Article(id=1279144174045868464, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, articleNumber=PA20260323_dzU2w6uo, orderNo=null, doi=10.19556/j.0258-7033.20241212-03, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1782901336443, onlineDateStr=2026-07-01, pubDate=1767110400000, pubDateStr=2025-12-31, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1782901336442, onlineIssueDateStr=2026-07-01, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1782901336442, creator=admin, updateTime=1782901336442, updator=admin, issue=Issue{id=1279144148057960780, tenantId=1146029695717560320, journalId=1279045329999892481, year='2026', volume='62', issue='2', pageStart='1', pageEnd='388', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1782901330245, creator='ztmeta', updateTime=1783650204703, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1282285155289108897, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1282285155289108898, tenantId=1146029695717560320, journalId=1279045329999892481, issueId=1279144148057960780, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=17, endPage=22, ext={CN=ArticleExt(id=1284209618272358683, articleId=1279144174045868464, tenantId=1146029695717560320, journalId=1279045329999892481, language=CN, title=干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展, columnId=1282278053371941581, journalTitle=中国畜牧杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=干扰素tau(IFNT)是由反刍动物胚胎滋养层细胞特异性分泌的一种I型干扰素,在妊娠早期发挥关键生理作用。IFNT的主要功能包括抑制子宫内膜前列腺F 2α (PGF 2α )的合成与分泌、阻断黄体溶解、维持孕酮持续分泌,同时具有抗炎、抗病毒、调节母体免疫耐受等作用,可促进胚胎着床与发育。IFNT的表达受特定转录因子及表观遗传修饰的动态调控。近年来,随着对IFNT作用机制的深入研究,其在提高反刍动物繁殖效率和加速遗传改良中的应用潜力日益凸显。本文综述了IFNT的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用,以期为相关领域的研究提供理论依据。, authors=成元炜璐, 庞洋, 曾申明,, authorsList=成元炜璐, 庞洋, 曾申明,, authorCompany=中国农业大学动物科学技术学院, correspAuthors=曾申明, authorNote=成元炜璐(2001-),女,仡佬族,贵州人,本科生,主要从事动物繁殖理论与技术研究,E-mail:3385133320@qq.com;, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=k9lJNAtYCGO0Io8/ztLH7w==, pdfFileSize=2237693, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划(2023YFD1300102-2);宁夏回族自治区中央引导地方科技发展专项项目(2024FRD05031-01);)}, authors=null, keywords=[Keyword(id=1284217178941535105, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144174045868464, language=CN, orderNo=1, keyword=IFNT), Keyword(id=1284217180589896578, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144174045868464, language=CN, orderNo=2, keyword=结构), Keyword(id=1284217180657005443, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144174045868464, language=CN, orderNo=3, keyword=抗黄体溶解), Keyword(id=1284217180740891524, tenantId=1146029695717560320, journalId=1279045329999892481, articleId=1279144174045868464, language=CN, orderNo=4, keyword=妊娠识别)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1279045211531776000, delFlag=0, nameCn=中国畜牧杂志, nameEn=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, issn=0258-7033, eissn=null, cn=11-2083/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=/LwzP9ODDP1104PfuP3+5A==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Animal Science, journalRemark=null, publicationField=null, createdTime=1782877741943, updatedTime=1784022333352, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=/LwzP9ODDP1104PfuP3+5A==, picEn=se+5xDE//YSxHqLJ0K7Jaw==, jcr=null, cjcr=null, exts=[JournalExt(id=1283845976133713988, language=CN, name=中国畜牧杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333415, updatedTime=1784022333415, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283845976184045637, language=EN, name=Chinese Journal of Animal Science, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784022333427, updatedTime=1784022333427, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=1, submissionEditorUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=3, submissionReviewUrl=https://zgxm.cbpt.cnki.net/EditorC3N/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1279045329999892481, websiteList=[Website(id=1279045564750869087, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/CN, language=CN, createTime=1782877826154, createBy=18614031015, updateTime=1782877970220, updateBy=18614031015, name=中国畜牧杂志-中文, tplId=1146099689490845704, title=中国畜牧杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046195876184733, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=articleTextType, value=kx, createTime=1782877976626, updateTime=1782877976626, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195855213210, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=banner, value=null, createTime=1782877976621, updateTime=1782877976621, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195892961952, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=grayFlag, value=0, createTime=1782877976630, updateTime=1782877976630, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195842630297, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877976618, updateTime=1782877976618, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195905544866, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=minRunFlag, value=0, createTime=1782877976633, updateTime=1782877976633, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195867796124, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/file/pic, createTime=1782877976624, updateTime=1782877976624, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195901350561, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=silenceFlag, value=0, createTime=1782877976632, updateTime=1782877976632, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195863601819, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1782877976623, updateTime=1782877976623, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195880379038, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeColor, value=null, createTime=1782877976627, updateTime=1782877976627, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046195888767647, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564750869087, code=themeStyle, value=null, createTime=1782877976629, updateTime=1782877976629, creator=18614031015, updator=18614031015)]), Website(id=1279045564864115298, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1279045329999892481, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxmzz/EN, language=EN, createTime=1782877826181, createBy=18614031015, updateTime=1782877964219, updateBy=18614031015, name=中国畜牧杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Animal Science, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1279046222778450599, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=articleTextType, value=kx, createTime=1782877983040, updateTime=1782877983040, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222749090468, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=banner, value=null, createTime=1782877983033, updateTime=1782877983033, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222816199338, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=grayFlag, value=0, createTime=1782877983049, updateTime=1782877983049, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222740701859, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic?fileId=HfoX2B/UbkzyU4RMsQSFQQ==, createTime=1782877983031, updateTime=1782877983031, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222832976556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=minRunFlag, value=0, createTime=1782877983053, updateTime=1782877983053, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222765867686, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/file/pic, createTime=1782877983037, updateTime=1782877983037, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222824587947, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=silenceFlag, value=0, createTime=1782877983051, updateTime=1782877983051, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222757479077, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1782877983035, updateTime=1782877983035, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222791033512, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeColor, value=null, createTime=1782877983043, updateTime=1782877983043, creator=18614031015, updator=18614031015), WebsiteProps(id=1279046222803616425, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1279045564864115298, code=themeStyle, value=null, createTime=1782877983046, updateTime=1782877983046, creator=18614031015, updator=18614031015)])], journalTitle=中国畜牧杂志, weixinUrl=null, journalUrl=https://www.zgxmzz.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Animal Science, journalPhotoCn=/LwzP9ODDP1104PfuP3+5A==, journalPhotoEn=se+5xDE//YSxHqLJ0K7Jaw==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20241212-03, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/10.19556/j.0258-7033.20241212-03, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxmzz/CN/PDF/10.19556/j.0258-7033.20241212-03, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxmzz/EN/PDF/10.19556/j.0258-7033.20241212-03, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1767110400000, fullTextJson=null, articleText=null, reference=[1]Talukder A K, McDonald M, Browne J A, et al. Response of bovine endometrium to interferon tau in the presence of lipopolysaccharide[J]. Theriogenology, 2024, 229:169-177.
[2]Feltrin I R. Study of genes stimulated by interferon-τin imune cells as candidates for pregnancy markers in bovine females[D].Claudia M B:UNESP, 2024.
[3]Bai H, Kawahara M, Takahashi M, et al. Recent progress of interferon-tau research and potential direction beyond pregnancy recognition[J]. J Reprod Dev, 2022, 68(5):299-306.
[4]Tekdal A E. Maternal acceptance of pregnancy and implantation process in sheep[J]. MAS J Appl Sci, 2022, 7(Özel Sayı):1171-1183.
[5]Geisert R D, Bazer F W, Lucas C G, et al. Maternal recognition of pregnancy in the pig:A servomechanism involving sex steroids, cytokines and prostaglandins[J]. Anim Reprod Sci,2024, 264:107452.
[6]Tinning H, Edge J C, DeBem T H C, et al. Review:Endometrial function in pregnancy establishment in cattle[J]. Animal,2023, 17(Suppl 1):100751.
[7]Ealy A D, Wooldridge L K. The evolution of interferon-tau[J].Reproduction, 2017, 154(5):F1-F10.
[8]Kowalczyk A, Czerniawska P E, Wrzecinska M. The importance of interferon-tau in the diagnosis of pregnancy[J].Biomed Res Int, 2021, 2021:9915814.
[9]Xu L, Yang L, Liu W. Distinct evolution process among type I interferon in mammals[J]. Protein Cell, 2013, 4(5):383-392.
[10]Inaba R, Kawahara-Miki R, Shinozawa A, et al. Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows[J]. J Reprod Dev,2022, 68(1):30-37.
[11]Kim M S, Min K S, Seong H H, et al. Regulation of conceptus interferon-tau gene subtypes expressed in the uterus during the peri-implantation period of cattle[J]. Anim Reprod Sci, 2018,190:39-46.
[12]Guo Y, Song Z, Li C, et al. A novel type-I interferon family,bovine interferon-chi, is involved in positive-feedback regulation of interferon production[J]. Front Immunol, 2020, 11:528854.
[13]Ealy A D, Larson S F, Liu L, et al. Polymorphic forms of expressed bovine interferon-τgenes:relative transcript abundance during early placental development, promoter sequences of genes and biological activity of protein products[J]. Endocrinology, 2001, 142(7):2906-2915.
[14]Bazer F W, Spencer T E, Ott T L. Interferon tau:a novel pregnancy recognition signal[J]. Am J Reprod Immunol, 1997,37(6):412-420.
[15]付加雷,宋长征.干扰素-τ的研究进展[J].药物生物技术,2006, 13(1):74-78.
[16]Torres E H, Peralta L D, Flores F R, et al. Therapeutic implications of interferon tau in medicine[J]. Med Res Arch, 2024,12(11).
[17]Zoler E, Meyer T, Bellón J S, et al. Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy[J]. Sci Signal, 2024,17(863):eadl1892.
[18]Novotny L A, Meissner E G. Expression and function of interferon lambda receptor 1 variants[J]. FEBS Lett, 2025, 599(4):466-475.
[19]Shemesh M, Lochte S, Piehler J, et al. IFNAR1 and IFNAR2play distinct roles in initiating type I interferon-induced JAKSTAT signaling and activating STATs[J]. Sci Signal, 2021,14(710):eabe4627.
[20]Swaraj S, Tripathi S. Interference without interferon:interferonindependent induction of interferon-stimulated genes and its role in cellular innate immunity[J]. mBio, 2024, 15(10):e02582-24.
[21]Li C, Long L, Wang Y, et al. Constitutive type-1 interferons signaling activity in malignant gliomas[J]. J Neurooncol, 2024,168(3):381-391.
[22]Yousef M S, Imakawa K. Epithelial-Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants:Early Pregnancy Events in Cattle[J]. Int J Mol Sci, 2025, 26(8):3772.
[23]Ezashi T, Imakawa K. Transcriptional control of IFNT expression[J]. Reproduction, 2017, 154(5):F21-F31.
[24]Ezashi T, Roberts R M. Regulation of interferon-τ(IFN-τ)gene promoters by growth factors that target the Ets-2 composite enhancer:a possible model for maternal control of IFN-τproduction by the conceptus during early pregnancy[J]. Endocrinology, 2004, 145(10):4452-4460.
[25]Akizawa H, Saito S, Kohri N, et al. Deciphering two rounds of cell lineage segregations during bovine preimplantation development[J]. FASEB J, 2021, 35(10):e21904.
[26]Bai H, Sakurai T, Kim M S, et al. The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2[J]. Mol Reprod Dev, 2009, 76(12):1143-1152.
[27]Das P, Ezashi T, Gupta R, et al. Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line[J]. Mol Endocrinol, 2008, 22(2):331-343.
[28]Xu N, Takahashi Y, Matsuda F, et al. Coactivator CBP in the regulation of conceptus IFNtau gene transcription[J]. Mol Reprod Dev, 2003, 65(1):23-29.
[29]Perez G A, Gonzalez L, Bermejo A P, et al. Lineage differentiation markers as a proxy for embryo viability in farm ungulates[J]. Front Vet Sci, 2021, 8:680539.
[30]Sakurai T, Bai H, Konno T, et al. Function of a transcription factor CDX2 beyond its trophectoderm lineage specification[J].Endocrinology, 2010, 151(12):5873-5881.
[31]Sakurai T, Sakamoto A, Muroi Y, et al. Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells[J]. Biol Reprod, 2009, 80(6):1223-1231.
[32]Shi Y, Hu B, Wang Z, et al. Functional role of GATA3 and CDX2 in lineage specification during bovine early embryonic development[J]. Reproduction, 2023, 165(3):325-333.
[33]Bai H, Sakurai T, Kim M S, et al. Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-tau gene transcription[J]. Mol Reprod Dev, 2009,76(12):1143-1152.
[34]Kusama K, Bai R, Sakurai T, et al. A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses[J]. Domest Anim Endocrinol, 2016, 57:21-30.
[35]Ezashi T, Ghosh D, Roberts R M. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J]. Mol Cell Biol, 2001, 21(23):7883-7891.
[36]Aguila L, Osycka S C, Treulen F, et al. Pluripotent core in bovine embryos:a review[J]. Animals, 2022, 12(8):1010.
[37]Sakurai T, Bai H, Bai R, et al. Down-regulation of interferon tau gene transcription with a transcription factor, EOMES[J].Mol Reprod Dev, 2013, 80(5):371-383.
[38]Kim M S, Lim H J, Lee J H, et al. Temporal regulation of ovine interferon-tau gene by the transcription factor Eomesodermin in the peri-implantation period[J]. J Anim Reprod Biotechnol,2019, 34(4):292-299.
[39]Casano A B, Barile V L, Menchetti L, et al. Interferon tau(IFNt)and interferon-stimulated genes(ISGs)expression in peripheral blood leukocytes and correlation with circulating pregnancy-associated glycoproteins(PAGs)during peri-implantation and early pregnancy in buffalo cows[J]. Animals, 2022,12(22):3068.
[40]Bu L G, Wang B, Li T Y, et al. An IFNT/FOXO1/PTGS2 axis regulates prostaglandin F2α synthesis in goat uterus during early pregnancy[J]. J Dairy Sci, 2023, 106(11):8060-8071.
[41]Bai R, Kusama K, Matsuno Y, et al. Expression of NFIL3and CEBPA regulated by IFNT induced PGE2 in bovine endometrial stromal cells during the pre-implantation period[J].Front Endocrinol, 2023, 14:1075030.
[42]Johnson G A, Bazer F W, Burghardt R C, et al. The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs[J]. Reproduction, 2024, 168(4):e240130.
[43]Ma B, Cui H, Wang X, et al. IFNT-induced IRF1 enhances bovine endometrial receptivity by transactivating LIFR[J]. J Reprod Immunol, 2024, 163:104212.
[44]Kim M S, Min K S, Imakawa K. Regulation of interferon-stimulated gene(ISG)12, ISG15, and MX1 and MX2 by conceptus interferons(IFNTs)in bovine uterine epithelial cells[J]. AsianAustralas J Anim Sci, 2013, 26:795-803.
[45]Talukder A K, Rabaglino M B, Browne J A, et al. Dose-and time-dependent effects of interferon tau on bovine endometrial gene expression[J]. Theriogenology, 2023, 211:1-10.
[46]Zhao G, Wu H, Jiang K, et al. The anti-inflammatory effects of interferon tau by suppressing NF-κB/MMP9 in macrophages stimulated with Staphylococcus aureus[J]. J Interferon Cytokine Res, 2016, 36(8):516-524.
[47]Kasimanickam R K, Kasimanickam V R. mRNA expressions of candidate genes in gestational day 16 conceptus and corresponding endometrium in repeat breeder dairy cows with suboptimal uterine environment following transfer of different quality day 7 embryos[J]. Animals, 2021, 11(4):1092.
[48]Bazer F W, Seo H, Wu G, et al. Interferon tau:influences on growth and development of the conceptus[J]. Theriogenology,2020, 150:75-83.
[49]Bao Z J, Zhao S, Haq I U, et al. Recombinant bovine interferon-τenhances in vitro development of bovine embryos by upregulating expression of connexin 43 and E-cadherin[J]. J Dairy Sci, 2014, 97(11):6917-6925.
[50]Meyer M D, Hansen P J, Thatcher W W, et al. Extension of corpus luteum lifespan and reduction of uterine secretion of prostaglandin F2 alpha of cows in response to recombinant interferon-tau[J]. J Dairy Sci, 1995, 78(9):1921-1931.
[51]Guzeloglu A, Bishop J V, Van Campen H, et al. Interferon-tau infusion into the ovine corpus luteum delays luteolysis[J]. Biol Reprod, 2024, 111(3):667-677.
[52]Kubisch H M, Rasmussen T A, Johnson K M. Interferon-tau in bovine blastocysts following parthenogenetic activation of oocytes:pattern of secretion and polymorphism in expressed mRNA sequences[J]. Mol Reprod Dev, 2003, 64(1):79-85.
[53]Hirayama H, Moriyasu S, Kageyama S, et al. Enhancement of maternal recognition of pregnancy with parthenogenetic embryos in bovine embryo transfer[J]. Theriogenology, 2014,81(8):1108-1115.
[54]Hashiyada Y, Okada M, Imai K. Transition of the pregnancy rate of bisected bovine embryos after co-transfer with trophoblastic vesicles prepared from in vivo-cultured in vitro-fertilized embryos[J]. J Reprod Dev, 2005, 51(6):749-756.
[55]Bishop J V, Guzeloglu A, Scheller T, et al. Early identification of bovine pregnancy status and embryonic mortality[J]. Biol Reprod, 2025:ioaf066.
[56]Barbato O, Menchetti L, Casano A B, et al. Interferon-tau in maternal peripheral blood and its relationship with progesterone and pregnancy-associated glycoproteins in the early phases of gestation in water buffalo[J]. Animals, 2024, 14(11):1658.
[57]Casano A B, Menchetti L, Trabalza M M, et al. Gene expression of pregnancy-associated glycoproteins-1(PAG-1), interferontau(IFNt)and interferon stimulated genes(ISGs)as diagnostic and prognostic markers of maternal-fetal cellular interaction in buffalo cows[J]. Theriogenology, 2023, 209:89-97.
[58]郝海生.奶牛早期妊娠诊断技术的应用进展[J].中国草食动物科学, 2025, 45(3):80-86.
[59]Docchio M J, Campanile G, Baruselli P S. Transforming growth factor-β superfamily and interferon-τin ovarian function and embryo development in female cattle:review of biology and application[J]. Reprod Fertil Dev, 2020, 32(6):539-552.
[60]Schanzenbach C I, Bernal-Ulloa S M, Van der Weijden V A, et al. Blastocysts exhibit sex-specific signalling of IFNT transcription and activity[J]. Reproduction, 2019, 157(3):245-258.
[61]Palay P, Fathi D, Fathi R. Oocyte quality evaluation:a review of engineering approaches toward clinical challenges[J]. Biol Reprod, 2023, 108(3):393-407.
[62]Magata F. Time-lapse monitoring technologies for the selection of bovine in vitro fertilized embryos with high implantation potential[J]. J Reprod Dev, 2023, 69(2):57-64.
[63]Jochems R, Canedo-Ribeiro C, Silvestri G, et al. Preimplantation genetic testing for aneuploidy(PGT-A)reveals high levels of chromosomal errors in in vivo-derived pig embryos, with an increased incidence when produced in vitro[J]. Cells, 2023,12(5):790.
[64]Park J, Lee W, Saadelin I M, et al. Improved pregnancy rate and sex ratio in fresh/frozen in vivo derived embryo transfer of Hanwoo(Bos taurus coreanae)cows[J]. J Anim Sci Technol,2023, 65(4):779-790.
[65]Leme L O, Carvalho J O, Mendes C M, et al. Impact of sperm sex sorting on sperm quality and in vitro embryo production in bovine[J]. Anim Reprod Sci, 2024, 270:107604..")
收藏切换
干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展
收藏切换
PDF下载
中国畜牧杂志 | 综述 2026,62(2): 17-22
收起
收藏切换
中国畜牧杂志 |综述 2026 , 62 (2) : 17 -22
干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展
全屏
成元炜璐, 庞洋, 曾申明,
作者信息
    中国农业大学动物科学技术学院
通讯作者:
曾申明
作者简介:
成元炜璐(2001-),女,仡佬族,贵州人,本科生,主要从事动物繁殖理论与技术研究,E-mail:3385133320@qq.com;
  • Affiliations
    出版时间: 2025-12-31 doi: 10.19556/j.0258-7033.20241212-03
    文章导航
    收藏切换
    干扰素tau(IFNT)是由反刍动物胚胎滋养层细胞特异性分泌的一种I型干扰素,在妊娠早期发挥关键生理作用。IFNT的主要功能包括抑制子宫内膜前列腺F 2α (PGF 2α )的合成与分泌、阻断黄体溶解、维持孕酮持续分泌,同时具有抗炎、抗病毒、调节母体免疫耐受等作用,可促进胚胎着床与发育。IFNT的表达受特定转录因子及表观遗传修饰的动态调控。近年来,随着对IFNT作用机制的深入研究,其在提高反刍动物繁殖效率和加速遗传改良中的应用潜力日益凸显。本文综述了IFNT的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用,以期为相关领域的研究提供理论依据。
    IFNT  /  结构  /  抗黄体溶解  /  妊娠识别
    成元炜璐, 庞洋, 曾申明,. 干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展. 中国畜牧杂志, 2026 , 62 (2) : 17 -22 . DOI: 10.19556/j.0258-7033.20241212-03

      国家重点研发计划(2023YFD1300102-2);宁夏回族自治区中央引导地方科技发展专项项目(2024FRD05031-01);

    参考文献 引证文献
    排序方式:
    [1]Talukder A K, McDonald M, Browne J A, et al. Response of bovine endometrium to interferon tau in the presence of lipopolysaccharide[J]. Theriogenology, 2024, 229:169-177.
    [2]Feltrin I R. Study of genes stimulated by interferon-τin imune cells as candidates for pregnancy markers in bovine females[D].Claudia M B:UNESP, 2024.
    [3]Bai H, Kawahara M, Takahashi M, et al. Recent progress of interferon-tau research and potential direction beyond pregnancy recognition[J]. J Reprod Dev, 2022, 68(5):299-306.
    [4]Tekdal A E. Maternal acceptance of pregnancy and implantation process in sheep[J]. MAS J Appl Sci, 2022, 7(Özel Sayı):1171-1183.
    [5]Geisert R D, Bazer F W, Lucas C G, et al. Maternal recognition of pregnancy in the pig:A servomechanism involving sex steroids, cytokines and prostaglandins[J]. Anim Reprod Sci,2024, 264:107452.
    [6]Tinning H, Edge J C, DeBem T H C, et al. Review:Endometrial function in pregnancy establishment in cattle[J]. Animal,2023, 17(Suppl 1):100751.
    [7]Ealy A D, Wooldridge L K. The evolution of interferon-tau[J].Reproduction, 2017, 154(5):F1-F10.
    [8]Kowalczyk A, Czerniawska P E, Wrzecinska M. The importance of interferon-tau in the diagnosis of pregnancy[J].Biomed Res Int, 2021, 2021:9915814.
    [9]Xu L, Yang L, Liu W. Distinct evolution process among type I interferon in mammals[J]. Protein Cell, 2013, 4(5):383-392.
    [10]Inaba R, Kawahara-Miki R, Shinozawa A, et al. Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows[J]. J Reprod Dev,2022, 68(1):30-37.
    [11]Kim M S, Min K S, Seong H H, et al. Regulation of conceptus interferon-tau gene subtypes expressed in the uterus during the peri-implantation period of cattle[J]. Anim Reprod Sci, 2018,190:39-46.
    [12]Guo Y, Song Z, Li C, et al. A novel type-I interferon family,bovine interferon-chi, is involved in positive-feedback regulation of interferon production[J]. Front Immunol, 2020, 11:528854.
    [13]Ealy A D, Larson S F, Liu L, et al. Polymorphic forms of expressed bovine interferon-τgenes:relative transcript abundance during early placental development, promoter sequences of genes and biological activity of protein products[J]. Endocrinology, 2001, 142(7):2906-2915.
    [14]Bazer F W, Spencer T E, Ott T L. Interferon tau:a novel pregnancy recognition signal[J]. Am J Reprod Immunol, 1997,37(6):412-420.
    [15]付加雷,宋长征.干扰素-τ的研究进展[J].药物生物技术,2006, 13(1):74-78.
    [16]Torres E H, Peralta L D, Flores F R, et al. Therapeutic implications of interferon tau in medicine[J]. Med Res Arch, 2024,12(11).
    [17]Zoler E, Meyer T, Bellón J S, et al. Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy[J]. Sci Signal, 2024,17(863):eadl1892.
    [18]Novotny L A, Meissner E G. Expression and function of interferon lambda receptor 1 variants[J]. FEBS Lett, 2025, 599(4):466-475.
    [19]Shemesh M, Lochte S, Piehler J, et al. IFNAR1 and IFNAR2play distinct roles in initiating type I interferon-induced JAKSTAT signaling and activating STATs[J]. Sci Signal, 2021,14(710):eabe4627.
    [20]Swaraj S, Tripathi S. Interference without interferon:interferonindependent induction of interferon-stimulated genes and its role in cellular innate immunity[J]. mBio, 2024, 15(10):e02582-24.
    [21]Li C, Long L, Wang Y, et al. Constitutive type-1 interferons signaling activity in malignant gliomas[J]. J Neurooncol, 2024,168(3):381-391.
    [22]Yousef M S, Imakawa K. Epithelial-Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants:Early Pregnancy Events in Cattle[J]. Int J Mol Sci, 2025, 26(8):3772.
    [23]Ezashi T, Imakawa K. Transcriptional control of IFNT expression[J]. Reproduction, 2017, 154(5):F21-F31.
    [24]Ezashi T, Roberts R M. Regulation of interferon-τ(IFN-τ)gene promoters by growth factors that target the Ets-2 composite enhancer:a possible model for maternal control of IFN-τproduction by the conceptus during early pregnancy[J]. Endocrinology, 2004, 145(10):4452-4460.
    [25]Akizawa H, Saito S, Kohri N, et al. Deciphering two rounds of cell lineage segregations during bovine preimplantation development[J]. FASEB J, 2021, 35(10):e21904.
    [26]Bai H, Sakurai T, Kim M S, et al. The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2[J]. Mol Reprod Dev, 2009, 76(12):1143-1152.
    [27]Das P, Ezashi T, Gupta R, et al. Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line[J]. Mol Endocrinol, 2008, 22(2):331-343.
