Article(id=1320326743425139038, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320326738383585614, articleNumber=null, orderNo=null, doi=10.12377/1671-4393.25.06.03, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792720026117, onlineDateStr=2026-10-23, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792720026117, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792720026117, creator=13701087609, updateTime=1792720026117, updator=13701087609, issue=Issue{id=1320326738383585614, tenantId=1146029695717560320, journalId=1296801528146919473, year='2025', volume='', issue='6', pageStart='1', pageEnd='139', issueExtLink='null', onlineDate='null', pubDate='1750780800000', pubDateStr='2025-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792720024915, creator='13701087609', updateTime=1792720084473, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320326988263440941, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320326738383585614, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320326988263440942, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320326738383585614, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=14, endPage=20, ext={EN=ArticleExt(id=1320326744276582753, articleId=1320326743425139038, tenantId=1146029695717560320, journalId=1296801528146919473, language=EN, title=Application of Buserelin in Dairy Cattle Reproduction Production, columnId=null, journalTitle=China Dairy, columnName=null, runingTitle=null, highlight=null, articleAbstract=This paper delved into the application of Buserelin in timed artificial insemination （TAI） protocols for dairy cattle,while also elaborating on strategies for improving conception rates and its use in treating ovarian disorders. Additionally,a comparative analysis is conducted between Buserelin and Gonadorelin,highlighting their functional differences,mechanisms of action,and respective advantages in applicable scenarios thereby revealing the unique role and value of Buserelin in dairy cattle reproduction. Through extensive and rigorous field trial data,this study evaluated the practical efficacy of Buserelin. Furthermore it explored the potential impact of this product on early pregnancy embryo loss in dairy cows,integrating other reproductive technologies to mitigate the risk of early embryonic loss and enhance reproductive efficiency and economic benefits. By providing an in-depth analysis of Buserelin’s pharmacological mechanisms and empirical research on its practical application in dairy reproduction,this paper aimed to offer scientifically sound methods and strategies for efficient breeding in the dairy industry,promoting more scientific,efficient,and sustainable development in dairy farming., authors=GUO Zhijian, LI Qiang, authorsList=GUO Zhijian, LI Qiang, authorCompany=Ningbo Sansheng Biotechnology Co., Ltd., Ningbo Zhejiang 315000, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320326744008147296, articleId=1320326743425139038, tenantId=1146029695717560320, journalId=1296801528146919473, language=CN, title=布舍瑞林在奶牛繁殖生产中的应用, columnId=1319995133970460838, journalTitle=中国乳业, columnName=奶牛繁殖健康管理专栏, runingTitle=null, highlight=null, articleAbstract=本文深入研究布舍瑞林在奶牛同期定时输精程序中的应用,同时对提高受胎率方案策略及治疗卵巢疾病中的应用也进行阐述。本文还对比分析了布舍瑞林（Buserelin）与戈那瑞林在功能、作用机制以及适用场景等方面的区别与优势,揭示了布舍瑞林在奶牛繁殖领域独特的作用和价值。通过大量严谨的田间试验数据,本文评估了布舍瑞林在实际应用中的效果,此外,还探讨了该产品对早期妊娠奶牛胚胎损失可能产生的影响,结合其他繁殖技术方案,以降低早期胚胎损失风险,提高奶牛繁殖效率和经济效益。本文通过对布舍瑞林药理作用机制的深度剖析,以及其在奶牛繁殖实践中具体应用效果的实证研究,旨在为奶牛养殖业提供一套高效繁育的科学方法和策略,助力奶牛养殖业向更科学、更高效、更可持续的方向发展。, authors=郭志坚, 李强, authorsList=郭志坚, 李强, authorCompany=宁波三生生物科技股份有限公司, 浙江宁波 315000, correspAuthors=null, authorNote=郭志坚（1991-）,男,黑龙江齐齐哈尔人,本科,研究方向为反刍动物繁殖与生理学;李强（1972-）,男,江苏南通人,专科,研究方向为反刍动物繁殖与生理学。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=HzmUXou9faVra7x/t86Hxg==, pdfFileSize=2857235, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1320326744746344803, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=CN, orderNo=1, keyword=布舍瑞林（Buserelin）), Keyword(id=1320326745115443556, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=CN, orderNo=2, keyword=同期定时输精), Keyword(id=1320326745526485350, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=CN, orderNo=3, keyword=早期胚胎死亡), Keyword(id=1320326745597788519, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=CN, orderNo=4, keyword=繁殖效率提升), Keyword(id=1320326746386317672, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=EN, orderNo=1, keyword=Buserelin), Keyword(id=1320326747401339241, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=EN, orderNo=2, keyword=timed artificial insemination), Keyword(id=1320326747493613930, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=EN, orderNo=3, keyword=early embryonic death), Keyword(id=1320326747619443051, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320326743425139038, language=EN, orderNo=4, keyword=reproductive efficiency improvement)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1296801172792901679, delFlag=0, nameCn=中国乳业, nameEn=China Dairy, nameHistory1=null, nameHistory2=null, issn=1671-4393, eissn=null, cn=11-4768/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=fy0U6rTUhrcBdKszdYVe3w==, journalPrice=null, startedYear=null, abbrevIsoEn=China