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Article(id=1190375273624343008, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, articleNumber=1001-2494(2025)03-0284-06, orderNo=null, doi=10.11669/cpj.2025.03.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1722268800000, receivedDateStr=2024-07-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1761737181335, onlineDateStr=2025-10-29, pubDate=1738944000000, pubDateStr=2025-02-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1761737181335, onlineIssueDateStr=2025-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1761737181335, creator=13701087609, updateTime=1761737181335, updator=13701087609, issue=Issue{id=1190375270847710190, tenantId=1146029695717560320, journalId=1190317699101192196, year='2025', volume='60', issue='3', pageStart='209', pageEnd='312', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1761737180673, creator=13701087609, updateTime=1761793989024, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1190613542412890252, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1190613542412890253, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1190375270847710190, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=284, endPage=289, ext={EN=ArticleExt(id=1190375273846641121, articleId=1190375273624343008, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Construction of Fingerprints and Compositional Analysis of Natural Myrrh and Colloidal Myrrh Based on GC-MS with Different Matrices, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To investigate the components and characteristic chromatograms of natural myrrh and colloidal myrrh from different origins using gas chromatography-mass spectrometry(GC-MS).METHODS Based on the study of molecular identification techniques for determining the botanical origins of myrrh, GC-MS was utilized to conduct a qualitative analysis of the volatile oil components in 10 batches of colloidal myrrh and 15 batches of natural myrrh. Furthermore, the Traditional Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System was used to establish the characteristic chromatograms for natural myrrh and colloidal myrrh,respectively.The similarity between different origins and the same commercial type of myrrh with their common mode chromatograms was evaluated. RESULTS Natural myrrh contained significantly more volatile components than colloidal myrrh. Colloidal myrrh primarily consisted of low-boiling-point components,whereas natural myrrh contained both low-and high-boiling-point components.The main components of the volatile oils in both types of myrrh were sesquiterpenes. CONCLUSION There are notable differences in the characteristic chromatograms between natural myrrh and colloidal myrrh. However,there are no significant differences in the volatile components between myrrh of the same commercial type but different botanical origins. There are significant differences in the volatile components between natural myrrh and colloidal myrrh.The volatile components of myrrh are related to its commercial type but not to its botanical origin.

, correspAuthors=Hui CAO, Menghua WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Changhong CAO, Wenting ZHONG, Feng GAO, Ying ZHANG, Zhiguo MA, Hui CAO, Menghua WU), CN=ArticleExt(id=1190375441006432788, articleId=1190375273624343008, tenantId=1146029695717560320, journalId=1190317699101192196, language=CN, title=基于GC-MS法构建不同基原的天然没药和胶质没药指纹图谱及成分分析, columnId=1190352405612040510, journalTitle=中国药学杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=

目的 采用气相色谱-质谱联用法(GC-MS)对不同基原来源的天然没药和胶质没药进行成分鉴别及特征图谱的研究。方法 以分子鉴定技术鉴定没药的基原研究为基础,采用GC-MS对10批次胶质没药和15批次天然没药的挥发油成分进行定性分析。同时,通过中药色谱指纹图谱相似度评价系统分别建立天然没药和胶质没药的特征图谱,对不同基原、相同商品类型的没药与其共有模式图进行相似度评价。结果 天然没药的挥发性成分远多于胶质没药,胶质没药主要含有低沸点成分,天然没药则低、高沸点成分兼具,两者挥发油主要成分均为倍半萜类化合物。结论 天然没药和胶质没药特征图谱差异明显,相同商品类型但是基原不同的没药之间挥发性成分无明显差异。天然没药与胶质没药挥发性成分差异明显,没药挥发性成分与商品类型有关,与基原无关。

, correspAuthors=曹晖, 吴孟华, authorNote=null, correspAuthorsNote=
*曹晖,男,博士,研究员 研究方向:本草考证、中药鉴定、饮片炮制规范和质量标准研究 Tel:(020)85220010;
吴孟华,女,博士,副教授 研究方向:本草考证与生药鉴定,中药质量标准研 Tel:(020)85220010
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=svQvMGXfk0PfUPgW3nZQWA==, magXml=uOevB0LxhAjgbKacPvPKHg==, pdfUrl=null, pdf=eIxCoHGTLety9og5R6A3Qg==, pdfFileSize=1656484, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=D3Gfin9llPoGm4VVP3yskg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=HvDcP1+EXXcTPNPudhcNzQ==, mapNumber=null, authorCompany=null, fund=null, authors=

曹长鸿,男,硕士研究生 研究方向:生药质量研究的新技术应用

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曹长鸿,男,硕士研究生 研究方向:生药质量研究的新技术应用

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曹长鸿,男,硕士研究生 研究方向:生药质量研究的新技术应用

