Article(id=1321500869569392851, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_Qlnq0VXj, orderNo=null, doi=10.12307/2025.575, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1741017600000, acceptedDateStr=2025-03-04, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792999959603, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792999959604, creator=admin, updateTime=1792999959604, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=9, ext={EN=ArticleExt(id=1321500871922397397, articleId=1321500869569392851, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Protection of exosomes derived from bone marrow mesenchymal stem cells of different mouse ages on radiation-induced lung injury, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: Mesenchymal stem cells show extremely therapeutic potential for radiation-induced lung injury through delivering exosomes. Age is a primary factor affecting the function and biological efficacy of mesenchymal stem cells. OBJECTIVE: To investigate the protective effects of exosomes derived from bone marrow mesenchymal stem cells of different mouse ages on radiation-induced lung injury in mice. METHODS: Bone marrow mesenchymal stem cells of young mice and old mice were obtained by whole bone marrow adherent culture. The exosomes were isolated from the supernatant of passage 3 bone marrow mesenchymal stem cells. Ten 2-month-old C57BL/6J mice were randomly selected as the control group after anesthesia and not irradiated. The remaining 30 2-month-old C57BL/6J mice were used to establish a mouse radiation-induced lung injury model and were randomly divided into three groups. Exosomes derived from bone marrow mesenchymal stem cells of young mice, exosomes derived from bone marrow mesenchymal stem cells of old mice, and PBS were injected through the tail vein, respectively. The survival rate of mice was monitored. The lung function, lung inflammation and fibrosis were assessed at 1 and 12 weeks after irradiation. RESULTS AND CONCLUSION: (1) The concentrations of particles and proteins in exosomes derived from bone marrow mesenchymal stem cells of young mice were higher than those in exosomes derived from bone marrow mesenchymal stem cells of old mice. (2) Compared with the control group, the survival rate of mice in the PBS group was low, and lung inflammation was obvious at week 1 after irradiation, and the levels and mRNA expressions of interleukin-1β, interleukin-6, and tumor necrosis factor-α were increased. Collagen deposition in lung tissues was observed at week 12 after irradiation, and the mRNA level of E-cadherin was decreased, while the mRNA levels of α-smooth muscle actin, transforming growth factor-β1, and β-catenin were increased. (3) Compared with the PBS group, the survival rate of mice in the exosome group was significantly improved, and the level of proinflammatory factors and their mRNA expression were reduced at week 1 after irradiation, the mRNA level of E-cadherin was increased, and the mRNA levels of α-smooth muscle actin, transforming growth factor β1 and β-catenin were reduced at week 12 after irradiation. (4) Among all the above indicators, the therapeutic effect of exosomes derived from bone marrow mesenchymal stem cells of young mice was better than that of exosomes derived from bone marrow mesenchymal stem cells of old mice. (5) The results showed that exosomes derived from bone marrow mesenchymal stem cells of young mice contained more particles and proteins, and the effect of alleviating early inflammation and late fibrosis of radiation-induced lung injury in mice was better than that of exosomes derived from bone marrow mesenchymal stem cells of old mice., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321500871846899924, articleId=1321500869569392851, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=不同鼠龄骨髓间充质干细胞来源外泌体保护放射性肺损伤, columnId=null, journalTitle=中国组织工程研究, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=背景：间充质干细胞通过递送外泌体对放射性肺损伤具有巨大的治疗潜力，而年龄是影响间充质干细胞功能和生物疗效的主要因素之一。 目的：探究不同鼠龄骨髓间充质干细胞来源外泌体对小鼠放射性肺损伤的保护作用。 方法：采用全骨髓贴壁培养法获得青年小鼠骨髓间充质干细胞和老年小鼠骨髓间充质干细胞，从第3代骨髓间充质干细胞上清液中分离出外泌体。随机取10只2月龄C57BL/6J小鼠进行假照射作为对照组，剩余30只2月龄C57BL/6J小鼠建立放射性肺损伤模型，随机分为3组，分别经尾静脉注射青年小鼠骨髓间充质干细胞来源外泌体、老年小鼠骨髓间充质干细胞来源外泌体和PBS，观察各组小鼠存活率，在照射后第1，12周检测肺功能、肺组织炎症和纤维化情况。 结果与结论：①青年小鼠骨髓间充质干细胞来源外泌体的颗粒物和蛋白质浓度高于老年小鼠骨髓间充质干细胞来源外泌体；②与对照组相比，PBS组小鼠存活率低，照射后第1周肺组织炎症明显，白细胞介素1β、白细胞介素6、肿瘤坏死因子α水平及mRNA表达升高；照射后第12周肺组织内胶原沉积，E-钙黏蛋白mRNA水平降低，而α-平滑肌肌动蛋白、转化生长因子β1和β-连环蛋白mRNA表达升高；③与PBS组相比，外泌体组小鼠存活率显著提高，照射后第1周促炎因子水平及mRNA表达降低，照射后第12周E-钙黏蛋白mRNA表达升高，α-平滑肌肌动蛋白、转化生长因子β1和β-连环蛋白mRNA表达降低；④上述所有指标中，青年小鼠骨髓间充质干细胞来源外泌体的疗效均优于老年小鼠骨髓间充质干细胞来源外泌体；⑤结果表明，青年小鼠骨髓间充质干细胞来源外泌体含有更多颗粒物和蛋白质，对小鼠放射性肺损伤早期炎症和晚期纤维化的缓解效果优于老年小鼠骨髓间充质干细胞来源外泌体。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, 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