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tenantId=1146029695717560320, journalId=1279045329999892481, language=CN, title=藏羊源性粪肠球菌无细胞上清液对沙门氏菌的抑菌机制及转录组学分析, columnId=1282278072095326533, journalTitle=中国畜牧杂志, columnName=动物健康, runingTitle=null, highlight=null, articleAbstract=为探究益生性粪肠球菌无细胞上清液（Cell-Free Supernatant,CFS）对沙门氏菌的抑菌机制，本研究采用琼脂扩散法评估粪肠球菌CFS的抑菌效果，96孔板法绘制沙门氏菌的生长抑制曲线，通过扫描电镜观察菌体超微结构的变化，转录组测序分析沙门氏菌差异基因的表达。结果表明：CFS对沙门氏菌抑菌圈约为16.30 mm,30%（体积分数）终浓度CFS抑制共培养体系中沙门氏菌的生长（P<0.001）。电镜结果显示处理组沙门氏菌菌体出现胞膜塌陷、表面褶皱等形态学损伤。转录组学测序结果显示，与对照组相比，处理组有1 520个差异表达基因，其中747个基因上调，773个基因下调，差异基因显著富集于碳水化合物代谢、氨基酸生物合成及双组分信号系统等通路。研究结果提示CFS可通过破坏沙门氏菌细胞膜完整性、干扰碳水化合物代谢（三羧酸循环、丙酮酸代谢）以及下调磷酸转移酶系统和有氧呼吸过程中关键基因的表达，来抑制沙门氏菌细胞的能量供应从而发挥抑菌作用，可为开发新型替抗制剂提供理论基础。, authors=李培键, 龙金桃, 白小兰, 秦绍敏, 陈慧琳, 王震, 郑雨晨, 贺晓龙, 冶贵生,, authorsList=李培键, 龙金桃, 白小兰, 秦绍敏, 陈慧琳, 王震, 郑雨晨, 贺晓龙, 冶贵生,, authorCompany=青海大学农牧学院, correspAuthors=冶贵生, authorNote=李培键（1999-），男，甘肃古浪人，硕士研究生，主要从事动物微生物学与免疫学研究，E-mail:lipeijian0816@163.com;, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, 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