    [28]Xu N, Takahashi Y, Matsuda F, et al. Coactivator CBP in the regulation of conceptus IFNtau gene transcription[J]. Mol Reprod Dev, 2003, 65(1):23-29.
    [29]Perez G A, Gonzalez L, Bermejo A P, et al. Lineage differentiation markers as a proxy for embryo viability in farm ungulates[J]. Front Vet Sci, 2021, 8:680539.
    [30]Sakurai T, Bai H, Konno T, et al. Function of a transcription factor CDX2 beyond its trophectoderm lineage specification[J].Endocrinology, 2010, 151(12):5873-5881.
    [31]Sakurai T, Sakamoto A, Muroi Y, et al. Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells[J]. Biol Reprod, 2009, 80(6):1223-1231.
    [32]Shi Y, Hu B, Wang Z, et al. Functional role of GATA3 and CDX2 in lineage specification during bovine early embryonic development[J]. Reproduction, 2023, 165(3):325-333.
    [33]Bai H, Sakurai T, Kim M S, et al. Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-tau gene transcription[J]. Mol Reprod Dev, 2009,76(12):1143-1152.
    [34]Kusama K, Bai R, Sakurai T, et al. A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses[J]. Domest Anim Endocrinol, 2016, 57:21-30.
    [35]Ezashi T, Ghosh D, Roberts R M. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J]. Mol Cell Biol, 2001, 21(23):7883-7891.
    [36]Aguila L, Osycka S C, Treulen F, et al. Pluripotent core in bovine embryos:a review[J]. Animals, 2022, 12(8):1010.
    [37]Sakurai T, Bai H, Bai R, et al. Down-regulation of interferon tau gene transcription with a transcription factor, EOMES[J].Mol Reprod Dev, 2013, 80(5):371-383.
    [38]Kim M S, Lim H J, Lee J H, et al. Temporal regulation of ovine interferon-tau gene by the transcription factor Eomesodermin in the peri-implantation period[J]. J Anim Reprod Biotechnol,2019, 34(4):292-299.
    [39]Casano A B, Barile V L, Menchetti L, et al. Interferon tau(IFNt)and interferon-stimulated genes(ISGs)expression in peripheral blood leukocytes and correlation with circulating pregnancy-associated glycoproteins(PAGs)during peri-implantation and early pregnancy in buffalo cows[J]. Animals, 2022,12(22):3068.
    [40]Bu L G, Wang B, Li T Y, et al. An IFNT/FOXO1/PTGS2 axis regulates prostaglandin F2α synthesis in goat uterus during early pregnancy[J]. J Dairy Sci, 2023, 106(11):8060-8071.
    [41]Bai R, Kusama K, Matsuno Y, et al. Expression of NFIL3and CEBPA regulated by IFNT induced PGE2 in bovine endometrial stromal cells during the pre-implantation period[J].Front Endocrinol, 2023, 14:1075030.
    [42]Johnson G A, Bazer F W, Burghardt R C, et al. The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs[J]. Reproduction, 2024, 168(4):e240130.
    [43]Ma B, Cui H, Wang X, et al. IFNT-induced IRF1 enhances bovine endometrial receptivity by transactivating LIFR[J]. J Reprod Immunol, 2024, 163:104212.
    [44]Kim M S, Min K S, Imakawa K. Regulation of interferon-stimulated gene(ISG)12, ISG15, and MX1 and MX2 by conceptus interferons(IFNTs)in bovine uterine epithelial cells[J]. AsianAustralas J Anim Sci, 2013, 26:795-803.
    [45]Talukder A K, Rabaglino M B, Browne J A, et al. Dose-and time-dependent effects of interferon tau on bovine endometrial gene expression[J]. Theriogenology, 2023, 211:1-10.
    [46]Zhao G, Wu H, Jiang K, et al. The anti-inflammatory effects of interferon tau by suppressing NF-κB/MMP9 in macrophages stimulated with Staphylococcus aureus[J]. J Interferon Cytokine Res, 2016, 36(8):516-524.
    [47]Kasimanickam R K, Kasimanickam V R. mRNA expressions of candidate genes in gestational day 16 conceptus and corresponding endometrium in repeat breeder dairy cows with suboptimal uterine environment following transfer of different quality day 7 embryos[J]. Animals, 2021, 11(4):1092.
    [48]Bazer F W, Seo H, Wu G, et al. Interferon tau:influences on growth and development of the conceptus[J]. Theriogenology,2020, 150:75-83.
    [49]Bao Z J, Zhao S, Haq I U, et al. Recombinant bovine interferon-τenhances in vitro development of bovine embryos by upregulating expression of connexin 43 and E-cadherin[J]. J Dairy Sci, 2014, 97(11):6917-6925.