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Pharmacy, Jinan University, Guangzhou 510632, China), AuthorCompanyExt(id=1190958846580503427, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, companyId=1190958846563726209, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1 暨南大学药学院,岭南传统中药研究中心, 广州 510632)])]), Author(id=1190958847482278822, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1190958847582942123, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, authorId=1190958847482278822, language=EN, stringName=Ying ZHANG, firstName=Ying, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, 3, address=1 Lingnan Research Center of Traditional Chinese Medicines, School of Pharmacy, Jinan University, Guangzhou 510632, China
2 National Inheritance Workshop of Famous Elderly Traditional Chinese Medicine Experts of Cao Hui, Guangzhou 510632, China
3 Lingnan Sub-center of Resources, National Research Center for Modernization of Traditional Chinese Medicines (NRCMM), Guangzhou 510632, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1190958847641662381, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, authorId=1190958847482278822, language=CN, stringName=张英, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, 3, address=1 暨南大学药学院,岭南传统中药研究中心, 广州 510632
2 曹晖全国名老中医药专家传承工作室, 广州 510632
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2 National Inheritance Workshop of Famous Elderly Traditional Chinese Medicine Experts of Cao Hui, Guangzhou 510632, China
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2 曹晖全国名老中医药专家传承工作室, 广州 510632
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Fitoterapia, 2004, 75(2): 204-208., articleTitle=Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul, refAbstract=null), Reference(id=1190958851819189235, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=1954, volume=8, issue=2, pageStart=152, pageEnd=163, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=MOLDENKE H N, journalName=Econ Bot, refType=null, unstructuredReference=MOLDENKE H N. The economic plants of the Bible[J]. Econ Bot, 1954, 8(2): 152-163., articleTitle=The economic plants of the Bible, refAbstract=null), Reference(id=1190958851898881012, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=null, pageStart=193, pageEnd=194, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=Ch.P(2020) Vol Ⅰ(中国药典2020年版.一部)[S]. 2020:193-194., articleTitle=Ch.P(2020) Vol Ⅰ(中国药典2020年版.一部), refAbstract=null), Reference(id=1190958851974378485, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=5259, pageEnd=5260, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=35, refType=null, unstructuredReference=USP 35[S]. 2017:5259-5260., articleTitle=null, refAbstract=null), Reference(id=1190958852058264566, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=2016, volume=null, issue=null, pageStart=1446, pageEnd=1447, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=9, refType=null, unstructuredReference=EP 9[S]. 2016:1446-1447., articleTitle=null, refAbstract=null), Reference(id=1190958852133762039, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=1996, volume=null, issue=4, pageStart=235, pageEnd=237, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=TIAN J G, SHI S M, journalName=China J Chin Mater Med(中国中药杂志), refType=null, unstructuredReference=TIAN J G, SHI S M. Study on the volatile oil components of imported natural myrrh and colloidal myrrh[J]. China J Chin Mater Med(中国中药杂志), 1996(4):235-237,256., articleTitle=Study on the volatile oil components of imported natural myrrh and colloidal myrrh, refAbstract=null), Reference(id=1190958852209259512, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, doi=null, pmid=null, pmcid=null, year=2003, volume=18, issue=2, pageStart=153, pageEnd=156, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=BAŞER K H C, DEMIRCI B, DEKEBO A, journalName=Flavour Frag J, refType=null, unstructuredReference=BAŞER K H C, DEMIRCI B, DEKEBO A, et al. Essential oils of some Boswellia spp., Myrrh and Opopanax[J]. 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Peaks A1-A16 in Fig.2-4 are the same as A1-A16 in Tab.4; Peaks B1-B10 in Fig.2-3 and Fig.5 are the same as B1-B10 in Tab.5.

, figureFileSmall=nWGFbcZe6pNPKxmcHESCMw==, figureFileBig=VZyXjxqiD+miL2J6emnOJA==, tableContent=null), ArticleFig(id=1190958849491350483, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=图2, caption=天然没药(A)与胶质没药(B)的气相色谱-质谱联用(GC-MS)特征图谱

图2~4中峰A1~A16同表4中A1~A16;图2~3,5中峰B1~B10同表5中B1~B10。

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Sample information on natural and colloidal myrrh

, figureFileSmall=null, figureFileBig=null, tableContent=
Sample No. Origin(in Chinese) Collection point(in Chinese) Collection time Species
J1 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J2 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J3 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J4 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J5 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J6 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J7 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J8 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J9 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora edulis Engl.
J10 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T1 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T2 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora myrrha Engl.
T3 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T4 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T5 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T6 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T7 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T8 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T9 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T10 Kenya(肯尼亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T11 Kenya(肯尼亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T12 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T13 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T14 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T15 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora myrrha Engl.
), ArticleFig(id=1190958849969501147, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表1, caption=

天然没药与胶质没药样本信息

, figureFileSmall=null, figureFileBig=null, tableContent=
Sample No. Origin(in Chinese) Collection point(in Chinese) Collection time Species
J1 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J2 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J3 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J4 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J5 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J6 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J7 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J8 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
J9 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora edulis Engl.
J10 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T1 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T2 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora myrrha Engl.
T3 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T4 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T5 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T6 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T7 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T8 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T9 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T10 Kenya(肯尼亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T11 Kenya(肯尼亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T12 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T13 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T14 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora gileadensis C. Chr.
T15 Ethiopia(埃塞俄比亚) Guangzhou markets(广州市场) 2023.04 Commiphora myrrha Engl.
), ArticleFig(id=1190958850032415708, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=EN, label=Tab.2, caption=

Types and relative contents of volatile components of natural myrrh

, figureFileSmall=null, figureFileBig=null, tableContent=
No. Retention index(RI) t/min Compound Molecular formula Relative percentage/%
1 1 339 15.37 δ-Elemene C15H24 6.16
2 1 351 15.87 α-Cubebene C15H24 0.27
3 1 376 17.06 α-Copaene C15H24 3.95
4 1 385 17.48 β-Bourbonene C15H24 3.5
5 1 392 17.81 β-Elemene C15H24 4.26
6 1 408 18.61 α-Gurjunene C15H24 0.52
7 1 417 19 β-Caryophyllene C15H24 1.4
8 1 428 19.52 β-Copaene C15H24 0.82
9 1 442 20.25 Isogermacrene D C15H24 0.67
10 1 451 20.69 α-Caryophyllene C15H24 0.54
11 1 470 21.67 (4R,4aS,6S)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene C15H24 0.67
12 1 474 21.89 γ-Muurolene C15H24 0.44
13 1 478 22.14 Germacrene D C15H24 6.17
14 1 483 22.38 β-Selinene C15H24 1.12
15 1 486 22.55 γ-Gurjunene C15H24 1.18
16 1 491 22.86 α-Selinene C15H24 0.71
17 1 494 23.04 Curzerene C15H20O 2.18
18 1 522 24.6 δ-Cadinene C15H24 1.13
19 1 549 26.17 Elemol C15H26O 1.36
20 1 554 26.51 Germacrene B C15H24 1.9
21 1 603 29.66 Epicurzerenone C15H18O2 7.65
22 1 623 30.76 Furanoeudesma-1,3-diene C15H18O 9.49
23 1 629 31.12 Lindestrene C15H18O 4.29
24 1 637 31.59 T-Cadinol C15H26O 0.82
25 1 688 34.62 Germacrone C15H22O 1.31
26 1 716 36.22 (R,5E,9E)-8-Methoxy-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan C16H22O2 1.53
27 1 737 37.36 Hydroxypentanoic acid C15H22O3 3.66
28 1 751 38.11 Furanodienon C15H18O2 0.53
29 1 794 40.52 Isofuranodienone C15H18O2 1.21
30 1 837 42.75 Dihydropyrocurzerenone C15H18O 0.97
31 1 855 43.67 Zederone C15H18O3 0.74
32 1 869 44.39 2-Hydroxy-5-(3-methylbut-2-en-1-yl)-4-(prop-1-en-2-yl)cyclohepta-2,4,6-trien-1-one C15H18O2 2.16
33 1 887 45.36 (3aS,5S,8S)-3a-Hydroxy-1,5,8-trimethyl-4,5,8,9-tetrahydronaphtho[2,1-b]furan-2,6(3aH,7H)-dione C15H18O4 3.64
34 1 973 49.62 Paraxylene C24H30N2O3 1
35 1 981 49.99 2-Isopropenyl-2,3-dihydrofuro[3,2-g]chromen-7-one C14H12O3 0.23
), ArticleFig(id=1190958850099524573, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表2, caption=

天然没药挥发性成分种类及相对含量

, figureFileSmall=null, figureFileBig=null, tableContent=
No. Retention index(RI) t/min Compound Molecular formula Relative percentage/%
1 1 339 15.37 δ-Elemene C15H24 6.16
2 1 351 15.87 α-Cubebene C15H24 0.27
3 1 376 17.06 α-Copaene C15H24 3.95
4 1 385 17.48 β-Bourbonene C15H24 3.5
5 1 392 17.81 β-Elemene C15H24 4.26
6 1 408 18.61 α-Gurjunene C15H24 0.52
7 1 417 19 β-Caryophyllene C15H24 1.4
8 1 428 19.52 β-Copaene C15H24 0.82
9 1 442 20.25 Isogermacrene D C15H24 0.67
10 1 451 20.69 α-Caryophyllene C15H24 0.54
11 1 470 21.67 (4R,4aS,6S)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene C15H24 0.67
12 1 474 21.89 γ-Muurolene C15H24 0.44
13 1 478 22.14 Germacrene D C15H24 6.17
14 1 483 22.38 β-Selinene C15H24 1.12
15 1 486 22.55 γ-Gurjunene C15H24 1.18
16 1 491 22.86 α-Selinene C15H24 0.71
17 1 494 23.04 Curzerene C15H20O 2.18
18 1 522 24.6 δ-Cadinene C15H24 1.13
19 1 549 26.17 Elemol C15H26O 1.36
20 1 554 26.51 Germacrene B C15H24 1.9
21 1 603 29.66 Epicurzerenone C15H18O2 7.65
22 1 623 30.76 Furanoeudesma-1,3-diene C15H18O 9.49
23 1 629 31.12 Lindestrene C15H18O 4.29
24 1 637 31.59 T-Cadinol C15H26O 0.82
25 1 688 34.62 Germacrone C15H22O 1.31
26 1 716 36.22 (R,5E,9E)-8-Methoxy-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan C16H22O2 1.53
27 1 737 37.36 Hydroxypentanoic acid C15H22O3 3.66
28 1 751 38.11 Furanodienon C15H18O2 0.53
29 1 794 40.52 Isofuranodienone C15H18O2 1.21
30 1 837 42.75 Dihydropyrocurzerenone C15H18O 0.97
31 1 855 43.67 Zederone C15H18O3 0.74
32 1 869 44.39 2-Hydroxy-5-(3-methylbut-2-en-1-yl)-4-(prop-1-en-2-yl)cyclohepta-2,4,6-trien-1-one C15H18O2 2.16
33 1 887 45.36 (3aS,5S,8S)-3a-Hydroxy-1,5,8-trimethyl-4,5,8,9-tetrahydronaphtho[2,1-b]furan-2,6(3aH,7H)-dione C15H18O4 3.64
34 1 973 49.62 Paraxylene C24H30N2O3 1
35 1 981 49.99 2-Isopropenyl-2,3-dihydrofuro[3,2-g]chromen-7-one C14H12O3 0.23
), ArticleFig(id=1190958850175022046, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=EN, label=Tab.3, caption=

