Article(id=1321500910560326027, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_0yc3voPZ, orderNo=null, doi=10.12307/2025.927, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1735142400000, acceptedDateStr=2024-12-26, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792999969376, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792999969376, creator=admin, updateTime=1792999969376, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=43, endPage=49, ext={EN=ArticleExt(id=1321500913882214797, articleId=1321500910560326027, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Effect of miR-196b-5p in adipose-derived stem cell exosomes on burn wound healing in rats, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=工程化脂肪干细胞, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: Currently, miR-196b-5p has been found to play a role in cell proliferation, migration and inhibition of scar hyperplasia, but there is a lack of relevant studies on whether it plays a role in the process of wound healing. OBJECTIVE: To investigate the effect of miR-196b-5p in adipose stem cell-derived exosomes on burn wound healing. METHODS: The models of deep second degree skin burn in SD rats were established and randomly divided into four groups: blank control group, exosome group, agomiR-196b-5p group, and exosome + antagomiR-196b-5p group, with 10 rats in each group. PBS, adipose-derived stem cell-derived exosomes, miR-196b-5p agonist, and miR-196b-5p inhibitor were injected around the wound according to different groups. Wound healing was observed immediately after injury and on days 7, 14, and 21 after injury. On day 7 after surgery, hematoxylin-eosin staining was used to observe the expression of inflammation in the wound surface. On day 14 after suregery, Masson staining was used to observe the expression of collagen and immunohistochemical staining was used to observe the expression of CD31 in the wound surface. On day 7 after surgery, western blot assay was performed to detect the expression of α-smooth muscle actin and type I collagen in the wound surface. RESULTS AND CONCLUSION: (1) The wound healing was faster in the agomiR-196b-5p group, while it was slower in the blank control group and the exosome+antagomiR-196b-5p group. (2) Compared with the blank control group and the exosome+antagomiR-196b-5p group, the wound infiltration of inflammatory cells was less in the exosome group and the agomiR-196b-5p group, and the expression of CD31 was significantly increased (P < 0.01). (3) Compared with the blank control group and the exosome+antagomiR-196b-5p group, the expression levels of α-smooth muscle actin and type I collagen were increased in the exosome group and the agomiR-196b-5p group (P < 0.05). These findings indicate that miR-196b-5p in adipose stem cell-derived exosomes can promote burn wound healing in rats., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321500913815105932, articleId=1321500910560326027, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=脂肪干细胞源性外泌体中 miR-196b-5p 对大鼠烧伤创面愈合的影响, columnId=null, journalTitle=中国组织工程研究, columnName=工程化脂肪干细胞, runingTitle=null, highlight=null, articleAbstract=背景:目前发现miR-196b-5p在细胞增殖、迁移及抑制瘢痕增生中发挥作用,但在创面愈合过程中是否发挥作用缺乏相关研究。 目的:探讨脂肪干细胞源性外泌体中miR-196b-5p对烧伤创面愈合的影响。 方法:构建SD大鼠皮肤深Ⅱ度烧伤模型,随机分为4组:空白对照组、外泌体组、agomiR-196b-5p组和外泌体+antagomiR-196b-5p组,每组10只,根据不同分组于创周注射PBS、脂肪干细胞源性外泌体、miR-196b-5p激动剂和miR-196b-5p抑制剂,伤后即刻和伤后7,14,21 d观察创面愈合情况,伤后7 d苏木精-伊红染色观察创面炎症表达,伤后14 d Masson染色观察创面胶原表达及免疫组化染色观察创面CD31表达,伤后7 d Western blot检测创面中α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达。 结果与结论:①agomiR-196b-5p组创面愈合较快,空白对照组和外泌体+antagomiR-196b-5p组愈合较慢;②与空白对照组和外泌体+antagomiR-196b-5p组相比,外泌体组和agomiR-196b-5p组创面炎性细胞浸润较少,CD31表达明显增加(P < 0.01);③与空白对照组和外泌体+antagomiR-196b-5p组相比,外泌体组和agomiR-196b-5p组中α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达升高(P < 0.05)。结果表明,脂肪干细胞源性外泌体中miR-196b-5p能促进大鼠烧伤创面愈合。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/bdea96f90f5c48acbcb7b0b2c4a5a6ae.pdf?response-content-disposition=attachment%3B%20filename%3D%22%E8%84%82%E8%82%AA%E5%B9%B2%E7%BB%86%E8%83%9E%E6%BA%90%E6%80%A7%E5%A4%96%E6%B3%8C%E4%BD%93%E4%B8%ADmiR-196b-5p%E5%AF%B9%E5%A4%A7%E9%BC%A0%E7%83%A7%E4%BC%A4%E5%88%9B%E9%9D%A2%E6%84%88%E5%90%88%E7%9A%84%E5%BD%B1%E5%93%8D.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20261026T073148Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20261026%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=cc8e0915a89d2d51f21cfa54d35031171f5e399cbe719a7770af33de5eb33b3c, pdf=NOjHxt2tgRCHAf1EhZbX0g==, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=[Author(id=1321500914368754066, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=左娜, orcid=0009-0007-2986-889X, stid=null, country=null, authorPic=null, dead=null, email=[], emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914469417364, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914368754066, language=CN, stringName=左娜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=左娜: 左娜,女,1989年生,辽宁省沈阳市人,汉族,2015年中国医科大学毕业,硕士,主治医师,主要从事瘢痕的综合治疗、烧创伤创面修复、激光美容等, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914540720533, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=唐琪, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914632995223, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914540720533, language=CN, stringName=唐琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=唐琪: 