Article(id=1193674742768042263, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1193674740352119804, articleNumber=1001-2494(2025)06-0604-08, orderNo=null, doi=10.11669/cpj.2025.06.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1731513600000, receivedDateStr=2024-11-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1762523836080, onlineDateStr=2025-11-07, pubDate=1742572800000, pubDateStr=2025-03-22, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762523836080, onlineIssueDateStr=2025-11-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762523836080, creator=13701087609, updateTime=1762523836080, updator=13701087609, issue=Issue{id=1193674740352119804, tenantId=1146029695717560320, journalId=1190317699101192196, year='2025', volume='60', issue='6', pageStart='553', pageEnd='662', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762523835503, creator=13701087609, updateTime=1762524041683, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1193675605205025683, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1193674740352119804, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1193675605205025684, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1193674740352119804, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=604, endPage=611, ext={EN=ArticleExt(id=1193674742998728986, articleId=1193674742768042263, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Nalmefene Alleviates Postoperative Cognitive Dysfunction in Aged Rats via the Sirt1/TLR4/NF-κB Pathway, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To explore the effect and molecular mechanism of nalmefene on postoperative cognitive dysfunction (POCD) in aged rats. METHODS Seventeen-month-old SD rats were randomly divided into control group (Control), model group (Model), model + nalmefene group (Model+Nal), model+nalmefene+EX527 group (Model+Nal+EX527) with 8 rats in each group after one week of acclimatization. The POCD animal models (excluding the Control group) were established by sevoflurane anesthesia and exploratory laparotomy. The rats in Model+Nal group were subcutaneously injected with 0.1 mg·kg^-1 nalmefene hydrochloride 30 min before anesthesia induction. The rats in Model+Nal+EX527 group were injected subcutaneously with 0.1 mg·kg^-1 nalmefene hydrochloride and intraperitoneally with 10 mg·kg^-1 EX527 (Sirt1 inhibitor) 30 min before anesthesia induction. Morris water maze experiment was conducted to analyze the cognitive abilities of rats. Hippocampal tissues were collected 3 d after surgery. The pathological changes of the hippocampus were observed by HE staining. Neuron apoptosis was analyzed by Tunel staining. ELISA method was used to detect the contents of TNF-α and IL-6. The protein expression levels of Bax, Bcl-2, Sirt1, TLR4 and NF-κB p65 were determined by Western blot. RESULTS Compared with the Control group, the cognitive dysfunction was seen, neuronal damage and the proportion of apoptotic neurons in hippocampal DG region were increased, TNF-α and IL-6 contents as well as the expression of Bax, TLR4 and NF-κB p65 were elevated, while the expression of Bcl-2 and Sirt1 was decreased in the Model group (P<0.001). Compared with the Model group, the cognitive ability was enhanced, neuronal damage and the proportion of apoptotic neurons in hippocampal DG region were decreased, TNF-α and IL-6 contents as well as the expression of Bax, TLR4 and NF-κB p65 were reduced, whereas the expression of Bcl-2 and Sirt1 was elevated in the Model+Nal group (P<0.001). Compared with the Model+Nal group, the cognitive ability was suppressed, neuronal damage and the proportion of apoptotic neurons in hippocampal DG region were increased, TNF-α and IL-6 contents as well as the expression of Bax, TLR4 and NF-κB p65 were elevated, while the expression of Bcl-2 and Sirt1 was decreased in the Model+Nal+EX527 group (P<0.001). CONCLUSION Nalmefene can reduce neuroinflammation and neuronal damage, and improve cognitive dysfunction in aged POCD rats through regulating Sirt1/TLR4/NF-κB pathway.

, correspAuthors=Hongfang GENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Lin ZHANG, Fudong TANG, Yuedan LIU, Hongfang GENG), CN=ArticleExt(id=1193675147505795911, articleId=1193674742768042263, tenantId=1146029695717560320, journalId=1190317699101192196, language=CN, title=纳美芬通过调控Sirt1/TLR4/NF-κB通路改善老年大鼠术后认知功能障碍, columnId=1190352405612040510, journalTitle=中国药学杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=