Types and relative contents of volatile components of colloidal myrrh

, figureFileSmall=null, figureFileBig=null, tableContent=
No. RI t/min Compound Molecular formula Relative percentage/%
1 1 035 6.03 cis-β-Ocimene C10H16 1.82
2 1 049 6.29 trans-β-Ocimene C10H16 42.76
3 1 416 18.97 cis-α-Bergamotene C15H24 1.59
4 1 421 19.19 α-Santalene C15H24 9.41
5 1 436 19.95 trans-α-Bergamotene C15H24 4.22
6 1 479 22.19 Germacrene D C15H24 2.78
7 1 503 23.51 α-Bisabolene C15H24 9.78
8 1 509 23.85 β-Bisabolene C15H24 1.78
9 1 519 24.44 Teresantalol C10H16O 2.73
10 1 649 32.26 4(15),5,10(14)-Germacratrien-1-ol C15H24O 0.58
11 1 669 33.48 (Z)-Sesquisabinene hydrate C15H26O 2.45
12 1 675 33.83 (E)-5-((1R,3R,6S)-2,3-Dimethyltricyclo[2.2.1.02,6]heptan-3-yl)-2-methylpent-2-enal C15H22O 0.8
), ArticleFig(id=1190958850237936607, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表3, caption=

胶质没药挥发性成分种类及相对含量

, figureFileSmall=null, figureFileBig=null, tableContent=
No. RI t/min Compound Molecular formula Relative percentage/%
1 1 035 6.03 cis-β-Ocimene C10H16 1.82
2 1 049 6.29 trans-β-Ocimene C10H16 42.76
3 1 416 18.97 cis-α-Bergamotene C15H24 1.59
4 1 421 19.19 α-Santalene C15H24 9.41
5 1 436 19.95 trans-α-Bergamotene C15H24 4.22
6 1 479 22.19 Germacrene D C15H24 2.78
7 1 503 23.51 α-Bisabolene C15H24 9.78
8 1 509 23.85 β-Bisabolene C15H24 1.78
9 1 519 24.44 Teresantalol C10H16O 2.73
10 1 649 32.26 4(15),5,10(14)-Germacratrien-1-ol C15H24O 0.58
11 1 669 33.48 (Z)-Sesquisabinene hydrate C15H26O 2.45
12 1 675 33.83 (E)-5-((1R,3R,6S)-2,3-Dimethyltricyclo[2.2.1.02,6]heptan-3-yl)-2-methylpent-2-enal C15H22O 0.8
), ArticleFig(id=1190958850309239776, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=EN, label=Tab.4, caption=

Results of identification of characteristic peaks of natural myrrh profiles

, figureFileSmall=null, figureFileBig=null, tableContent=
Peak No. Compound t/min
A1 δ-Elemene 15.37
A2 α-Copaene 17.14
A3 β-Bourbonene 17.48
A4 β-Elemene 18.81
A5 β-Caryophyllene 19.15
A6 α-Caryophyllene 20.69
A7 Germacrene D 22.14
A8 Elemol 26.17
A9 Germacrene B 26.63
A10 Epicurzerenone 29.66
A11 Germacrone 34.62
A12 Hydroxypentanoic acid 37.36
A13 Isofuranodienone 40.52
A14 Dihydropyrocurzerenone 42.75
A15 2-Hydroxy-5-(3-methylbut-2-en-1-yl)-4-(prop-1-en-2-yl)cyclohepta-2,4,6-trien-1-one 44.39
A16 (3aS,5S,8S)-3a-Hydroxy-1,5,8-trimethyl-4,5,8,9-tetrahydronaphtho[2,1-b]furan-2,6(3aH,7H)-dione 45.36
), ArticleFig(id=1190958850376348641, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表4, caption=