陶凯,博士,主任医师,中国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914704298392, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=于猛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914792378778, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914704298392, language=CN, stringName=于猛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914855293339, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=陶凯, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1321500915119534493, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914855293339, language=CN, stringName=陶凯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])])], keywords=[Keyword(id=1321500915450884510, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=1, keyword=脂肪干细胞), Keyword(id=1321500915513799071, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=2, keyword=外泌体), Keyword(id=1321500915585102240, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=3, keyword=miR-196b-5p), Keyword(id=1321500915668988321, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=4, keyword=烧伤), Keyword(id=1321500915866120610, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=5, keyword=创面愈合), Keyword(id=1321500915929035171, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=6, keyword=炎症反应), Keyword(id=1321500917569008036, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=7, keyword=血管新生), Keyword(id=1321500917657088421, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=CN, orderNo=8, keyword=工程化外泌体), Keyword(id=1321500917732585894, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=1, keyword=adipose-derived stem cell), Keyword(id=1321500917799694759, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=2, keyword=exosome), Keyword(id=1321500917904552360, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=3, keyword=miR-196b-5p), Keyword(id=1321500917975855529, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=4, keyword=burn), Keyword(id=1321500918042964394, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=5, keyword=wound healing), Keyword(id=1321500918118461867, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=6, keyword=inflammatory response), Keyword(id=1321500918177182124, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=7, keyword=angiogenesis), Keyword(id=1321500918240096685, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, language=EN, orderNo=8, keyword=engineered exosome)], refs=[Reference(id=1321500920370803119, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG QZ, ZHAO ZL, LIU C, et al. Exosome-derived miR-196b-5p facilitates intercellular interaction in infantile hemangioma via down-regulating CDKN1B. Ann Transl Med. 2021;9(5):394., articleTitle=null, refAbstract=null), Reference(id=1321500920370803120, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=LI Z, GONG C, WEI H. Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p. Bioengineered. 2022;13(1):1447-1458., articleTitle=null, refAbstract=null), Reference(id=1321500920370803121, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHU D, HU Y, KONG X, et al. Enhanced burn wound healing by controlled-release 3D ADMSC-derived exosome-loaded hyaluronan hydrogel. Regen Biomater. 2024;11:rbae035., articleTitle=null, refAbstract=null), Reference(id=1321500920374997424, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHU YG, SHI MM, MONSEL A, et al. Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study. Stem Cell Res Ther. 2022;13(1):220., articleTitle=null, refAbstract=null), Reference(id=1321500920374997425, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=HEO JS, KIM S, YANG CE, et al. Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing. Tissue Eng Regen Med. 2021;18(4):537-548., articleTitle=null, refAbstract=null), Reference(id=1321500920374997426, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG J, DENG P, QI Y, et al. NEAT1 Knockdown Inhibits Keloid Fibroblast Progression by miR-196b-5p/FGF2 Axis. J Surg Res. 2021;259:261-270., articleTitle=null, refAbstract=null), Reference(id=1321500920374997427, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=刘忠钰,李文娅,范永鸿,等.甲基丙烯酰化改性真皮细胞外基质水凝胶促进腹壁缺损修复[J].中国组织工程研究,2025,29(10): 2074-2082., articleTitle=null, refAbstract=null), Reference(id=1321500920374997428, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG X, JIAO Y, PAN Y, et al. Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling. Stem Cells Int. 2019;2019:2402916., articleTitle=null, refAbstract=null), Reference(id=1321500920374997429, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=SHAFEI S, KHANMOHAMMADI M, HEIDARI R, et al. Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: An in vivo study. J Biomed Mater Res A. 2020;108(3):545-556., articleTitle=null, refAbstract=null), Reference(id=1321500920374997430, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=KWON HH, YANG SH, LEE J, et al. Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta Derm Venereol. 2020;100(18):adv00310., articleTitle=null, refAbstract=null), Reference(id=1321500920374997431, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG M, HU S, LIU L, et al. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduct Target Ther. 2023;8(1):124., articleTitle=null, refAbstract=null), Reference(id=1321500920374997432, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=CHU M, WANG H, BIAN L, et al. Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia. Stem Cell Rev Rep. 2022;18(6):2152-2163., articleTitle=null, refAbstract=null), Reference(id=1321500920374997433, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=JO H, BRITO S, KWAK BM, et al. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation. Int J Mol Sci. 2021;22(5):2410., articleTitle=null, refAbstract=null), Reference(id=1321500920374997434, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHU W, YU Y, YE Y, et al. MiR-196b-5p activates NF-κB signaling in non-small cell lung cancer by directly targeting NFKBIA. Transl Oncol. 2023;37:101755., articleTitle=null, refAbstract=null), Reference(id=1321500920374997435, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=LI L, MA Y, HE G, et al. Pilose antler extract restores type I and III collagen to accelerate wound healing. Biomed Pharmacother. 2023; 161:114510., articleTitle=null, refAbstract=null), Reference(id=1321500920374997436, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=HSIEH MW, WANG WT, LIN CY, et al. Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing. Biomedicines. 2022;10(9):2085., articleTitle=null, refAbstract=null), Reference(id=1321500920374997437, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=WU LL, ZHANG XY, LI X, et al. miR-196b-5p promotes myoblast proliferation and differentiation. Yi Chuan. 2023;45(5):435-446., articleTitle=null, refAbstract=null), Reference(id=1321500920374997438, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=丁毅,吾拉尔•阿德力,李敏,等.一种简便的大鼠Ⅱ度烫伤模型制备方法[J].临床与病理杂志,2021,41(3):517-522., articleTitle=null, refAbstract=null), Reference(id=1321500920374997439, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=XU C, ZHANG H, YANG C, et al. miR-125b-5p delivered by adipose-derived stem cell exosomes alleviates hypertrophic scarring by suppressing Smad2. Burns Trauma. 2024;12:tkad064., articleTitle=null, refAbstract=null), Reference(id=1321500920374997440, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=BOLLA SR, MOHAMMED AL-SUBAIE A, YOUSUF AL-JINDAN R, et al. In vitro wound healing potency of methanolic leaf extract of Aristolochia saccata is possibly mediated by its stimulatory effect on collagen-1 expression. Heliyon. 2019;5(5):e01648., articleTitle=null, refAbstract=null), Reference(id=1321500920374997441, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=REZAEI YAZDI F, GHAHARY A, MIRDORAGHI M, et al. Promotion of Burn Wound Healing by Local Application of Adipose-Derived Mesenchymal Stem Cells: An Experimental Study. Med J Islam Repub Iran. 2021;35:172., articleTitle=null, refAbstract=null), Reference(id=1321500920374997442, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=ZENG QL, LIU DW. Mesenchymal stem cell-derived exosomes: An emerging therapeutic strategy for normal and chronic wound healing. World J Clin Cases. 2021;9(22):6218-6233., articleTitle=null, refAbstract=null), Reference(id=1321500920374997443, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=ABDUL KAREEM N, AIJAZ A, JESCHKE MG. Stem Cell Therapy for Burns: Story so Far. Biologics. 2021;15:379-397., articleTitle=null, refAbstract=null), Reference(id=1321500920379191729, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=TANG XH, GUO T, GAO XY, et al. Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications. Mol Cancer. 2021;20(1):99., articleTitle=null, refAbstract=null), Reference(id=1321500920379191730, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=PI L, YANG L, FANG BR, et al. Exosomal microRNA-125a-3p from human adipose-derived mesenchymal stem cells promotes angiogenesis of wound healing through inhibiting PTEN. Mol Cell Biochem. 2022; 477(1):115-127., articleTitle=null, refAbstract=null), Reference(id=1321500920379191731, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG ZY, WEN ZJ, XU HM, et al. Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications. Front Mol Neurosci. 2022;15:1004221., articleTitle=null, refAbstract=null), Reference(id=1321500920379191732, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=TRAMS EG, LAUTER CJ, SALEM N JR, et al. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 1981;645(1):63-70., articleTitle=null, refAbstract=null), Reference(id=1321500920379191733, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=HOSSEINI M, DALLEY AJ, SHAFIEE A. Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing. Pharmaceutics. 2022;14(12):2749., articleTitle=null, refAbstract=null), Reference(id=1321500920379191734, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=王宏宇,刘玲英,巴特.间充质干细胞在烧伤创面修复中的研究进展[J].中华损伤与修复杂志(电子版),2020,15(6):495-498., articleTitle=null, refAbstract=null), Reference(id=1321500920379191735, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=LOU R, CHEN J, ZHOU F, et al. Exosome-cargoed microRNAs: Potential therapeutic molecules for diabetic wound healing. Drug Discov Today. 