=69, authorNames=null, journalName=null, refType=null, unstructuredReference=POUREBRAHIM R, HEINZ MONTOYA R, ALANIZ Z, et al. Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage. Cell Death Dis. 2023; 14(6):371., articleTitle=null, refAbstract=null), Reference(id=1321500883788083520, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[71], rfOrder=70, authorNames=null, journalName=null, refType=null, unstructuredReference=REVUELTA M, MATHEU A. Autophagy in stem cell aging. Aging Cell. 2017; 16(5):912-915., articleTitle=null, refAbstract=null), Reference(id=1321500883788083521, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[72], rfOrder=71, authorNames=null, journalName=null, refType=null, unstructuredReference=LÓPEZ-OTÍN C, BLASCO MA, PARTRIDGE L, et al. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243-278., articleTitle=null, refAbstract=null), Reference(id=1321500883788083522, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[73], rfOrder=72, authorNames=null, journalName=null, refType=null, unstructuredReference=PILLERON S, SOTO-PEREZ-DE-CELIS E, VIGNAT J, et al. Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050. Int J Cancer. 2021;148(3):601-608., articleTitle=null, refAbstract=null), Reference(id=1321500883788083523, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[74], rfOrder=73, authorNames=null, journalName=null, refType=null, unstructuredReference=施伟丽,刘珊珊,常红波,等.血管内皮生长因子联合碱性成纤维细胞生长因子改善骨髓间充质干细胞复制性衰老[J].中国组织工程研究, 2024,28(31):4958-4963., articleTitle=null, refAbstract=null), Reference(id=1321500883788083524, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[75], rfOrder=74, authorNames=null, journalName=null, refType=null, unstructuredReference=PALMER AK, GUSTAFSON B, KIRKLAND JL, et al. Cellular senescence: at the nexus between ageing and diabetes. Diabetologia. 2019;62(10): 1835-1841., articleTitle=null, refAbstract=null), Reference(id=1321500883788083525, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[76], rfOrder=75, authorNames=null, journalName=null, refType=null, unstructuredReference=BAI B, LIU Y, HUANG J, et al. Tolerant and Rapid Endochondral Bone Regeneration Using Framework-Enhanced 3D Biomineralized Matrix Hydrogels. Adv Sci (Weinh). 2024;11(9):e2305580., articleTitle=null, refAbstract=null), Reference(id=1321500883788083526, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[77], rfOrder=76, authorNames=null, journalName=null, refType=null, unstructuredReference=DENG P, YUAN Q, CHENG Y, et al. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell Stem Cell. 2021;28(6):1057-1073.e7., articleTitle=null, refAbstract=null), Reference(id=1321500883788083527, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[78], rfOrder=77, authorNames=null, journalName=null, refType=null, unstructuredReference=冯乙芮,高天芸,王亚萍,等.白细胞介素10工程化修饰人脐带间充质干细胞优效治疗炎症性肠病[J].中国组织工程研究,2025,29(23): 4878-4887., articleTitle=null, refAbstract=null), Reference(id=1321500883788083528, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[79], rfOrder=78, authorNames=null, journalName=null, refType=null, unstructuredReference=VENKATARAMANA NK, KUMAR SK, BALARAJU S, et al. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson’s disease. Transl Res. 2010;155(2):62-70., articleTitle=null, refAbstract=null), Reference(id=1321500883788083529, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500878708781319, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[80], rfOrder=79, authorNames=null, journalName=null, refType=null, unstructuredReference=BAI L, LIU Y, ZHANG X, et al. Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy. 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