天然没药特征图谱特征峰的指认结果

, figureFileSmall=null, figureFileBig=null, tableContent=
Peak No. Compound t/min
A1 δ-Elemene 15.37
A2 α-Copaene 17.14
A3 β-Bourbonene 17.48
A4 β-Elemene 18.81
A5 β-Caryophyllene 19.15
A6 α-Caryophyllene 20.69
A7 Germacrene D 22.14
A8 Elemol 26.17
A9 Germacrene B 26.63
A10 Epicurzerenone 29.66
A11 Germacrone 34.62
A12 Hydroxypentanoic acid 37.36
A13 Isofuranodienone 40.52
A14 Dihydropyrocurzerenone 42.75
A15 2-Hydroxy-5-(3-methylbut-2-en-1-yl)-4-(prop-1-en-2-yl)cyclohepta-2,4,6-trien-1-one 44.39
A16 (3aS,5S,8S)-3a-Hydroxy-1,5,8-trimethyl-4,5,8,9-tetrahydronaphtho[2,1-b]furan-2,6(3aH,7H)-dione 45.36
), ArticleFig(id=1190958850443457506, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=EN, label=Tab.5, caption=

Results of identification of characteristic peaks of colloidal myrrh profiles

, figureFileSmall=null, figureFileBig=null, tableContent=
Peak No. Compound t/min
B1 cis-β-Ocimene 6.03
B2 trans-β-Ocimene 6.29
B3 cis-α-Bergamotene 18.97
B4 α-Santalene 19.19
B5 trans-α-Bergamotene 19.95
B6 Germacrene D 22.19
B7 α-Bisabolene 23.51
B8 β-Bisabolene 23.85
B9 (Z)-Sesquisabinene hydrate 33.48
B10 (E)-5-((1R,3R,6S)-2,3-Dimethyltricyclo[2.2.1.02,6]heptan-3-yl)-2-methylpent-2-enal 33.83
), ArticleFig(id=1190958850510566371, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表5, caption=

胶质没药特征图谱特征峰的指认结果

, figureFileSmall=null, figureFileBig=null, tableContent=
Peak No. Compound t/min
B1 cis-β-Ocimene 6.03
B2 trans-β-Ocimene 6.29
B3 cis-α-Bergamotene 18.97
B4 α-Santalene 19.19
B5 trans-α-Bergamotene 19.95
B6 Germacrene D 22.19
B7 α-Bisabolene 23.51
B8 β-Bisabolene 23.85
B9 (Z)-Sesquisabinene hydrate 33.48
B10 (E)-5-((1R,3R,6S)-2,3-Dimethyltricyclo[2.2.1.02,6]heptan-3-yl)-2-methylpent-2-enal 33.83
), ArticleFig(id=1190958850581869540, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=EN, label=Tab.6, caption=

Similarity of shared mode maps of J9 and T2, T15 with their respective GC-MS characterization profiles

, figureFileSmall=null, figureFileBig=null, tableContent=
No. Sample No. Similarity
1 J9 0.993
2 T2 0.960
3 T15 0.960
), ArticleFig(id=1190958850653172709, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1190375273624343008, language=CN, label=表6, caption=

胶质没药J9与天然没药T2、T15与各自GC-MS特征图谱共有模式图相似度

, figureFileSmall=null, figureFileBig=null, tableContent=
No. Sample No. Similarity
1 J9 0.993
2 T2 0.960
3 T15 0.960
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基于GC-MS法构建不同基原的天然没药和胶质没药指纹图谱及成分分析
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曹长鸿 1 , 钟文婷 1 , 高枫 1 , 张英 1, 2, 3 , 马志国 1, 2, 3 , 曹晖 1, 2, 3, * , 吴孟华 1, 2, 3, *
中国药学杂志 | 论著 2025,60(3): 284-289
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中国药学杂志 | 论著 2025, 60(3): 284-289
基于GC-MS法构建不同基原的天然没药和胶质没药指纹图谱及成分分析
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曹长鸿1, 钟文婷1, 高枫1, 张英1, 2, 3, 马志国1, 2, 3, 曹晖1, 2, 3, *, 吴孟华1, 2, 3, *
作者信息
  • 1 暨南大学药学院,岭南传统中药研究中心, 广州 510632
  • 2 曹晖全国名老中医药专家传承工作室, 广州 510632
  • 3 国家中药现代化工程技术研究中心岭南资源分中心, 广州 510632

    • 曹长鸿,男,硕士研究生 研究方向:生药质量研究的新技术应用

通讯作者:

