Article(id=1195664141189951491, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195664138694341616, articleNumber=1001-2494(2024)02-0151-10, orderNo=null, doi=10.11669/cpj.2024.02.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1682438400000, receivedDateStr=2023-04-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1762998145625, onlineDateStr=2025-11-13, pubDate=1705852800000, pubDateStr=2024-01-22, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762998145625, onlineIssueDateStr=2025-11-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762998145625, creator=13701087609, updateTime=1762998145625, updator=13701087609, issue=Issue{id=1195664138694341616, tenantId=1146029695717560320, journalId=1190317699101192196, year='2024', volume='59', issue='2', pageStart='101', pageEnd='190', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762998145030, creator=13701087609, updateTime=1762998511460, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1195665675697045692, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195664138694341616, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1195665675701239997, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195664138694341616, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=151, endPage=160, ext={EN=ArticleExt(id=1195664141374500870, articleId=1195664141189951491, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Effect of 717 Jiedu Decoction on Local Tissue Damage Repair of Rats After Agkistrodon halys Bite Through NETs-CYR61/CCN1 Signaling Pathway, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To investigate the effect of 717 Jiedu decoction on neutrophil extracellular traps (NETs) and CYR61/CCN1 expression in local tissue of rats after Agkistrodon halys bite. METHODS SD rats were randomly divided into normal control group, Agkistrodon halys bite group and high-dose and low-dose 717 Jiedu decoction groups. The serum and thigh gastrocnemius were collected, and the pathological changes of gastrocnemius in each group were observed by Hematoxylin-Eosin staining(HE) and Masson staining, the ultrastructure of gastrocnemius in each group was observed by transmission electron microscopy, the apoptosis of gastrocnemius cells in each group was detected by TUNEL method, and the serum circulating-free cell (cf-DNA) level was detected by PicoGreen fluorescence. The expression levels of myeloperoxidase (MPO) in serum and gastrocnemius were detected by enzyme-linked immunosorbent assay(ELISA), the change of neutrophil elastase (NE) in gastrocnemius was detected by immunohistochemistry, and the level of citcitinic histone H3 (CitH3) in gastrocnemius was detected by immunofluorescence. The expressions of CYR61/CCN1 protein and its mRNA in gastrocnemius were detected by Western blot and PCR. RESULTS Compared with the normal group, the model group showed significant inflammatory infiltration and bleeding reaction, and the degree of collagen fibrosis increased. Ultrastructure showed that the structure of gastrocnemius cells in the model group was seriously damaged, and the distribution of muscle segments was asymmetrical. The contents of cf-DNA and MPO in serum were significantly increased (P<0.01), the protein expressions of MPO and CitH3 in gastrocnemius were increased (P<0.05 or P<0.01), and the protein and mRNA expressions of CYR61/CCN1 in gastrocnemius were up-regulated. All the administration groups of 717 Jiedu decoction significantly improved the local inflammatory response and bleeding symptoms of rats, reduced the degree of collagen fibrosis, effectively inhibited the apoptosis rate of gastrocnemius cells of pit viper bitten rats, and reduced the contents of cf-DNA and MPO in serum (P<0.05 or P<0.01). The expressions of NE and MPO in gastrocnemius were inhibited in the high-dose 717 Jiedu decoction group, and the expression of CitH3 in gastrocnemius muscle was decreased in all administration groups of 717 Jiedu decoction (P<0.05 or P<0.01), and the high expression of CYR61/CCN1 protein and its mRNA was inhibited. CONCLUSION The venom of Agkistrodon halys can induce the formation of neutrophil NETs in local tissue and the overexpression of CYR61/CCN1. The 717 Jiedu decoction could improve the ultrastructure of gastrocnemius muscle and inhibit cell apoptosis, which may also improve snitch symptoms by regulating the NETs-Cyr61/CCN1 pathway. The signaling molecules of NETs and CYR61/CCN1 are expected to be new targets for the prevention and treatment of local tissue damage caused by Agkistrodon halys venom.

, correspAuthors=YAN Zhangren, WANG Wanchun, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=DONG Degang, YANG yue, ZHENG Xianglong, MAO Wenli, SONG Mei, YAN Zhangren, WANG Wanchun), CN=ArticleExt(id=1195664677398164084, articleId=1195664141189951491, tenantId=1146029695717560320, journalId=1190317699101192196, language=CN, title=717解毒合剂通过NETs-CYR61/CCN1信号通路对蝮蛇咬伤大鼠局部组织损伤修复作用, columnId=1190352405612040510, journalTitle=中国药学杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=