Dairy, journalRemark=null, publicationField=null, createdTime=1787111092997, updatedTime=1788949480572, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Agriculture, subjectName=null, subjectCodeEn=Agriculture, subjectNameEn=null, picCn=fy0U6rTUhrcBdKszdYVe3w==, picEn=1lm7RNSd456gWkkoaDGdEQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511929255481461, language=CN, name=中国乳业, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480594, updatedTime=1788949480594, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511929301618806, language=EN, name=China Dairy, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480605, updatedTime=1788949480605, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1296801528146919473, websiteList=[Website(id=1296802542923572121, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/CN, language=CN, createTime=1787111419659, createBy=18614031015, updateTime=1787111471367, updateBy=18614031015, name=中国乳业-中文, tplId=1146099689490845704, title=中国乳业, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802881777198042, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=articleTextType, value=kx, createTime=1787111500448, updateTime=1787111500448, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881747837911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=banner, value=null, createTime=1787111500441, updateTime=1787111500441, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881827529693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=grayFlag, value=0, createTime=1787111500460, updateTime=1787111500460, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881735254998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111500438, updateTime=1787111500438, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881844306911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=minRunFlag, value=0, createTime=1787111500464, updateTime=1787111500464, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881768809433, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic, createTime=1787111500446, updateTime=1787111500446, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881835918302, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=silenceFlag, value=0, createTime=1787111500462, updateTime=1787111500462, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881760420824, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1787111500444, updateTime=1787111500444, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881810752475, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeColor, value=null, createTime=1787111500456, updateTime=1787111500456, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881819141084, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeStyle, value=null, createTime=1787111500458, updateTime=1787111500458, creator=18614031015, updator=18614031015)]), Website(id=1296802543032624028, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/EN, language=EN, createTime=1787111419685, createBy=18614031015, updateTime=1787111462939, updateBy=18614031015, name=中国乳业-英文, tplId=1146101810881728533, title=China Dairy, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802850798068681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=articleTextType, value=kx, createTime=1787111493062, updateTime=1787111493062, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850768708550, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=banner, value=null, createTime=1787111493055, updateTime=1787111493055, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850819040204, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=grayFlag, value=0, createTime=1787111493067, updateTime=1787111493067, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850760319941, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111493053, updateTime=1787111493053, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850831623118, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=minRunFlag, value=0, createTime=1787111493070, updateTime=1787111493070, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850789680072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic, createTime=1787111493060, updateTime=1787111493060, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850823234509, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=silenceFlag, value=0, createTime=1787111493068, updateTime=1787111493068, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850781291463, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1787111493058, updateTime=1787111493058, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850802262986, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeColor, value=null, createTime=1787111493063, updateTime=1787111493063, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850810651595, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeStyle, value=null, createTime=1787111493065, updateTime=1787111493065, creator=18614031015, updator=18614031015)])], journalTitle=中国乳业, weixinUrl=null, journalUrl=http://zhgry.aiijournal.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=China Dairy, journalPhotoCn=fy0U6rTUhrcBdKszdYVe3w==, journalPhotoEn=1lm7RNSd456gWkkoaDGdEQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/10.12377/1671-4393.25.06.03, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/10.12377/1671-4393.25.06.03, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/PDF/10.12377/1671-4393.25.06.03, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/PDF/10.12377/1671-4393.25.06.03, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1792720026117, fullTextJson=null, articleText=null, reference=[1] 代涛,尹志峰,赵红玲,等.布舍瑞林的合成[J].中国新药杂志,2014,23(15):1806-1810.
