Article(id=1190375273666281481, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, articleNumber=1001-2494(2025)03-0250-07, orderNo=null, doi=10.11669/cpj.2025.03.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1723478400000, receivedDateStr=2024-08-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1761737181345, onlineDateStr=2025-10-29, pubDate=1738944000000, pubDateStr=2025-02-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1761737181345, onlineIssueDateStr=2025-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1761737181345, creator=13701087609, updateTime=1761737181345, updator=13701087609, issue=Issue{id=1190375270847710190, tenantId=1146029695717560320, journalId=1190317699101192196, year='2025', volume='60', issue='3', pageStart='209', pageEnd='312', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1761737180673, creator=13701087609, updateTime=1761793989024, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1190613542412890252, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1190613542412890253, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=250, endPage=256, ext={EN=ArticleExt(id=1190375273922134030, articleId=1190375273666281481, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Effect and Mechanism of Saikosaponin A on Inflammatory Injury in Rats with Reflux Esophagitis, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To investigate the effect of saikosaponin A (SA) on inflammatory injury in rats with reflux esophagitis (RE) by regulating the interleukin (IL)-6/tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway. METHODS SD rats were randomly divided into RE group, normal group, SA low-dose group (gavage of 12.5 mg·kg^-1 SA), SA high-dose group (gavage of 50 mg·kg^-1 SA), omeprazole group (gavage of 2 mg·kg^-1 omeprazole), SA high-dose+IL-6 activator recombinant rat IL-6 protein (rRIL-6) group (gavage of 50 mg·kg^-1 SA+intraperitoneal injection of 0.05 mg·kg^-1 rRIL-6), with 12 rats in each group. Except for the normal group, rats in all other groups were required to undergo RE model construction through fore-stomach ligation combined with partial ligation of the external pylorus. After successful modeling, the drug was administered once a day for 2 weeks. The damage rate of esophageal mucosa was detected. Hematoxylin-eosin staining(HE) was applied to detect pathological changes in esophageal tissue. Enzyme-linked immunosorbent assay (ELISA) was applied to detect levels of tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), and IL-8 in esophageal tissue. Terminal dexynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was applied to detect cell apoptosis in esophageal tissue. Immunohistochemical staining was applied to detect the expression of claudin-5 in esophageal tissue. Western blot was applied to detect IL-6, p-JAK2, and p-STAT3 proteins in esophageal tissue. RESULTS Compared with the normal group, the esophageal tissue compactness of rats in the RE group decreased, and there was a large amount of inflammatory cell infiltration, the incidence of esophageal mucosal injury, levels of TNF-α, COX-2, IL-8 in esophageal tissue, apoptosis rate, and the expression of IL-6, p-JAK2, and p-STAT3 proteins increased, while the average optical density of claudin-5 in esophageal tissue decreased (P<0.05). Compared with the RE group, the pathological damage to the esophageal tissue of rats in the SA low-dose group, SA high-dose group, and omeprazole group was reduced, the incidence of esophageal mucosal injury, levels of TNF-α, COX-2, IL-8 in esophageal tissue, apoptosis rate, and the expression of IL-6, p-JAK2, and p-STAT3 proteins decreased, while the average optical density of claudin-5 in esophageal tissue increased (P<0.05). Compared with the SA high-dose group, the SA high-dose+rRIL-6 group had severe pathological damage to the esophageal tissue, the incidence of esophageal mucosal injury, levels of TNF-α, COX-2, IL-8 in esophageal tissue, apoptosis rate, and the expression of IL-6, p-JAK2, and p-STAT3 proteins increased, while the average optical density of claudin-5 in esophageal tissue decreased (P<0.05). CONCLUSION SA may improve inflammatory injury in RE rats by inhibiting the IL-6/JAK2/STAT3 signaling pathway.

