中国畜牧杂志

ACSL基因家族鉴定及其在大别山牛组织中的表达分析

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中国畜牧杂志 | 遗传育种 2026,62(2): 238-246

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中国畜牧杂志 |遗传育种 2026 , 62 (2) : 238 -246

ACSL基因家族鉴定及其在大别山牛组织中的表达分析

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章会斌, 金磊, 李倩, 许娟, 金海, 赵拴平, 徐磊,

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徐磊

作者简介:

章会斌（1997-），男，安徽太湖人，博士，助理研究员，主要从事动物遗传育种研究，E-mail:zhanghuibin1997@126.com;

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出版时间: 2025-12-29 doi: 10.19556/j.0258-7033.20250508-07

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长链酰基辅酶A合成酶（Long-chain fatty Acyl-CoA synthetases,ACSLs）家族对脂质代谢至关重要。为明确家牛ACSL基因功能，本研究利用隐马尔可夫模型对家牛ACSL基因家族进行鉴定，通过生物信息学技术对ACSL基因家族进行分析，基于转录组数据解析ACSL基因家族在大别山牛不同组织中的表达规律。结果表明，ACSL基因家族保守性较高，进化分析表明ACSL基因可分为2个亚家族ACSL1/5/6和ACSL3/4，其中家牛、水牛和瘤牛的同源性较高。基因结构分析显示ACSL基因家族在不同物种间存在结构相似性，染色体定位表明ACSL基因在家牛和瘤牛的相同染色体上分布。蛋白互作网络分析显示ACSL基因家族可能与FASN等基因发生潜在的互作关系，涉及到脂肪酸合成、代谢及降解等关键生物过程。转录组数据显示，大别山牛ACSL表现出不同的组织表达分布特征，其中ACSL1在肌肉中高度表达，ACSLL3/4/6在瘤胃中高度表达，相关性分析表明ACSL6与大别山牛肌肉棕榈酸（C16:0）呈正相关，而ACSL1和ACSL4分别与硬脂酸（C18:0）和油酸（C18:1n9c）呈负相关。本研究不仅为进一步了解ACSL基因家族的功能提供了理论参考，也为大别山牛肉质遗传改良的分子机制提供了新的见解。

关键词

家牛 / ACSL / 基因结构 / 脂质代谢 / 基因表达

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章会斌, 金磊, 李倩, 许娟, 金海, 赵拴平, 徐磊,. ACSL基因家族鉴定及其在大别山牛组织中的表达分析. 中国畜牧杂志, 2026 , 62 (2) : 238 -246 . DOI: 10.19556/j.0258-7033.20250508-07

基金

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国家肉牛牦牛产业技术体系合肥综合试验站（CARS-37）;安徽省科技攻坚计划项目子课题（202423m10050001）;安徽省肉牛良种联合攻关项目（[2021]1146）;安徽省农业科学院新进博士项目（XJBS-202432）;

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2026年第62卷第2期

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doi: 10.19556/j.0258-7033.20250508-07

首发时间：2026-07-01
出版时间：2025-12-29

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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