Article(id=1321500899948736860, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_3YdiZLuV, orderNo=null, doi=10.12307/2026.507, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1742140800000, acceptedDateStr=2025-03-17, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792999966847, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792999966847, creator=admin, updateTime=1792999966847, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=34, endPage=42, ext={EN=ArticleExt(id=1321500902373044574, articleId=1321500899948736860, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Bone marrow mesenchymal stem cell nanovesicles fusion neutrophil apoptotic bodies promote skin wound healing in diabetic mice, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: Nanocell vesicles possess functions such as re-epithelialization, antioxidation, anti-inflammation, and regulation of extracellular matrix remodeling. Meanwhile, apoptotic bodies have the immunomodulatory effects. Therefore, the combination of the two to form nanofusion vesicles can synergistically promote the healing of diabetic skin wounds. OBJECTIVE: To elucidate the impact of nanofusion vesicles on skin wound healing in a diabetic murine model. METHODS: (1) Material preparation and characterization: The primary bone marrow mesenchymal stem cells of C57BL/6J neonatal mice and the neutrophil apoptotic bodies of C57BL/6J mice were isolated and extracted. The nanofusion vesicles were prepared by micro-extrusion mechanism. (2) In vitro experiment: MTT assay was used to detect the proliferative effect of different concentrations of nanofusion vesicles on NIH-3T3 cells and human umbilical vein endothelial cells. Reactive oxygen species fluorescence probe was used to detect the antioxidant effect of nano-fusion vesicles on NIH-3T3 cells treated with hydrogen peroxide (H2O2). The inhibitory effect of nanofusion vesicles on RAW 264.7 macrophage inflammation induced by lipopolyside was detected by real-time quantitative RT-qPCR. (3) In vivo experiment: 36 male C57BL/6J mice were employed to develop a murine model of diabetes mellitus. Following the successful induction of diabetes, two circular full-thickness wounds, each with a diameter of 6 mm, were created on either side of the diabetic mice’s spine using a skin punch. The mice were divided into three groups by random number table method. The control group was injected with 0.1 mL of phosphate buffer solution. The nanovesicle group was injected with 0.1 mL nanovesicles (25 μg/mL). The nanofusion vesicle group was injected with 0.1 mL nanofusion (25 μg/mL) vesicles. After treatment for three consecutive days, the wound healing and histomorphological changes were observed. RESULTS AND CONCLUSION: (1) In vitro experiment: nanofusion vesicles, when administered at concentrations ranging from 0 to 100 μg/mL, exhibited no toxic effects and promoted the proliferation of NIH-3T3 and HUVEC cell lines. Notably, a concentration of 25 μg/mL nanofusion vesicle significantly enhanced the proliferation of NIH-3T3 cells. Furthermore, the survival rate of human umbilical vein endothelial cells was observed to increase in correlation with escalating concentrations of nanofusion vesicles. Nanofusion vesicles had a good antioxidant effect. In comparison to the H2O2 group, the fluorescence signal indicative of reactive oxygen species was progressively diminished in both the nanovesicle group and the nanofusion vesicle group. Furthermore, nanofusion vesicles possessed anti-inflammatory capabilities, effectively mitigating the inflammatory response in macrophages triggered by lipopolysaccharide stimulation. (2) In vivo experiment: Hematoxylin-eosin and Masson's trichrome staining revealed that in comparison to the control group, both the nanovesicle group and the nanofusion vesicle group exhibited a significant increase in granulation tissue formation and collagen fiber deposition within the wounds by day 6. Notably, the nanofusion vesicle group displayed the most pronounced effects. On day 12, the wound of nanofusion vesicle group was significantly reduced, and the healing rate was significantly faster than that of other groups (P < 0.01), and the effect of promoting wound healing was the most significant. Our findings demonstrated that nanofusion vesicles exhibited superior pro-cell proliferative, antioxidant, and anti-inflammatory properties, thereby exerting a beneficial effect on the promotion of skin wound healing in diabetic mouse models., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321500902301741405, articleId=1321500899948736860, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=骨髓间充质干细胞纳米囊泡融合中性粒细胞凋亡小体促进糖尿病小鼠皮肤创面愈合, columnId=null, journalTitle=中国组织工程研究, columnName=骨髓干细胞, runingTitle=null, highlight=null, articleAbstract=背景：纳米细胞囊泡具有再上皮化、抗氧化、抗炎以及调节细胞外基质重塑等功能，凋亡小体具有免疫调节作用，因此二者结合所形成的纳米融合囊泡可协同促进糖尿病皮肤创面愈合。 目的：探讨纳米融合囊泡对糖尿病小鼠皮肤创面的愈合作用。 方法：①材料制备及表征：分离提取C57BL/6J乳鼠原代骨髓间充质干细胞纳米囊泡和C57BL/6J小鼠骨髓来源中性粒细胞凋亡小体，将二者结合采用微型挤出机制备纳米融合囊泡。②体外实验：采用MTT检测不同浓度纳米融合囊泡对NIH-3T3细胞和人脐静脉内皮细胞的增殖作用；采用活性氧荧光探针检测纳米融合囊泡对过氧化氢干预的NIH-3T3细胞的抗氧化作用；采用实时定量RT-qPCR法检测纳米融合囊泡对脂多糖引发的RAW 264.7巨噬细胞炎症反应的抑制效果。③体内实验：36只雄性C57BL/6J小鼠构建糖尿病小鼠模型，造模成功后在糖尿病小鼠脊柱两侧使用打孔机分别制备直径6 mm的2个圆形创面，采用随机数字表法分为3组，对照组创缘皮下注射0.1 mL磷酸盐缓冲液，纳米囊泡组注射0.1 mL 25 μg/mL纳米囊泡，纳米融合囊泡组注射0.1 mL 25 μg/mL纳米融合囊泡，连续治疗3 d，观察创面愈合情况与组织形态学变化。 结果与结论：①体外实验：纳米融合囊泡在质量浓度为0-100 μg/mL时均无毒性作用，且可促进NIH-3T3细胞和人脐静脉内皮细胞的增殖，其中25 μg/mL纳米融合囊泡促进NIH-3T3细胞增殖的效果最明显，而人脐静脉内皮细胞的存活率则随着纳米融合囊泡质量浓度的增加不断增强。纳米融合囊泡具有良好的抗氧化效果，与过氧化氢组相比，纳米囊泡组和纳米融合囊泡组的活性氧荧光信号依次减弱。此外，纳米融合囊泡还具有抗炎能力，降低了脂多糖诱导的巨噬细胞炎症反应。②体内实验：苏木精-伊红染色与Masson染色显示，与对照组相比，术后第6天纳米囊泡组和纳米融合囊泡组创面均表达出丰富的胶原纤维以及肉芽组织，其中以纳米融合囊泡组最多；术后第12天，纳米融合囊泡组创面显著缩小，且愈合速度显著快于其他组，促创面愈合效果最为显著。结果表明，纳米融合囊泡能够展现出促细胞增殖、抗氧化和抗炎特性，从而在促进糖尿病小鼠皮肤创面愈合过程中发挥积极作用。, 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More Evidence for a Prevention-Related Indication for Metformin: Let the Arguments Resume! Diabetes Care. 2019;42(4):499-501., articleTitle=null, refAbstract=null), Reference(id=1321500910031843735, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500899948736860, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN P, ZHENG L, WANG Y, et al. Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration. 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