中国畜牧杂志

ATAC-seq技术及其在家禽重要性状中的研究进展

PDF下载

中国畜牧杂志 | 综述 2026,62(2): 23-27

收起

中国畜牧杂志 |综述 2026 , 62 (2) : 23 -27

ATAC-seq技术及其在家禽重要性状中的研究进展

全屏

李劭明^1,2, 柯文涛^1,2, 梁豪^1,2, 董天舒^1,2, 方春¹, 田光明¹, 皮劲松², 游蕾³, 吴艳²

作者信息

通讯作者:

游蕾

作者简介:

李劭明（2001-），男，湖北恩施人，硕士研究生，主要从事家禽遗传育种与分子生物学研究，E-mail:2797792686@qq.com;

Affiliations

出版时间: 2025-11-03 doi: 10.19556/j.0258-7033.20250513-08

文章导航

摘要

收起

家禽作为全球畜牧业的重要经济物种，表观遗传调控对其生长、繁殖、抗病能力具有关键影响。近年来，染色质转座酶可及性测序（Assay for Transposase Accessible Chromatin With High-Throughput Sequencing,ATAC-seq）技术的兴起，为解析家禽表观遗传的调控机制提供了关键技术支撑。本文综述了ATAC-seq技术在家禽生长发育、繁殖性状及疾病研究中的进展，旨在为染色质可及性及基因表达调控的相关研究提供参考资料。

关键词

家禽 / ATAC-seq / 染色质可及性 / 生长发育 / 繁殖性状 / 家禽疾病

引用本文

李劭明, 柯文涛, 梁豪, 董天舒, 方春, 田光明, 皮劲松, 游蕾, 吴艳. ATAC-seq技术及其在家禽重要性状中的研究进展. 中国畜牧杂志, 2026 , 62 (2) : 23 -27 . DOI: 10.19556/j.0258-7033.20250513-08

基金

收起

国家自然科学基金项目（32202665）;国家重点研发计划资助（2022YFD1300100）;国家现代农业产业技术体系资助（CARS-40、CARS-41）;湖北省支持种业高质量发展资金项目（HBZY2023B007）;