    [50]Meyer M D, Hansen P J, Thatcher W W, et al. Extension of corpus luteum lifespan and reduction of uterine secretion of prostaglandin F2 alpha of cows in response to recombinant interferon-tau[J]. J Dairy Sci, 1995, 78(9):1921-1931.
    [51]Guzeloglu A, Bishop J V, Van Campen H, et al. Interferon-tau infusion into the ovine corpus luteum delays luteolysis[J]. Biol Reprod, 2024, 111(3):667-677.
    [52]Kubisch H M, Rasmussen T A, Johnson K M. Interferon-tau in bovine blastocysts following parthenogenetic activation of oocytes:pattern of secretion and polymorphism in expressed mRNA sequences[J]. Mol Reprod Dev, 2003, 64(1):79-85.
    [53]Hirayama H, Moriyasu S, Kageyama S, et al. Enhancement of maternal recognition of pregnancy with parthenogenetic embryos in bovine embryo transfer[J]. Theriogenology, 2014,81(8):1108-1115.
    [54]Hashiyada Y, Okada M, Imai K. Transition of the pregnancy rate of bisected bovine embryos after co-transfer with trophoblastic vesicles prepared from in vivo-cultured in vitro-fertilized embryos[J]. J Reprod Dev, 2005, 51(6):749-756.
    [55]Bishop J V, Guzeloglu A, Scheller T, et al. Early identification of bovine pregnancy status and embryonic mortality[J]. Biol Reprod, 2025:ioaf066.
    [56]Barbato O, Menchetti L, Casano A B, et al. Interferon-tau in maternal peripheral blood and its relationship with progesterone and pregnancy-associated glycoproteins in the early phases of gestation in water buffalo[J]. Animals, 2024, 14(11):1658.
    [57]Casano A B, Menchetti L, Trabalza M M, et al. Gene expression of pregnancy-associated glycoproteins-1(PAG-1), interferontau(IFNt)and interferon stimulated genes(ISGs)as diagnostic and prognostic markers of maternal-fetal cellular interaction in buffalo cows[J]. Theriogenology, 2023, 209:89-97.
    [58]郝海生.奶牛早期妊娠诊断技术的应用进展[J].中国草食动物科学, 2025, 45(3):80-86.
    [59]Docchio M J, Campanile G, Baruselli P S. Transforming growth factor-β superfamily and interferon-τin ovarian function and embryo development in female cattle:review of biology and application[J]. Reprod Fertil Dev, 2020, 32(6):539-552.
    [60]Schanzenbach C I, Bernal-Ulloa S M, Van der Weijden V A, et al. Blastocysts exhibit sex-specific signalling of IFNT transcription and activity[J]. Reproduction, 2019, 157(3):245-258.
    [61]Palay P, Fathi D, Fathi R. Oocyte quality evaluation:a review of engineering approaches toward clinical challenges[J]. Biol Reprod, 2023, 108(3):393-407.
    [62]Magata F. Time-lapse monitoring technologies for the selection of bovine in vitro fertilized embryos with high implantation potential[J]. J Reprod Dev, 2023, 69(2):57-64.
    [63]Jochems R, Canedo-Ribeiro C, Silvestri G, et al. Preimplantation genetic testing for aneuploidy(PGT-A)reveals high levels of chromosomal errors in in vivo-derived pig embryos, with an increased incidence when produced in vitro[J]. Cells, 2023,12(5):790.
    [64]Park J, Lee W, Saadelin I M, et al. Improved pregnancy rate and sex ratio in fresh/frozen in vivo derived embryo transfer of Hanwoo(Bos taurus coreanae)cows[J]. J Anim Sci Technol,2023, 65(4):779-790.
    [65]Leme L O, Carvalho J O, Mendes C M, et al. Impact of sperm sex sorting on sperm quality and in vitro embryo production in bovine[J]. Anim Reprod Sci, 2024, 270:107604.."
    2026年第62卷第2期
    PDF下载
    38
    3
    引用本文
    BibTeX
    文章信息
    doi: 10.19556/j.0258-7033.20241212-03
    • 首发时间:2026-07-01
    • 出版时间:2025-12-31
    补充材料
    相关文章
    文章信息
    作者
    出版历史
    基金
    作者信息
    参考文献
    分享链接
    https://castjournals.cast.org.cn/joweb/zgxmzz/CN/10.19556/j.0258-7033.20241212-03
    分享至
    全文二维码

    扫描看全文

    引用本文
    BibTeX
    本文的引用情况
    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
    关闭全屏