Article(id=1279144217788265137, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, articleNumber=PA20260323_foxUkRmD, orderNo=null, doi=10.19556/j.0258-7033.20250208-04, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782901346871, onlineDateStr=2026-07-01, pubDate=1768320000000, pubDateStr=2026-01-14, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782901346870, onlineIssueDateStr=2026-07-01, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782901346870, creator=admin, updateTime=1782901346870, updator=admin, issue=Issue{id=1279144148057960780, tenantId=1146029695717560320, journalId=1279045329999892481, year='2026', volume='62', issue='2', pageStart='1', pageEnd='388', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782901330245, creator='ztmeta', updateTime=1783650204703, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1282285155289108897, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1282285155289108898, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=78, endPage=82, ext={CN=ArticleExt(id=1284209623745938302, articleId=1279144217788265137, tenantId=1146029695717560320, journalId=1279045329999892481, language=CN, title=CST3基因结构及功能研究进展, columnId=1282278053371941581, journalTitle=中国畜牧杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=随着分子生物学研究的不断发展，越来越多机体的生物学特性都从分子水平找到了答案。胱抑素C(Cystatin C,CysC)蛋白是一种半胱氨酸蛋白酶抑制剂，广泛存在于各种组织的有核细胞和体液中，作为近年来发展起来的肾功能评估指标，它不仅满足理想内源性肾小球滤过率标志物的要求，还具备敏感性高、特异性强的突出优势。CST3是CysC的编码基因，其多态性在心脑血管疾病、神经系统疾病等领域的研究中长期备受关注，同时在生殖系统和细胞免疫等方面也发挥重要的作用。本文综述了CST3基因及其蛋白质的分子结构和生物学功能研究进展，系统梳理了CST3基因在人类疾病、畜禽繁殖中的功能研究进展，旨在为该基因作为遗传标记在人类疾病诊疗及畜禽育种中的开发应用提供理论基础与实践依据。, authors=施巧婷¹, 张彬¹, 吕晨晨¹, 祁兴山², 黄永震³, 王二耀¹, authorsList=施巧婷, 张彬, 吕晨晨, 祁兴山, 黄永震, 王二耀, authorCompany=1.河南省农业科学院畜牧兽医研究所河南省畜禽繁育与营养调控重点实验室;
2.泌阳县夏南牛科技开发有限公司;
3.西北农林科技大学动物科技学院, correspAuthors=王二耀, authorNote=施巧婷（1972-），女，壮族，广西邕宁人，博士，研究员，主要从事动物遗传育种与繁殖工作，E-mail:sqtsw@126.com;, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=RynX1yNP/lffaLiyBVs9Qw==, pdfFileSize=1756094, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家肉牛牦牛产业技术体系专项（CARS-37）;河南省农业科学院科技创新团队：牛羊繁育与生产（2026TD25）;河南省科技攻关（252102110073）;河南省自然科学基金项目（252300420687）;河南省肉牛产业技术体系项目（HARS-22-13-S）;)}, authors=null, keywords=[Keyword(id=1284217186973627287, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144217788265137, language=CN, orderNo=1, keyword=CST3基因), Keyword(id=1284217187296588696, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144217788265137, language=CN, orderNo=2, keyword=CysC), Keyword(id=1284217187359503257, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144217788265137, language=CN, orderNo=3, keyword=结构特征), Keyword(id=1284217187736990618, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144217788265137, language=CN, orderNo=4, keyword=生物学功能)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1279045211531776000, delFlag=0, nameCn=中国畜牧杂志, nameEn=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, issn=0258-7033, eissn=null, cn=11-2083/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=/LwzP9ODDP1104PfuP3+5A==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Animal Science, journalRemark=null, publicationField=null, createdTime=1782877741943, updatedTime=1784022333352, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=/LwzP9ODDP1104PfuP3+5A==, picEn=se+5xDE//YSxHqLJ0K7Jaw==, jcr=null, cjcr=null, exts=[JournalExt(id=1283845976133713988, language=CN, name=中国畜牧杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333415, updatedTime=1784022333415, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283845976184045637, language=EN, name=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333427, updatedTime=1784022333427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1279045329999892481, websiteList=[Website(id=1279045564750869087, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/CN, language=CN, createTime=1782877826154, createBy=18614031015, updateTime=1782877970220, updateBy=18614031015, name=中国畜牧杂志-中文, tplId=1146099689490845704, title=中国畜牧杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046195876184733, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=articleTextType, value=kx, createTime=1782877976626, updateTime=1782877976626, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195855213210, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=banner, value=null, createTime=1782877976621, updateTime=1782877976621, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195892961952, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