目的 探究纳美芬对老年大鼠术后认知功能障碍(postoperative cognitive dysfunction,POCD)的影响及其分子机制。方法 将17月龄的SD大鼠适应饲养一周后,随机分成对照(Control)组、模型(Model)组、模型+纳美芬(Model+Nal)组、模型+纳美芬+EX527(Model+Nal+EX527)组,每组8只。除Control组外,使用七氟烷麻醉和剖腹探查术建立POCD模型。Model+Nal组大鼠在麻醉诱导前30 min皮下注射0.1 mg·kg^-1盐酸纳美芬;Model+Nal+EX527组大鼠在麻醉诱导前30 min皮下注射0.1 mg·kg^-1盐酸纳美芬,并腹腔注射10 mg·kg^-1 EX527 [沉默信息调节因子1(Sirt1)抑制剂]。Morris水迷宫实验评估大鼠认知能力。术后第3天处死大鼠,苏木素-伊红(HE)染色观察海马组织病理学改变,Tunel染色分析神经元凋亡,酶联免疫吸附测定(ELISA)方法分析肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)含量,蛋白质免疫印迹(Western blot)法检测B-细胞淋巴瘤因子2(Bcl-2)、Bcl-2 相关X蛋白(Bax)、Sirt1、Toll样受体4(TLR4)和核因子κB亚基p65(NF-κB p65)蛋白表达水平。结果 与Control组相比,Model组大鼠出现认知障碍,海马DG区神经元出现损伤,DG区神经元凋亡比例增多,TNF-α和IL-6含量增加,Bax、TLR4和NF-κB p65蛋白表达增加,Bcl-2和Sirt1表达降低(P<0.001);与Model组相比,Model+Nal组大鼠认知能力增强,海DG区神经元损伤减轻,DG区神经元凋亡比例减少,TNF-α和IL-6含量降低,Bax、TLR4和NF-κB p65蛋白表达减少,Bcl-2和Sirt1表达增加(P<0.001);与Model+Nal组相比,Model+Nal +EX527组大鼠认知能力减弱,海马DG区神经元损伤增加,DG区神经元凋亡比例增多,TNF-α和IL-6含量增加,Bax、TLR4和NF-κB p65蛋白表达增加,Bcl-2和Sirt1表达降低(P<0.001)。结论 纳美芬可通过Sirt1/TLR4/NF-κB通路减轻POCD老年大鼠神经炎症和神经元损伤,改善认知功能障碍。

, correspAuthors=耿红芳, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=fDNomnhGl5X9OjmC8vP0dA==, magXml=cvgBIJOy2xNnjAc/xpP9bQ==, pdfUrl=null, pdf=Scoj0bF0aOrwDHRYJQMQVg==, pdfFileSize=3615201, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=C5AcbhnsyPCTjfvTn75VrA==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=eKIlxN60aMDOYul9MPLu0w==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=张琳, 唐富东, 刘跃丹, 耿红芳)}, authors=[Author(id=1193713123963139056, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1193713124034442226, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713123963139056, language=EN, stringName=Lin ZHANG, firstName=Lin, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1193713124105745395, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713123963139056, language=CN, stringName=张琳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003, bio={"content":"