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目的 探讨柴胡皂苷A(saikosaponin A,SA)调节白细胞介素(interleukin,IL)-6/酪氨酸激酶2(tyrosine kinase 2,JAK2)/信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)通路对反流性食管炎(reflux esophagitis,RE)大鼠炎性损伤的影响。方法 SD大鼠随机分为RE组、正常组、SA低剂量组(灌胃12.5 mg·kg^-1 SA)、SA高剂量组(灌胃50 mg·kg^-1 SA)、奥美拉唑组(灌胃2 mg·kg^-1奥美拉唑)、SA高剂量+IL-6激活剂重组大鼠IL-6蛋白(recombinant rat IL-6 protein,rRIL-6)组(灌胃50 mg·kg^-1 SA+腹腔注射0.05 mg·kg^-1 rRIL-6),每组12只。除正常组外,其他组大鼠均需通过结扎前胃+部分结扎外置幽门法构建RE模型,建模成功第二天开始给药,给药1天1次,持续2周。检测大鼠食管黏膜损伤率;苏木精-伊红染色(hematoxylin-eosin staining,HE)检测食管组织的病理学变化;酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测食管组织中肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、环氧化酶-2(cyclooxygenase-2,COX-2)、IL-8水平;末端脱氧核苷酸转移酶介导的dUTP缺口末端标记测定法(terminal dexynucleotidyl transferase-mediated dUTP nick end labeling,TUNEL)检测食管组织中的细胞凋亡;免疫组化染色检测食管组织中紧密连接蛋白-5(claudin-5)表达;Western blot检测食管组织中IL-6、磷酸化JAK2(p-JAK2)、p-STAT3蛋白。结果 与正常组相比,RE组大鼠食管组织紧密性降低,且有大量炎性细胞浸润,食管黏膜损伤率、食管组织中TNF-α、COX-2、IL-8水平、细胞凋亡率、IL-6、磷酸化-JAK2(p-JAK2)、p-STAT3蛋白表达升高,食管组织中claudin-5平均光密度值降低(P<0.05);与RE组相比,SA低剂量组、SA高剂量组、奥美拉唑组大鼠食管组织病理损伤减轻,食管黏膜损伤率、食管组织中TNF-α、COX-2、IL-8水平、细胞凋亡率、IL-6、p-JAK2、p-STAT3蛋白表达降低,食管组织中claudin-5平均光密度值升高(P<0.05);与SA高剂量组相比,SA高剂量+rRIL-6组大鼠食管组织病理损伤严重,食管黏膜损伤率、食管组织中TNF-α、COX-2、IL-8水平、细胞凋亡率、IL-6、p-JAK2、p-STAT3蛋白表达升高,食管组织中claudin-5平均光密度值降低(P<0.05)。结论 SA可能通过抑制IL-6/JAK2/STAT3信号通路改善RE大鼠炎性损伤。

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J Agric Food Chem, 2022, 70(14):4353-4361., articleTitle=Chlorogenic acid alleviates chronic stress-induced duodenal ferroptosis via the inhibition of the IL-6/JAK2/STAT3 signaling pathway in rats, refAbstract=null)], funds=[Fund(id=1190958846374982527, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, awardId=2021RC124, language=CN, fundingSource=2021年浙江省卫生健康科技计划项目资助(2021RC124), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1190958842159706963, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, xref=1, ext=[AuthorCompanyExt(id=1190958842168095572, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, companyId=1190958842159706963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ Zhejiang University of Traditional Chinese Medicine, Lishui 323400, China), AuthorCompanyExt(id=1190958842172289877, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, companyId=1190958842159706963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹ 浙江中医药大学, 浙江 丽水 323400)]), AuthorCompany(id=1190958842235204438, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, xref=2, ext=[AuthorCompanyExt(id=1190958842243593047, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, companyId=1190958842235204438, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² General Medicine of the First Affiliated Hospital of Ningbo University, Ningbo 315201, China), AuthorCompanyExt(id=1190958842251981656, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, companyId=1190958842235204438, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=² 宁波大学附属第一医院全科医学, 浙江 宁波 315201)])], figs=[ArticleFig(id=1190958843589964654, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Fig.1, caption=Effects of SA on esophageal mucosal injury in RE rats. n=12, $\bar{x}\pm s$

A-results of esophageal mucosal damage in each group of rats; B-changes in the damage rate of esophageal mucosa in each group of rats;¹⁾P<0.05, vs normal group;²⁾P<0.05, vs RE group; ³⁾P<0.05, vs SA high dose group.

, figureFileSmall=3O/mSbcVredgb/m3mlKzTw==, figureFileBig=Usdin1YoedLo3SPEQhv7qQ==, tableContent=null), ArticleFig(id=1190958843665462127, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=图1, caption=柴胡皂苷A(SA)对反流性食管炎(RE)大鼠食管黏膜损伤的影响。n=12, $\bar{x}\pm s$

A-各组大鼠食管黏膜损伤结果;B-各组大鼠食管黏膜损伤率变化;与正常组比较,¹⁾P<0.05;与RE组比较,²⁾P<0.05;与SA高剂量组相比,³⁾P<0.05。

, figureFileSmall=3O/mSbcVredgb/m3mlKzTw==, figureFileBig=Usdin1YoedLo3SPEQhv7qQ==, tableContent=null), ArticleFig(id=1190958843745153904, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Fig.2, caption=Effects of SA on hematoxylin-eosin(HE) staining in esophageal tissue of RE rats, figureFileSmall=Z411513Ca3waf0bAkirv7A==, figureFileBig=kV2UBFeOYpknN6GDcnDB/w==, tableContent=null), ArticleFig(id=1190958843816457073, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=图2, caption=SA对RE大鼠食管组织苏木精-伊红(HE)染色结果的影响, figureFileSmall=Z411513Ca3waf0bAkirv7A==, figureFileBig=kV2UBFeOYpknN6GDcnDB/w==, tableContent=null), ArticleFig(id=1190958843883565938, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Fig.3, caption=Effect of SA on apoptosis of esophageal histopathocytes in RE rats. n=6, $\bar{x}\pm s$

A-TUNEL staining results of rat esophageal tissues in each group; B-changes in cell apoptosis rate in esophageal tissue of rats in each group; ¹⁾P<0.05, vs normal group; ²⁾P<0.05, vs RE group; ³⁾P<0.05, vs 50 mg·kg^-1 SA.

, figureFileSmall=JEiPOKybIop9jkn9EUCDpA==, figureFileBig=dFuwCeVjb6xArZEFgciBLA==, tableContent=null), ArticleFig(id=1190958845812945780, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=图3, caption=SA对RE大鼠食管组织细胞凋亡的影响。 n=6, $\bar{x}\pm s$

A-各组大鼠食管组织TUNEL染色结果;B-各组大鼠食管组织细胞凋亡率变化; 与正常组比较,¹⁾P<0.05;与RE组比较,²⁾P<0.05;与50 mg·kg^-1 SA相比,³⁾P<0.05。

, figureFileSmall=JEiPOKybIop9jkn9EUCDpA==, figureFileBig=dFuwCeVjb6xArZEFgciBLA==, tableContent=null), ArticleFig(id=1190958845901026166, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Fig.4, caption=Effects of SA on the immunohistochemical staining results of claudin-5 expression in esophageal tissue of RE rats. n=6, $\bar{x}\pm s$

A-immunohistochemical staining results of claudin-5 expression in the esophageal tissues of rats in each group; B-changes in average optical density values of claudin-5 in the esophageal tissues of rats in each group; ¹⁾P<0.05, vs normal group; ²⁾P<0.05, vs RE group; ³⁾P<0.05, vs 50 mg·kg^-1 SA.

, figureFileSmall=JQE9R2FJcDCw94/IsUfsbQ==, figureFileBig=FuXiIu0JTdob807CJJOuzg==, tableContent=null), ArticleFig(id=1190958845963940728, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=图4, caption=SA对RE大鼠食管组织中claudin-5表达的免疫组化染色结果的影响。n=6, $\bar{x}\pm s$

A-各组大鼠食管组织claudin-5表达免疫组化染色结果;B-各组大鼠食管组织中claudin-5平均光密度值的变化; 与正常组比较,¹⁾P<0.05;与RE组比较,²⁾P<0.05;与50 mg·kg^-1 SA相比,³⁾P<0.05。

, figureFileSmall=JQE9R2FJcDCw94/IsUfsbQ==, figureFileBig=FuXiIu0JTdob807CJJOuzg==, tableContent=null), ArticleFig(id=1190958846043632507, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Fig.5, caption=Effects of SA on the expression of IL-6, p-JAK2 and p-STAT3 proteins in esophageal tissue of RE rats. n=6, $\bar{x}\pm s$

¹⁾P<0.05, vs normal group; ²⁾P<0.05, vs RE group; ³⁾P<0.05, vs 50 mg·kg^-1 SA.

, figureFileSmall=T+i5mV1dmOtXgF5X5eNFJQ==, figureFileBig=UR7kPTFVW9gu2HzFE1DBmQ==, tableContent=null), ArticleFig(id=1190958846102352764, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=图5, caption=SA对RE大鼠食管组织中白细胞介素、磷酸化酪氨酸激酶2及信号转导和转录激活因子3蛋白表达的影响。 n=6, $\bar{x}\pm s$

与正常组比较,¹⁾P<0.05;与RE组比较,²⁾P<0.05;与50 mg·kg^-1 SA相比,³⁾P<0.05。

, figureFileSmall=T+i5mV1dmOtXgF5X5eNFJQ==, figureFileBig=UR7kPTFVW9gu2HzFE1DBmQ==, tableContent=null), ArticleFig(id=1190958846190433149, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=EN, label=Tab.1, caption=

Comparison of related inflammatory factors levels in rat esophageal tissue. n=6, $\bar{x}\pm s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Groups	TNF-α/pg·mg-1	COX-2/pg·mg-1	IL-8/pg·mg-1
Normal	46.65±2.11	1.76±0.05	23.69±1.01
RE	90.86±3.431)	9.66±0.421)	51.52±2.081)
12.5 mg·kg-1 SA	72.25±3.022)	7.77±0.512)	43.35±1.762)
50 mg·kg-1 SA	53.36±2.182)3)	3.23±0.152)3)	29.93±1.252)3)
Omeprazole	51.99±2.062)3)	3.26±0.132)3)	30.06±1.372)3)
50 mg·kg-1 SA+rRIL-6	65.58±3.034)	6.57±0.184)	36.14±1.724)

), ArticleFig(id=1190958846253347710, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273666281481, language=CN, label=表1, caption=

大鼠食管组织相关炎症因子水平比较。n=6, $\bar{x}\pm s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Groups	TNF-α/pg·mg-1	COX-2/pg·mg-1	IL-8/pg·mg-1
Normal	46.65±2.11	1.76±0.05	23.69±1.01
RE	90.86±3.431)	9.66±0.421)	51.52±2.081)
12.5 mg·kg-1 SA	72.25±3.022)	7.77±0.512)	43.35±1.762)
50 mg·kg-1 SA	53.36±2.182)3)	3.23±0.152)3)	29.93±1.252)3)
Omeprazole	51.99±2.062)3)	3.26±0.132)3)	30.06±1.372)3)
50 mg·kg-1 SA+rRIL-6	65.58±3.034)	6.57±0.184)	36.14±1.724)

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