Article(id=1218290946203112168, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1218290941232861879, articleNumber=1001-2494(2024)15-1416-08, orderNo=null, doi=10.11669/cpj.2024.15.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1676217600000, receivedDateStr=2023-02-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1768392796326, onlineDateStr=2026-01-14, pubDate=1723046400000, pubDateStr=2024-08-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1768392796326, onlineIssueDateStr=2026-01-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1768392796326, creator=13701087609, updateTime=1768392796326, updator=13701087609, issue=Issue{id=1218290941232861879, tenantId=1146029695717560320, journalId=1190317699101192196, year='2024', volume='59', issue='15', pageStart='1361', pageEnd='1452', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1768392795141, creator=13701087609, updateTime=1768394622953, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1218298607682376061, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1218290941232861879, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1218298607682376062, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1218290941232861879, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1416, endPage=1423, ext={EN=ArticleExt(id=1218290947390100212, articleId=1218290946203112168, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Nebulization Characteristics Study of Houning Inhalation Solution, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To investigate the nebulization characteristics of Houning inhalation solution (HNIS)in vitro and to provide the reference for the clinical administration. METHODS The delivery rate (DR),delivered amount (DA) and aerodynamic particle size distribution (APSD) in vitro of HNIS were determined by means of respiratory simulator and the next generation impactor(NGI)with the syringin as the indication component and compared among the different types of nebulizers, compressors, atomization modes and breathing patterns. RESULTS In the same atomization condition and under the adult breathing pattern,the DR were between 23.3-52.2 μg·min-1, the DA were between 178.8-353.2 μg and the deposition fraction in simulated throat (DFST) was about 2.1% for the jet nebulizers, the DR were between 3.2-21.2 μg·min-1, the DA were between 12.9-82.7 μg and the DFST were about 0.7% for the ultrasonic nebulizers, the DR were between 7.2-16.5 μg·min-1, the DA were between 93.5-217.2 μg and the DFST were about 0.1% for the mesh nebulizers, the mass median aerodynamic diameter (MMAD ) were between 2.2-3.6 μm. In the same atomization condition and under the child breathing simulation,the DR were between 1.5-24.3 μg·min-1, the DA were between 26.3-215.4 μg. CONCLUSION The nebulization characteristics of HNIS are significant affected by the patterns and brands of the atomiztion equipment, suggesting that the atomization system should be selected according to the requirement in the clinical. Under the child breathing pattern, with the DA and DR reduced, the dosage and atomization time should be adjusted according to the age and pulmonary function of the patients to ensure the safety and efficiency of clinical medication.
, correspAuthors=Quanhong YAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Heng TIAN, Yixue YANG, Chunmin WU, Quanhong YAN), CN=ArticleExt(id=1218290948774220613, articleId=1218290946203112168, tenantId=1146029695717560320, journalId=1190317699101192196, language=CN, title=喉宁雾化吸入溶液的雾化特性分析, columnId=1190352405612040510, journalTitle=中国药学杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 对喉宁雾化吸入溶液的雾化特性进行研究,为该类制剂的临床用药提供参考。方法 采用呼吸模拟器和新一代撞击器,以紫丁香苷为指标性组分,建立喉宁雾化吸入溶液递送速率、递送总量和体外空气动力学分布的测定方法,考察不同的压缩机、雾化器、雾化方式和呼吸模式对雾化效果的影响。结果 在相同的雾化条件下,采用成人呼吸模式,压缩型雾化器的递送速率为23.3~52.2 μg·min-1、递送总量为178.8~353.2 μg、模拟喉部沉积比为2.1%,超声雾化器的递送速率为3.2~21.2 μg·min-1、递送总量为12.9~82.7 μg、模拟喉部沉积比为0.7%,振动筛网式雾化器的递送速率为7.2~16.5 μg·min-1、递送总量为93.5~217.2 μg、模拟喉部沉积比为0.1%,各类装置的质量中值动力学粒径在2.2~3.6 μm之间;儿童呼吸模式下各类型装置的递送速率为1.5~24.3 μg·min-1、递送总量为26.3~215.4 μg。结论 雾化器的类型和品牌对喉宁雾化吸入溶液的递送速率和递送总量有较大影响,建议临床使用时应尽量根据实际需要选择适宜的雾化装置;儿童呼吸模式下喉宁雾化吸入溶液递送速率及递送总量均有所降低,提示临床应根据患者年龄和肺部功能情况调整雾化剂用量和雾化时间。
