Article(id=1279144407295308623, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, articleNumber=PA20260323_uPkiL2ly, orderNo=null, doi=10.19556/j.0258-7033.20250606-11, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782901392053, onlineDateStr=2026-07-01, pubDate=1767456000000, pubDateStr=2026-01-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782901392053, onlineIssueDateStr=2026-07-01, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782901392053, creator=admin, updateTime=1782901392053, updator=admin, issue=Issue{id=1279144148057960780, tenantId=1146029695717560320, journalId=1279045329999892481, year='2026', volume='62', issue='2', pageStart='1', pageEnd='388', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782901330245, creator='ztmeta', updateTime=1783650204703, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1282285155289108897, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1282285155289108898, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=309, endPage=316, ext={CN=ArticleExt(id=1284209640938390446, articleId=1279144407295308623, tenantId=1146029695717560320, journalId=1279045329999892481, language=CN, title=母猪妊娠后期日粮中添加亮氨酸对新生仔猪能量代谢的影响, columnId=1282278071529083639, journalTitle=中国畜牧杂志, columnName=营养饲料, runingTitle=null, highlight=null, articleAbstract=本试验旨在研究妊娠后期日粮中添加亮氨酸(Leu)对新生仔猪能量代谢的调控机制。选取200头妊娠70的健康长×大母猪(胎次为4~5胎),随机分为对照组、0.40%Leu组、0.80%Leu组和1.20%Leu组。试验期从母猪妊娠第70天开始,至母猪分娩结束。结果显示:妊娠84 d,0.40%Leu组和0.80%Leu组母猪血浆高密度脂蛋白(HDL)降低(P<0.01);妊娠98 d,0.40%Leu组甘油三酯(TG)下降(P<0.01);妊娠110 d,各Leu组TG均降低(P<0.01),0.40%Leu组母猪血浆葡萄糖(GLU)升高(P<0.05);3个处理组新生仔猪脐带血总胆固醇(TC)、HDL升高(P<0.05),背最长肌TG降低(P<0.05);0.80%Leu组新生仔猪背最长肌中SIRT-1和PGC-1α mRNA表达升高(P<0.05),各Leu组p-AMPK蛋白表达下降(P<0.05);0.40%Leu组和0.80%Leu组新生仔猪ACACA、GPAM的mRNA和FASN蛋白表达上调(P<0.05);0.40%Leu组新生仔猪ACSL1、CPT-1和FABP3 mRNA表达上调(P<0.05),而0.80%Leu组CD36和FATP4表达下降(P<0.05);0.40%Leu组SREBP1、PPARα和PPARγ表达下调(P<0.05);0.40%Leu组PEPCK的mRNA和0.80%Leu组GLUT1蛋白和ACL mRNA表达增加(P<0.05)。本试验条件下,妊娠后期日粮中添加0.4%、0.8%Leu可提高新生仔猪背最长肌中脂肪酸和GLU的氧化代谢,降低TG合成提高能量代谢水平,为其促进蛋白质沉积提供能量。, authors=刘涛1 , 唐燕妮2 , 李浪3 , 周雪梅3 , 管武太3 , 陈芳3 , 邵丹1,4 , authorsList=刘涛, 唐燕妮, 李浪, 周雪梅, 管武太, 陈芳, 邵丹, authorCompany=1.华南理工大学医学院; 2.咸宁市农业科学院; 3.华南农业大学动物科学学院; 4.广东省人民医院, correspAuthors=陈芳, authorNote=刘涛(1989-),男,江西上饶人,硕士研究生,研究方向为动物医学健康,E-mail:535008765@qq.com;, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=0vwweiM5Shp998tp7r+eOQ==, pdfFileSize=2325172, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划(2021YFD1300401);)}, authors=[Author(id=1288182955029803974, tenantId=1146029695717560320, journalId=null, articleId=1279144407295308623, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={CN=AuthorExt(id=null, tenantId=null, journalId=1279045329999892481, articleId=1279144407295308623, authorId=1288182955029803974, language=CN, stringName=刘涛, 唐燕妮, 李浪, 周雪梅, 管武太, 陈芳, 