Article(id=1195386783044256236, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195386781278449897, articleNumber=1001-2494(2024)01-0039-06, orderNo=null, doi=10.11669/cpj.2024.01.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1665158400000, receivedDateStr=2022-10-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1762932018290, onlineDateStr=2025-11-12, pubDate=1704643200000, pubDateStr=2024-01-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762932018290, onlineIssueDateStr=2025-11-12, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762932018290, creator=13701087609, updateTime=1762932018290, updator=13701087609, issue=Issue{id=1195386781278449897, tenantId=1146029695717560320, journalId=1190317699101192196, year='2024', volume='59', issue='1', pageStart='1', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762932017868, creator=13701087609, updateTime=1762998488032, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1195665577399333609, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195386781278449897, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1195665577399333610, tenantId=1146029695717560320, journalId=1190317699101192196, issueId=1195386781278449897, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=39, endPage=44, ext={EN=ArticleExt(id=1195386783337857519, articleId=1195386783044256236, tenantId=1146029695717560320, journalId=1190317699101192196, language=EN, title=Effect of Total Saponin of Aralia taibaiensis on Cognitive Dysfunction in Mice with Traumatic Brain Injury by Mediating SIRT1/ FoxO1/PGC-1α Pathway, columnId=null, journalTitle=Chinese Pharmaceutical Journal, columnName=null, runingTitle=null, highlight=null, articleAbstract=

OBJECTIVE To investigate the effect of total saponin of Aralia taibaiensis (SAT) on cognitive dysfunction of mice with traumatic brain injury (TBI) by mediating silent information regulator 1 (SIRT1)/ forkhead transcription factor 1 (FoxO1)/peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway. METHODS C57BL/6 mice were divided into Con group, model group, SAT group (135 mg·kg^-1), EX-527 group (10 mg·kg^-1 SIRT1 inhibitor EX-527), and SAT+EX-527 group, 12 per group. Mice in the Con group received all surgical operations except cortical shock, and the controllable cortical shock method was used to construct the TBI model for the other groups. After the modeling was successful, the corresponding administration was performed, once a day for 7 d. Morris water maze test was performed to measure the learning and spatial memory abilities of mice; HE staining was performed to measure the pathological changes of damaged cortex; ELISA method was performed to measure the contents of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in damaged cortex; TUNEL staining was performed to measure neuronal apoptosis; and Western blot was performed to measure the expressions of Caspase-3, Bcl-2 related X protein (Bax), SIRT1, Ace-FoxO1, and Ace-PGC-1α proteins in damaged cortex. RESULTS Compared with the Con group, the mice in the model group had severe pathological damage to the cerebral cortex, the escape latency was extended and the number of crossing platforms was reduced, the levels of IL-6 and TNF-α, neuronal apoptosis rate, and the expressions of Caspase-3, Bax, Ace-FoxO1, and Ace-PGC-1α proteins in damaged cortex were increased, the expression of SIRT1 proteins was decreased (P<0.05). Compared with the model group, the pathological damage of the cerebral cortex of the mice in the SAT group was reduced, the escape latency was shortened and the number of crossing platforms was increased, the levels of IL-6 and TNF-α, neuronal apoptosis rate, and the expressions of Caspase-3, Bax, Ace-FoxO1, and Ace-PGC-1α proteins in damaged cortex were decreased, the expression of SIRT1 proteins was increased (P<0.05), the changes in the corresponding indicators of the EX-527 group showed an opposite trend. EX-527 reversed the improvement effect of SAT on cognitive dysfunction in TBI mice. CONCLUSION SAT may improve the cognitive dysfunction of TBI mice by activating the SIRT1/FoxO1/PGC-1α pathway.