=grayFlag, value=0, createTime=1782877976630, updateTime=1782877976630, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195842630297, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877976618, updateTime=1782877976618, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195905544866, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=minRunFlag, value=0, createTime=1782877976633, updateTime=1782877976633, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195867796124, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic, createTime=1782877976624, updateTime=1782877976624, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195901350561, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=silenceFlag, value=0, createTime=1782877976632, updateTime=1782877976632, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195863601819, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1782877976623, updateTime=1782877976623, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195880379038, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeColor, value=null, createTime=1782877976627, updateTime=1782877976627, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195888767647, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeStyle, value=null, createTime=1782877976629, updateTime=1782877976629, creator=18614031015, updator=18614031015)]), Website(id=1279045564864115298, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/EN, language=EN, createTime=1782877826181, createBy=18614031015, updateTime=1782877964219, updateBy=18614031015, name=中国畜牧杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Animal Science, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046222778450599, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=articleTextType, value=kx, createTime=1782877983040, updateTime=1782877983040, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222749090468, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=banner, value=null, createTime=1782877983033, updateTime=1782877983033, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222816199338, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=grayFlag, value=0, createTime=1782877983049, updateTime=1782877983049, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222740701859, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877983031, updateTime=1782877983031, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222832976556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=minRunFlag, value=0, createTime=1782877983053, updateTime=1782877983053, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222765867686, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic, createTime=1782877983037, updateTime=1782877983037, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222824587947, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=silenceFlag, value=0, createTime=1782877983051, updateTime=1782877983051, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222757479077, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1782877983035, updateTime=1782877983035, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222791033512, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeColor, value=null, createTime=1782877983043, updateTime=1782877983043, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222803616425, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeStyle, value=null, createTime=1782877983046, updateTime=1782877983046, creator=18614031015, updator=18614031015)])], journalTitle=中国畜牧杂志, weixinUrl=null, journalUrl=https://www.zgxmzz.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Animal Science, journalPhotoCn=/LwzP9ODDP1104PfuP3+5A==, journalPhotoEn=se+5xDE//YSxHqLJ0K7Jaw==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20250208-04, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/10.19556/j.0258-7033.20250208-04, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/PDF/10.19556/j.0258-7033.20250208-04, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/PDF/10.19556/j.0258-7033.20250208-04, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1768320000000, fullTextJson=null, articleText=null, reference=[1]王要鑫,刘洁云,秦雷.胱抑素C与心血管疾病关系的研究进展[J].中国全科医学, 2013, 16(11):961-962, 970.
[2]许迅辉,邹建洲,丁小强,等.血清胱抑素C:一种简便测定肾小球滤过率的标志物[J].中国临床医学, 2001, 6(8):240-241.
[3]张松雨,姚明杨,周晓铎. I型心肾综合征患者血清脑钠肽、胱抑素C、肾损伤分子水平及与急性肾损伤的相关性和预测价值[J].中国血液净化, 2022, 21(4):231-234.
[4]黄生金,郑利平,陆俊佳,等.广西地区壮族和汉族冠心病患者胱抑素C水平及其基因多态性的比较研究[J].现代检验医学杂志, 2017, 32(3):26-29, 33.
[5]Eriksson P, Deguchi H, Samnegard A, et al. Human evidence that the cystatinC gene is implicated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2004,24(3):551-557.
[6]李玉豪,丁建平.胱抑素C、MPV/PLT对冠心病的影响及临床意义[J].检验医学与临床, 2023, 20(2):228-231.
[7]Zou J, Chen Z Y, Wei X B, et al. Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGFinduced angiogenesis and enhanced neuronal autophagy in neurovascular units[J]. Cell Death Dis, 2017, 8(6):2854.
[8]Wada Y K, Nagai A, Sheikh A M, et al. Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis[J]. J Neurol Sci, 2018, 384:67-74.
[9]Kim Y I, Shin H W, Chun Y S, et al. CST3 and GDF15 ameliorate renal fibrosis by inhibiting fibroblast growth and activation[J]. Biochem Biophys Res Commun, 2018, 500(2):288-295.
[10]Kim Y I, ShinN H W, Chun Y S, et al. Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis[J]. Cell Death Dis, 2018, 9(5):506.
[11]Lee R K, Tseng H C, Hwu Y M et al. Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation[J]. Reprod Biol Endocrinol, 2018, 16(1):8.
[12]徐志强,黄少华,王骏.汉族人CST3单核苷酸多态性与冠心病、胱抑素C水平相关性研究[J].国际心血管病杂志,2014, 41(6):406-408.
[13]王玉明,李冬梅,赵莹,等.巢式PCR-RFLP法检测Cystatin C基因多态性的实验研究[J].昆明医学院学报, 2008(4):33-36.
[14]朱文成.血清胱抑素C、同型半胱氨酸和尿酸水平与老年慢性心力衰竭的相关性分析[D].长春:吉林大学, 2024.
[15]Mitaki S, Nagai A, Sheikh A M, et al. Contribution of Cystatin C gene polymorphisms to cerebral white matter lesion[J].Cerebrovasc Dis, 2011, 32(5):489-496.
[16]孙梦姣.血清尿酸及胱抑素C与脑白质病变的相关性研究[D].重庆:第三军医大学, 2017.
[17]侯振江.胱抑素C及其在肾脏疾病中的应用价值[J].中国微循环, 2008(2):126-128.
[18]Yu N, Chen X Y, Du M Y, et al. Long Non Coding RNA ZEB2 AS1 augments activity of trophoblast cells and prevents the development of recurrent spontaneous Abortion in Mice Through EZH2 Mediated CST3 inhibition[J]. Rep Sci, 2022,29:963-974.
[19]陈雨寒. Cst3参与调节精原干细胞的自噬[D].广州:南方医科大学, 2020.
[20]Huh C, Nagle J W, Kozka C A, et al. Structural organization,expression and chromosomal mapping of the mouse cystatinCencoding gene(Cst3)[J]. Gene, 1995, 152(2):221-226.
[21]Hamil K G, Liu Q, Sivashanmugam P, et al. Cystatin 11:a new member of the cystatin type 2 family[J]. Endocrinology, 2002,143(7):2787-2796.
[22]李春海,陈晓英,王红梅,等.牦牛CST3基因的克隆、表达及生物信息学分析[J].生物技术, 2022, 58(10):230-234.
[23]Hernández-Silva G, Chirinos M. Proteins from male and female reproductive tracts involved in sperm function regulation[J].Zygote, 2019, 27(1):5-16.
[24]Guo K B, Chen Q H, He X B, et al. Expression and significance of Cystatin-C in clear cell renal cell carcinoma[J]. Biomed Pharmacother, 2018, 107:1237-1245.
[25]Yasueda T, Abe Y, Shiba M, et al. A new insight into cystatin C contained in milk basic protein to bone metabolism:Effects on osteoclasts and osteoblastic MC3T3-E1 cells in vitro[J]. Anim Sci J, 2018, 89:1027-1032.)