2022;27(10):103323., articleTitle=null, refAbstract=null), Reference(id=1321500920379191736, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG K, ZHAO X, CHEN X, et al. Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018;10(36):30081-30091., articleTitle=null, refAbstract=null), Reference(id=1321500920379191737, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG Z, YANG L, LEI X, et al. Mechanism of non-small cell lung cancer cell-derived exosome miR-196b-5p promoting pyroptosis of tumor T cells and tumor cell proliferation by downregulating ING5. J Biochem Mol Toxicol. 2024;38(1):e23629., articleTitle=null, refAbstract=null), Reference(id=1321500920379191738, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=PAK H, HADIZADEH A, HEIRANI-TABASI A, et al. Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non-Crohn’s cases: Clinical trial phase I. J Gastroenterol Hepatol. 2023;38(4):539-547., articleTitle=null, refAbstract=null), Reference(id=1321500920379191739, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=EL KAHI CG, ATIYEH BS, ABDALLAH HAJJ HUSSEIN I, et al. Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit’s experimental model. Int Wound J. 2009;6(3):214-224., articleTitle=null, refAbstract=null), Reference(id=1321500920379191740, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=KOLANTHAI E, FU Y, KUMAR U, et al. Nanoparticle mediated RNA delivery for wound healing. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022;14(2):e1741., articleTitle=null, refAbstract=null), Reference(id=1321500920379191741, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=PI L, YANG L, FANG BR, et al. LncRNA MALAT1 from human adipose-derived stem cell exosomes accelerates wound healing via miR-378a/FGF2 axis. Regen Med. 2022;17(9):627-641., articleTitle=null, refAbstract=null), Reference(id=1321500920379191742, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=郑明魁,薛晨晖,关晓明,等.人脐带间充质干细胞来源外泌体降低脊髓损伤后血脊髓屏障的通透性[J].中国组织工程研究,2024, 28(1):50-55., articleTitle=null, refAbstract=null), Reference(id=1321500920379191743, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=MAO X, ZHOU X, LIU J, et al. Up-regulated Linc00472 suppresses development of lung cancer cell via inhibition of MiR-196b-5p. Biosci Biotechnol Biochem. 2022;86(8):1160., articleTitle=null, refAbstract=null), Reference(id=1321500920379191744, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=SADEGHI S, TEHRANI FR, TAHMASEBI S, et al. Exosome engineering in cell therapy and drug delivery. Inflammopharmacology. 2023;31(1): 145-169., articleTitle=null, refAbstract=null)], funds=[Fund(id=1321500920232391086, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, awardId=2031066524912537602, language=CN, fundingSource=辽宁省科学技术计划, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1321500914205176206, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=1, ext=[AuthorCompanyExt(id=1321500914221953423, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914205176206, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=1.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)]), AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])], figs=null, attaches=null, journal=Journal(id=1246415294369935424, delFlag=0, nameCn=中国组织工程研究, nameEn=Chinese Journal of Tissue Engineering Research, nameHistory1=null, nameHistory2=null, issn=2095-4344, eissn=null, cn=21-1581/R, coden=null, periodic=4, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=Z8GUGTZyRoc+cZI9v+UXIQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Tissue Engineering Research, journalRemark=null, publicationField=null, createdTime=1775098163455, updatedTime=1784020022996, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=Z8GUGTZyRoc+cZI9v+UXIQ==, picEn=sS3E3RhpIvw/+mCxJnlQjw==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836286578443023, language=CN, name=中国组织工程研究, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020023245, updatedTime=1784020023245, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgzzgcauthor.manuscriptcloud.com/, submissionEditorUrl=https://zgzzgceditor.manuscriptcloud.com/, submissionReviewUrl=https://zgzzgcauthor.manuscriptcloud.com/, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283836286641357584, language=EN, name=Chinese Journal of Tissue Engineering Research, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020023260, updatedTime=1784020023260, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgzzgcauthor.manuscriptcloud.com/, submissionEditorUrl=https://zgzzgceditor.manuscriptcloud.com/, submissionReviewUrl=https://zgzzgcauthor.manuscriptcloud.com/, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1246415837536497731, websiteList=[Website(id=1246421196720460703, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415837536497731, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN, language=CN, createTime=1775099570684, createBy=18614031015, updateTime=1775100523356, updateBy=18614031015, name=中国组织工程研究-中文, tplId=1146099689490845704, title=中国组织工程研究, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246425325081613254, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=articleTextType, value=kx, createTime=1775100554962, updateTime=1775100554962, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325052253123, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=banner, value=null, createTime=1775100554955, updateTime=1775100554955, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325110973385, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=grayFlag, value=0, createTime=1775100554969, updateTime=1775100554969, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325043864514, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=logo, value=https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN/file/pic?fileId=3HSzTUf/nj4CbNAHtU7s5g==, createTime=1775100554953, updateTime=1775100554953, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325123556299, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=minRunFlag, value=0, createTime=1775100554972, updateTime=1775100554972, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325073224645, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN/file/pic, createTime=1775100554960, updateTime=1775100554960, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325115167690, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=silenceFlag, value=0, createTime=1775100554970, updateTime=1775100554970, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325064836036, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775100554958, updateTime=1775100554958, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325094196167, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=themeColor, value=null, createTime=1775100554965, updateTime=1775100554965, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425325102584776, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196720460703, code=themeStyle, value=null, createTime=1775100554967, updateTime=1775100554967, creator=18614031015, updator=18614031015)]), Website(id=1246421196875649954, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415837536497731, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgzzgcyj/EN, language=EN, createTime=1775099570721, createBy=18614031015, updateTime=1775100518855, updateBy=18614031015, name=中国组织工程研究-英文, tplId=1146101810881728533, title=Chinese Journal of Tissue Engineering Research, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246425360989053080, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=articleTextType, value=kx, createTime=1775100563523, updateTime=1775100563523, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425360968081557, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=banner, value=null, createTime=1775100563518, updateTime=1775100563518, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425361014218907, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=grayFlag, value=0, createTime=1775100563529, updateTime=1775100563529, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425360955498644, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=logo, value=https://castjournals.cast.org.cn/joweb/zgzzgcyj/EN/file/pic?fileId=3HSzTUf/nj4CbNAHtU7s5g==, createTime=1775100563515, updateTime=1775100563515, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425361030996125, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=minRunFlag, value=0, createTime=1775100563533, updateTime=1775100563533, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425360984858775, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgzzgcyj/EN/file/pic, createTime=1775100563522, updateTime=1775100563522, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425361018413212, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=silenceFlag, value=0, createTime=1775100563530, updateTime=1775100563530, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425360976470166, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775100563520, updateTime=1775100563520, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425360997441689, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=themeColor, value=null, createTime=1775100563525, updateTime=1775100563525, creator=18614031015, updator=18614031015), WebsiteProps(id=1246425361005830298, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196875649954, code=themeStyle, value=null, createTime=1775100563527, updateTime=1775100563527, creator=18614031015, updator=18614031015)])], journalTitle=中国组织工程研究, weixinUrl=null, journalUrl=https://www.cjter.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Tissue Engineering Research, journalPhotoCn=Z8GUGTZyRoc+cZI9v+UXIQ==, journalPhotoEn=sS3E3RhpIvw/+mCxJnlQjw==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN/10.12307/2025.927, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgzzgcyj/EN/10.12307/2025.927, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN/PDF/10.12307/2025.927, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgzzgcyj/EN/PDF/10.12307/2025.927, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1767801600000, fullTextJson=null, articleText=null, reference=null)
收藏切换
脂肪干细胞源性外泌体中 miR-196b-5p 对大鼠烧伤创面愈合的影响
收藏切换
PDF下载
左娜 1, , 唐琪 1, , 于猛 1, , 陶凯 1,
中国组织工程研究 | 工程化脂肪干细胞 2026,30(1): 43-49
收起
收藏切换
中国组织工程研究 |工程化脂肪干细胞 2026 , 30 (1) : 43 -49
脂肪干细胞源性外泌体中 miR-196b-5p 对大鼠烧伤创面愈合的影响
全屏
