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刘树鹏
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专业方向为消化道恶性肿瘤的诊治与研究

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专业方向为消化道恶性肿瘤的诊治与研究

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A:腹部CT增强(蓝色箭头:胃壁明显增厚);B:胃镜检查结果(蓝色箭头:食管胃结合部溃疡)

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A:腹部CT增强(蓝色箭头:胃壁增厚明显缩小);B:胃镜检查结果(蓝色箭头:食管胃结合部肿瘤明显消失)

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经皮穿刺动脉灌注化疗联合PD-1抑制剂治疗晚期食管胃结合腺癌临床完全缓解1例
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张啸 1 , 邓波 1 , 刘树鹏 1, 2
中国肿瘤临床 | 病例报告与分析 2025,52(14): 753-754
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中国肿瘤临床 | 病例报告与分析 2025, 52(14): 753-754
经皮穿刺动脉灌注化疗联合PD-1抑制剂治疗晚期食管胃结合腺癌临床完全缓解1例
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张啸1 , 邓波1, 刘树鹏1, 2
作者信息
  • 1广州复大肿瘤医院肿瘤科(广州市510315)
  • 2暨南大学附属第一医院肿瘤科
  • 专业方向为消化道恶性肿瘤的诊治与研究

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出版时间: 2025-07-30 doi: 10.12354/j.issn.1000-8179.2025.20250687
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食管胃结合部腺癌  /  免疫治疗  /  经皮穿刺动脉灌注化疗  /  完全缓解
张啸, 邓波, 刘树鹏. 经皮穿刺动脉灌注化疗联合PD-1抑制剂治疗晚期食管胃结合腺癌临床完全缓解1例. 中国肿瘤临床, 2025 , 52 (14) : 753 -754 . DOI: 10.12354/j.issn.1000-8179.2025.20250687
. Chinese Journal of Clinical Oncology, 2025 , 52 (14) : 753 -754 . DOI: 10.12354/j.issn.1000-8179.2025.20250687
患者男性,58岁。2023年1月开始无明显诱因出现进食后吞咽不适,伴有哽噎感,食物下咽时有异物感,饮水后症状可缓解,伴有上腹部胀痛不适,偶有反酸,无嗳气,无恶心呕吐,无明显胸骨后烧灼感及牵拉样不适,进食无呛咳,声音无嘶哑,无畏寒发热。2023年2月在当地医院行胶囊胃镜检查示:慢性非萎缩性胃炎。2023年7月因“进食后吞咽不适,6个月内体质量下降15 kg”就诊于广州复大肿瘤医院。2023年8月CT示:食管胃结合部腺癌伴纵隔及腹膜后多发淋巴结转移(图1)。病理活检示:(贲门部)低分化腺癌,部分为黏液性腺癌,伴程序性死亡-配体 1(programmed death- ligand 1,PD-L1)<1%(图2)。按照美国癌症联合委员会(AJCC)第8版食管癌和食管胃交界癌的分期系统结合本院多学科讨论,行经皮穿刺动脉灌注化疗术(奥沙利铂85 mg/m2+氟尿嘧啶400 mg/m2动脉灌注,d1,然后1 200 mg/m2每日持续动脉泵入,d1~3,亚叶酸钙400 mg/m2静脉滴注,d1)联合替雷利珠单抗0.2 g/21 d免疫治疗。经过8次经皮动脉灌注化疗联合程序性死亡受体-1(programmed death-1,PD-1)抑制剂治疗后,按照实体瘤疗效评价标准(RECIST)1.1标准评估达到临床完全缓解(图3),肿瘤血清标志物降低至正常范围后未再升高(图4)。随访截至2025年4月以替雷利珠单抗0.2 g/21 d维持治疗。
小结 食管胃结合部腺癌患者经常在确诊时已至中晚期,无手术机会。常规全身化疗有效率低,不良反应较大[1]。经皮穿刺动脉灌注化疗在晚期肿瘤中疗效显著且安全耐受,相较全身静脉化疗,其病理缓解率更高,还能提高肿瘤内药物浓度,降低全身不良反应[2]
PD-1单抗联合化疗已成为晚期转移性一线治疗新标准[3]。替雷利珠单抗作为中国自主研发的免疫治疗药物,对PD-1受体亲和力与特异性高,抗肿瘤活性优于传统 PD-1单抗[4]。本例患者为PD-L1低表达的食管胃结合部腺癌,化疗联合PD-1抑制剂治疗后,肿瘤及转移灶缩小,活性受抑,肿瘤标志物正常,达临床完全缓解。提示该类患者可能从经皮穿刺动脉灌注化疗联合PD-1抑制剂治疗中获益。
参考文献 引证文献
排序方式:
1
陈佳鑫,隋红.局部进展期胃癌围手术期治疗研究进展[J].现代肿瘤医学,2023,31(4):784-788.
2
吴震峰,朱文强,曹勤洪,等.区域动脉灌注化疗在进展期胃癌短程新辅助化疗中的应用[J].中华胃肠外科杂志,2014(11):1092-1095.
3
李子禹,贾永宁,卢信星,等.免疫治疗时代下的胃癌外科[J].中华外科杂志,2024,62(5):353-358.
4
Lee SH, Lee HT, Lim H, et al. Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy[J]. Biochem Biophys Res Commun, 2020, 527(1):226-231.
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doi: 10.12354/j.issn.1000-8179.2025.20250687
  • 接收时间:2025-05-21
  • 首发时间:2026-04-09
  • 出版时间:2025-07-30
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  • 收稿日期:2025-05-21
  • 修回日期:2025-07-04
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    1广州复大肿瘤医院肿瘤科(广州市510315)
    2暨南大学附属第一医院肿瘤科

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2种不同金属材料的力学参数

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genus
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占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
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Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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