中国组织工程研究

细胞外囊泡介导细胞间通讯在女性卵泡发育、植入前胚胎发育及植入中的作用

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刘静 ¹,,², , 赵晓丽 ¹,,², , 夏天 ¹,,²,

中国组织工程研究 | 2026,30(1): 218-228

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中国组织工程研究 2026 , 30 (1) : 218 -228

细胞外囊泡介导细胞间通讯在女性卵泡发育、植入前胚胎发育及植入中的作用

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刘静¹,,²,, 赵晓丽¹,,²,, 夏天¹,,²,

作者信息

^1.津中医药大学第一附属医院，天津市 300193

^2.家中医针灸临床医学研究中心，天津市 300193

^3.津中医药大学第一附属医院，天津市 300193

^4.家中医针灸临床医学研究中心，天津市 300193

Role of extracellular vesicle-mediated intercellular communication in female follicle reproduction, preimplantation embryo development and implantation

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出版时间: 2026-01-08 doi: 10.12307/2025.554

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摘要

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背景：细胞外囊泡及其携带的蛋白质、核酸和脂质等生物分子介导细胞之间的信号传导，影响靶细胞的功能。细胞外囊泡介导的这种细胞间通讯机制参与对女性生殖发育过程的调控。目的：总结和分析细胞外囊泡介导的细胞间通讯在女性生殖发育中的调控作用。方法：以“extracellular vesicles，exosomes，reproduction，maternal-embryo communication，maternal-fetal crosstalk，embryo implantation，endometrium，oviduct，follicle”为检索词检索PubMed数据库，通过阅读文献标题和摘要进行初筛，再根据纳入和排除标准排除了与研究目的相关性差、内容陈旧、重复的文献，最终纳入了69篇相关文献进行归纳分析。结果与结论：在女性生殖发育的关键过程中，从卵泡发生到着床都有细胞外囊泡的参与。①细胞外囊泡介导卵泡内的细胞间通讯，涉及卵母细胞与卵泡体细胞之间的相互作用，从而在卵泡发育和成熟中发挥重要作用；②细胞外囊泡及其内容物可以介导胚胎与输卵管之间的相互作用，影响胚胎的发育路径；③细胞外囊泡及其内容物通过介导胚胎与子宫内膜间的双向通讯促进着床，子宫来源细胞外囊泡调节胚胎黏附、侵袭和蜕膜化等过程，胚胎来源细胞外囊泡调节子宫内膜容受性、传递胚胎信号、调节子宫内膜微环境等。研究细胞外囊泡在女性生殖发育中的作用，能够为理解不孕症的机制及开发新的治疗策略提供重要理论依据。

关键词

细胞外囊泡 / 细胞间通讯 / 母胎交流 / 着床 / 卵泡 / 输卵管 / 胚胎 / 子宫内膜 / 综述

Abstract

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BACKGROUND: Extracellular vesicles mediate intercellular signal transduction through the proteins, nucleic acids, and lipids they carry, thereby influencing the function of target cells. This vesicle-mediated communication mechanism is involved in regulating female reproductive development. OBJECTIVE: To summarize and analyze the regulatory roles of extracellular vesicle-mediated intercellular communication in female reproductive development. METHODS: A search was conducted in the PubMed database using the search terms “extracellular vesicles, exosomes, reproduction, maternal-embryo communication, maternal-fetal crosstalk, embryo implantation, endometrium, oviduct, follicle.” The initial screening was carried out by reading the titles and abstracts of the literature, and then the literature with poor relevance to the research purpose, outdated content, and duplication was excluded according to the inclusion and exclusion criteria. Ultimately, 69 relevant articles were included for comprehensive analysis. RESULTS AND CONCLUSION: Extracellular vesicles play a crucial role in key processes of female reproductive development, from folliculogenesis to implantation. (1) Extracellular vesicles mediate intercellular communication within the follicle, particularly the interactions between oocytes and follicular cells, which are essential for follicle development and maturation. (2) Extracellular vesicles and their contents facilitate interactions between the embryo and the fallopian tube, influencing the trajectory of embryonic development. (3) Extracellular vesicles and their contents promote implantation by mediating bidirectional communication between the embryo and the endometrium. Uterine-derived extracellular vesicles regulate processes such as embryo adhesion, invasion, and decidualization, while embryo-derived extracellular vesicles modulate endometrial receptivity, convey embryonic signals, and adjust the endometrial microenvironment. Studying the roles of extracellular vesicles in female reproductive development can provide valuable insights into the mechanisms of infertility and support the development of new therapeutic strategies.

Key words

extracellular vesicles / intercellular communication / maternal-embryo communication / implantation / follicle / oviduct / embryo / endometrium / review

引用本文

刘静, 赵晓丽, 夏天. 细胞外囊泡介导细胞间通讯在女性卵泡发育、植入前胚胎发育及植入中的作用. 中国组织工程研究, 2026 , 30 (1) : 218 -228 . DOI: 10.12307/2025.554

. Role of extracellular vesicle-mediated intercellular communication in female follicle reproduction, preimplantation embryo development and implantation[J]. Chinese Journal of Tissue Engineering Research, 2026 , 30 (1) : 218 -228 . DOI: 10.12307/2025.554

基金

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国家自然科学基金项目

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2026年第30卷第1期

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doi: 10.12307/2025.554

首发时间：2025-05-30
出版时间：2026-01-08

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录用日期：2024-10-31

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^1.津中医药大学第一附属医院，天津市 300193

^2.家中医针灸临床医学研究中心，天津市 300193

^3.津中医药大学第一附属医院，天津市 300193

^4.家中医针灸临床医学研究中心，天津市 300193

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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