[2] 顾文源,苏硕青,刘玉,等.布舍瑞林在奶牛同期发情-定时输精中的应用效果分析[J].中国畜牧杂志,2021,57(5):149-153.
[3] 琚滢蓥, 徐宏伟, 叶小惠,等.布舍瑞林的研究概述[J]. 海峡药学,2014,26(4):12-14.
[4] 佟太锋. 布舍瑞林的液相全合成研究[D]. 北京:北京化工大学,2006.
[5] Diskin M G,Murphy J J,Sreenan J M.Embryo survival in dairy cows managed under pastoral conditions[J]. Animal Reproduction Science,2006,96(3-4):297-311.
[6] Wijma R,Stangaferro M L,Kamat M M,et al.Embryo mortality around the period of maintenance of the corpus luteum causes alterations to the ovarian function of lactating dairy cows[J]. Biology of Reproduction,2016,95(5):112.
[7] Dailey R A,Inskeep E K,Lewis P L.Pregnancy failures in cattle:a perspective on embryo loss[C]//Proceedings of the 18th International Conference on Reproduction of Farm Animals. Slovakia,2002:1-8.
[8] Puget C,Joueidi Y,Bauville E,et al.Serial HCG and progesterone levels to predict early pregnancy outcomes in pregnancies of uncertain viability:a prospective study[J]. European Journal of Obstetrics & Gynecology and Reproductive Biology,2018,220:100-105.
[9] Ortega H H,Díaz P U,Salvetti N R,et al.Follicular cysts:a single sign and different diseases. A view from comparative medicine[J]. Current Pharmaceutical Design,2016,22(36):5634-5645.
[10] Pesántez J L,Ortiz O,Hernández-Cerón J.Incidence of ovarian follicular cysts and their effect on reproductive performance in dairy cows:A case study in Mexico[J]. Austral Journal of Veterinary Science,2016,48(3):289-291.
[11] Roman L,Broshkov M,Popova I,et al.Influence of ovarian follicular cysts on reproductive performance in the cattle of new Ukrainian red dairy breed[J]. Ukrainian Journal of Ecology,2020,10(2):426-434.
[12] Cook D L,Woods G L,Smith C A,et al.Secretory patterns of LH and FSH during development and hypothalamic and hypophysial characteristics following development of steroid-induced ovarian follicular cysts in dairy cattle[J]. Reproduction,1991,91(1):19-28.
[13] 邵亚群,李强.布舍瑞林在治疗奶牛卵巢囊肿中的应用[J].中国乳业,2024(5):49-52.
[14] Beam S W,Butler W R.Effects of energy balance on follicular development and first ovulation in postpartum dairy cows[J]. Journal of Reproduction and Fertility-Supplement,1999: 411-424.
[15] Ijaz A,Fahning M L,Zemjanis R.Treatment and control of cystic ovarian disease in dairy cattle:A review[J].British Veterinary Journal,1987,143(3):226-237.
[16] Bierschwal C J,Garverick H A,Martin C E,et al.Clinical response of dairy cows with ovarian cysts to GnRH[J].Journal of Animal Science,1975,41:1660-1665.
[17] Picard-Hagen N,Lhermie G,Florentin S,et al.Effect of gonadorelin,lecirelin,and buserelin on LH surge,ovulationand progesterone in cattle[J].Theriogenology, 2015,84(2):177-183.
[18] Probo M,Comin A,Mollo A,et al.Reproductive performance of dairy cows with luteal or follicular ovarian cysts after treatment with buserelin[J].Animal Reproduction Science, 2011,127(3/4):135-139.)