目的 探究717解毒合剂对蝮蛇咬伤大鼠局部组织中性粒细胞胞外陷阱(neutrophil extracellular traps, NETs)水平,以及对富含半胱氨酸蛋白61(CYR61/CCN1)表达的影响。方法 将SD大鼠随机分为正常对照组、蝮蛇咬伤组及抗蝮蛇毒血清组及717解毒合剂高、低剂量组。收集血清、大腿腓肠肌,采用苏木素-伊红(Hematoxylin-Eosin staining, HE)和马松(Masson)染色观察各组腓肠肌病理学变化,透射电镜观察腓肠肌超微结构,原位末端凋亡(TUNEL)法检测各组大鼠腓肠肌细胞凋亡情况,PicoGreen荧光检测各组血清游离DNA(cf-DNA)水平,酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测各组血清与腓肠肌中髓过氧化物酶(myeloperoxidase, MPO)的表达水平,免疫组化检测腓肠肌中性粒细胞弹性蛋白酶(neutrophil elastase, NE)的改变,免疫荧光法检测各组大鼠腓肠肌瓜氨酸化组蛋白H3(CitH3)水平,Western blot与聚合酶链式反应(polymerase chain reaction,PCR)技术检测腓肠肌组织CYR61/CCN1蛋白及其mRNA表达情况。结果 与正常组比较,模型组出现显著的炎性浸润与出血反应,且胶原纤维化程度均升高;超微结构显示模型组大鼠腓肠肌细胞结构损伤严重,肌节呈非对称性分布,肌原纤维丝断裂;并分布有大量凋亡细胞,血清cf-DNA、MPO含量显著上升(P<0.01),腓肠肌MPO及CitH3蛋白表达均有升高(P<0.05或P<0.01),腓肠肌CYR61/CCN1蛋白及其mRNA表达均有上调;717解毒合剂各给药组均能显著改善大鼠局部炎性反应及出血症状,降低胶原纤维化程度,有效抑制蝮蛇咬伤大鼠腓肠肌细胞凋亡率,减少血清cf-DNA、MPO含量(P<0.05或P<0.01),717解毒合剂高剂量组抑制了腓肠肌NE、MPO的表达,717解毒合剂各给药组均能降低腓肠肌CitH3的表达(P<0.05或P<0.01),抑制了CYR61/CCN1蛋白及其mRNA高表达。结论 蝮蛇毒诱导局部组织中性粒细胞NETs形成,CYR61/CCN1地过表达,717解毒合剂改善了大鼠腓肠肌超微结构,抑制了细胞凋亡,并可能通过调控NETs-CYR61/CCN1信号通路改善蛇伤症状,NETs信号分子及CYR61/CCN1有望成为蝮蛇毒致局部组织损伤防治的新靶点。

, correspAuthors=严张仁, 王万春, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=3E/18enIONclZ7ZcfL2N1A==, magXml=xT4t/tBUhzksMxCrZQ9aSg==, pdfUrl=null, pdf=2vEx3g0v6ejxjGyqc6gncw==, pdfFileSize=2938344, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=fvVarFaUrmeuyL0wopoBlg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=i9T7ljQARPqeHtQfAd1lqw==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=董德刚, 杨悦, 郑向龙, 毛文丽, 宋梅, 严张仁, 王万春)}, authors=[Author(id=1197098408738604017, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1197098408822490099, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098408738604017, language=EN, stringName=DONG Degang, firstName=DONG, middleName=null, lastName=Degang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹ School of Life Sciences, Jiangxi University of Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098408881210356, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098408738604017, language=CN, stringName=董德刚, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹ 江西中医药大学生命科学学院, 南昌 330004, bio={"content":"