张琳,女,硕士,副主任医师 研究方向:小儿麻醉基础与临床

"}, bioImg=null, bioContent=

张琳,女,硕士,副主任医师 研究方向:小儿麻醉基础与临床

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1193713123866670060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, xref=null, ext=[AuthorCompanyExt(id=1193713123875058669, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China), AuthorCompanyExt(id=1193713123879252974, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003)])]), Author(id=1193713124160271349, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1193713124239963127, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124160271349, language=EN, stringName=Fudong TANG, firstName=Fudong, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1193713124302877688, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124160271349, language=CN, stringName=唐富东, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1193713123866670060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, xref=null, ext=[AuthorCompanyExt(id=1193713123875058669, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China), AuthorCompanyExt(id=1193713123879252974, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003)])]), Author(id=1193713124378375162, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1193713124458066940, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124378375162, language=EN, stringName=Yuedan LIU, firstName=Yuedan, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1193713124516787197, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124378375162, language=CN, stringName=刘跃丹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1193713123866670060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, xref=null, ext=[AuthorCompanyExt(id=1193713123875058669, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China), AuthorCompanyExt(id=1193713123879252974, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003)])]), Author(id=1193713124575507455, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1193713124642615296, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124575507455, language=EN, stringName=Hongfang GENG, firstName=Hongfang, middleName=null, lastName=GENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^*, address=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1193713124705529857, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, authorId=1193713124575507455, language=CN, stringName=耿红芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^*, address=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1193713123866670060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, xref=null, ext=[AuthorCompanyExt(id=1193713123875058669, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China), AuthorCompanyExt(id=1193713123879252974, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003)])])], keywords=[Keyword(id=1193713124843941890, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, orderNo=1, keyword=nalmefene), Keyword(id=1193713124911050755, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, orderNo=2, keyword=aged rat), Keyword(id=1193713124973965316, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, orderNo=3, keyword=postoperative cognitive dysfunction), Keyword(id=1193713125041074181, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, orderNo=4, keyword=Sirt1), Keyword(id=1193713126085455878, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, orderNo=5, keyword=TLR4/NF-κB), Keyword(id=1193713126160953351, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, orderNo=1, keyword=纳美芬), Keyword(id=1193713126232256520, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, orderNo=2, keyword=老年大鼠), Keyword(id=1193713126295171081, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, orderNo=3, keyword=术后认知功能障碍), Keyword(id=1193713126362279946, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, orderNo=4, keyword=沉默信息调节因子1), Keyword(id=1193713126437777419, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, orderNo=5, keyword=Toll 样受体 4/核因子κB)], refs=[Reference(id=1193713127960309785, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=18, issue=null, pageStart=1328790, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=ZHAO Q, WAN H, PAN H, journalName=Front Behav Neurosci, refType=null, unstructuredReference=ZHAO Q, WAN H, PAN H, et al. Postoperative cognitive dysfunction-current research progress[J]. Front Behav Neurosci, 2024, 18: 1328790. DOI: 10.3389/fnbeh.2024.1328790., articleTitle=Postoperative cognitive dysfunction-current research progress, refAbstract=null), Reference(id=1193713128027418650, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=53, issue=7, pageStart=afae160, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=SURAARUNSUMRIT P, SRINONPRASERT V, KONGMALAI T, journalName=Age Ageing, refType=null, unstructuredReference=SURAARUNSUMRIT P, SRINONPRASERT V, KONGMALAI T, et al. Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis[J]. Age Ageing, 2024, 53(7): afae160. DOI: 10.1093/ageing/afae160., articleTitle=Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis, refAbstract=null), Reference(id=1193713128111304731, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2008, volume=108, issue=1, pageStart=18, pageEnd=30, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=MONK T G, WELDON B C, GARVAN C W, journalName=Anesthesiology, refType=null, unstructuredReference=MONK T G, WELDON B C, GARVAN C W, et al. Predictors of cognitive dysfunction after major noncardiac surgery[J]. Anesthesiology, 2008, 108(1): 18-30., articleTitle=Predictors of cognitive dysfunction after major noncardiac surgery, refAbstract=null), Reference(id=1193713128203579420, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2022, volume=16, issue=null, pageStart=843069, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=LI Z, ZHU Y, KANG Y, journalName=Front Cell Neurosci, refType=null, unstructuredReference=LI Z, ZHU Y, KANG Y, et al. Neuroinflammation as the Underlying Mechanism of Postoperative Cognitive Dysfunction and Therapeutic Strategies[J]. Front Cell Neurosci, 2022, 16: 843069. DOI: 10.3389/fncel.2022.843069., articleTitle=Neuroinflammation as the Underlying Mechanism of Postoperative Cognitive Dysfunction and Therapeutic Strategies, refAbstract=null), Reference(id=1193713128308437021, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2023, volume=167, issue=null, pageStart=115582, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=LIU Y, YANG W, XUE J, journalName=Biomed Pharmacother, refType=null, unstructuredReference=LIU Y, YANG W, XUE J, et al. Neuroinflammation: The central enabler of postoperative cognitive dysfunction[J]. Biomed Pharmacother, 2023, 167: 115582. DOI: 10.1016/j.biopha.2023.115582., articleTitle=Neuroinflammation: The central enabler of postoperative cognitive dysfunction, refAbstract=null), Reference(id=1193713128383934494, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=1997, volume=14, issue=12, pageStart=931, pageEnd=941, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=DEWITT D S, PROUGH D S, UCHIDA T, journalName=J Neurotrauma, refType=null, unstructuredReference=DEWITT D S, PROUGH D S, UCHIDA T, et al. Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage[J]. J Neurotrauma, 1997, 14(12): 931-941., articleTitle=Effects of nalmefene, CG3703, tirilazad, or dopamine on cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and hemorrhage, refAbstract=null), Reference(id=1193713128446849055, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2018, volume=143, issue=null, pageStart=66, pageEnd=72, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=WU G, ZHAO X, WANG F, journalName=Brain Res Bull, refType=null, unstructuredReference=WU G, ZHAO X, WANG F, et al. Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro[J]. Brain Res Bull, 2018, 143: 66-72., articleTitle=Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro, refAbstract=null), Reference(id=1193713128522346528, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2017, volume=41, issue=7, pageStart=1257, pageEnd=1270, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=MONTESINOS J, GIL A, GUERRI C, journalName=Alcohol Clin Exp Res, refType=null, unstructuredReference=MONTESINOS J, GIL A, GUERRI C. Nalmefene prevents alcohol-induced neuroinflammation and alcohol drinking preference in adolescent female mice: Role of TLR4[J]. Alcohol Clin Exp Res, 2017, 41(7): 1257-1270., articleTitle=Nalmefene prevents alcohol-induced neuroinflammation and alcohol drinking preference in adolescent female mice: Role of TLR4, refAbstract=null), Reference(id=1193713128593649697, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2020, volume=40, issue=2, pageStart=380, pageEnd=388, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=LI M Y, CHEN C, WANG Z G, journalName=Curr Med Sci, refType=null, unstructuredReference=LI M Y, CHEN C, WANG Z G, et al. Effect of nalmefene on delayed neurocognitive recovery in elderly patients undergoing video-assisted thoracic surgery with one lung ventilation[J]. Curr Med Sci, 2020, 40(2): 380-388., articleTitle=Effect of nalmefene on delayed neurocognitive recovery in elderly patients undergoing video-assisted thoracic surgery with one lung ventilation, refAbstract=null), Reference(id=1193713128656564258, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2020, volume=21, issue=10, pageStart=757, pageEnd=765, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=SHI J, ZOU X, JIANG K, journalName=World J Biol Psychiatry, refType=null, unstructuredReference=SHI J, ZOU X, JIANG K, et al. SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-kappaB pathway[J]. World J Biol Psychiatry, 2020, 21(10): 757-765., articleTitle=SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-kappaB pathway, refAbstract=null), Reference(id=1193713128723673123, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2023, volume=46, issue=10, pageStart=993, pageEnd=1001, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=XU B L M, WANG J W, LI W H, GAO R, HU HL, journalName=Chin J Tuberc Respir Dis(中华结核和呼吸杂志), refType=null, unstructuredReference=XU B L M, WANG J W, LI W H, GAO R, HU HL. Post-ischemic treatment of nalmefene hydrochloride attenuated lung ischemia-reperfusion injury in rats via the Sirt1/Nrf2/HO-1 pathway with inhibition of ferroptosis[J]. Chin J Tuberc Respir Dis(中华结核和呼吸杂志), 2023, 46(10): 993-1001., articleTitle=Post-ischemic treatment of nalmefene hydrochloride attenuated lung ischemia-reperfusion injury in rats via the Sirt1/Nrf2/HO-1 pathway with inhibition of ferroptosis, refAbstract=null), Reference(id=1193713128803364900, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2018, volume=18, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=ZHANG Q, LI Y, BAO Y, journalName=BMC Anesthesiol, refType=null, unstructuredReference=ZHANG Q, LI Y, BAO Y, et al. Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats[J]. BMC Anesthesiol, 2018, 18(1): 42. DOI: 10.1186/s12871-018-0501-0., articleTitle=Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats, refAbstract=null), Reference(id=1193713128870473765, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2022, volume=14, issue=null, pageStart=943842, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=SUN Y, WANG Y, YE F, journalName=Front Aging Neurosci, refType=null, unstructuredReference=SUN Y, WANG Y, YE F, et al. SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction[J]. Front Aging Neurosci, 2022, 14: 943842. DOI: 10.3389/fnagi.2022.943842., articleTitle=SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction, refAbstract=null), Reference(id=1193713128941776934, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2016, volume=173, issue=16, pageStart=2490, pageEnd=2505, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=CALLEJA-CONDE J, ECHEVERRY-ALZATE V, GINE E, journalName=Br J Pharmacol, refType=null, unstructuredReference=CALLEJA-CONDE J, ECHEVERRY-ALZATE V, GINE E, et al. Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood[J]. Br J Pharmacol, 2016, 173(16): 2490-2505., articleTitle=Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood, refAbstract=null), Reference(id=1193713129008885799, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2021, volume=18, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=XIE S, JIANG X, DOYCHEVA D M, journalName=J Neuroinflamm, refType=null, unstructuredReference=XIE S, JIANG X, DOYCHEVA D M, et al. Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1alpha/Nrf2 pathway post-neonatal hypoxic-ischemic injury in rats[J]. J Neuroinflamm, 2021, 18(1): 226. DOI: 10.1186/s12974-021-02289-7., articleTitle=Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1alpha/Nrf2 pathway post-neonatal hypoxic-ischemic injury in rats, refAbstract=null), Reference(id=1193713129075994664, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=59, issue=1, pageStart=39, pageEnd=44, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=TAN W W L Z, YANG C X, journalName=Chin Pharm J(中国药学杂志), refType=null, unstructuredReference=TAN W W L Z, YANG C X. Effect of total saponin of aralia taibaiensis on cognitive dysfunction in mice with traumatic brain injury by mediating SIRT1/FoxO1/PGC-1α pathway[J]. Chin Pharm J(中国药学杂志), 2024, 59(1): 39-44., articleTitle=Effect of total saponin of aralia taibaiensis on cognitive dysfunction in mice with traumatic brain injury by mediating SIRT1/FoxO1/PGC-1α pathway, refAbstract=null), Reference(id=1193713129143103529, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=9, pageStart=2415, pageEnd=2426, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=XIE X, SHEN Z, HU C, journalName=Neurochem Res, refType=null, unstructuredReference=XIE X, SHEN Z, HU C, et al. Dexmedetomidine ameliorates postoperative cognitive dysfunction in aged mice[J]. Neurochem Res, 2021, 46(9): 2415-2426., articleTitle=Dexmedetomidine ameliorates postoperative cognitive dysfunction in aged mice, refAbstract=null), Reference(id=1193713129210212394, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=20, issue=5, pageStart=1927, pageEnd=1946, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=YANG N S, ZHONG W J, SHA H X, journalName=Int J Biol Sci, refType=null, unstructuredReference=YANG N S, ZHONG W J, SHA H X, et al. mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice[J]. Int J Biol Sci, 2024, 20(5): 1927-1946., articleTitle=mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice, refAbstract=null), Reference(id=1193713129277321259, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=38, issue=null, pageStart=101688, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=KOGA M, INADA K, YAMADA A, journalName=Biochem Biophys Rep, refType=null, unstructuredReference=KOGA M, INADA K, YAMADA A, et al. Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages[J]. Biochem Biophys Rep, 2024, 38: 101688. DOI: 10.1016/j.bbrep.2024.101688., articleTitle=Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages, refAbstract=null), Reference(id=1193713129352818732, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2019, volume=44, issue=5, pageStart=1866, pageEnd=1876, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=LI X, SUN Y, JIN Q, journalName=Int J Mol Med, refType=null, unstructuredReference=LI X, SUN Y, JIN Q, et al. Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway[J]. Int J Mol Med, 2019, 44(5): 1866-1876., articleTitle=Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway, refAbstract=null), Reference(id=1193713129415733293, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2021, volume=23, issue=4, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=FAN J, LI L, QU P, journalName=Mol Med Rep, refType=null, unstructuredReference=FAN J, LI L, QU P, et al. kappa-opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO-1 pathway[J]. Mol Med Rep, 2021, 23(4): 293. DOI: 10.3892/mmr.2021.11933., articleTitle=kappa-opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO-1 pathway, refAbstract=null), Reference(id=1193713129478647854, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2023, volume=24, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=MA X, LIU J, TANG Y, journalName=Trials, refType=null, unstructuredReference=MA X, LIU J, TANG Y, et al. The efficacy of nalmefene on anesthetic recovery of patients: a study protocol for a multicenter randomized controlled trial[J]. Trials, 2023, 24(1): 156. DOI: 10.1186/s13063-023-07169-4., articleTitle=The efficacy of nalmefene on anesthetic recovery of patients: a study protocol for a multicenter randomized controlled trial, refAbstract=null), Reference(id=1193713129549951023, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2018, volume=18, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=WEI L, YAO M, ZHAO Z, journalName=BMC Anesthesiol, refType=null, unstructuredReference=WEI L, YAO M, ZHAO Z, et al. High-fat diet aggravates postoperative cognitive dysfunction in aged mice[J]. BMC Anesthesiol, 2018, 18(1): 20. DOI: 10.1186/s12871-018-0482-z., articleTitle=High-fat diet aggravates postoperative cognitive dysfunction in aged mice, refAbstract=null), Reference(id=1193713130598527024, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=1822, issue=null, pageStart=148607, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=XU Y, LU Y, XU R, journalName=Brain Res, refType=null, unstructuredReference=XU Y, LU Y, XU R, et al. Gastrodin ameliorates postoperative cognitive dysfunction in aged mice by promoting nuclear translocation of Nrf2 through activation of AMPK[J]. Brain Res, 2024, 1822: 148607. DOI: 10.1016/j.brainres.2023.148607., articleTitle=Gastrodin ameliorates postoperative cognitive dysfunction in aged mice by promoting nuclear translocation of Nrf2 through activation of AMPK, refAbstract=null), Reference(id=1193713130657247281, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2024, volume=40, issue=1, pageStart=63, pageEnd=73, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=XU H J, LI X P, HAN L Y, journalName=Kaohsiung J Med Sci, refType=null, unstructuredReference=XU H J, LI X P, HAN L Y. Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway[J]. Kaohsiung J Med Sci, 2024, 40(1): 63-73., articleTitle=Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway, refAbstract=null), Reference(id=1193713130783076402, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2023, volume=807, issue=null, pageStart=137259, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=YU K, ZHANG X K, XIONG H C, journalName=Neurosci Lett, refType=null, unstructuredReference=YU K, ZHANG X K, XIONG H C, et al. Stellate ganglion block alleviates postoperative cognitive dysfunction via inhibiting TLR4/NF-kappaB signaling pathway[J]. Neurosci Lett, 2023, 807: 137259. DOI: 10.1016/j.neulet.2023.137259., articleTitle=Stellate ganglion block alleviates postoperative cognitive dysfunction via inhibiting TLR4/NF-kappaB signaling pathway, refAbstract=null), Reference(id=1193713130871156787, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2020, volume=24, issue=1, pageStart=461, pageEnd=468, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=ZHANG N L, WANG H Q, YANG J, journalName=Eur Rev Med Pharmacol Sci, refType=null, unstructuredReference=ZHANG N L, WANG H Q, YANG J, et al. Effects of nalmefene hydrochloride on TLR4 signaling pathway in rats with lung ischemia-reperfusion injury[J]. Eur Rev Med Pharmacol Sci, 2020, 24(1): 461-468., articleTitle=Effects of nalmefene hydrochloride on TLR4 signaling pathway in rats with lung ischemia-reperfusion injury, refAbstract=null), Reference(id=1193713130942459956, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, doi=null, pmid=null, pmcid=null, year=2023, volume=172, issue=null, pageStart=113561, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=WU J, HAO Z, WANG Y, journalName=Food Chem Toxicol, refType=null, unstructuredReference=WU J, HAO Z, WANG Y, et al. Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-kappaB pathway[J]. Food Chem Toxicol, 2023, 172: 113561. DOI: 10.1016/j.fct.2022.113561., articleTitle=Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-kappaB pathway, refAbstract=null)], funds=[Fund(id=1193713127809314840, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, awardId=LHGJ20220065, language=CN, fundingSource=河南省医学科技攻关联合共建项目资助(LHGJ20220065), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1193713123866670060, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, xref=null, ext=[AuthorCompanyExt(id=1193713123875058669, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou 450003, China), AuthorCompanyExt(id=1193713123879252974, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, companyId=1193713123866670060, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河南省人民医院 麻醉与围术期医学科, 郑州大学人民医院, 河南大学人民医院, 郑州 450003)])], figs=[ArticleFig(id=1193713126710407180, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Fig.1, caption=Changes in swimming trajectories of rats in each group during the navigation test and spatial probe test.n=8

