中国畜牧杂志

畜禽血常规分析及其在遗传育种中的应用研究进展

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苏岩, 郑伟杰, 贺巾锋, 郭子骄, 韩博, 孙东晓,

中国畜牧杂志 | 综述 2026,62(2): 1-6

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中国畜牧杂志 |综述 2026 , 62 (2) : 1 -6

畜禽血常规分析及其在遗传育种中的应用研究进展

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苏岩, 郑伟杰, 贺巾锋, 郭子骄, 韩博, 孙东晓,

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作者简介:

苏岩（2002-），女，河北石家庄人，博士研究生，主要从事奶牛分子遗传育种研究，E-mail:1846121966@qq.com;

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出版时间: 2025-12-24 doi: 10.19556/j.0258-7033.20250221-04

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血常规作为临床医学中最常用的血液学指标，可以有效评估动物的健康状况、免疫功能及生理反应。不同畜禽物种的血常规指标存在差异，与物种特性、环境适应性、饲养管理水平以及遗传背景密切相关，其在畜牧业中的应用已从传统的健康监测逐步扩展到遗传育种领域。本文综述了主要畜禽的血常规指标及其在遗传育种中的应用进展。随着多组学技术的发展，基因组、转录组和蛋白质组等方法为解析畜禽血常规性状的遗传机制提供了新策略，也为其作为遗传标记助力畜禽健康与抗病育种开辟了新途径。

关键词

血常规指标 / 畜禽 / 健康评估 / 遗传育种

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苏岩, 郑伟杰, 贺巾锋, 郭子骄, 韩博, 孙东晓,. 畜禽血常规分析及其在遗传育种中的应用研究进展. 中国畜牧杂志, 2026 , 62 (2) : 1 -6 . DOI: 10.19556/j.0258-7033.20250221-04

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国家重点研发计划项目（2021YFF1000700）;教育部创新团队发展计划（IRT＿15R62）;