[Author(id=1321500914368754066, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=左娜, orcid=0009-0007-2986-889X, stid=null, country=null, authorPic=null, dead=null, email=[], emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914469417364, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914368754066, language=CN, stringName=左娜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=左娜: 左娜,女,1989年生,辽宁省沈阳市人,汉族,2015年中国医科大学毕业,硕士,主治医师,主要从事瘢痕的综合治疗、烧创伤创面修复、激光美容等, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914540720533, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=唐琪, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914632995223, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914540720533, language=CN, stringName=唐琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=唐琪: 陶凯,博士,主任医师,中国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914704298392, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=于猛, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=2, ext={CN=AuthorExt(id=1321500914792378778, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914704298392, language=CN, stringName=于猛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])]), Author(id=1321500914855293339, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=陶凯, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=2, ext={CN=AuthorExt(id=1321500915119534493, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, authorId=1321500914855293339, language=CN, stringName=陶凯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1,, address=2国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321500914289062288, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, xref=2*, ext=[AuthorCompanyExt(id=1321500914297450897, tenantId=1146029695717560320, journalId=1246415837536497731, articleId=1321500910560326027, companyId=1321500914289062288, language=CN, country=null, province=null, city=null, postcode=null, companyName=国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000, departmentName=null, remark=2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000)])])]
左娜1, , 唐琪1,, 于猛1,, 陶凯1,
作者信息
  • 1.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000
  • 2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000
Effect of miR-196b-5p in adipose-derived stem cell exosomes on burn wound healing in rats
Affiliations
出版时间: 2026-01-08 doi: 10.12307/2025.927
文章导航
收藏切换
背景:目前发现miR-196b-5p在细胞增殖、迁移及抑制瘢痕增生中发挥作用,但在创面愈合过程中是否发挥作用缺乏相关研究。 目的:探讨脂肪干细胞源性外泌体中miR-196b-5p对烧伤创面愈合的影响。 方法:构建SD大鼠皮肤深Ⅱ度烧伤模型,随机分为4组:空白对照组、外泌体组、agomiR-196b-5p组和外泌体+antagomiR-196b-5p组,每组10只,根据不同分组于创周注射PBS、脂肪干细胞源性外泌体、miR-196b-5p激动剂和miR-196b-5p抑制剂,伤后即刻和伤后7,14,21 d观察创面愈合情况,伤后7 d苏木精-伊红染色观察创面炎症表达,伤后14 d Masson染色观察创面胶原表达及免疫组化染色观察创面CD31表达,伤后7 d Western blot检测创面中α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达。 结果与结论:①agomiR-196b-5p组创面愈合较快,空白对照组和外泌体+antagomiR-196b-5p组愈合较慢;②与空白对照组和外泌体+antagomiR-196b-5p组相比,外泌体组和agomiR-196b-5p组创面炎性细胞浸润较少,CD31表达明显增加(P < 0.01);③与空白对照组和外泌体+antagomiR-196b-5p组相比,外泌体组和agomiR-196b-5p组中α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达升高(P < 0.05)。结果表明,脂肪干细胞源性外泌体中miR-196b-5p能促进大鼠烧伤创面愈合。
脂肪干细胞  /  外泌体  /  miR-196b-5p  /  烧伤  /  创面愈合  /  炎症反应  /  血管新生  /  工程化外泌体
BACKGROUND: Currently, miR-196b-5p has been found to play a role in cell proliferation, migration and inhibition of scar hyperplasia, but there is a lack of relevant studies on whether it plays a role in the process of wound healing. OBJECTIVE: To investigate the effect of miR-196b-5p in adipose stem cell-derived exosomes on burn wound healing. METHODS: The models of deep second degree skin burn in SD rats were established and randomly divided into four groups: blank control group, exosome group, agomiR-196b-5p group, and exosome + antagomiR-196b-5p group, with 10 rats in each group. PBS, adipose-derived stem cell-derived exosomes, miR-196b-5p agonist, and miR-196b-5p inhibitor were injected around the wound according to different groups. Wound healing was observed immediately after injury and on days 7, 14, and 21 after injury. On day 7 after surgery, hematoxylin-eosin staining was used to observe the expression of inflammation in the wound surface. On day 14 after suregery, Masson staining was used to observe the expression of collagen and immunohistochemical staining was used to observe the expression of CD31 in the wound surface. On day 7 after surgery, western blot assay was performed to detect the expression of α-smooth muscle actin and type I collagen in the wound surface. RESULTS AND CONCLUSION: (1) The wound healing was faster in the agomiR-196b-5p group, while it was slower in the blank control group and the exosome+antagomiR-196b-5p group. (2) Compared with the blank control group and the exosome+antagomiR-196b-5p group, the wound infiltration of inflammatory cells was less in the exosome group and the agomiR-196b-5p group, and the expression of CD31 was significantly increased (P < 0.01). (3) Compared with the blank control group and the exosome+antagomiR-196b-5p group, the expression levels of α-smooth muscle actin and type I collagen were increased in the exosome group and the agomiR-196b-5p group (P < 0.05). These findings indicate that miR-196b-5p in adipose stem cell-derived exosomes can promote burn wound healing in rats.