*曹晖,男,博士,研究员 研究方向:本草考证、中药鉴定、饮片炮制规范和质量标准研究 Tel:(020)85220010;
吴孟华,女,博士,副教授 研究方向:本草考证与生药鉴定,中药质量标准研 Tel:(020)85220010
Construction of Fingerprints and Compositional Analysis of Natural Myrrh and Colloidal Myrrh Based on GC-MS with Different Matrices
Changhong CAO1, Wenting ZHONG1, Feng GAO1, Ying ZHANG1, 2, 3, Zhiguo MA1, 2, 3, Hui CAO1, 2, 3, *, Menghua WU1, 2, 3, *
Affiliations
  • 1 Lingnan Research Center of Traditional Chinese Medicines, School of Pharmacy, Jinan University, Guangzhou 510632, China
  • 2 National Inheritance Workshop of Famous Elderly Traditional Chinese Medicine Experts of Cao Hui, Guangzhou 510632, China
  • 3 Lingnan Sub-center of Resources, National Research Center for Modernization of Traditional Chinese Medicines (NRCMM), Guangzhou 510632, China
出版时间: 2025-02-08 doi: 10.11669/cpj.2025.03.011
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摘要
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目的 采用气相色谱-质谱联用法(GC-MS)对不同基原来源的天然没药和胶质没药进行成分鉴别及特征图谱的研究。方法 以分子鉴定技术鉴定没药的基原研究为基础,采用GC-MS对10批次胶质没药和15批次天然没药的挥发油成分进行定性分析。同时,通过中药色谱指纹图谱相似度评价系统分别建立天然没药和胶质没药的特征图谱,对不同基原、相同商品类型的没药与其共有模式图进行相似度评价。结果 天然没药的挥发性成分远多于胶质没药,胶质没药主要含有低沸点成分,天然没药则低、高沸点成分兼具,两者挥发油主要成分均为倍半萜类化合物。结论 天然没药和胶质没药特征图谱差异明显,相同商品类型但是基原不同的没药之间挥发性成分无明显差异。天然没药与胶质没药挥发性成分差异明显,没药挥发性成分与商品类型有关,与基原无关。

天然没药  /  胶质没药  /  气相色谱-质谱联用法  /  特征图谱  /  基原

OBJECTIVE To investigate the components and characteristic chromatograms of natural myrrh and colloidal myrrh from different origins using gas chromatography-mass spectrometry(GC-MS).METHODS Based on the study of molecular identification techniques for determining the botanical origins of myrrh, GC-MS was utilized to conduct a qualitative analysis of the volatile oil components in 10 batches of colloidal myrrh and 15 batches of natural myrrh. Furthermore, the Traditional Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System was used to establish the characteristic chromatograms for natural myrrh and colloidal myrrh,respectively.The similarity between different origins and the same commercial type of myrrh with their common mode chromatograms was evaluated. RESULTS Natural myrrh contained significantly more volatile components than colloidal myrrh. Colloidal myrrh primarily consisted of low-boiling-point components,whereas natural myrrh contained both low-and high-boiling-point components.The main components of the volatile oils in both types of myrrh were sesquiterpenes. CONCLUSION There are notable differences in the characteristic chromatograms between natural myrrh and colloidal myrrh. However,there are no significant differences in the volatile components between myrrh of the same commercial type but different botanical origins. There are significant differences in the volatile components between natural myrrh and colloidal myrrh.The volatile components of myrrh are related to its commercial type but not to its botanical origin.