Nal-nalmefene; EX527-Sirt1 inhibitor.

, figureFileSmall=hHAmXf2iOXVOfieRqF4Nqg==, figureFileBig=79AWiFUFUGe62hcn0O/e3A==, tableContent=null), ArticleFig(id=1193713126777516045, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=图1, caption=各组大鼠定位航行实验和空间探索实验中游泳轨迹的变化。n=8

Nal-纳美芬;EX527-沉默信息调节因子1(Sirt1)抑制剂。

, figureFileSmall=hHAmXf2iOXVOfieRqF4Nqg==, figureFileBig=79AWiFUFUGe62hcn0O/e3A==, tableContent=null), ArticleFig(id=1193713126899150862, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Fig.2, caption=Pathological changes of neurons in the hippocampal DG regions of rats were detected by HE staining(×40 and ×200), figureFileSmall=0GVyPyaL7//ZLioJybVHKA==, figureFileBig=+7zy1179Rs8iuRX54dYZ6A==, tableContent=null), ArticleFig(id=1193713126974648335, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=图2, caption=苏木素-伊红(HE)染色检测大鼠海马齿状回(DG)区神经元病理变化(×40和×200), figureFileSmall=0GVyPyaL7//ZLioJybVHKA==, figureFileBig=+7zy1179Rs8iuRX54dYZ6A==, tableContent=null), ArticleFig(id=1193713127062728720, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Fig.3, caption=Comparison of neuronal apoptosis in the hippocampal DG regions of rats in different groups.n=4,$\bar{x} \pm s$

A-Tunel staining for hippocampal neurons (×200 and ×400); B-apoptotic rate of neurons in hippocampal DG region; C-Western blot assay for the protein levels of Bax and Bcl-2 in hippocampal tissues; D-statistical analysis for Bax protein relative expression; E-statistical analysis for Bcl-2 protein relative expression; ¹⁾P<0.001, compared with control group; ²⁾P<0.001, compared with model group; ³⁾P<0.001, compared with model+Nal group.