董德刚,男,副教授,硕士生导师 研究方向:中药药理与毒理

"}, bioImg=null, bioContent=

董德刚,男,副教授,硕士生导师 研究方向:中药药理与毒理

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408457585638, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=1, ext=[AuthorCompanyExt(id=1197098408486945767, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408457585638, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ School of Life Sciences, Jiangxi University of Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1197098408495334376, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408457585638, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ 江西中医药大学生命科学学院, 南昌 330004)])]), Author(id=1197098408939930617, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1197098409011233790, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098408939930617, language=EN, stringName=YANG yue, firstName=YANG, middleName=null, lastName=yue, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=² Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098409099313153, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098408939930617, language=CN, stringName=杨悦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=² 江西中医药大学附属医院中医外科, 南昌 330006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408600191977, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=2, ext=[AuthorCompanyExt(id=1197098408608580586, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China), AuthorCompanyExt(id=1197098408612774891, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² 江西中医药大学附属医院中医外科, 南昌 330006)])]), Author(id=1197098409162227717, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1197098409225142278, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409162227717, language=EN, stringName=ZHENG Xianglong, firstName=ZHENG, middleName=null, lastName=Xianglong, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=² Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098409279668233, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409162227717, language=CN, stringName=郑向龙, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=² 江西中医药大学附属医院中医外科, 南昌 330006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408600191977, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=2, ext=[AuthorCompanyExt(id=1197098408608580586, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China), AuthorCompanyExt(id=1197098408612774891, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² 江西中医药大学附属医院中医外科, 南昌 330006)])]), Author(id=1197098409359360012, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1197098409434857487, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409359360012, language=EN, stringName=MAO Wenli, firstName=MAO, middleName=null, lastName=Wenli, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098409501966355, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409359360012, language=CN, stringName=毛文丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³ 南昌医学院公共学科教学部, 南昌 330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408671495149, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=3, ext=[AuthorCompanyExt(id=1197098408675689454, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China), AuthorCompanyExt(id=1197098408684078063, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ 南昌医学院公共学科教学部, 南昌 330004)])]), Author(id=1197098409573269524, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1197098409636184086, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409573269524, language=EN, stringName=SONG Mei, firstName=SONG, middleName=null, lastName=Mei, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=⁴, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098409694904345, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409573269524, language=CN, stringName=宋梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=⁴, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null), Author(id=1197098409762013212, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1197098409837510687, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409762013212, language=EN, stringName=YAN Zhangren, firstName=YAN, middleName=null, lastName=Zhangren, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{3, *}, address=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098409913008162, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409762013212, language=CN, stringName=严张仁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{3, *}, address=³ 南昌医学院公共学科教学部, 南昌 330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408671495149, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=3, ext=[AuthorCompanyExt(id=1197098408675689454, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China), AuthorCompanyExt(id=1197098408684078063, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ 南昌医学院公共学科教学部, 南昌 330004)])]), Author(id=1197098409967534117, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1197098410059808808, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409967534117, language=EN, stringName=WANG Wanchun, firstName=WANG, middleName=null, lastName=Wanchun, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{3, *}, address=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1197098410152083498, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, authorId=1197098409967534117, language=CN, stringName=王万春, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{3, *}, address=³ 南昌医学院公共学科教学部, 南昌 330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1197098408671495149, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=3, ext=[AuthorCompanyExt(id=1197098408675689454, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China), AuthorCompanyExt(id=1197098408684078063, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ 南昌医学院公共学科教学部, 南昌 330004)])])], keywords=[Keyword(id=1197098410294689841, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=1, keyword=717 Jiedu decoction), Keyword(id=1197098410370187315, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=2, keyword=Agkistrodon halys bite), Keyword(id=1197098410437296183, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=3, keyword=neutrophil extracellular trap), Keyword(id=1197098410491822139, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=4, keyword=extracellular matrix), Keyword(id=1197098410554736701, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=5, keyword=CYR61/CCN1), Keyword(id=1197098410626039871, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, orderNo=6, keyword=local tissue), Keyword(id=1197098410680565828, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=1, keyword=717解毒合剂), Keyword(id=1197098410747674694, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=2, keyword=蝮蛇咬伤), Keyword(id=1197098410810589255, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=3, keyword=中性粒细胞胞外陷阱), Keyword(id=1197098410877698121, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=4, keyword=细胞外基质), Keyword(id=1197098410995138639, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=5, keyword=富含半胱氨酸蛋白61), Keyword(id=1197098411037081680, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, orderNo=6, keyword=局部组织)], refs=[Reference(id=1197098413054541955, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2019, volume=24, issue=18, pageStart=3276, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=GóMEZ-BETANCUR I, GOGINENI V, SALAZAR-OSPINA A, journalName=Molecules, refType=null, unstructuredReference=GóMEZ-BETANCUR I, GOGINENI V, SALAZAR-OSPINA A, et al. Perspective on the therapeutics of anti-Snake venom[J]. Molecules, 2019, 24(18):3276. DOI:10.3390/molecules24183276, articleTitle=Perspective on the therapeutics of anti-Snake venom, refAbstract=null), Reference(id=1197098413109067909, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2010, volume=19, issue=3, pageStart=94, pageEnd=96, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=ZHU M J, ZHONG J F, HE G G, journalName=Chin Ethnic and Folk Med(中国民族民间医药), refType=null, unstructuredReference=ZHU M J, ZHONG J F, HE G G. Study on epidemiology and preventive measures of bites of Agkistrodon halys in Jiangxi[J]. Chin Ethnic and Folk Med(中国民族民间医药), 2010, 19(3):94-96., articleTitle=Study on epidemiology and preventive measures of bites of Agkistrodon halys in Jiangxi, refAbstract=null), Reference(id=1197098413176176775, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=152, issue=null, pageStart=23, pageEnd=29, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=SILVA L M G, ZAMUNER L F, DAVID A C, journalName=Toxicon, refType=null, unstructuredReference=SILVA L M G, ZAMUNER L F, DAVID A C, et al. Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review[J]. Toxicon, 2018, 152:23-29., articleTitle=Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review, refAbstract=null), Reference(id=1197098413230702728, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=1998, volume=36, issue=11, pageStart=1529, pageEnd=1538, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=GUTIÉRREZ J M, LEÓN G, ROJAS G, journalName=Toxicon, refType=null, unstructuredReference=GUTIÉRREZ J M, LEÓN G, ROJAS G, et al. Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom[J]. Toxicon, 1998, 36(11):1529-1538., articleTitle=Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom, refAbstract=null), Reference(id=1197098413310394506, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=148, issue=null, pageStart=123, pageEnd=131, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=GUTIÉRREZ, JOSÉ MARÍA, RUCAVADO A, journalName=Toxicon, refType=null, unstructuredReference=GUTIÉRREZ, JOSÉ MARÍA, RUCAVADO A, et al. Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms[J]. Toxicon, 2018, 148:123-131., articleTitle=Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms, refAbstract=null), Reference(id=1197098413385891980, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=187, issue=null, pageStart=188, pageEnd=197, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=ZULIANI J P, SOARES A M, GUTIÉRREZ J M, journalName=Toxicon, refType=null, unstructuredReference=ZULIANI J P, SOARES A M, GUTIÉRREZ J M. Polymorphonuclear neutrophil leukocytes in snakebite envenoming[J]. Toxicon. 2020, 187:188-197., articleTitle=Polymorphonuclear neutrophil leukocytes in snakebite envenoming, refAbstract=null), Reference(id=1197098413499138190, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=26, issue=null, pageStart=e20200053, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=DONG D G, DENG Z P, YAN Z R, journalName=J Venom Anim Toxins Incl Trop Dis, refType=null, unstructuredReference=DONG D G, DENG Z P, YAN Z R, et al. Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity[J]. J Venom Anim Toxins Incl Trop Dis, 2020, 26:e20200053. DOI:10.1590/1678-9199-JVATITD-2020-0053, articleTitle=Oxidative stress and antioxidant defense in detoxification systems of snake venom-induced toxicity, refAbstract=null), Reference(id=1197098413578829968, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=28, issue=2, pageStart=203, pageEnd=208, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=DONG D G, SONG M, CHEN J, journalName=Chin J Integr Tradit West Med Intensive Crit Care(中国中西医结合急救杂志), refType=null, unstructuredReference=DONG D G, SONG M, CHEN J, et al. Study of the protection effect and mechanism of 717 Jiedu decoction on the local tissue damage caused by Agkistrodon halys venom[J]. Chin J Integr Tradit West Med Intensive Crit Care(中国中西医结合急救杂志), 2021, 28(2):203-208., articleTitle=Study of the protection effect and mechanism of 717 Jiedu decoction on the local tissue damage caused by Agkistrodon halys venom, refAbstract=null), Reference(id=1197098413654327442, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=2021, issue=null, pageStart=8243378, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=ZHU Y, HUANG Y, JI Q, journalName=J Immunol Res, refType=null, unstructuredReference=ZHU Y, HUANG Y, JI Q, et al. Interplay between extracellular matrix and neutrophils in diseases[J]. J Immunol Res, 2021, 2021:8243378. DOI:10.1155/2021/8243378, articleTitle=Interplay between extracellular matrix and neutrophils in diseases, refAbstract=null), Reference(id=1197098413717242004, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=12, issue=1, pageStart=273, pageEnd=279, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=KIM K H, WON J H, CHENG N, journalName=J Cell Commun Signal, refType=null, unstructuredReference=KIM K H, WON J H, CHENG N, et al. The matricellular protein CCN1 in tissue injury repair[J]. J Cell Commun Signal, 2018, 12(1):273-279., articleTitle=The matricellular protein CCN1 in tissue injury repair, refAbstract=null), Reference(id=1197098413775962262, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=505, issue=4, pageStart=966, pageEnd=972, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=DU H, ZHOU Y, SUO Y, journalName=Biochem Biophys Res Commun, refType=null, unstructuredReference=DU H, ZHOU Y, SUO Y, et al. CCN1 accelerates re-epithelialization by promoting keratinocyte migration and proliferation during cutaneous wound healing[J]. Biochem Biophys Res Commun, 2018, 505(4):966-972., articleTitle=CCN1 accelerates re-epithelialization by promoting keratinocyte migration and proliferation during cutaneous wound healing, refAbstract=null), Reference(id=1197098413834682520, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=2020, issue=null, pageStart=4910280, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=SHOME D, VON WOEDTKE T, RIEDEL K, journalName=Oxid Med Cell Longev, refType=null, unstructuredReference=SHOME D, VON WOEDTKE T, RIEDEL K, et al. The HIPPO transducer YAP and its targets CTGF and Cyr61 drive a paracrine signalling in cold atmospheric plasma-mediated wound healing[J]. Oxid Med Cell Longev, 2020, 2020:4910280. DOI:10.1155/2020/4910280, articleTitle=The HIPPO transducer YAP and its targets CTGF and Cyr61 drive a paracrine signalling in cold atmospheric plasma-mediated wound healing, refAbstract=null), Reference(id=1197098413901791386, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=10, issue=5, pageStart=182, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=GUTIÉRREZ JM, ESCALANTE T, HERNÁNDEZ R, journalName=Toxins (Basel), refType=null, unstructuredReference=GUTIÉRREZ JM, ESCALANTE T, HERNÁNDEZ R, et al. Why is skeletal muscle regeneration impaired after myonecrosis induced by viperid snake venoms?