, correspAuthors=严全鸿, authorNote=null, correspAuthorsNote=
* 严全鸿,男,博士,主任药师 研究方向:药物分析 Tel:(020)32447921
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2021., articleTitle=null, refAbstract=null)], funds=[Fund(id=1218484898059436043, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, awardId=20221057, language=CN, fundingSource=2022年度广东省中医药局项目(20221057), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1218484892967551765, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, xref=null, ext=[AuthorCompanyExt(id=1218484892980134677, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, companyId=1218484892967551765, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=NMPA Key Laboratory for Quality Control and Evaluation of Pharmaceutical Excipients, Guangdong Institute for Drug Control, Guangzhou 510180, China), AuthorCompanyExt(id=1218484892984328982, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, companyId=1218484892967551765, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广东省药品检验所, 国家药品监督管理局药用辅料质量控制与评价重点实验室, 广州 510180)])], figs=[ArticleFig(id=1218484895769346981, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Fig.1, caption=
HPLC chromatograms of reference substance solution of syringin(A), blank solution(B) and HNIS sample solution(C), figureFileSmall=i3opMwPIYFwukG4bb9X7CQ==, figureFileBig=ZmwpVQpOz03SVG8lxJoMrg==, tableContent=null), ArticleFig(id=1218484895844844457, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=图1, caption=
紫丁香苷对照品溶液(A)、空白溶剂溶液(B)和喉宁雾化吸入溶液(HNIS)供试品溶液(C)的HPLC色谱图, figureFileSmall=i3opMwPIYFwukG4bb9X7CQ==, figureFileBig=ZmwpVQpOz03SVG8lxJoMrg==, tableContent=null), ArticleFig(id=1218484895945507760, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Fig.2, caption=
Deposition data of HNIS atomized by different types of atomization devices in the different stages of NGI. n=3,$\bar{x}±s$, figureFileSmall=XTmoOvtZskmqd+/FFrjpvg==, figureFileBig=yv8rfSGsrIlNeHCNNPV7Jw==, tableContent=null), ArticleFig(id=1218484896050365364, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=图2, caption=
HNIS采用不同雾化装置雾化后在新一代撞击器(NGI)各层级中的沉积情况。n=3,$\bar{x}±s$, figureFileSmall=XTmoOvtZskmqd+/FFrjpvg==, figureFileBig=yv8rfSGsrIlNeHCNNPV7Jw==, tableContent=null), ArticleFig(id=1218484896146834360, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Fig.3, caption=
Bubble chart of deliver data of HNIS atomized by different types of atomization devices in the different breathing patterns 1-Ultrasonic-W001; 2-Ultrasonic-WH-2000a; 3-Mesh-NE-U100J; 4-Mesh-Air Kids; 5-Jet-PARI LC SPRINT Junior; 6-Jet-PARI LC SPRINT; 7-Jet-403E; 8-Jet-NE-C28.
, figureFileSmall=snAaeX4tM3HkwfGcaF1yjA==, figureFileBig=zUemICD9ncCsPlvUTVr9IQ==, tableContent=null), ArticleFig(id=1218484896205554622, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=图3, caption=
HNIS采用不同雾化装置雾化后在不同呼吸模式下的递送数据的气泡图 1-超声式-W001;2-超声式-WH-2000;3-网式-NE-U100J;4-网式-Air Kids;5-压缩式-帕瑞黄芯(儿童用);6-压缩式-帕瑞蓝芯;7-压缩式-403E;8-压缩式-NE-C28。
, figureFileSmall=snAaeX4tM3HkwfGcaF1yjA==, figureFileBig=zUemICD9ncCsPlvUTVr9IQ==, tableContent=null), ArticleFig(id=1218484896293635010, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Fig.4, caption=
Bubble chart of fine particle aerodynamic characteristics of HNIS atomized by different types of atomization devices 1-Jet-PARI LC SPRINT Junior; 2-Jet-PARI LC SPRINT; 3-Ultrasonic; 4-Mesh.