adipose-derived stem cell  /  exosome  /  miR-196b-5p  /  burn  /  wound healing  /  inflammatory response  /  angiogenesis  /  engineered exosome
左娜, 唐琪, 于猛, 陶凯. 脂肪干细胞源性外泌体中 miR-196b-5p 对大鼠烧伤创面愈合的影响. 中国组织工程研究, 2026 , 30 (1) : 43 -49 . DOI: 10.12307/2025.927
. Effect of miR-196b-5p in adipose-derived stem cell exosomes on burn wound healing in rats[J]. Chinese Journal of Tissue Engineering Research, 2026 , 30 (1) : 43 -49 . DOI: 10.12307/2025.927
  • 辽宁省科学技术计划
参考文献 引证文献
排序方式:
1
WANG QZ, ZHAO ZL, LIU C, et al. Exosome-derived miR-196b-5p facilitates intercellular interaction in infantile hemangioma via down-regulating CDKN1B. Ann Transl Med. 2021;9(5):394.
2
LI Z, GONG C, WEI H. Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p. Bioengineered. 2022;13(1):1447-1458.
3
ZHU D, HU Y, KONG X, et al. Enhanced burn wound healing by controlled-release 3D ADMSC-derived exosome-loaded hyaluronan hydrogel. Regen Biomater. 2024;11:rbae035.
4
ZHU YG, SHI MM, MONSEL A, et al. Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study. Stem Cell Res Ther. 2022;13(1):220.
5
HEO JS, KIM S, YANG CE, et al. Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing. Tissue Eng Regen Med. 2021;18(4):537-548.
6
YANG J, DENG P, QI Y, et al. NEAT1 Knockdown Inhibits Keloid Fibroblast Progression by miR-196b-5p/FGF2 Axis. J Surg Res. 2021;259:261-270.
7
刘忠钰,李文娅,范永鸿,等.甲基丙烯酰化改性真皮细胞外基质水凝胶促进腹壁缺损修复[J].中国组织工程研究,2025,29(10): 2074-2082.
8
WANG X, JIAO Y, PAN Y, et al. Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling. Stem Cells Int. 2019;2019:2402916.
9
SHAFEI S, KHANMOHAMMADI M, HEIDARI R, et al. Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: An in vivo study. J Biomed Mater Res A. 2020;108(3):545-556.
10
KWON HH, YANG SH, LEE J, et al. Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta Derm Venereol. 2020;100(18):adv00310.
11
ZHANG M, HU S, LIU L, et al. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduct Target Ther. 2023;8(1):124.
12
CHU M, WANG H, BIAN L, et al. Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia. Stem Cell Rev Rep. 2022;18(6):2152-2163.
13
JO H, BRITO S, KWAK BM, et al. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation. Int J Mol Sci. 2021;22(5):2410.
14
ZHU W, YU Y, YE Y, et al. MiR-196b-5p activates NF-κB signaling in non-small cell lung cancer by directly targeting NFKBIA. Transl Oncol. 2023;37:101755.
15
LI L, MA Y, HE G, et al. Pilose antler extract restores type I and III collagen to accelerate wound healing. Biomed Pharmacother. 2023; 161:114510.
16
HSIEH MW, WANG WT, LIN CY, et al. Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing. Biomedicines. 2022;10(9):2085.
17
WU LL, ZHANG XY, LI X, et al. miR-196b-5p promotes myoblast proliferation and differentiation. Yi Chuan. 2023;45(5):435-446.
18
丁毅,吾拉尔•阿德力,李敏,等.一种简便的大鼠Ⅱ度烫伤模型制备方法[J].临床与病理杂志,2021,41(3):517-522.
19
XU C, ZHANG H, YANG C, et al. miR-125b-5p delivered by adipose-derived stem cell exosomes alleviates hypertrophic scarring by suppressing Smad2. Burns Trauma. 2024;12:tkad064.
20
BOLLA SR, MOHAMMED AL-SUBAIE A, YOUSUF AL-JINDAN R, et al. In vitro wound healing potency of methanolic leaf extract of Aristolochia saccata is possibly mediated by its stimulatory effect on collagen-1 expression. Heliyon. 2019;5(5):e01648.
21
REZAEI YAZDI F, GHAHARY A, MIRDORAGHI M, et al. Promotion of Burn Wound Healing by Local Application of Adipose-Derived Mesenchymal Stem Cells: An Experimental Study. Med J Islam Repub Iran. 2021;35:172.
22
ZENG QL, LIU DW. Mesenchymal stem cell-derived exosomes: An emerging therapeutic strategy for normal and chronic wound healing. World J Clin Cases. 2021;9(22):6218-6233.
23
ABDUL KAREEM N, AIJAZ A, JESCHKE MG. Stem Cell Therapy for Burns: Story so Far. Biologics. 2021;15:379-397.
24
TANG XH, GUO T, GAO XY, et al. Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications. Mol Cancer. 2021;20(1):99.
25
PI L, YANG L, FANG BR, et al. Exosomal microRNA-125a-3p from human adipose-derived mesenchymal stem cells promotes angiogenesis of wound healing through inhibiting PTEN. Mol Cell Biochem. 2022; 477(1):115-127.
26
WANG ZY, WEN ZJ, XU HM, et al. Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications. Front Mol Neurosci. 2022;15:1004221.
27
TRAMS EG, LAUTER CJ, SALEM N JR, et al. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 1981;645(1):63-70.
28
HOSSEINI M, DALLEY AJ, SHAFIEE A. Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing. Pharmaceutics. 2022;14(12):2749.
29
王宏宇,刘玲英,巴特.间充质干细胞在烧伤创面修复中的研究进展[J].中华损伤与修复杂志(电子版),2020,15(6):495-498.
30
LOU R, CHEN J, ZHOU F, et al. Exosome-cargoed microRNAs: Potential therapeutic molecules for diabetic wound healing. Drug Discov Today. 2022;27(10):103323.
31
ZHANG K, ZHAO X, CHEN X, et al. Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018;10(36):30081-30091.
32
ZHANG Z, YANG L, LEI X, et al. Mechanism of non-small cell lung cancer cell-derived exosome miR-196b-5p promoting pyroptosis of tumor T cells and tumor cell proliferation by downregulating ING5. J Biochem Mol Toxicol. 2024;38(1):e23629.
33
PAK H, HADIZADEH A, HEIRANI-TABASI A, et al. Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non-Crohn’s cases: Clinical trial phase I. J Gastroenterol Hepatol. 2023;38(4):539-547.
34
EL KAHI CG, ATIYEH BS, ABDALLAH HAJJ HUSSEIN I, et al. Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit’s experimental model. Int Wound J. 2009;6(3):214-224.
35
KOLANTHAI E, FU Y, KUMAR U, et al. Nanoparticle mediated RNA delivery for wound healing. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022;14(2):e1741.
36
PI L, YANG L, FANG BR, et al. LncRNA MALAT1 from human adipose-derived stem cell exosomes accelerates wound healing via miR-378a/FGF2 axis. Regen Med. 2022;17(9):627-641.
37
郑明魁,薛晨晖,关晓明,等.人脐带间充质干细胞来源外泌体降低脊髓损伤后血脊髓屏障的通透性[J].中国组织工程研究,2024, 28(1):50-55.
38
MAO X, ZHOU X, LIU J, et al. Up-regulated Linc00472 suppresses development of lung cancer cell via inhibition of MiR-196b-5p. Biosci Biotechnol Biochem. 2022;86(8):1160.
39
SADEGHI S, TEHRANI FR, TAHMASEBI S, et al. Exosome engineering in cell therapy and drug delivery. Inflammopharmacology. 2023;31(1): 145-169.
2026年第30卷第1期
PDF下载
47
7
引用本文
BibTeX
文章信息
doi: 10.12307/2025.927
  • 首发时间:2025-05-30
  • 出版时间:2026-01-08
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期:2024-12-26
基金
辽宁省科学技术计划
作者信息
    1.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000
    2.国医科大学附属第四医院烧伤整形显微外科,辽宁省沈阳市 110000

通讯作者:

参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgzzgcyj/CN/10.12307/2025.927
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