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目的 探讨太白楤木总皂苷(SAT)介导沉默信息调节因子1(silence infor-mation regulator 1, SIRT 1)/叉头转录因子1(forkhead transcription factor 1, FoxO1)/过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-1α)通路对创伤性脑损伤(traumatic brain injury,TBI)小鼠认知功能障碍的影响。方法 将C57BL/6小鼠分为Con组、Model组、SAT组(135 mg·kg^-1)、EX-527组(10 mg·kg^-1 SIRT1抑制剂EX-527)、SAT+EX-527组,每组12只。Con组小鼠接受除皮层冲击外的所有手术操作,其余各组小鼠均利用可控皮层冲击法构建TBI模型,建模成功后,进行相应给药处理,每天1次,持续7 d。Morris水迷宫实验检测小鼠学习与空间记忆能力;HE染色检测损伤皮质病理学变化;ELISA法检测损伤皮质中白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)含量;TUNEL染色检测神经元凋亡;Western blot检测损伤皮质中半胱氨酸蛋白酶3(Caspase-3)、Bcl-2相关X蛋白(Bax)、SIRT1、Ace-FoxO1、Ace-PGC-1α蛋白表达。结果 与Con组比较,Model组小鼠脑皮层组织病理损伤严重,逃避潜伏期延长,穿越平台次数减少,损伤皮质中IL-6、TNF-α含量、神经元凋亡率、Caspase-3、Bax、Ace-FoxO1、Ace-PGC-1α蛋白表达升高,SIRT1蛋白表达降低(P<0.05);与Model组比较,SAT组小鼠脑皮层组织病理学损伤减轻,逃避潜伏期缩短,穿越平台次数增多,损伤皮质中IL-6、TNF-α含量、神经元凋亡率、Caspase-3、Bax、Ace-FoxO1、Ace-PGC-1α蛋白表达降低,SIRT1蛋白表达升高(P<0.05),而EX-527组对应指标变化呈相反趋势;EX-527逆转了SAT对TBI小鼠认知功能障碍的改善作用。结论 SAT可能通过激活SIRT1/ FoxO1/PGC-1α通路改善TBI小鼠认知功能障碍。

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谭薇,女,主治医师 研究方向:中医儿科诊断及用药研究 Tel:(0851)85890210

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谭薇,女,主治医师 研究方向:中医儿科诊断及用药研究 Tel:(0851)85890210

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DOI: 10.1111/cpr.12964., articleTitle=20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: a translational study, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1195498565410796330, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, xref=null, ext=[AuthorCompanyExt(id=1195498565414990635, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, companyId=1195498565410796330, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pediatrics, The First Affiliated Hospital of Guizhou University of traditional Chinese medicine, Guiyang 550001, China), AuthorCompanyExt(id=1195498565423379245, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, companyId=1195498565410796330, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州中医药大学第一附属医院儿科, 贵阳 550001)])], figs=[ArticleFig(id=1195498567088517971, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=EN, label=Fig.1, caption=Comparison of escape latency and times of crossing platform of mice in each group. n=6, $\bar{x}±s$

A-comparison of escape latency; B-comparison of the times of crossing the platform; ¹⁾P<0.05, vs Con group;²⁾P<0.05, vs Model group; ³⁾P<0.05, vs SAT group.

, figureFileSmall=U9aUVpOTI/Nf0ll1yuxolA==, figureFileBig=U4mU+gnlfrIJSYTsYTvVwA==, tableContent=null), ArticleFig(id=1195498567180792661, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=CN, label=图1, caption=各组小鼠逃避潜伏期及穿越平台次数比较. n=6, $\bar{x}±s$