, figureFileSmall=8AKY41SJohealsnmW5OULA==, figureFileBig=9NB9EVHK7GPVy2AsyQEQRw==, tableContent=null), ArticleFig(id=1218484896356549574, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=图4, caption=
HNIS采用不同类型雾化装置雾化后的微细粒子空气动力学特性气泡图 1-压缩式-儿童用芯;2-压缩式-成人用芯;3-超声式;4-网式。
, figureFileSmall=8AKY41SJohealsnmW5OULA==, figureFileBig=9NB9EVHK7GPVy2AsyQEQRw==, tableContent=null), ArticleFig(id=1218484896440435657, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.1, caption=
The mobile phase gradient elution process of HPLC of syringin
, figureFileSmall=null, figureFileBig=null, tableContent=
| t/min | Mobile phase A/% | Mobile phaseB/% |
| 0 | 95 | 5 |
| 10 | 5 | 95 |
| 15 | 5 | 95 |
| 15.1 | 95 | 5 |
| 20 | 95 | 5 |
), ArticleFig(id=1218484896511738830, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表1, caption=
紫丁香苷指标组分测定高效液相色谱(HPLC)法梯度洗脱程序
, figureFileSmall=null, figureFileBig=null, tableContent=
| t/min | Mobile phase A/% | Mobile phaseB/% |
| 0 | 95 | 5 |
| 10 | 5 | 95 |
| 15 | 5 | 95 |
| 15.1 | 95 | 5 |
| 20 | 95 | 5 |
), ArticleFig(id=1218484896599819216, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.2, caption=
Respiratory simulator parameters corresponding to different breathing pattens
, figureFileSmall=null, figureFileBig=null, tableContent=
Breathing
pattern | Tidal volume
/mL | Frequency
/cycles·min-1 | Inhalation/exhalation
ratio |
| Adult | 500 | 15 | 1:1 |
| Child | 155 | 25 | 1:2 |
), ArticleFig(id=1218484896692093907, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表2, caption=
不同呼吸模式所对应的呼吸模拟器参数
, figureFileSmall=null, figureFileBig=null, tableContent=
Breathing
pattern | Tidal volume
/mL | Frequency
/cycles·min-1 | Inhalation/exhalation
ratio |
| Adult | 500 | 15 | 1:1 |
| Child | 155 | 25 | 1:2 |
), ArticleFig(id=1218484896763397078, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.3, caption=
Delivery data of different volumes of HNIS after atomization. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
V(Sample)
/mL | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| 2 | 53.0±4.7 | 222.0±5.3 | 116.0±3.4 | 96.0±10.5 | 4.2±0.5 | 85.1±3.8 |
| 3 | 52.2±2.8 | 335.8±7.2 | 184.4±8.0 | 145.0±11.9 | 6.7±0.3 | 86.0±0.7 |
| 5 | 50.8±2.0 | 506.1±5.8 | 276.6±32.2 | 279.7±11.3 | 10.0±0.5 | 80.5±1.0 |
), ArticleFig(id=1218484896851477467, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表3, caption=
不同体积的HNIS雾化后的递送数据。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
V(Sample)
/mL | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| 2 | 53.0±4.7 | 222.0±5.3 | 116.0±3.4 | 96.0±10.5 | 4.2±0.5 | 85.1±3.8 |
| 3 | 52.2±2.8 | 335.8±7.2 | 184.4±8.0 | 145.0±11.9 | 6.7±0.3 | 86.0±0.7 |
| 5 | 50.8±2.0 | 506.1±5.8 | 276.6±32.2 | 279.7±11.3 | 10.0±0.5 | 80.5±1.0 |
), ArticleFig(id=1218484896926974944, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.4, caption=
Delivery data of HNIS atomized by different compressors. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Compressor | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| NE-C28 | 38.9±2.1a | 353.2 | ±2.8a | 149.9±3.7a | 169.7 | ±5.5a | 9.1±0.6a | 85.1±1.7a |
| Junior BOY SX | 52.2±2.8b | 335.8 | ±7.2b | 184.4±8.0b | 145.0 | ±11.9b | 6.7±0.3b,c | 86.0±0.7a |
| 403E | 36.6±2.9c | 322.0 | ±15.1b | 157.1±7.0a | 183.5 | ±36.6b | 8.8±1.0a,c | 79.7±2.3b |
), ArticleFig(id=1218484897052804069, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表4, caption=
HNIS采用不同压缩机雾化后的递送数据。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Compressor | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| NE-C28 | 38.9±2.1a | 353.2 | ±2.8a | 149.9±3.7a | 169.7 | ±5.5a | 9.1±0.6a | 85.1±1.7a |
| Junior BOY SX | 52.2±2.8b | 335.8 | ±7.2b | 184.4±8.0b | 145.0 | ±11.9b | 6.7±0.3b,c | 86.0±0.7a |
| 403E | 36.6±2.9c | 322.0 | ±15.1b | 157.1±7.0a | 183.5 | ±36.6b | 8.8±1.0a,c | 79.7±2.3b |
), ArticleFig(id=1218484897157661671, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.5, caption=
Delivery data of HNIS atomized by different nebulizers. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Nebulizer | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| Omron type C | 23.3±0.7a | 198.0±1.0a | - | 109.3 | ±8.6a | 8.6±0.2a | 89.6±1.3a |
| PARI LC SPRINT | 52.2±2.8b | 335.8±7.2b | 184.4±8.0a | 145.0 | ±11.9b | 6.7±0.3b | 86.0±0.7a |
| PARI LC SPRINT Star | 36.4±0.9c | 327.2±6.5b,c | 178.9±13.2a | 165.9 | ±4.6c | 9.0±0.1c | 81.9±0.4a,b |
| PARI LCD | 32.0±1.1d | 178.8±1.4d | 2.8±0.8b | 103.5 | ±10.3a | 5.6±0.2d | 91.1±0.2a,c |
), ArticleFig(id=1218484897275102188, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表5, caption=
HNIS采用不同雾化器雾化后的递送数据。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Nebulizer | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| Omron type C | 23.3±0.7a | 198.0±1.0a | - | 109.3 | ±8.6a | 8.6±0.2a | 89.6±1.3a |
| PARI LC SPRINT | 52.2±2.8b | 335.8±7.2b | 184.4±8.0a | 145.0 | ±11.9b | 6.7±0.3b | 86.0±0.7a |
| PARI LC SPRINT Star | 36.4±0.9c | 327.2±6.5b,c | 178.9±13.2a | 165.9 | ±4.6c | 9.0±0.1c | 81.9±0.4a,b |
| PARI LCD | 32.0±1.1d | 178.8±1.4d | 2.8±0.8b | 103.5 | ±10.3a | 5.6±0.2d | 91.1±0.2a,c |
), ArticleFig(id=1218484897392542706, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.6, caption=
Delivery data of HNIS atomized by different types of nebulization device. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Device | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| W001 | 3.2±0.2 | 12.9 | ±0.9 | 0.5±0.8 | 502.9 | ±54.0 | 4.0±0.4 | 32.0±5.4 |
| WH-2000 | 21.2±1.8 | 82.7 | ±17.6 | 0.8±0.1 | 284.0 | ±32.8 | 3.9±0.5 | 75.8±2.8 |
| NE-U100J | 7.2±0.3 | 93.5 | ±7.0 | - | 434.0 | ±4.0 | 13.1±0.6 | 42.0±0.7 |
| Air kids | 16.5±0.6 | 217.2 | ±6.5 | - | 124.4 | ±7.1 | 13.1±0.8 | 82.2±0.5 |
), ArticleFig(id=1218484897480623094, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表6, caption=
HNIS采用不同类型的雾化装置雾化后的递送数据。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Device | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| W001 | 3.2±0.2 | 12.9 | ±0.9 | 0.5±0.8 | 502.9 | ±54.0 | 4.0±0.4 | 32.0±5.4 |
| WH-2000 | 21.2±1.8 | 82.7 | ±17.6 | 0.8±0.1 | 284.0 | ±32.8 | 3.9±0.5 | 75.8±2.8 |
| NE-U100J | 7.2±0.3 | 93.5 | ±7.0 | - | 434.0 | ±4.0 | 13.1±0.6 | 42.0±0.7 |
| Air kids | 16.5±0.6 | 217.2 | ±6.5 | - | 124.4 | ±7.1 | 13.1±0.8 | 82.2±0.5 |
), ArticleFig(id=1218484897560314873, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.7, caption=
Delivery data of atomized HNIS in the breathing pattern of children. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Device | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| PARI LC SPRINT | 24.3±3.1 | 215.4 | ±10.7 | 273.0 | ±13.1 | 170.0 | ±8.3 | 9.0±1.3 | 81.1±1.9 |