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[1]Okada Y,Kamatani Y.Common genetic factors for hematological traits in Humans[J].J Hum Genet,2012,57(3):161-169.
[2]George-Gay B,Parker K.Understanding the complete blood count with differential[J].J Perianesth Nurs,2003,18(2):96-114.
[3]Hoda S A,Hoda R S.Robbins and cotran pathologic basis of disease[J].Am J Clin Pathol,2020,154(6):869.
[4]Smyth S S,Mcever R P,Weyrich A S,et al.Platelet functions beyond hemostasis[J].J Thromb Haemost,2009,7(11):1759-1766.
[5]Elzey B D,Sprague D L,Ratliff T L.The emerging role of platelets in adaptive immunity[J].Cell Immunol,2005,238(1):1-9.
[6]Andrae J,Gallini R,Betsholtz C.Role of platelet-derived growth factors in physiology and medicine[J].Genes Dev,2008,22(10):1276-1312.
[7]Miyazono K.Shear activates platelet-derived latent TGF-β[J].Blood,2008,112(9):3533.
[8]吴清清,刘雯悦,王媛,等．猪繁殖与呼吸综合征抗病指示性状的分子标记筛查及检测[J].华中农业大学学报,2022,41(1):186-193.
[9]张巧霞,张玲妮,刘飞,等.基于GBLUP与惩罚类回归方法的猪血液性状基因组选择研究[J].畜牧兽医学报,2017,48(12):2258-2267.
[10]李潘,李平,王兆明,等.畜禽血液功能特性及加工适应性研究进展[J].食品研究与开发,2023,44(9):191-196.
[11]卢娜,刘高飞,王雅晶,等.不同品种奶牛产奶量、乳成分、血清生化指标与乳钙含量的相关性研究[J].动物营养学报,2018,30(8):3302-3310.
[12]Feldman B F,Zinkl J G,Jain N C,et al.Schalm's veterinary hematology,5th ed[M].Hoboken:Blackwell,2000.
[13]Al-Khalaifah H,Al-Nasser A.Cytokines as effective elements of the Avian immune system[J].J Microbiol Genet,2018,2018(1):1-7.
[14]王娅娜.现代化畜禽养殖业中动物遗传育种的杂种优势研究[J].科技风,2023(29):167-169.
[15]苏丽娟.畜禽遗传育种资源保护[J].中国畜牧业,2023(17):54-55.
[16]夏志.奶牛乳腺炎炎症因子检测与产奶性能的关联分析[D].杨凌:西北农林科技大学,2010.
[17]Huang C H,Kayano M,Kusaba N.Pathogen and severitydependent immune responses in bovine mastitis:highlight the dynamics of differential somatic cell count[J].Vet Med Sci,2024,86(1):7-17.
[18]Brooks M B,Harr K E,Seelig D M,et al.Schalm's veterinary hematology,7th ed[M].Hoboken:Wiley,2022.
[19]高鹏,叶苗苗,张永宁,等.非洲猪瘟病毒感染与致病机制的研究进展[J].中国兽医杂志,2024,60(7):77-88.
[20]付晓平,李嘉彬,猪瘟患猪白细胞与血小板的变化规律[J].中国畜牧兽医文摘,2016,32(4):46-47.
[21]Zhang J,Du K,Xie Y,et al.Integration of transcriptomic and metabolomic data reveals new tetraploid kiwifruit hybrids with enhanced nutrients[J].LWT,2022,170:114012.
[22]Stockham S,Scott M A.Fundamentals of veterinary clinical pathology,3rd ed[M].Hoboken:Wiley,2025.
[23]Lunney J K,Fang Y,Ladinig A,et al.Porcine reproductive and respiratory syndrome virus (PRRSV):pathogenesis and interaction with the immune system[J].Annu Rev Anim Biosci,2016,4(1):129-154.
[24]卫春晓.猪繁殖与呼吸综合征病猪的生理生化指标检验[J].中国畜牧兽医文摘,2014,30(12):45.
[25]Hong J,Lv J,Wu M,et al.The blood routine test holds screening values for influenza A in 2023:a retrospective study[J].Transl Pediatr,2024,13(2):236-247.
[26]Kamatani Y,Matsuda K,Okada Y,et al.Genome-wide association study of hematological and biochemical traits in a Japanese population[J].Nat Genet,2010,42(3):210-215.
[27]Ganesh S,Zakai N,Rooij F,et al.Multiple loci influence erythrocyte phenotypes in the CHARGE consortium[J].Nat Genet,2009,41(11):1191-1198.
[28]Kamatani Y,Wattanapokayakit S,Ochi H,et al.A genomewide association study identifies variants in the hla-dp locus associated with chronic hepatitis b in Asians[J].Nat Genet,2009,41(5):591-595.
[29]Li J,Glessner J T,Zhang H T,et al.GWAS of blood cell index identifies novel associated loci and epistatic interactions in caucasian and african american children[J].Hum Mol Genet,2012,22(7):641-647.
[30]Meisinger C,Prokisch H,Gieger C,et al.A genome-wide association study identifies three loci associated with mean platelet volume[J].Am J Hum Genet,2009,84(1):66-71.
[31]Nalls M,Wilson J,Patterson N,et al.Admixture mapping of white cell count:genetic locus responsible for lower white blood cell count in the health abc and jackson heart studies[J].Am J Hum Genet,2008,82(1):81-87.
[32]Soranzo N,Rendon A,Gieger C,et al.A novel variant on chromosome 7q22.3 associated with mean platelet volume,counts,and function[J].Blood,2009,113(16):3831-3837.