A-逃避潜伏期比较;B-穿越平台次数比较;与Con组比较,¹⁾P<0.05;与Model组比较, ²⁾P<0.05;与SAT组比较,³⁾P<0.05。

, figureFileSmall=U9aUVpOTI/Nf0ll1yuxolA==, figureFileBig=U4mU+gnlfrIJSYTsYTvVwA==, tableContent=null), ArticleFig(id=1195498567285650263, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=EN, label=Fig.2, caption=Pathological changes of damaged cortex of mice detected by HE staining(×200), figureFileSmall=vxvS0ZN1TaQcw5qEopOwvg==, figureFileBig=xT8badJddyZISDdqyFtAxw==, tableContent=null), ArticleFig(id=1195498567356953433, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=CN, label=图2, caption=苏木精-伊红(HE)染色检测小鼠损伤皮质病理变化(×200), figureFileSmall=vxvS0ZN1TaQcw5qEopOwvg==, figureFileBig=xT8badJddyZISDdqyFtAxw==, tableContent=null), ArticleFig(id=1195498568434889563, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=EN, label=Fig.3, caption=TUNEL staining for detection of neuronal apoptosis in mice(×200). n=6, $\bar{x}±s$

¹⁾P<0.05, vs Con group;²⁾P<0.05, vs Model group; ³⁾P<0.05, vs SAT group; white arrows indicate positive cells.

, figureFileSmall=yKnBjJV263f3d671b5POCg==, figureFileBig=gYRNFY9Pr8iuHtWOwaM8Mg==, tableContent=null), ArticleFig(id=1195498568531358556, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=CN, label=图3, caption=TUNEL染色检测小鼠神经元凋亡(×200). n=6, $\bar{x}±s$

与Con组比较,¹⁾P<0.05;与Model组比较,²⁾P<0.05;与SAT组比较,³⁾P<0.05;白色箭头指示阳性细胞。

, figureFileSmall=yKnBjJV263f3d671b5POCg==, figureFileBig=gYRNFY9Pr8iuHtWOwaM8Mg==, tableContent=null), ArticleFig(id=1195498568590078813, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=EN, label=Fig.4, caption=Western blot detection of Caspase-3, Bax, SIRT1, Ace-FoxO1, and Ace-PGC-1α protein expression. n=6, $\bar{x}±s$

¹⁾P<0.05, vs Con group; ²⁾P<0.05, vs Model group; ³⁾P<0.05, vs SAT group.

, figureFileSmall=kLZ88HkIKawGCGrlyozZRQ==, figureFileBig=QRYwty6zIhB+G5Pbf4m6SQ==, tableContent=null), ArticleFig(id=1195498568690742110, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=CN, label=图4, caption=Western blot检测Caspase-3、Bax、SIRT1、Ace-FoxO1、Ace-PGC-1α蛋白表达. n=6, $\bar{x}±s$

与Con组比较,¹⁾P<0.05;与Model组比较,²⁾P<0.05;与SAT组比较,³⁾P<0.05。

, figureFileSmall=kLZ88HkIKawGCGrlyozZRQ==, figureFileBig=QRYwty6zIhB+G5Pbf4m6SQ==, tableContent=null), ArticleFig(id=1195498568774628191, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=EN, label=Tab.1, caption=

Comparison of IL-6 and TNF-α contents in damaged cortex of mice in each group. n=6, $\bar{x}±s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	IL-6/pg·mg-1	TNF-α/pg·mg-1
Con	1.65±0.22	1.28±0.13
Model	7.24±0.411)	5.25±0.211)
SAT	3.66±0.292)	2.68±0.322)
EX-527	9.87±0.632)	6.85±0.462)
SAT+EX-527	5.68±0.363)	4.05±0.373)

), ArticleFig(id=1195498568887874400, tenantId=1146029695717560320, journalId=1190317699101192196, articleId=1195386783044256236, language=CN, label=表1, caption=

各组小鼠损伤皮质中IL-6、TNF-α含量比较. n=6, $\bar{x}±s$

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	IL-6/pg·mg-1	TNF-α/pg·mg-1
Con	1.65±0.22	1.28±0.13
Model	7.24±0.411)	5.25±0.211)
SAT	3.66±0.292)	2.68±0.322)
EX-527	9.87±0.632)	6.85±0.462)
SAT+EX-527	5.68±0.363)	4.05±0.373)

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