natural myrrh  /  colloidal myrrh  /  GC-MS  /  characteristic spectrum  /  origin
曹长鸿, 钟文婷, 高枫, 张英, 马志国, 曹晖, 吴孟华. 基于GC-MS法构建不同基原的天然没药和胶质没药指纹图谱及成分分析. 中国药学杂志, 2025 , 60 (3) : 284 -289 . DOI: 10.11669/cpj.2025.03.011
Changhong CAO, Wenting ZHONG, Feng GAO, Ying ZHANG, Zhiguo MA, Hui CAO, Menghua WU. Construction of Fingerprints and Compositional Analysis of Natural Myrrh and Colloidal Myrrh Based on GC-MS with Different Matrices[J]. Chinese Pharmaceutical Journal, 2025 , 60 (3) : 284 -289 . DOI: 10.11669/cpj.2025.03.011
正文
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橄榄科没药属植物全球共有150余种[1-2],多为灌木或小乔木,其广泛分布在非洲和阿拉伯半岛等地区[3-5]。没药是一种从没药属植物枝干中流出来的树脂,有研究[6-8]证明其含有2%~8%的挥发油、23%~40%的树脂、40%~60%的树胶,通常具有芳香气味。在古代埃及,人们用它制作木乃伊的防腐剂,更是将没药焚烧以献祭太阳神[9],在各种宗教场所中,随处可见由各种树脂制成的香,其中就包含了没药[10]。现代香水生产商常常提取没药的挥发油用来制作名贵香水。除在西方是一种名贵香料以外,没药还是中国传统药物,常用来治疗各种疾病,例如胸痹心痛、胃脘疼痛、痛经经闭[11]等。《中国药典》2020年版[11]规定没药为橄榄科植物地丁树(Commiphora myrrha Engl.)或哈地丁树(Commiphora molmol Engl.)的干燥树脂,分为天然没药和胶质没药两种商品类型。但《美国药典》[12]、《欧洲药典》[13]等则认为没药为C.myrrha及其同属近缘植物的树脂。本课题组之前的工作已经详细描述了没药的基原差异,但并未对两种没药之间化学成分的差异以及不同基原相同商品类型的没药进行分析。
有研究采用气相色谱-质谱联用(GC-MS)技术对天然没药和胶质没药挥发油的成分进行分析,发现两者挥发油主成分完全不同[14]。没药挥发油化学成分研究集中于萜类成分,尤其是倍半萜类[15]。但大部分研究只局限于对没药挥发油化学成分的定性研究,《中国药典》2020年版也仅仅是测量了挥发油的含量,并未深入研究化学成分与基原和商品类型之间的关系。不同基原的没药树是否会产生相同类型的树脂,相同基原的没药树是否会产生不同类型的树脂,仍然未曾得知。因此本研究建立了一种可靠适用于已确定基原的没药样本的GC-MS定性分析方法,同时建立了天然没药和胶质没药的特征图谱,结合分子鉴定结果,评估基原与商品类型之间的关系,为没药的质量标准提供参考,对市售没药的用药安全具有重要意义。
1 材料
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1.1 仪器与试剂
Thermo Scientific TRACE 1300型气相色谱仪、Thermo Scientific ISQ-QD质谱仪(美国赛默飞公司);万分之一分析天平(奥豪斯公司);XSR105/A十万分之一天平(瑞士梅特勒-托利多公司)。
正己烷、无水硫酸钠、乙酸乙酯均为分析纯;自制超纯水。
1.2 样品
收集不同基原的15批次天然没药和10批次胶质没药,对收集的25批次没药样本进行分子鉴定,发现胶质没药中J9为C.edulis Engl.,天然没药中T2、T15为C.myrrha Engl.,其余样本均为C.gileadensis C.Chr.。样本信息见表1。
2 方法与结果
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2.1 GC-MS条件
Agilent HP-5 ms色谱柱(250 μm×30 m,0.25 μm),载气为He,流量为1.0 mL·min-1,进样量为1 μL,分流比为50∶1,传输线温度为250 ℃,程序升温,初始温度为60 ℃,保留1 min;以10 ℃·min-1升至100 ℃,保留1 min;以2 ℃·min-1升至130 ℃,保留3 min;以2 ℃·min-1升至200 ℃,保留2 min。电离方式为EI,离子源温度为250 ℃,电子能量为70 eV,溶剂延迟5 min,全扫描数据采集模式。
2.2 供试品溶液的制备
取天然没药和胶质没药样本适量,敲碎为5 mm左右的均匀小块。精密称取各样本10 g,置于500 mL圆底烧瓶中,加蒸馏水200 mL,连接挥发油测定器及回流冷凝管,2 mL正己烷富集,加热并保持微沸5 h后,用正己烷分次洗涤测定器及冷凝管,转入同一量瓶中,用正己烷定容至刻度,过0.22 μm滤膜,即得供试品溶液,冷藏待用。
2.3 方法学考察
2.3.1 精密度实验
精密吸取“2.2”项下天然没药溶液(T4)和胶质没药溶液(J4)各1 μL,按照“2.1”项下色谱条件,连续进样6次,计算胶质没药和天然没药中各成分与对照峰的比值的相对标准偏差(RSD)。胶质没药中各成分的RSD值均小于2%,天然没药各成分的RSD均小于9%,表明仪器精密度良好。
2.3.2 稳定性试验
各精密称取胶质没药(J4)和天然没药(T4)10 g,按“2.2”项下条件制备供试品溶液,分别于0、4、8、12、16、20、24 h按“2.1”项下色谱条件进样测定,分别计算胶质没药和天然没药各成分峰与对照峰的比值的RSD。胶质没药中各成分的RSD值均小于9%,天然没药各成分的RSD均小于8%,表明24 h内供试品溶液稳定性良好。
2.3.3 重复性实验
各取胶质没药(J4)和天然没药(T4)样品各6份,按“2.2”项下条件制备供试品溶液,按“2.1”项下色谱条件进样测定。分别计算胶质没药和天然没药各成分峰与对照峰的比值的RSD。胶质没药中各成分的RSD值均小于8%,天然没药各成分的RSD均小于8%,表明该方法重复性良好。
2.4 天然没药和胶质没药挥发油成分分析
按“2.1”项下GC-MS条件对所有样品进行分析,天然没药和胶质没药的总离子流图见图1。经NIST MS数据库匹配并参考相关文献对检出成分进行定性,利用峰面积归一化法计算各挥发性成分的相对含量,并对鉴定出的所有挥发性组分进行分类,结果见表2~3。