, figureFileSmall=UXQMx82kBb/fnqbcwA7lzg==, figureFileBig=IyfqnvFP1hLv3gBYo0whTw==, tableContent=null), ArticleFig(id=1193713127188557841, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=图3, caption=各组大鼠海马DG区神经元凋亡情况比较。n=4,$\bar{x} \pm s$

A-海马DG区神经元Tunel染色(×200和×400);B-海马DG区神经元凋亡率统计;C-Western blot检测海马组织中Bax和Bcl-2蛋白表达情况;D-Bax蛋白表达量的统计分析;E-Bcl-2蛋白表达量的统计分析;与对照组比较,¹⁾P<0.001;与模型组比较,²⁾P<0.001;与模型+纳美芬组比较,³⁾P<0.001。

, figureFileSmall=UXQMx82kBb/fnqbcwA7lzg==, figureFileBig=IyfqnvFP1hLv3gBYo0whTw==, tableContent=null), ArticleFig(id=1193713127259861010, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Fig.4, caption=ELISA assay for TNF-α and IL-6 levels in hippocampal tissues of rats in different groups.n=4,$\bar{x} \pm s$

A-ELISA analysis for TNF-α levels; B-ELISA analysis for IL-6 levels; ¹⁾P<0.001, compared with control group; ²⁾P<0.001, compared with model group; ³⁾P<0.001, compared with model+Nal group.

, figureFileSmall=b3t0ZsITHFJlEg6ItUj09Q==, figureFileBig=emoP7RAHj0auwN3v8+MNUg==, tableContent=null), ArticleFig(id=1193713127335358483, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=图4, caption=ELISA检测各组大鼠海马组织中肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)表达。n=4,$\bar{x} \pm s$

A-ELISA检测TNF-α表达;B-ELISA检测IL-6表达;与对照组比较,¹⁾P<0.001;与模型组比较,²⁾P<0.001;与模型+纳美芬组比较,³⁾P<0.001。

, figureFileSmall=b3t0ZsITHFJlEg6ItUj09Q==, figureFileBig=emoP7RAHj0auwN3v8+MNUg==, tableContent=null), ArticleFig(id=1193713127436021780, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Fig.5, caption=Comparison of Sirt1, TLR4, and NF-κB p65 protein levels in hippocampal tissues of rats in each group. n=4,$\bar{x} \pm s$

A-Western blot assay for the protein levels of Sirt1, TLR4, and NF-κB p65; B-statistical analysis for Sirt1 protein relative expression; C-statistical analysis for TLR4 protein relative expression; D-statistical analysis for NF-κB p65 protein relative expression; ¹⁾P<0.001, compared with control group; ²⁾P<0.001, compared with model group; ³⁾P<0.001, compared with model+Nal group.

, figureFileSmall=E0A5OG34Bf1FZ3bAMzKjhg==, figureFileBig=N8RUYMNfqExJm6GhGfLtIg==, tableContent=null), ArticleFig(id=1193713127511519253, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=图5, caption=各组大鼠海马组织中沉默信息调节因子1 (Sirt1)、Toll 样受体 4(TLR4)和核因子κB亚基p65(NF-κB p65)蛋白表达比较。n=4,$\bar{x} \pm s$

A-Western blot检测Sirt1、TLR4和NF-κB p65蛋白表达情况;B-Sirt1蛋白表达量的统计分析;C-TLR4蛋白表达量的统计分析;D-NF-κB p65蛋白表达量的统计分析;与对照组比较,¹⁾P<0.001;与模型组比较,²⁾P<0.001;与模型+纳美芬组比较,³⁾P<0.001。

, figureFileSmall=E0A5OG34Bf1FZ3bAMzKjhg==, figureFileBig=N8RUYMNfqExJm6GhGfLtIg==, tableContent=null), ArticleFig(id=1193713127578628118, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=EN, label=Tab.1, caption=

Morris water maze experiment assay for the learning and memory abilities of rats.n=8,$\bar{x} \pm s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	Escape latency/s			Platform crossing times	Time spent in target quadrant/s
	1 d before surgery	1st day after surgery	3rd day after surgery
Control	13.88±2.85	12.12±2.90	10.87±3.48	7.12±1.13	46.75±4.06
Model	13.62±2.45	52.87±4.581)	42.50±4.751)	1.75±1.031)	24.75±5.341)
Model+Nal	13.25±2.82	40.12±5.222)	31.25±3.542)	5.37±0.922)	42.25±4.172)
Model+Nal+EX527	14.12±2.17	50.75±5.573)	40.12±3.683)	2.37±1.063)	31.50±4.043)

), ArticleFig(id=1193713127649931287, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1193674742768042263, language=CN, label=表1, caption=

Morris水迷宫实验分析各组大鼠学习和记忆能力。n=8,$\bar{x} \pm s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	Escape latency/s			Platform crossing times	Time spent in target quadrant/s
	1 d before surgery	1st day after surgery	3rd day after surgery
Control	13.88±2.85	12.12±2.90	10.87±3.48	7.12±1.13	46.75±4.06
Model	13.62±2.45	52.87±4.581)	42.50±4.751)	1.75±1.031)	24.75±5.341)
Model+Nal	13.25±2.82	40.12±5.222)	31.25±3.542)	5.37±0.922)	42.25±4.172)
Model+Nal+EX527	14.12±2.17	50.75±5.573)	40.12±3.683)	2.37±1.063)	31.50±4.043)