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

[1]Klemm S L, Shipony Z, Greenleaf W J. Chromatin accessibility and the regulatory epigenome[J]. Nat Rev Genet, 2019, 20(4):207-220.
[2]Gibney E R, Nolan C M. Epigenetics and gene expression[J].Heredity, 2010, 105(1):4-13.
[3]丁晓玲,刘源,冯雪,等.染色质转座酶可及性测序技术在畜禽分子育种中的应用研究进展[J].中国畜牧杂志, 2025,61(2):76-81.
[4]Buenrostro J D, Giresi P G, Zaba LC, et al. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position[J]. Nat Methods, 2013, 10(12):1213-1218.
[5]Foissac S, Djebali S, Munyard K, et al. Multi-species annotation of transcriptome and chromatin structure in domesticated animals[J]. BMC Biol, 2019, 17:108.
[6]陈彦名,周韵,吴函玥,等. ATAC-seq技术在人类发育相关研究领域中的应用进展[J].科技视界, 2024, 14(16):42-47.
[7]Sun Y Y, Miao N, Sun T. Detect accessible chromatin using ATAC-sequencing, from principle to applications[J]. Hereditas,2019, 156(1):29.
[8]Tsompana M, Buck M J. Chromatin accessibility:a window into the genome[J]. Epigenetics Chromatin, 2014, 7(1):33.
[9]廖彬,杨佳怡,陈桂芳,等.染色质转座酶可及性测序研究与数据分析[J].中国测试, 2020, 46(10):4-10.
[10]Buenrostro J D, Giresi P G, Zaba L C, et al. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position[J]. Nat Methods, 2013, 10(12):1213-1218.
[11]吴杰,全建平,叶勇,等.染色质转座酶可及性测序研究进展[J].遗传, 2020, 42(4):333-346.
[12]Gottesfeld J M, Carey M F. Introduction to the thematic minireview series:chromatin and transcription[J]. J Biol Chem,2018, 293(36):13775-13777.
[13]Zhu X N, Wang Y Z, Li C, et al. Chicken chromatin accessibility atlas accelerates epigenetic annotation of birds and gene fine-mapping associated with growth traits[J]. Zool Res, 2023,44(1):53-62.
[14]Cai B L, Ma M T, Yuan R S, et al. MYH1G-AS is a chromatinassociated lncRNA that regulates skeletal muscle development in chicken[J]. Cell Mol Biol Lett, 2024, 29:9.
[15]Wang Z, Tian W H, Guo Y L, et al. Dynamic alternations of three-dimensional chromatin architecture contribute to phenotypic characteristics of breast muscle in chicken[J]. Commun Biol, 2024, 7:910.
[16]Gu S, Huang Q, Jie Y C, et al. Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers[J]. J Anim Sci Biotechnol, 2024, 15:91.
[17]Sun X, Liu X Y, Wang C H, et al. Deciphering mechanisms of adipocyte differentiation in abdominal fat of broilers[J]. J Agric Food Chem, 2024, 72(45):25403-25413.
[18]Li X Q, Zhang F, Sun Y X, et al. A novel candidate gene CLN8regulates fat deposition in avian[J]. J Anim Sci Biotechnol,2023, 14:70.
[19]Tizard M L, Jenkins K A, Cooper C A, et al. Potential benefits of gene editing for the future of poultry farming[J]. Transgenic Res, 2019, 28(Suppl 2):87-92.
[20]Zhang X A, Li J B, Wang X Q, et al. ATAC-seq and RNAseq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken[J]. Epigenetics Chromatin,2023, 16:2.
[21]Li J B, Sun C J, Zheng J X, et al. Time-course transcriptional and chromatin accessibility profiling reveals genes associated with asymmetrical gonadal development in Chicken embryos[J]. Front Cell Dev Biol, 2022, 10:832132.
[22]Wang J, Zhao C C, Li J Q, et al. Transcriptome analysis of the potential roles of FOXL2 in chicken pre-hierarchical and preovulatory granulosa cells[J]. Comp Biochem Physiol D, 2017,21:56-66.
[23]Vainio S, HeikkiläM, Kispert A,et al. Female development in mammals is regulated by Wnt-4 signalling[J]. Nature, 1999,397(6718):405-409.
[24]杨爽.鹅卵巢早期发育过程中的染色质开放性和转录组学研究[D].成都:四川农业大学, 2019.
[25]Li D Y, Ning C Y, Zhang J M, et al. Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis[J]. Nat Commun, 2022, 13:131.
[26]Zhang J Y, Cui Y, Ruan J M, et al. Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls[J]. Poult Sci,2025, 104(3):104864.
[27]Lv Z P, Fan H, Gao M K, et al. The accessible chromatin landscape of lipopolysaccharide-induced systemic inflammatory response identifying epigenome signatures and transcription regulatory networks in chickens[J]. Int J Biol Macromol, 2024,266:131136.
[28]Li W Q, Ma X Y, Li X M, et al. Integrating single-cell RNASeq and ATAC-Seq analysis reveals uterine cell heterogeneity and regulatory networkslinked to pimpled eggs in Chickens[J].Int J Mol Sci, 2024, 25(24):13431.
[29]Hérault F, Houée-Bigot M, Baéza E, et al. RNA-seq analysis of hepatic gene expression of common Pekin, Muscovy, mule and hinny ducks fed ad libitum or overfed[J]. BMC Genomics,2019, 20:13.
[30]Xu M M, Gu L H, Lv W Y, et al. Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility[J]. Genomics, 2022, 114(6):110518.
[31]Alzahrani K. Genetic and epigenetic investigations on pulmonary hypertension syndrome in meat type-chickens[D].Fayetteville:University of Arkansas, 2018.
[32]Chanthavixay G, Kern C, Wang Y, et al. Integrated transcriptome and histone modification analysis reveals NDV infection under heat stress affects bursa development and proliferation in susceptible Chicken line[J]. Front Genet, 2020,11:567812.

2026年第62卷第2期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.19556/j.0258-7033.20250513-08

首发时间：2026-07-01
出版时间：2025-11-03

补充材料

相关文章

文章信息

作者

出版历史

基金

作者信息

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20250513-08

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT