中国畜牧杂志

组学技术在乳畜乳房炎研究中的应用进展

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中国畜牧杂志 | 综述 2026,62(2): 90-97

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中国畜牧杂志 |综述 2026 , 62 (2) : 90 -97

组学技术在乳畜乳房炎研究中的应用进展

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陈利强¹, 朱怡静², 刘权², 萨仁格勒², 郭子荣¹, 邱爽¹, 张立果², 苏小虎¹

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通讯作者:

张立果

作者简介:

陈利强（2000-），男，陕西榆林人，硕士研究生，研究方向为动物生殖生物学及生物技术，E-mail:736892949@qq.com;

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出版时间: 2025-12-19 doi: 10.19556/j.0258-7033.20250206-06

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乳房炎是影响奶牛和奶山羊等乳畜生产性能的主要疾病之一，微生物组学、代谢组学、蛋白质组学和基因组学技术为解析其机制提供了关键工具。微生物组学揭示肠道菌群通过肠-乳腺轴调控乳腺健康，发现次级胆汁酸、短链脂肪酸（Short-chain Fatty Acids,SCFAs）等与菌群紊乱相关的标志物。代谢组学筛选出粪便丙酮酸、血清丝氨酸、β-羟基丁酸（β-hydroxybutyrate）等反映炎症与代谢状态的核心标志物。蛋白质组学鉴定出乳汁中壳多糖酶3样蛋白I(Chitinase 3 Like Protein I,CHI3LI)、抗菌肽、血清淀粉样蛋白A(Serum Amyloid Protein A,SAA)等诊断靶点。基因组学挖掘出STAT3、PTK2B等跨物种的抗病候选基因，这些基因通过JAK-STAT、炎症信号通路参与抗性调控。本研究综述了上述4种组学技术在乳畜乳房炎研究中的核心发现，旨在为乳畜亚临床乳房炎型（Subclinical Mastitic,SM）的诊断及抗病筛选体系的建立提供参考。

关键词

乳房炎 / 组学技术 / 乳畜

引用本文

陈利强, 朱怡静, 刘权, 萨仁格勒, 郭子荣, 邱爽, 张立果, 苏小虎. 组学技术在乳畜乳房炎研究中的应用进展. 中国畜牧杂志, 2026 , 62 (2) : 90 -97 . DOI: 10.19556/j.0258-7033.20250206-06

基金

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内蒙古中央引导地方科技发展资金项目（2025ZY0149）;国家自然科学基金项目（32160768）;内蒙古自治区自然科学基金项目（2024LHMS03011）;

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2026年第62卷第2期

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doi: 10.19556/j.0258-7033.20250206-06

首发时间：2026-07-01
出版时间：2025-12-19

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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