[33]Soranzo N,Spector T,Mangino M,et al.A genome-wide metaanalysis identifies 22 loci associated with eight hematological parameters in the Haem Gen consortium[J].Nat Genet,2009,41(11):1182-1190.
[34]Zhao Y H,Liu Z H,Wang L,et al.Expression of the RORαgene in inner mongolian cashmere goat hair follicles[J].Genet Mol Res,2015,14(1):380-388.
[35]Keel B,Snelling W,Oliver W,et al.Using snp weights derived from gene expression modules to improve gwas power for feed efficiency in pigs[J].Front Genet,2020,10(2):1339.
[36]Zhang Z Y,Hong Y,Gao J,et al.Genome-wide association study reveals constant and specific loci for hematological traits at three times stages in a White Duroc×Erhualian F2 resource population[J].PLo S One,2013,8(5):e63665.
[37]Ballester M,Ramayo-Caldas Y,González-Rodríguez O,et al.Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs[J].Sci Rep,2020,10(1):18462.
[38]Maroilley T,Lemonnier G,Lecardonnel J,et al.Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allelespecific expression analysis[J].BMC Genomics,2017,18(1):967.
[39]Bovo S,Mazzoni G,Bertolini F,et al.Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes[J].Sci Rep,2019,9(1):7003.
[40]Bai X C,Yang T F,Putz A M,et al.Investigating the genetic architecture of disease resilience in pigs by genome-wide association studies of complete blood count traits collected from a natural disease challenge model[J].BMC Genomics,2021,22(1):535.
[41]Yang T T,Luo H P,Lou W Q,et al.Genetic background of hematological parameters in Holstein cattle based on genomewide association and RNA sequencing analyses[J].J Dairy Sci,2024,107(7):4772-4792.
[42]王哲.荷斯坦奶牛重要性状GWAS及关键基因鉴定[D].北京:中国农业大学,2024.
[43]Zhu S H,Guo T T,Zhao H C,et al.Genome-wide association study using individual single-nucleotide polymorphisms and haplotypes for erythrocyte traits in Alpine Merino Sheep[J].Front Genet,2020,11:848.
[44]Yang J Y,Chen S Q,Ma F P,et al.Pathogen stimulations and immune cells synergistically affect the gene expression profile characteristics of porcine peripheral blood mononuclear cells[J].BMC Genomics,2024,25(1):719.
[45]Ye M H,Bao H,Meng Y,et al.Comparative transcriptomic analysis of porcine peripheral blood reveals differentially expressed genes from the cytokine-cytokine receptor interaction pathway related to health status[J].Genome,2017,60(12):1021-1028.
[46]Fang L C,Lin W D,Jia H,et al.Potential diagnostic value of the peripheral blood mononuclear cell transcriptome from cattle with bovine tuberculosis[J].Front Vet Sci,2020,7:295.
[47]Tang Y J,Zhang J N,Li W L,et al.Identification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle[J].BMC Genomics,2024,25(1):445.
[48]Wang X,Gao Y H,Li C J,et al.The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese holstein cattle[J].BMC Genomic Data,2023,24(1):39.
[49]Singh A,Prasad M,Mishra B,et al.Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16) infected peripheral blood mononuclear cells (PBMCs)in sheep and goats[J].Genomics Data,2017,11:62-72.
[50]Yan Z,Yang J,Wei W T,et al.A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues[J].Nat Commun,2024,15(1):3970.
[51]Alharbi R A.Proteomics approach and techniques in identification of reliable biomarkers for diseases[J].Saudi J Biol Sci,2020,27(3):968-974.
[52]Deng Y T,You J,He Y,et al.Atlas of the plasma proteome in health and disease in 53,026 adults[J].Cell,2025,188(1):253-271.
[53]Wang X L,Xu J,Han Z Y.Plasma proteomic profiling reveals the regulatory factors of milk protein synthesis in Holstein cows[J].Biology,2022,11(8):1239.
[54]Elkhamary A,Gerner I,Bileck A,et al.Comparative proteomic profiling of the ovine and human PBMC inflammatory response[J].Sci Rep,2024,14(1):14939.
[55]Chiaradia E,Avellini L,Tartaglia M,et al.Proteomic evaluation of sheep serum proteins[J].BMC Vet Res,2012,8:66..

2026年第62卷第2期

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doi: 10.19556/j.0258-7033.20250221-04

首发时间：2026-07-01
出版时间：2025-12-24

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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