[J]. Toxins (Basel), 2018, 10(5):182. DOI:10.3390/toxins10050182, articleTitle=Why is skeletal muscle regeneration impaired after myonecrosis induced by viperid snake venoms?, refAbstract=null), Reference(id=1197098413964705946, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=32, issue=6, pageStart=1121, pageEnd=1130, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=OKAFOR AI, ONYIKE E, journalName=J Basic Clin Physiol Pharmacol, refType=null, unstructuredReference=OKAFOR AI, ONYIKE E. Inhibition of key enzymes linked to snake venom induced local tissue damage by kolaviron[J]. J Basic Clin Physiol Pharmacol, 2020, 32(6):1121-1130., articleTitle=Inhibition of key enzymes linked to snake venom induced local tissue damage by kolaviron, refAbstract=null), Reference(id=1197098414082146459, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2019, volume=49, issue=2, pageStart=221, pageEnd=227, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=YOUSEFI S, STOJKOV D, GERMIC N, journalName=Eur J Immunol, refType=null, unstructuredReference=YOUSEFI S, STOJKOV D, GERMIC N, et al. Untangling “NETosis” from NETs[J]. Eur J Immunol, 2019, 49(2):221-227., articleTitle=Untangling “NETosis” from NETs, refAbstract=null), Reference(id=1197098414136672413, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2017, volume=6, issue=null, pageStart=e24437, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=KENNY E F, HERZIG A, KRÜGER R, journalName=Elife, refType=null, unstructuredReference=KENNY E F, HERZIG A, KRÜGER R, et al. Diverse stimuli engage different neutrophil extracellular trap pathways[J]. Elife, 2017; 6:e24437. DOI:10.7554/eLife.24437, articleTitle=Diverse stimuli engage different neutrophil extracellular trap pathways, refAbstract=null), Reference(id=1197098414199586975, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=36, issue=null, pageStart=191, pageEnd=218, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=THIAM H R, WONG S L, WAGNER D D, journalName=Annu Rev Cell Dev Biol, refType=null, unstructuredReference=THIAM H R, WONG S L, WAGNER D D, et al. Cellular mechanisms of NETosis[J]. Annu Rev Cell Dev Biol, 2020, 36:191-218., articleTitle=Cellular mechanisms of NETosis, refAbstract=null), Reference(id=1197098414258307233, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=30, issue=12, pageStart=1485, pageEnd=1494, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=YU W H, CHEN L, LI T F, journalName=Chin J Gen Surg(中国普通外科杂志), refType=null, unstructuredReference=YU W H, CHEN L, LI T F, et al. Research progress of neutrophil extracellular traps induced tissue and organ damage[J]. Chin J Gen Surg(中国普通外科杂志), 2021, 30(12):1485-1494., articleTitle=Research progress of neutrophil extracellular traps induced tissue and organ damage, refAbstract=null), Reference(id=1197098414329610402, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=110, issue=4, pageStart=797, pageEnd=808, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=TAN C, AZIZ M, WANG P, journalName=J Leukoc Biol, refType=null, unstructuredReference=TAN C, AZIZ M, WANG P. The vitals of NETs[J]. J Leukoc Biol, 2021; 110(4):797-808., articleTitle=The vitals of NETs, refAbstract=null), Reference(id=1197098414384136356, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=1864, issue=6, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=SWETHAKUMAR B, NAVEENKUMAR S K, GIRISH K S, journalName=Biochim Biophys Acta Gen Subj, refType=null, unstructuredReference=SWETHAKUMAR B, NAVEENKUMAR S K, GIRISH K S, et al. The action of Echis carinatus and Naja naja venoms on human neutrophils; an emphasis on NETosis[J]. Biochim Biophys Acta Gen Subj, 2020, 1864(6):129561. DOI:10.1016/j.bbagen.2020.129561, articleTitle=The action of Echis carinatus and Naja naja venoms on human neutrophils; an emphasis on NETosis, refAbstract=null), Reference(id=1197098414438662310, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=27, issue=null, pageStart=e20200179, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=EL-BENNA J, HURTADO-NEDELEC M, GOUGEROT-POCIDALO M A, journalName=J Venom Anim Toxins Incl Trop Dis, refType=null, unstructuredReference=EL-BENNA J, HURTADO-NEDELEC M, GOUGEROT-POCIDALO M A, et al. Effects of venoms on neutrophil respiratory burst: a major inflammatory function[J]. J Venom Anim Toxins Incl Trop Dis, 2021, 27:e20200179. DOI:10.1590/1678-9199-JVATITD-2020-0179, articleTitle=Effects of venoms on neutrophil respiratory burst: a major inflammatory function, refAbstract=null), Reference(id=1197098414501576872, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=15, issue=2, pageStart=e0008596, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=RUDRESHA G V, URS A P, MANJUPRASANNA V N, journalName=PLoS Negl Trop Dis, refType=null, unstructuredReference=RUDRESHA G V, URS A P, MANJUPRASANNA V N, et al. Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram)[J]. PLoS Negl Trop Dis, 2021, 15(2):e0008596. DOI:10.1371/journal.pntd.0008596, articleTitle=Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram), refAbstract=null), Reference(id=1197098414572880042, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2016, volume=7, issue=null, pageStart=11361, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=KATKAR G D, SUNDARAM M S, NAVEENKUMAR S K, journalName=Nat Commun, refType=null, unstructuredReference=KATKAR G D, SUNDARAM M S, NAVEENKUMAR S K, et al. NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction[J]. Nat Commun, 2016, 7:11361. DOI:10.1038/ncomms11361, articleTitle=NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction, refAbstract=null), Reference(id=1197098414648377516, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2022, volume=13, issue=null, pageStart=867516, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=WANG Y, LIU F, CHEN L, journalName=Front Immunol, refType=null, unstructuredReference=WANG Y, LIU F, CHEN L, et al. Neutrophil extracellular traps (NETs) promote non-small cell lung cancer metastasis by suppressing lncRNA MIR503HG to activate the NF-κB/NLRP 3 inflammasome Pathway[J]. Front Immunol, 2022, 13:867516. DOI:10.3389/fimmu.2022.867516, articleTitle=Neutrophil extracellular traps (NETs) promote non-small cell lung cancer metastasis by suppressing lncRNA MIR503HG to activate the NF-κB/NLRP 3 inflammasome Pathway, refAbstract=null), Reference(id=1197098414715486382, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2019, volume=120, issue=5, pageStart=8319, pageEnd=8332, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=RUDRESHA G V, URS A P, MANJUPRASANNA V N, journalName=J Cell Biochem, refType=null, unstructuredReference=RUDRESHA G V, URS A P, MANJUPRASANNA V N, et al. Plant DNases are potent therapeutic agents against Echis carinatus venom-induced tissue necrosis in mice[J]. J Cell Biochem, 2019, 120(5):8319-8332., articleTitle=Plant DNases are potent therapeutic agents against Echis carinatus venom-induced tissue necrosis in mice, refAbstract=null), Reference(id=1197098414786789552, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2014, volume=49, issue=10, pageStart=833, pageEnd=836, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=CHEN H E, JIN X S, SONG D, journalName=Chin Pharm J(中国药学杂志), refType=null, unstructuredReference=CHEN H E, JIN X S, SONG D, et al. Effects of P38MAPK on Erythropoietin Postconditioning Attenuating Pneumocyte Apoptosis after Lung Ischemia/reperfusion Injury[J]. Chin Pharm J(中国药学杂志), 2014, 49(10):833-836., articleTitle=Effects of P38MAPK on Erythropoietin Postconditioning Attenuating Pneumocyte Apoptosis after Lung Ischemia/reperfusion Injury, refAbstract=null), Reference(id=1197098414853898418, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=405, issue=2, pageStart=112707, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=ZHU B, ZHANG X, SUN S, journalName=Exp Cell Res, refType=null, unstructuredReference=ZHU B, ZHANG X, SUN S, et al. NF-κB and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis[J]. Exp Cell Res, 2021, 405(2):112707. DOI:10.1016/j.yexcr.2021.112707, articleTitle=NF-κB and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis, refAbstract=null), Reference(id=1197098414925201588, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2019, volume=18, issue=21, pageStart=2928, pageEnd=2938, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=AN Z, LI J, YU J, journalName=Cell Cycle, refType=null, unstructuredReference=AN Z, LI J, YU J, et al. Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages[J]. Cell Cycle. 2019, 18(21):2928-2938., articleTitle=Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages, refAbstract=null), Reference(id=1197098414988116150, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=683803, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=MüNZER P, NEGRO R, FUKUI S, journalName=Front Immunol, refType=null, unstructuredReference=MüNZER P, NEGRO R, FUKUI S, et al. NLRP3 inflammasome assembly in ueutrophils is supported by PAD4 and promotes NETosis under sterile conditions[J]. Front Immunol, 2021, 12:683803. DOI:10.3389/fimmu.2021.683803, articleTitle=NLRP3 inflammasome assembly in ueutrophils is supported by PAD4 and promotes NETosis under sterile conditions, refAbstract=null), Reference(id=1197098415063613624, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2018, volume=38, issue=4, pageStart=672, pageEnd=678, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=ZHANG Y, GU F P, YAO S L, journalName=Curr Med Sci, refType=null, unstructuredReference=ZHANG Y, GU F P, YAO S L, et al. Stretch-induced Expression of CYR61 Increases the Secretion of IL-8 in A549 Cells via the NF-κβ/lκβ Pathway[J]. Curr Med Sci, 2018, 38(4):672-678., articleTitle=Stretch-induced Expression of CYR61 Increases the Secretion of IL-8 in A549 Cells via the NF-κβ/lκβ Pathway, refAbstract=null), Reference(id=1197098415118139578, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2020, volume=22, issue=1, pageStart=275, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=CHOI C, JEONG W, GHANG B, journalName=Arthritis Res Ther, refType=null, unstructuredReference=CHOI C, JEONG W, GHANG B, et al. Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis[J]. Arthritis Res Ther, 2020, 22(1):275. DOI:10.1186/s13075-020-02369-8, articleTitle=Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis, refAbstract=null), Reference(id=1197098415185248444, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2019, volume=12, issue=9, pageStart=3197, pageEnd=3207, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=SU R L, QIAO Y, GUO R F, journalName=Int J Clin Exp Pathol, refType=null, unstructuredReference=SU R L, QIAO Y, GUO R F, et al. Cyr61 overexpression induced by interleukin 8 via NF-kB signaling pathway and its role in tumorigenesis of gastric carcinoma in vitro[J]. Int J Clin Exp Pathol, 2019, 12(9):3197-3207., articleTitle=Cyr61 overexpression induced by interleukin 8 via NF-kB signaling pathway and its role in tumorigenesis of gastric carcinoma in vitro, refAbstract=null), Reference(id=1197098415269134525, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, doi=null, pmid=null, pmcid=null, year=2015, volume=6, issue=null, pageStart=7386, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=JUN J I, KIM K H, LAU L F, journalName=Nat Commun, refType=null, unstructuredReference=JUN J I, KIM K H, LAU L F. The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing[J]. Nat Commun, 2015, 6:7386. DOI:10.1038/ncomms8386., articleTitle=The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing, refAbstract=null)], funds=[Fund(id=1197098412383453298, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=81360288, language=CN, fundingSource=国家自然科学基金地区项目资助(81360288), fundOrder=null, country=null), Fund(id=1197098412450562164, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=81960874, language=CN, fundingSource=国家自然科学基金地区项目资助(81960874), fundOrder=null, country=null), Fund(id=1197098412521865334, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=82260937, language=CN, fundingSource=国家自然科学基金地区项目资助(82260937), fundOrder=null, country=null), Fund(id=1197098412584779896, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=20202ACB206010, language=CN, fundingSource=江西省自然科学基金重点项目资助(20202ACB206010), fundOrder=null, country=null), Fund(id=1197098412647694458, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=CXTD22009, language=CN, fundingSource=江西中医药大学首批科技创新团队资助项目资助(CXTD22009), fundOrder=null, country=null), Fund(id=1197098412781912188, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=GJJ201236, language=CN, fundingSource=江西省教育厅科技一般项目资助(GJJ201236), fundOrder=null, country=null), Fund(id=1197098412840632446, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=江西省双一流学科, language=CN, fundingSource=江西中医药大学中西医结合一级学科资助(江西省双一流学科), fundOrder=null, country=null), Fund(id=1197098412899352704, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, awardId=zxyylxk20220103, language=CN, fundingSource=江西中医药大学中西医结合一级学科资助(zxyylxk20220103), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1197098408457585638, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=1, ext=[AuthorCompanyExt(id=1197098408486945767, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408457585638, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ School of Life Sciences, Jiangxi University of Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1197098408495334376, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408457585638, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ 江西中医药大学生命科学学院, 南昌 330004)]), AuthorCompany(id=1197098408600191977, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=2, ext=[AuthorCompanyExt(id=1197098408608580586, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² Department of TCM Surgery, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China), AuthorCompanyExt(id=1197098408612774891, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408600191977, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² 江西中医药大学附属医院中医外科, 南昌 330006)]), AuthorCompany(id=1197098408671495149, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, xref=3, ext=[AuthorCompanyExt(id=1197098408675689454, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ Department of Public Science, Nanchang Medical College, Nanchang 330004, China), AuthorCompanyExt(id=1197098408684078063, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, companyId=1197098408671495149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³ 南昌医学院公共学科教学部, 南昌 330004)])], figs=[ArticleFig(id=1197098411192270931, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.1, caption=HE staining results of gastrocnemius tissue of rats in each group (×400)

Green arrows-inflammatory cell infiltration; Black arrows-bleeding.

, figureFileSmall=uJlltIb14AIYMV/6D9bJNQ==, figureFileBig=dhXvNjzbgoHN19r5HMrDBA==, tableContent=null), ArticleFig(id=1197098411250991189, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图1, caption=各组大鼠腓肠肌组织苏木素-伊红(HE)染色结果(×400)

绿色箭头-炎症细胞浸润;黑色箭头-出血。

, figureFileSmall=uJlltIb14AIYMV/6D9bJNQ==, figureFileBig=dhXvNjzbgoHN19r5HMrDBA==, tableContent=null), ArticleFig(id=1197098411334877271, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.2, caption=Masson staining results of gastrocnemius tissue in each group. n=8, \stackrel{-}{x}±s

Green arrows-collagen fibers; Red arrows-head muscle fibers, cytoplasm, cellulose, keratin, and red blood cells; ¹⁾P<0.01, compared with control group;²⁾P<0.01, compared with model group.

, figureFileSmall=nWj9qy8dxI4JNrO1OWaZJw==, figureFileBig=MB8iDdatgcGUHz5oQNWXcQ==, tableContent=null), ArticleFig(id=1197098411439734873, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图2, caption=各组腓肠肌组织马松(Masson)染色结果(×400). n=8, \stackrel{-}{x}±s

绿色箭头-胶原纤维;红色箭头-肌纤维、胞质、纤维素、角蛋白及红细胞;与正常对照组比较,¹⁾P<0.01;与模型组比较,²⁾P<0.01。

, figureFileSmall=nWj9qy8dxI4JNrO1OWaZJw==, figureFileBig=MB8iDdatgcGUHz5oQNWXcQ==, tableContent=null), ArticleFig(id=1197098411506843739, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.3, caption=Ultrastructural changes of gastrocnemius of rats by TEM(×7 000), figureFileSmall=Nu+szCsoeg0hDRiOQWh8bg==, figureFileBig=iubebibB10uRavm3V97+iw==, tableContent=null), ArticleFig(id=1197098411565563997, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图3, caption=大鼠腓肠肌透射电镜观察超微结构变化(×7 000), figureFileSmall=Nu+szCsoeg0hDRiOQWh8bg==, figureFileBig=iubebibB10uRavm3V97+iw==, tableContent=null), ArticleFig(id=1197098411641061471, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig4, caption=Apoptosis of rat gastrocnemius by TUNEL assay(×200), figureFileSmall=/ZpjICe3PDCjVFCau1jCKw==, figureFileBig=dUjjmWldUrPHyMpK/vuf8w==, tableContent=null), ArticleFig(id=1197098411724947553, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图4, caption=大鼠腓肠肌TUNEL荧光细胞凋亡(×200), figureFileSmall=/ZpjICe3PDCjVFCau1jCKw==, figureFileBig=dUjjmWldUrPHyMpK/vuf8w==, tableContent=null), ArticleFig(id=1197098411783667811, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.5, caption=cf-DNA and MPO levels in serum and MPO levels in gastrocnemius of rats. n=8, \stackrel{-}{x}±s

A-cf-DNA in serum; B-MPO in serum; C-MPO in gastrocnemius;¹⁾ P<0.01, compared with control group;²⁾P<0.05,³⁾P<0.01, compared with model group.

, figureFileSmall=qhe+d8NiwyFHQPr1EjeTPg==, figureFileBig=GbbdylPOWPrrwyeE59ss9Q==, tableContent=null), ArticleFig(id=1197098411854970980, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图5, caption=大鼠血清游离DNA(cf-DNA)水平、髓过氧化物酶(MPO)水平及腓肠肌MPO水平. n=8, \stackrel{-}{x}±s

A-血清cf-DNA;B-血清MPO;C-腓肠肌MPO;与正常对照组比较,¹⁾P <0.01;与模型组比较,²⁾P<0.05,³⁾P<0.01。

, figureFileSmall=qhe+d8NiwyFHQPr1EjeTPg==, figureFileBig=GbbdylPOWPrrwyeE59ss9Q==, tableContent=null), ArticleFig(id=1197098411934662758, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.6, caption=Results of NE IHC staining of gastrocnemius tissue of rats(×400). n=8, \stackrel{-}{x}±s

¹⁾P<0.01, compared with control group;²⁾P<0.01, compared with model group.

, figureFileSmall=ydmJJlrms0969/YNtA9gXw==, figureFileBig=pbiyJMFH5LnAe6hmPczl7Q==, tableContent=null), ArticleFig(id=1197098411993383016, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图6, caption=大鼠腓肠肌组织中性粒细胞弹性蛋白酶(NE)免疫组化染色结果(×400). n=8, \stackrel{-}{x}±s

与正常对照组比较,¹⁾P<0.01;与模型组比较,²⁾P<0.01。

, figureFileSmall=ydmJJlrms0969/YNtA9gXw==, figureFileBig=pbiyJMFH5LnAe6hmPczl7Q==, tableContent=null), ArticleFig(id=1197098412064686185, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.7, caption=Results of NE IF staining of gastrocnemius tissue of rats(×400). n=8, \stackrel{-}{x}±s

¹⁾P<0.05,²⁾P<0.01, compared with control group;³⁾P<0.05,⁴⁾P<0.01, compared with model group.