由图1可知,天然没药样品中挥发油成分峰比胶质没药样品中更多,两者在成分上差异明显。天然没药成分保留时间多位于15~40 min,胶质没药成分保留时间多位于5~35 min。表明胶质没药含低沸点成分为主,天然没药兼有低沸点成分与较高沸点成分。
由表2~3得知,天然没药挥发油中共检测出35个化合物,其中含量较高的是大根香叶烯D(germacrene D)和表蓬莪术烯酮(epicurzerenone);胶质没药挥发油中共检测出12个化合物,其中含量较高的是反式-β-罗勒烯(trans-β-ocimene)和α-红没药烯(α-bisabolene)。所有天然没药和胶质没药中都检测出了大根香叶烯D(germacrene D)。两者挥发油主要成分均为倍半萜类化合物。两者所含成分差异较大,区别明显。
2.5 特征图谱的建立及特征峰的鉴定
将所有批次的天然没药和胶质没药的GC-MS检测数据导入《中药指纹图谱相似度评价系统》(2012年版)软件,得到胶质没药和天然没药的特征图谱和共有模式图谱,见图2~3。分别选择天然没药和胶质没药样品挥发油成分中分离度较好,含量较高的峰为特征峰,可知天然没药特征峰为16个,胶质没药特征峰为10个,天然没药A7号特征峰和胶质没药B6号特征峰鉴定为共有峰,为大根香叶烯D。通过质谱数据库NIST MS检索并与对照品比对后指认,鉴定结果见表4~5。
2.6 不同基原没药特征图谱比较
分别将胶质没药J9与胶质没药共有模式图做对比,天然没药T2、T15与天然没药共有模式图做对比,见图4~5,不同没药与其对应商品类型的共有模式图无明显差异,相似度结果见表6。胶质没药J9与胶质没药共有模式图的相似度为0.993,天然没药T2、T15与天然没药共有模式图的相似度均为0.960,表明没药挥发性成分与商品类型有关,但是与基原无关。
3 讨论
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本研究先对25批没药进行DNA分子鉴定,其中胶质没药J9经分子鉴定为C.edulis Engl.,天然没药T2、T15鉴定为C.myrrha Engl.。通过采用GC-MS法对10批次胶质没药和15批次天然没药进行挥发性成分的分析,天然没药挥发性成分远多于胶质没药,天然没药指认成分为35个,胶质没药为12个,两者在成分上差异明显。胶质没药含低沸点成分为主,天然没药兼有低沸点成分与较高沸点成分。两者挥发油成分中倍半萜含量最高。使用《中药指纹图谱相似度评价系统》(2012年版)软件分别构建天然没药和胶质没药的GC-MS特征图谱,选择分离度较好,含量较高的峰为特征峰。天然没药特征峰为16个,胶质没药特征峰为10个,两者共有峰仅1个,为大根香叶烯D。
《中国药典》2020年版规定没药分为天然没药和胶质没药两种类型,但并未详细说明两种没药的化学成分差异,也并未解释商品类型与基原之间的关系。根据分子鉴定结果,将胶质没药J9与胶质没药共有模式图比对,相似度为0.993;天然没药T2、T15与天然没药共有模式图比对,相似度均为0.960。表明没药挥发性成分很可能只与商品类型有关,与基原无关,并且商品类型与基原无关。没药为常用进口中药材,国内未见种植,关于没药的产地、采收、加工等信息国内研究甚少,也不清楚没药为何分为天然没药和胶质没药。本研究结果可为天然没药和胶质没药的化学成分差异提供参考数据,也为基原与商品类型的联系提供一些建议。建议《中国药典》增加没药化学成分的研究,厘清没药基原与商品类型的关系。
基金
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  • 国家重点研发计划项目资助(2023YFC3504200)
  • 国家药典委员会药品标准制订研究课题资助(2020Z003)
  • 三种进口树脂药材(血竭、乳香、没药)项目商品规格市场调研与基原的分子鉴定研究项目资助(2023GSMPA-KL01)
  • 全国中药特色技术传承人才培训项目资助(T20234832002)
文献
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THULIN M. Flora of Somalis:Vol 2[M]. Britain: Royal Botanic Gardens Kew, 2000:187-228.
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MASSOUD A, MASSOUD A, SALAMA O, et al. Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).[J]. Am J Trop Med Hyg, 2001, 65(2): 96-99.
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HANUŠ L O, ŘEZANKA T, DEMBITSKY V M, et al. Myrrh-commiphora chemistry[J]. Biomed Papers, 2005, 149(1):3-28.
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文章信息
doi: 10.11669/cpj.2025.03.011
  • 接收时间：2024-07-30
  • 首发时间：2025-10-29
  • 出版时间：2025-02-08
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出版历史
  • 收稿日期：2024-07-30
基金
国家重点研发计划项目资助(2023YFC3504200)
国家药典委员会药品标准制订研究课题资助(2020Z003)
三种进口树脂药材(血竭、乳香、没药)项目商品规格市场调研与基原的分子鉴定研究项目资助(2023GSMPA-KL01)
全国中药特色技术传承人才培训项目资助(T20234832002)
作者信息
    1 暨南大学药学院,岭南传统中药研究中心, 广州 510632
    2 曹晖全国名老中医药专家传承工作室, 广州 510632
    3 国家中药现代化工程技术研究中心岭南资源分中心, 广州 510632

通讯作者:

*曹晖,男,博士,研究员 研究方向:本草考证、中药鉴定、饮片炮制规范和质量标准研究 Tel:(020)85220010;
吴孟华,女,博士,副教授 研究方向:本草考证与生药鉴定,中药质量标准研 Tel:(020)85220010
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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