邵丹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)], keywords=[Keyword(id=1284217200236007709, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144407295308623, language=CN, orderNo=1, keyword=妊娠后期), Keyword(id=1284217200298922270, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144407295308623, language=CN, orderNo=2, keyword=亮氨酸), Keyword(id=1284217200361836831, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144407295308623, language=CN, orderNo=3, keyword=能量代谢), Keyword(id=1284217200420557088, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144407295308623, language=CN, orderNo=4, keyword=母猪), Keyword(id=1284217200479277345, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144407295308623, language=CN, orderNo=5, keyword=仔猪)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1279045211531776000, delFlag=0, nameCn=中国畜牧杂志, nameEn=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, issn=0258-7033, eissn=null, cn=11-2083/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=/LwzP9ODDP1104PfuP3+5A==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Animal Science, journalRemark=null, publicationField=null, createdTime=1782877741943, updatedTime=1784022333352, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=/LwzP9ODDP1104PfuP3+5A==, picEn=se+5xDE//YSxHqLJ0K7Jaw==, jcr=null, cjcr=null, exts=[JournalExt(id=1283845976133713988, language=CN, name=中国畜牧杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333415, updatedTime=1784022333415, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283845976184045637, language=EN, name=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333427, updatedTime=1784022333427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1279045329999892481, websiteList=[Website(id=1279045564750869087, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/CN, language=CN, createTime=1782877826154, createBy=18614031015, updateTime=1782877970220, updateBy=18614031015, name=中国畜牧杂志-中文, tplId=1146099689490845704, title=中国畜牧杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046195876184733, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=articleTextType, value=kx, createTime=1782877976626, updateTime=1782877976626, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195855213210, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=banner, value=null, createTime=1782877976621, updateTime=1782877976621, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195892961952, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=grayFlag, value=0, createTime=1782877976630, updateTime=1782877976630, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195842630297, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877976618, updateTime=1782877976618, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195905544866, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=minRunFlag, value=0, createTime=1782877976633, updateTime=1782877976633, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195867796124, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic, createTime=1782877976624, updateTime=1782877976624, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195901350561, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=silenceFlag, value=0, createTime=1782877976632, updateTime=1782877976632, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195863601819, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1782877976623, updateTime=1782877976623, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195880379038, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeColor, value=null, createTime=1782877976627, updateTime=1782877976627, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195888767647, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeStyle, value=null, createTime=1782877976629, updateTime=1782877976629, creator=18614031015, updator=18614031015)]), Website(id=1279045564864115298, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/EN, language=EN, createTime=1782877826181, createBy=18614031015, updateTime=1782877964219, updateBy=18614031015, name=中国畜牧杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Animal Science, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046222778450599, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=articleTextType, value=kx, createTime=1782877983040, updateTime=1782877983040, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222749090468, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=banner, value=null, createTime=1782877983033, updateTime=1782877983033, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222816199338, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=grayFlag, value=0, createTime=1782877983049, updateTime=1782877983049, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222740701859, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877983031, updateTime=1782877983031, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222832976556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=minRunFlag, value=0, createTime=1782877983053, updateTime=1782877983053, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222765867686, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic, createTime=1782877983037, updateTime=1782877983037, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222824587947, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=silenceFlag, value=0, createTime=1782877983051, updateTime=1782877983051, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222757479077, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1782877983035, updateTime=1782877983035, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222791033512, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeColor, value=null, createTime=1782877983043, updateTime=1782877983043, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222803616425, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeStyle, value=null, createTime=1782877983046, updateTime=1782877983046, creator=18614031015, updator=18614031015)])], journalTitle=中国畜牧杂志, weixinUrl=null, journalUrl=https://www.zgxmzz.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Animal Science, journalPhotoCn=/LwzP9ODDP1104PfuP3+5A==, journalPhotoEn=se+5xDE//YSxHqLJ0K7Jaw==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20250606-11, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/10.19556/j.0258-7033.20250606-11, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/PDF/10.19556/j.0258-7033.20250606-11, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/PDF/10.19556/j.0258-7033.20250606-11, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1767456000000, fullTextJson=null, articleText=null, reference=[1]Wu G, Bazer F W, Wallace J M, et al. Board-invited review:intrauterine growth retardation:implications for the animal sciences[J]. J Anim Sci, 2006, 84(9):2316-2337. [2]李文刚.母猪年产断奶仔猪数(PSY)达到最大是猪场效益提升的关键[J].畜牧与兽医, 2015, 47(8):127-129. [3]王超先,王旭贞,管武太,等.母猪妊娠后期日粮添加亮氨酸对断奶仔猪生长性能及乳成分的影响[J].中国畜牧杂志,2016, 52(9):48-52. [4]Wang C X, Chen F C, Zhang W F, et al. Leucine promotes the growth of fetal pigs by increasing protein synthesis through the mTOR signaling pathway in longissimus dorsi muscle at late gestation[J]. J Agric Food Chem, 2018, 66(15):3840-3849. [5]付域泽,王强,焦帅,等.低蛋白代乳粉调控断奶仔猪肠道微生物区系及缓解腹泻的作用[J].中国畜牧杂志, 2023,59(11):270-279. [6]刘杰,李永明,徐子伟,等.大豆黄酮对母仔猪生产性能和免疫功能的影响[J].浙江农业科学, 2012(3):400-402. [7]王超先.亮氨酸对妊娠后期胎猪蛋白质沉积的影响及机理研究[D].广州:华南农业大学, 2018. [8]唐燕妮.妊娠后期日粮中添加亮氨酸对新生仔猪蛋白质沉积能量来源的影响[D].广州:华南农业大学, 2020. [9]郑溜丰.低蛋白日粮添加支链氨基酸对仔猪采食量和骨路肌生长的影响及调控机制研究[D].武汉:华中农业大学,2017. [10]焦俊.亮氨酸通过脂肪组织控制肥胖的机制研究[D].苏州:苏州大学, 2016. [11]Suryawan A, Nguyen H V, Almonaci R D, et al. Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway[J]. J Anim Sci Biotechnol, 2012, 3(3):3. [12]施魁.亮氨酸对猪胎盘和乳腺上皮细胞营养转运的影响及调控机制[D].广州:华南农业大学, 2020. [13]Nishitani S, Matsumura T, Fujitani S, et al. Leucine promotes glucose uptake in skeletal muscles of rats[J]. Biochem Biophys Res Commun, 2002, 299(5):693-696. [14]Sun X, Zemel M B. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells[J]. Lipids, 2007, 42(4):297-305. [15]Cui C, Wu C C, Wang J, et al. Leucine supplementation during late gestation globally alters placental metabolism and nutrient transport via modulation of the PI3K/AKT/mTOR signaling pathway in sows[J]. Food Funct, 2022, 13(4):2083-2097. [16]Chen L Q, Cheung L S, Feng L, et al. Transport of sugars[J].Annu Rev Biochem, 2015, 84:865-894. [17]赵惠奇,张青海,郑昭芬.从心肌能量代谢角度探讨射血分数保留的心力衰竭的治疗进展[J].实用心脑肺血管病杂志,2023, 31(2):1-7. [18]江赵宁,王文惠,吴飞,等.妊娠后期能量饲喂水平对母猪繁殖性能和血脂代谢相关指标的影响[J].动物营养学报,2018, 30(8):2960-2968. [19]Nevoral J, Landsmann L, Stiavnicka M, et al. Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression[J]. J Anim Sci Biotechnol, 2019, 10:67. [20]Elesawy W H, El-Sahar A E, Sayed R H, et al. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats:Role of AMPK/SIRT-1/PGC-1α signaling and autophagy[J]. Int Immunopharmacol, 2024,138:112640. [21]Foretz M, Ancellin N, Andreelli F, et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver[J]. Diabetes, 2005, 54(5):1331-1339. [22]Xu S, Jay A, Brunaldi K, et al. CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane[J]. Biochemistry, 2013,52(41):7254-7261. [23]Nickerson J G, Alkhateeb H, Benton C R, et al. Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1and differential effects on fatty acid esterification and oxidation in rat skeletal muscle[J]. J Biol Chem, 2009, 284(24):16522-16530. [24]Ngo J, Choi DW, Stanley IA, et al. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA[J]. EMBO J, 2023, 42(11):111901. [25]高芳芳.两种非常规饲料原料对猪,鸡氧化还原状态和脂代谢的影响[D].南京:南京农业大学, 2020. [26]Huang L Z, Xu R, Chen S Y, et al. Modulating lipid metabolism by nanoparticles(NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis[J]. Mol Cancer, 2025, 24(1):73. [27]Geng F, Guo D L. SREBF1/SREBP-1 concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis and tumor growth[J]. Autophagy, 2024, 20(5):1183-1185. [28]姜志浩.脱氢表雄酮对高脂日粮诱导的大鼠脂代谢紊乱和胰岛素抵抗的影响及其机制研究[D].南京:南京农业大学,2020. [29]Ioannou M S, Jackson J, Sheu S H, et al. Neuron-Astrocyte metabolic coupling protects against activity-induced fatty acid toxicity[J]. Cell, 2019, 177(6):1522-1535. [30]杨青.过表达乙酰辅酶A羧化酶以提高谷氨酸棒杆菌重组菌株中脂肪酸合成的研究[D].呼尔浩特:内蒙古农业大学,2021. [31]慈文佳,陈欣,蒋梦琪,等.四逆散加葛根混合物对产蛋后期蛋鸡肝脏脂质代谢和氧化还原状态的影响[J].动物营养学报, 2023, 35(3):1540-1551. [32]Yoon J C, Puigserver P, Chen G, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1[J].Nature, 2001, 413(6852):131-138. [33]Granchi C. ATP citrate lyase(ACLY)inhibitors:An anti-cancer strategy at the crossroads of glucose and lipid metabolism[J].Eur J Med Chem, 2018, 157:1276-1291. [34]Xu Q T, Yue Y P, Liu B, et al. ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation[J]. Nat Commun, 2023, 14(1):3265.)
中国畜牧杂志
|营养饲料
2026
, 62
(2) :
309
-316
母猪妊娠后期日粮中添加亮氨酸对新生仔猪能量代谢的影响
全屏
[Author(id=1288182955029803974, tenantId=1146029695717560320, journalId=null, articleId=1279144407295308623, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={CN=AuthorExt(id=null, tenantId=null, journalId=1279045329999892481, articleId=1279144407295308623, authorId=1288182955029803974, language=CN, stringName=刘涛, 唐燕妮, 李浪, 周雪梅, 管武太, 陈芳, 邵丹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=null)]
刘涛, 唐燕妮, 李浪, 周雪梅, 管武太, 陈芳, 邵丹
作者信息
作者简介:
刘涛(1989-),男,江西上饶人,硕士研究生,研究方向为动物医学健康,E-mail:535008765@qq.com;
Affiliations
出版时间: 2026-01-04
doi: 10.19556/j.0258-7033.20250606-11
文章导航
本试验旨在研究妊娠后期日粮中添加亮氨酸(Leu)对新生仔猪能量代谢的调控机制。选取200头妊娠70的健康长×大母猪(胎次为4~5胎),随机分为对照组、0.40%Leu组、0.80%Leu组和1.20%Leu组。试验期从母猪妊娠第70天开始,至母猪分娩结束。结果显示:妊娠84 d,0.40%Leu组和0.80%Leu组母猪血浆高密度脂蛋白(HDL)降低(P<0.01);妊娠98 d,0.40%Leu组甘油三酯(TG)下降(P<0.01);妊娠110 d,各Leu组TG均降低(P<0.01),0.40%Leu组母猪血浆葡萄糖(GLU)升高(P<0.05);3个处理组新生仔猪脐带血总胆固醇(TC)、HDL升高(P<0.05),背最长肌TG降低(P<0.05);0.80%Leu组新生仔猪背最长肌中SIRT-1和PGC-1α mRNA表达升高(P<0.05),各Leu组p-AMPK蛋白表达下降(P<0.05);0.40%Leu组和0.80%Leu组新生仔猪ACACA、GPAM的mRNA和FASN蛋白表达上调(P<0.05);0.40%Leu组新生仔猪ACSL1、CPT-1和FABP3 mRNA表达上调(P<0.05),而0.80%Leu组CD36和FATP4表达下降(P<0.05);0.40%Leu组SREBP1、PPARα和PPARγ表达下调(P<0.05);0.40%Leu组PEPCK的mRNA和0.80%Leu组GLUT1蛋白和ACL mRNA表达增加(P<0.05)。本试验条件下,妊娠后期日粮中添加0.4%、0.8%Leu可提高新生仔猪背最长肌中脂肪酸和GLU的氧化代谢,降低TG合成提高能量代谢水平,为其促进蛋白质沉积提供能量。
妊娠后期
/
亮氨酸
/
能量代谢
/
母猪
/
仔猪
刘涛, 唐燕妮, 李浪, 周雪梅, 管武太, 陈芳, 邵丹.
母猪妊娠后期日粮中添加亮氨酸对新生仔猪能量代谢的影响.
中国畜牧杂志,
2026
, 62
(2)
: 309
-316
.
DOI: 10.19556/j.0258-7033.20250606-11
参考文献
引证文献
[1]Wu G, Bazer F W, Wallace J M, et al. Board-invited review:intrauterine growth retardation:implications for the animal sciences[J]. J Anim Sci, 2006, 84(9):2316-2337. [2]李文刚.母猪年产断奶仔猪数(PSY)达到最大是猪场效益提升的关键[J].畜牧与兽医, 2015, 47(8):127-129. [3]王超先,王旭贞,管武太,等.母猪妊娠后期日粮添加亮氨酸对断奶仔猪生长性能及乳成分的影响[J].中国畜牧杂志,2016, 52(9):48-52. [4]Wang C X, Chen F C, Zhang W F, et al. Leucine promotes the growth of fetal pigs by increasing protein synthesis through the mTOR signaling pathway in longissimus dorsi muscle at late gestation[J]. J Agric Food Chem, 2018, 66(15):3840-3849. [5]付域泽,王强,焦帅,等.低蛋白代乳粉调控断奶仔猪肠道微生物区系及缓解腹泻的作用[J].中国畜牧杂志, 2023,59(11):270-279. [6]刘杰,李永明,徐子伟,等.大豆黄酮对母仔猪生产性能和免疫功能的影响[J].浙江农业科学, 2012(3):400-402. [7]王超先.亮氨酸对妊娠后期胎猪蛋白质沉积的影响及机理研究[D].广州:华南农业大学, 2018. [8]唐燕妮.妊娠后期日粮中添加亮氨酸对新生仔猪蛋白质沉积能量来源的影响[D].广州:华南农业大学, 2020. [9]郑溜丰.低蛋白日粮添加支链氨基酸对仔猪采食量和骨路肌生长的影响及调控机制研究[D].武汉:华中农业大学,2017. [10]焦俊.亮氨酸通过脂肪组织控制肥胖的机制研究[D].苏州:苏州大学, 2016. [11]Suryawan A, Nguyen H V, Almonaci R D, et al. Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway[J]. J Anim Sci Biotechnol, 2012, 3(3):3. [12]施魁.亮氨酸对猪胎盘和乳腺上皮细胞营养转运的影响及调控机制[D].广州:华南农业大学, 2020. [13]Nishitani S, Matsumura T, Fujitani S, et al. Leucine promotes glucose uptake in skeletal muscles of rats[J]. Biochem Biophys Res Commun, 2002, 299(5):693-696. [14]Sun X, Zemel M B. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells[J]. Lipids, 2007, 42(4):297-305. [15]Cui C, Wu C C, Wang J, et al. Leucine supplementation during late gestation globally alters placental metabolism and nutrient transport via modulation of the PI3K/AKT/mTOR signaling pathway in sows[J]. Food Funct, 2022, 13(4):2083-2097. [16]Chen L Q, Cheung L S, Feng L, et al. Transport of sugars[J].Annu Rev Biochem, 2015, 84:865-894. [17]赵惠奇,张青海,郑昭芬.从心肌能量代谢角度探讨射血分数保留的心力衰竭的治疗进展[J].实用心脑肺血管病杂志,2023, 31(2):1-7. [18]江赵宁,王文惠,吴飞,等.妊娠后期能量饲喂水平对母猪繁殖性能和血脂代谢相关指标的影响[J].动物营养学报,2018, 30(8):2960-2968. [19]Nevoral J, Landsmann L, Stiavnicka M, et al. Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression[J]. J Anim Sci Biotechnol, 2019, 10:67. [20]Elesawy W H, El-Sahar A E, Sayed R H, et al. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats:Role of AMPK/SIRT-1/PGC-1α signaling and autophagy[J]. Int Immunopharmacol, 2024,138:112640. [21]Foretz M, Ancellin N, Andreelli F, et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver[J]. Diabetes, 2005, 54(5):1331-1339. [22]Xu S, Jay A, Brunaldi K, et al. CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane[J]. Biochemistry, 2013,52(41):7254-7261. [23]Nickerson J G, Alkhateeb H, Benton C R, et al. Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1and differential effects on fatty acid esterification and oxidation in rat skeletal muscle[J]. J Biol Chem, 2009, 284(24):16522-16530. [24]Ngo J, Choi DW, Stanley IA, et al. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA[J]. EMBO J, 2023, 42(11):111901. [25]高芳芳.两种非常规饲料原料对猪,鸡氧化还原状态和脂代谢的影响[D].南京:南京农业大学, 2020. [26]Huang L Z, Xu R, Chen S Y, et al. Modulating lipid metabolism by nanoparticles(NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis[J]. Mol Cancer, 2025, 24(1):73. [27]Geng F, Guo D L. SREBF1/SREBP-1 concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis and tumor growth[J]. Autophagy, 2024, 20(5):1183-1185. [28]姜志浩.脱氢表雄酮对高脂日粮诱导的大鼠脂代谢紊乱和胰岛素抵抗的影响及其机制研究[D].南京:南京农业大学,2020. [29]Ioannou M S, Jackson J, Sheu S H, et al. Neuron-Astrocyte metabolic coupling protects against activity-induced fatty acid toxicity[J]. Cell, 2019, 177(6):1522-1535. [30]杨青.过表达乙酰辅酶A羧化酶以提高谷氨酸棒杆菌重组菌株中脂肪酸合成的研究[D].呼尔浩特:内蒙古农业大学,2021. [31]慈文佳,陈欣,蒋梦琪,等.四逆散加葛根混合物对产蛋后期蛋鸡肝脏脂质代谢和氧化还原状态的影响[J].动物营养学报, 2023, 35(3):1540-1551. [32]Yoon J C, Puigserver P, Chen G, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1[J].Nature, 2001, 413(6852):131-138. [33]Granchi C. ATP citrate lyase(ACLY)inhibitors:An anti-cancer strategy at the crossroads of glucose and lipid metabolism[J].Eur J Med Chem, 2018, 157:1276-1291. [34]Xu Q T, Yue Y P, Liu B, et al. ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation[J]. Nat Commun, 2023, 14(1):3265.
2026年第62卷第2期
PDF下载
38
5
引用本文
BibTeX
文章信息
doi: 10.19556/j.0258-7033.20250606-11
首发时间:2026-07-01
出版时间:2026-01-04
https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20250606-11
复制链接
引用本文
BibTeX
2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
关闭全屏
BibTeX
EndNote
RefWorks
TxT