)], attaches=null, journal=Journal(id=1190317596361715715, delFlag=0, nameCn=中国药学杂志, nameEn=Chinese Pharmaceutical Journal, nameHistory1=null, nameHistory2=null, issn=1001-2494, eissn=null, cn=11-2162/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=hRN1R6HnoNwYkve/JRn0DA==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1761723430007, updatedTime=1761735858241, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=hRN1R6HnoNwYkve/JRn0DA==, picEn=xSRntM4yOh2wVIE2w+OjYg==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369724262355196, language=CN, name=中国药学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735858264, updatedTime=1761735858264, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionEditorUrl=https://zgyxzzeditor.manuscriptcloud.com/login, submissionReviewUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369724358824189, language=EN, name=Chinese Pharmaceutical Journal, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735858287, updatedTime=1761735858287, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionEditorUrl=https://zgyxzzeditor.manuscriptcloud.com/login, submissionReviewUrl=https://zgyxzzauthor.manuscriptcloud.com/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1190317699101192196, websiteList=[Website(id=1190317834875011552, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1190317699101192196, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgyxzz/CN, language=CN, createTime=1761723486870, createBy=18614031015, updateTime=1761723510130, updateBy=18614031015, name=中国药学杂志-中文, tplId=1146099689490845704, title=中国药学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1190318144041353703, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=articleTextType, value=kx, createTime=1761723560581, updateTime=1761723560581, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144016187876, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=banner, value=null, createTime=1761723560575, updateTime=1761723560575, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144062325226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=grayFlag, value=0, createTime=1761723560586, updateTime=1761723560586, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144007799267, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=logo, value=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/file/pic?fileId=puyAm9wIHqZks7K8hj8APQ==, createTime=1761723560573, updateTime=1761723560573, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144074908140, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=minRunFlag, value=0, createTime=1761723560589, updateTime=1761723560589, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144032965094, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/file/pic, createTime=1761723560579, updateTime=1761723560579, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144070713835, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=silenceFlag, value=0, createTime=1761723560588, updateTime=1761723560588, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144024576485, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761723560577, updateTime=1761723560577, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144049742312, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=themeColor, value=null, createTime=1761723560583, updateTime=1761723560583, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318144053936617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834875011552, code=themeStyle, value=null, createTime=1761723560584, updateTime=1761723560584, creator=18614031015, updator=18614031015)]), Website(id=1190317834937926113, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1190317699101192196, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgyxzz/EN, language=EN, createTime=1761723486885, createBy=18614031015, updateTime=1761723527689, updateBy=18614031015, name=中国药学杂志-英文, tplId=1146101810881728533, title=Chinese Pharmaceutical Journal, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1190318170478051825, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=articleTextType, value=kx, createTime=1761723566884, updateTime=1761723566884, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170461274606, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=banner, value=null, createTime=1761723566880, updateTime=1761723566880, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170494829044, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=grayFlag, value=0, createTime=1761723566888, updateTime=1761723566888, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170452885997, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=logo, value=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/file/pic?fileId=puyAm9wIHqZks7K8hj8APQ==, createTime=1761723566878, updateTime=1761723566878, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170507411958, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=minRunFlag, value=0, createTime=1761723566891, updateTime=1761723566891, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170473857520, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/file/pic, createTime=1761723566883, updateTime=1761723566883, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170503217653, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=silenceFlag, value=0, createTime=1761723566890, updateTime=1761723566890, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170465468911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761723566881, updateTime=1761723566881, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170482246130, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=themeColor, value=null, createTime=1761723566885, updateTime=1761723566885, creator=18614031015, updator=18614031015), WebsiteProps(id=1190318170486440435, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1190317834937926113, code=themeStyle, value=null, createTime=1761723566886, updateTime=1761723566886, creator=18614031015, updator=18614031015)])], journalTitle=中国药学杂志, weixinUrl=null, journalUrl=http://www.zgyxzz.com.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Pharmaceutical Journal, journalPhotoCn=hRN1R6HnoNwYkve/JRn0DA==, journalPhotoEn=xSRntM4yOh2wVIE2w+OjYg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/10.11669/cpj.2025.06.006, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/10.11669/cpj.2025.06.006, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgyxzz/CN/PDF/10.11669/cpj.2025.06.006, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgyxzz/EN/PDF/10.11669/cpj.2025.06.006, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)