, figureFileSmall=RgxZvH8JDf9woXPajN/NOA==, figureFileBig=yBIme434OAeEaPasPmVv4w==, tableContent=null), ArticleFig(id=1197098412123406443, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图7, caption=大鼠腓肠肌组织NE免疫荧光染色结果(×400). n=8, \stackrel{-}{x}±s

与正常对照组比较,¹⁾P<0.05,²⁾P<0.01;与模型组比较,³⁾P<0.05,⁴⁾P<0.01。

, figureFileSmall=RgxZvH8JDf9woXPajN/NOA==, figureFileBig=yBIme434OAeEaPasPmVv4w==, tableContent=null), ArticleFig(id=1197098412186321005, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=EN, label=Fig.8, caption=Expression of CYR61 protein and its mRNA in gastrocnemius of rats. n=3, \stackrel{-}{x}±s

A-Western blot; B-the relative expression of CYR61 protein; C-the relative expression of CYR61 mRNA;¹⁾P<0.05,²⁾P<0.01, compared with control group;³⁾P<0.05,⁴⁾P<0.01, compared with model group.

, figureFileSmall=84/3a5yPi+a7MnnZemJ/ZA==, figureFileBig=t4Xzg35vW04djfQXemdhtw==, tableContent=null), ArticleFig(id=1197098412249235567, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195664141189951491, language=CN, label=图8, caption=大鼠腓肠肌CYR61蛋白及其mRNA表达. n=3, \stackrel{-}{x}±s

A-免疫印迹图;B-CYR61蛋白相对表达量;C-CYR61 mRNA相对表达量; 与正常对照组比较,¹⁾P<0.05,²⁾P<0.01;与模型组比较,³⁾P<0.05,⁴⁾P<0.01。

, figureFileSmall=84/3a5yPi+a7MnnZemJ/ZA==, figureFileBig=t4Xzg35vW04djfQXemdhtw==, tableContent=null)], attaches=null, journal=Journal(id=1190317596361715715, delFlag=0, nameCn=中国药学杂志, nameEn=Chinese Pharmaceutical Journal, nameHistory1=null, nameHistory2=null, issn=1001-2494, eissn=null, cn=11-2162/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=hRN1R6HnoNwYkve/JRn0DA==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761723430007, updatedTime=1761735858241, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=hRN1R6HnoNwYkve/JRn0DA==, picEn=xSRntM4yOh2wVIE2w+OjYg==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369724262355196, language=CN, name=中国药学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735858264, updatedTime=1761735858264, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionEditorUrl=https://zgyxzzeditor.manuscriptcloud.com/login, submissionReviewUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369724358824189, language=EN, name=Chinese Pharmaceutical Journal, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735858287, updatedTime=1761735858287, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionEditorUrl=https://zgyxzzeditor.manuscriptcloud.com/login, submissionReviewUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1190317699101192196, websiteList=[Website(id=1190317834875011552, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1190317699101192196, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgyxzz/CN, language=CN, createTime=1761723486870, createBy=18614031015, updateTime=1761723510130, updateBy=18614031015, name=中国药学杂志-中文, tplId=1146099689490845704, title=中国药学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1190318144041353703, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=articleTextType, value=kx, createTime=1761723560581, updateTime=1761723560581, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144016187876, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=banner, value=null, createTime=1761723560575, updateTime=1761723560575, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144062325226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=grayFlag, value=0, createTime=1761723560586, updateTime=1761723560586, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144007799267, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=logo, value=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/file/pic?fileId=puyAm9wIHqZks7K8hj8APQ==, createTime=1761723560573, updateTime=1761723560573, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144074908140, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=minRunFlag, value=0, createTime=1761723560589, updateTime=1761723560589, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144032965094, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/file/pic, createTime=1761723560579, updateTime=1761723560579, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144070713835, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=silenceFlag, value=0, createTime=1761723560588, updateTime=1761723560588, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144024576485, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761723560577, updateTime=1761723560577, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144049742312, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=themeColor, value=null, createTime=1761723560583, updateTime=1761723560583, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144053936617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=themeStyle, value=null, createTime=1761723560584, updateTime=1761723560584, creator=18614031015, updator=18614031015)]), Website(id=1190317834937926113, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1190317699101192196, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgyxzz/EN, language=EN, createTime=1761723486885, createBy=18614031015, updateTime=1761723527689, updateBy=18614031015, name=中国药学杂志-英文, tplId=1146101810881728533, title=Chinese Pharmaceutical Journal, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1190318170478051825, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=articleTextType, value=kx, createTime=1761723566884, updateTime=1761723566884, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170461274606, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=banner, value=null, createTime=1761723566880, updateTime=1761723566880, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170494829044, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=grayFlag, value=0, createTime=1761723566888, updateTime=1761723566888, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170452885997, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=logo, value=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/file/pic?fileId=puyAm9wIHqZks7K8hj8APQ==, createTime=1761723566878, updateTime=1761723566878, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170507411958, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=minRunFlag, value=0, createTime=1761723566891, updateTime=1761723566891, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170473857520, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/file/pic, createTime=1761723566883, updateTime=1761723566883, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170503217653, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=silenceFlag, value=0, createTime=1761723566890, updateTime=1761723566890, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170465468911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761723566881, updateTime=1761723566881, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170482246130, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=themeColor, value=null, createTime=1761723566885, updateTime=1761723566885, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170486440435, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=themeStyle, value=null, createTime=1761723566886, updateTime=1761723566886, creator=18614031015, updator=18614031015)])], journalTitle=中国药学杂志, weixinUrl=null, journalUrl=http://www.zgyxzz.com.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Pharmaceutical Journal, journalPhotoCn=hRN1R6HnoNwYkve/JRn0DA==, journalPhotoEn=xSRntM4yOh2wVIE2w+OjYg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/10.11669/cpj.2024.02.007, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2024.02.007, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/PDF/10.11669/cpj.2024.02.007, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/PDF/10.11669/cpj.2024.02.007, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)