Article(id=1321501082342240328, tenantId=1146029695717560320, journalId=1246415837536497731, issueId=1321500868936052946, articleNumber=PA20260310_yClv19oX, orderNo=null, doi=10.12307/2025.569, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1736179200000, acceptedDateStr=2025-01-07, onlineDate=1748534400000, onlineDateStr=2025-05-30, pubDate=1767801600000, pubDateStr=2026-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793000010332, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793000010332, creator=admin, updateTime=1793000010332, updator=admin, issue=Issue{id=1321500868936052946, tenantId=1146029695717560320, journalId=1246415837536497731, year='2026', volume='30', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='1767801600000', pubDateStr='2026-01-08', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792999959453, creator='ztmeta', updateTime=1792999959453, updator='ztmeta', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=175, endPage=183, ext={EN=ArticleExt(id=1321501085768986698, articleId=1321501082342240328, tenantId=1146029695717560320, journalId=1246415837536497731, language=EN, title=Stem cell exosomes and biomaterial-assisted exosomes in bone defect repair, columnId=null, journalTitle=Chinese Journal of Tissue Engineering Research, columnName=null, runingTitle=null, highlight=null, articleAbstract=BACKGROUND: A large number of studies have demonstrated that stem cell exosomes play an important role in the repair of bone defects, either directly as carriers for loading other small molecules or surface modifications, or by binding to biomaterials to promote the repair and regeneration of bone tissue. OBJECTIVE: To summarize the osteogenic mechanisms of stem cell exosomes from different sources and their research progress in bone defect repair. METHODS: Chinese search terms “stem cell, exosome, bone, biomaterial, carrier, bioceramic, polymer, metal, hydrogel, engineered exosome” were used to search CNKI. English search terms “stem cell, exosome, bone defect, biomaterial, carrier, bioceramic, ploymer, metal material, hydrogel, engineering exosome” were used to search PubMed database. According to the inclusion and exclusion criteria, 77 relevant articles were finally included for summary. RESULTS AND CONCLUSION: Exosomes from stem cells of different origins can promote osteoblast proliferation and differentiation, promote angiogenesis, and regulate osteoclast activity and macrophage phenotype to promote bone formation and bone mineralization. In addition, many achievements of exosomes in the field of bone defect repair were described from two aspects: biomaterial-assisted exosomes and engineered exosomes. However, the current research on stem cell exosomes in bone tissue engineering is still insufficient, and most of these studies are limited to small animal models, while the treatment of bone defects in large animals, including humans, will be more complex, which will also become a major challenge for the treatment of bone defects. This will also be a great challenge in the dissemination of exosome therapy., authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321501085383110729, articleId=1321501082342240328, tenantId=1146029695717560320, journalId=1246415837536497731, language=CN, title=干细胞外泌体和生物材料辅助外泌体修复骨缺损, columnId=null, journalTitle=中国组织工程研究, columnName=null, runingTitle=null, highlight=null, articleAbstract=背景：已有大量研究表明，干细胞外泌体在骨缺损修复过程中发挥着重要作用，既能直接作为载体负载其他小分子或表面修饰，也能与生物材料结合促进骨组织的修复和再生。 目的：综述不同来源干细胞外泌体的成骨机制及在骨缺损修复中的研究进展。 方法：以“干细胞，外泌体，骨，生物材料，载体，生物陶瓷，聚合物，金属，水凝胶，工程化外泌体”为中文检索词，检索中国知网，以“stem cell，exosome，bone defect，biomaterial，carrier，bioceramic，ploymer，metal material，hydrogel，engineering exosome”为英文检索词，检索PubMed数据库，依据纳入和排除标准，最终纳入相关文献77篇进行归纳总结。 结果与结论：不同来源干细胞外泌体可以促进成骨细胞增殖和分化，促进血管生成，并调节破骨细胞活性和巨噬细胞表型进而促进骨形成和骨矿化。另外，从生物材料辅助外泌体和工程化外泌体两个方面阐述了外泌体在骨缺损修复领域取得的诸多成果。然而目前关于干细胞外泌体在骨组织工程中的研究仍然不足，且这些研究大多仅限于小动物模型，而包括人类在内的大型动物骨缺损治疗更加复杂，这也将是外泌体疗法推广过程中的巨大挑战。, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, 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