Article(id=1200147838354162431, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1200147837586604797, articleNumber=1001-2494(2024)10-0904-07, orderNo=null, doi=10.11669/cpj.2024.10.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1703779200000, receivedDateStr=2023-12-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1764067142332, onlineDateStr=2025-11-25, pubDate=1716307200000, pubDateStr=2024-05-22, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1764067142332, onlineIssueDateStr=2025-11-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1764067142332, creator=13701087609, updateTime=1764067142332, updator=13701087609, issue=Issue{id=1200147837586604797, tenantId=1146029695717560320, journalId=1190317699101192196, year='2024', volume='59', issue='10', pageStart='857', pageEnd='950', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1764067142149, creator=13701087609, updateTime=1764067345188, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1200148689244225889, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1200147837586604797, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1200148689244225890, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1200147837586604797, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=904, endPage=910, ext={EN=ArticleExt(id=1200147838547100416, articleId=1200147838354162431, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=The Effect and Mechanism of Salvianolic Acid A on OGD/R-Induced Apoptosis and Oxidative Stress Damage in Cerebral Microvascular Endothelial Cells, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To investigate the protective effect and mechanism of salvianolic acid A (SAL-A) on mouse brain microvascular endothelial (b.End.3) cell apoptosis and oxidative stress injury after oxygen-glucose deprivation/reoxygenation (OGD/R). METHODS OGD/R injury was established with b. End.3 cells for injury model. Cell apoptosis was detected by Annexin V-fluorescein isothiocyanate (Annexin V-FITC) probe and propidium iodide (PI) staining; Reactive oxygen species (ROS) generation was detected by 2,7-dichlorofluorescein diacetate (DCFH-DA) probe; Mitochondrial membrane potential was detected by JC-1 staining. The expression of proteins related to apoptosis, oxidative stress, and Akt/GSK3β/Nrf2 pathway was detected by Western Blot. RESULTS Compared with the control group, the expression of anti-apoptotic proteins, mitochondrial membrane potential, expression of related antioxidant proteins and Akt/GSK3β/Nrf2 pathway were significantly decreased in the OGD/R group (P<0.05). In addition, the number of apoptotic cells, the expression of apoptosis-inducing proteins, and the production of intracellular ROS were significantly increased in the OGD/R group (P<0.05). Whereas, the SAL-A treatment can improve OGD/R-induced cell apoptosis and oxidative stress, the expression of Akt/GSK3β/Nrf2 pathway were significantly increased in the SAL-A-10 group. CONCLUSION SAL-A inhibited OGD/R-induced apoptosis and oxidative stress injury in b.End.3 cells, and the mechanism may be related with affecting the Akt/GSK3β/Nrf2 pathway.

, correspAuthors=Guanhua DU, Yuehua WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yufu SHANG, Man LIU, Dongni LIU, Wenfang ZHANG, Danhong FENG, Shuang XU, Wandi FENG, Guanhua DU, Yuehua WANG), CN=ArticleExt(id=1200147840497451819, articleId=1200147838354162431, tenantId=1146029695717560320, journalId=1190317699101192196, language=CN, title=丹酚酸A对OGD/R诱导脑微血管内皮细胞凋亡和氧化应激损伤的作用及机制, columnId=1190352405612040510, journalTitle=中国药学杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=

目的 研究丹酚酸A(salvianolic acid A,SAL-A)对氧糖剥夺/复氧(oxygen-glucose deprivation/reoxygenation,OGD/R)诱导脑微血管内皮细胞(brain microvascular endothelial cells,b.End.3)凋亡和氧化应激损伤的作用及机制。方法 应用b.End.3细胞OGD/R损伤模型评价SAL-A对OGD/R诱导b.End.3细胞凋亡和氧化应激的作用及机制。膜联蛋白V-异硫氰酸荧光素探针(Annexin V-fluorescein isothiocyanate,Annexin V-FITC)以及碘化丙啶(propidium iodide,PI)染色检测细胞凋亡;2,7-二氯荧光素二乙酸酯(2',7'-dichlorodihydrofluorescein diacetate,DCFH-DA)探针检测细胞活性氧(reactive oxygen species,ROS)生成;JC-1染色法检测细胞线粒体膜电位;以免疫印迹法检测细胞凋亡、氧化应激及蛋白激酶B(protein kinase B,Akt) /糖原合成酶激酶-3β(glycogen synthase kinase-3β,GSK3β)/核转录因子E2相关因子(nuclear factor erythroid 2 related factor 2,Nrf2)通路相关蛋白的表达。结果 与正常对照组比较,OGD/R组抗凋亡蛋白表达、线粒体膜电位水平、相关抗氧化蛋白表达、Akt/GSK3β/Nrf2通路表达均显著降低(P<0.05),而细胞凋亡数、凋亡诱导蛋白表达、细胞内ROS产生均显著增高(P<0.05);而SAL-A处理后可改善OGD/R诱导的细胞凋亡和氧化应激,Akt/GSK3β/Nrf2通路蛋白表达显著增高。结论 SAL-A能够抑制OGD/R所诱导的脑微血管内皮细胞凋亡与氧化应激损伤,机制与调控Akt/GSK3β/Nrf2通路相关。

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Biochem Pharmacol, 2018, 155:494-509., articleTitle=Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway, refAbstract=null)], funds=[Fund(id=1200147846394642471, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, awardId=7232299, language=CN, fundingSource=北京市自然科学基金面上项目资助(7232299), fundOrder=null, country=null), Fund(id=1200147846545637420, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, awardId=82141204, language=CN, fundingSource=国家自然科学基金专项资助(82141204), fundOrder=null, country=null), Fund(id=1200147846667272237, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, awardId=2021-I2M-1-069, language=CN, fundingSource=中国医学科学院医学与健康科技创新工程项目资助(2021-I2M-1-069), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1200147840753304377, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, xref=null, ext=[AuthorCompanyExt(id=1200147840761692986, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, companyId=1200147840753304377, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China), AuthorCompanyExt(id=1200147840770081595, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, companyId=1200147840753304377, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院药物研究所, 药物靶点研究与新药筛选北京市重点实验室, 北京 100050)])], figs=[ArticleFig(id=1200147844867915786, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=EN, label=Fig.1, caption=Effects of SAL-A on apoptosis induced by OGD/R in b.End.3 cells. n=3, $\bar{x}±s$

A-Annexin V, PI staining to detect apoptosisscale(scale bar=100 μm); B-apoptosis-related protein expression;¹⁾P<0.05, vs control group; ²⁾P<0.05, vs OGD/R group.

, figureFileSmall=2HhjhWs+o+fZQ9B/Q0hX8A==, figureFileBig=CABf4Z5QKktoWZhGswBBog==, tableContent=null), ArticleFig(id=1200147845010522126, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=CN, label=图1, caption=丹酚酸A(SAL-A)对氧糖剥夺/复氧(OGD/R)诱导小鼠脑微血管内皮细胞(b.End.3)凋亡的影响. n=3, $\bar{x}±s$

A-膜联蛋白V、碘化丙啶染色检测细胞凋亡(标尺=100 μm);B-凋亡相关蛋白表达;与对照组相比,¹⁾P<0.05;与OGD/R组相比,²⁾P<0.05。

, figureFileSmall=2HhjhWs+o+fZQ9B/Q0hX8A==, figureFileBig=CABf4Z5QKktoWZhGswBBog==, tableContent=null), ArticleFig(id=1200147845354455060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=EN, label=Fig.2, caption=Effects of SAL-A on ROS production and mitochondrial membrane potential induced by OGD/R in b.End.3 cells. n=3, $\bar{x}±s$

A-fluorescent probe for ROS production(scale bar=100 μm); B-JC-1 staining for mitochondrial membrane potential(scale bar=50 μm);¹⁾P<0.05, vs control group; ²⁾P<0.05, vs OGD/R group.

, figureFileSmall=ZFVh/2KxjhmfrtPmo7479Q==, figureFileBig=ffn3G8xmGcuytl6UUx5+5w==, tableContent=null), ArticleFig(id=1200147845497061399, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=CN, label=图2, caption=SAL-A对OGD/R诱导b.End.3细胞活性氧(ROS)产生及线粒体膜电位的影响. n=3, $\bar{x}±s$

A-荧光探针检测细胞内ROS生成(标尺=100 μm);B-JC-1法检测细胞线粒体膜电位(标尺=50 μm);与对照组相比,¹⁾P<0.05;与OGD/R组相比,²⁾P<0.05。

, figureFileSmall=ZFVh/2KxjhmfrtPmo7479Q==, figureFileBig=ffn3G8xmGcuytl6UUx5+5w==, tableContent=null), ArticleFig(id=1200147845706776600, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=EN, label=Fig.3, caption=Effects of SAL-A on antioxidant enzymes induced by OGD/R in b.End.3 cells. n=4, $\bar{x}±s$

¹⁾P<0.05, vs control group; ²⁾P<0.05, vs OGD/R group.

, figureFileSmall=AF6mCETi4kOmS5/g+8Rv4g==, figureFileBig=MumHXAdtVpM4dgPUGhN6dw==, tableContent=null), ArticleFig(id=1200147845887131678, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=CN, label=图3, caption=SAL-A对OGD/R诱导b.End.3细胞抗氧化酶的影响. n=4, $\bar{x}±s$

与对照组相比,¹⁾P<0.05;与OGD/R组相比,²⁾P<0.05。

, figureFileSmall=AF6mCETi4kOmS5/g+8Rv4g==, figureFileBig=MumHXAdtVpM4dgPUGhN6dw==, tableContent=null), ArticleFig(id=1200147846080069664, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=EN, label=Fig.4, caption=Effects of SAL-A on Akt/GSK3β/Nrf2 pathway induced by OGD/R in b.End.3 cells. n=4, $\bar{x}±s$

¹⁾P<0.05, vs control group; ²⁾P<0.05, vs OGD/R group.

, figureFileSmall=tY2Rk9jU1ZfNxYTJ4T9eqQ==, figureFileBig=Sz3JfLXBiAGK2kJagVOLsw==, tableContent=null), ArticleFig(id=1200147846247841828, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1200147838354162431, language=CN, label=图4, caption=SAL-A对OGD/R诱导b.End.3细胞Akt/GSK3β/Nrf2通路的影响. n=4, $\bar{x}±s$

与对照组相比,¹⁾P<0.05;与OGD/R组相比,²⁾P<0.05。

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