| PARI LC SPRINT Junior | 17.4±2.6 | 188.6 | ±9.7 | 256.1 | ±8.2 | 211.5 | ±4.8 | 11.0±1.3 | 75.5±1.2 |
| WH-2000 | 1.5±0.9 | 26.3 | ±2.6 | 10.6 | ±4.3 | 317.6 | ±29.6 | - | 64.5±4.1 |
| Air Kids | 12.7±1.3 | 171.9 | ±5.6 | | - | 99.2 | ±18.3 | 13.5±0.9 | 83.2±1.5 |
), ArticleFig(id=1218484897644200957, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表7, caption=
HNIS雾化后儿童呼吸模式下的递送数据。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Device | Delivery rate
/μg·min-1 | m(Total delivered)
/μg | m(Total exhaled)
/μg | m(Residue)
/μg | t(Effective atomization)
/min | Atomization
ratio/% |
| PARI LC SPRINT | 24.3±3.1 | 215.4 | ±10.7 | 273.0 | ±13.1 | 170.0 | ±8.3 | 9.0±1.3 | 81.1±1.9 |
| PARI LC SPRINT Junior | 17.4±2.6 | 188.6 | ±9.7 | 256.1 | ±8.2 | 211.5 | ±4.8 | 11.0±1.3 | 75.5±1.2 |
| WH-2000 | 1.5±0.9 | 26.3 | ±2.6 | 10.6 | ±4.3 | 317.6 | ±29.6 | - | 64.5±4.1 |
| Air Kids | 12.7±1.3 | 171.9 | ±5.6 | | - | 99.2 | ±18.3 | 13.5±0.9 | 83.2±1.5 |
), ArticleFig(id=1218484897828749312, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=EN, label=Tab.8, caption=
Deposition data of HNIS atomized by different types of atomization devices. n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Position | Cut-off diametre
/μm | Deposition/% |
| PARI LC SPRINT | PARI LC SPRINT Junior | Air Kids | W001 |
| Device | - | 17.4 | ±2.7 | 18.7 | ±5.3 | 22.7 | ±6.1 | 68.0 | ±7.3 |
| Linduction port | >14.1 | 2.1 | ±0.4 | 1.4 | ±0.4 | 0.7 | ±0.1 | 0.1 | ±0.0 |
| Stage 1 | >14.1 | 5.6 | ±0.5 | 2.4 | ±0.5 | 2.3 | ±0.2 | 0.1 | ±0.0 |
| Stage 2 | 8.61-14.1 | 10.9 | ±0.8 | 3.8 | ±0.8 | 4.6 | ±0.5 | 0.2 | ±0.1 |
| Stage 3 | 5.39-8.61 | 14.7 | ±0.1 | 11.0 | ±0.2 | 14.3 | ±1.1 | 0.5 | ±0.3 |
| Stage 4 | 3.30-5.39 | 16.7 | ±2.1 | 18.4 | ±2.2 | 21.8 | ±0.8 | 1.0 | ±0.6 |
| Stage 5 | 2.08-3.30 | 19.6 | ±3.5 | 15.8 | ±0.0 | 11.0 | ±0.3 | 0.7 | ±0.4 |
| Stage 6 | 1.36-2.08 | 12.8 | ±2.7 | 9.1 | ±0.5 | 3.3 | ±0.1 | 0.1 | ±0.0 |
| Stage 7 | 0.98-1.36 | 2.9 | ±0.51 | 3.9 | ±0.3 | 0.9 | ±0.0 | - |
| Micro-orifice collector(MOC) | <0.98 | 0.7 | ±0.0 | 0.8 | ±0.5 | 0.1 | ±0.0 | - |
), ArticleFig(id=1218484897904246788, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1218290946203112168, language=CN, label=表8, caption=
HNIS采用不同类型雾化装置雾化后的体外沉积情况。n=3,$\bar{x}±s$
, figureFileSmall=null, figureFileBig=null, tableContent=
| Position | Cut-off diametre
/μm | Deposition/% |
| PARI LC SPRINT | PARI LC SPRINT Junior | Air Kids | W001 |
| Device | - | 17.4 | ±2.7 | 18.7 | ±5.3 | 22.7 | ±6.1 | 68.0 | ±7.3 |
| Linduction port | >14.1 | 2.1 | ±0.4 | 1.4 | ±0.4 | 0.7 | ±0.1 | 0.1 | ±0.0 |
| Stage 1 | >14.1 | 5.6 | ±0.5 | 2.4 | ±0.5 | 2.3 | ±0.2 | 0.1 | ±0.0 |
| Stage 2 | 8.61-14.1 | 10.9 | ±0.8 | 3.8 | ±0.8 | 4.6 | ±0.5 | 0.2 | ±0.1 |
| Stage 3 | 5.39-8.61 | 14.7 | ±0.1 | 11.0 | ±0.2 | 14.3 | ±1.1 | 0.5 | ±0.3 |
| Stage 4 | 3.30-5.39 | 16.7 | ±2.1 | 18.4 | ±2.2 | 21.8 | ±0.8 | 1.0 | ±0.6 |
| Stage 5 | 2.08-3.30 | 19.6 | ±3.5 | 15.8 | ±0.0 | 11.0 | ±0.3 | 0.7 | ±0.4 |
| Stage 6 | 1.36-2.08 | 12.8 | ±2.7 | 9.1 | ±0.5 | 3.3 | ±0.1 | 0.1 | ±0.0 |
| Stage 7 | 0.98-1.36 | 2.9 | ±0.51 | 3.9 | ±0.3 | 0.9 | ±0.0 | - |
| Micro-orifice collector(MOC) | <0.98 | 0.7 | ±0.0 | 0.8 | ±0.5 | 0.1 | ±0.0 | - |
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