Article(id=1297139267000619901, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297139249468433079, articleNumber=null, orderNo=null, doi=10.12377/1671-4393.26.05.11, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1787191700935, onlineDateStr=2026-08-20, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1787191700935, onlineIssueDateStr=2026-08-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1787191700935, creator=13701087609, updateTime=1787191700935, updator=13701087609, issue=Issue{id=1297139249468433079, tenantId=1146029695717560320, journalId=1296801528146919473, year='2026', volume='', issue='5', pageStart='2', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1787191696754, creator='13701087609', updateTime=1787192231935, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1297141494226383122, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297139249468433079, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1297141494226383123, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297139249468433079, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=71, endPage=78, ext={EN=ArticleExt(id=1297139267197752190, articleId=1297139267000619901, tenantId=1146029695717560320, journalId=1296801528146919473, language=EN, title=Clinical Efficacy of the Chinese Medicine Compound Rulikang in the Treatment of Bovine Mastitis, columnId=1297134042869158672, journalTitle=China Dairy, columnName=DISEASE PREVENTION, runingTitle=null, highlight=null, articleAbstract=
[Objective]

This study aimed to verify the antibacterial effect and clinical efficacy of Chinese Medicine Compound Rulikang against pathogenic bacteria of bovine mastitis.

[Method]

Chinese Medicine Compound Rulikang, consisting of Taraxacum mongolicum, Forsythia suspensa, Akebia quinata, Vaccaria segetalis and Astragalus membranaceus, was prepared into liquid with a crude drug concentration of 1 g/mL by water decoction and concentration. Escherichia coli, Staphylococcus aureus and Streptococcus agalactiae isolated from clinical bovine mastitis cases were used to assess its in vitro antibacterial activity. Thirty bovines suffering from clinical mastitis were assigned into low, medium and high dose groups, while 10 healthy bovines were set as the control group. Intramammary perfusion was performed twice a day for 7 consecutive days. The clinical efficacy and variations of milk protein indicators were observed.

[Result]

Chinese Medicine Compound Rulikang exhibited strong inhibitory effects on the three pathogenic strains. After 7 days of treatment, the effective rate and cure rate of the high dose group reached 88.2% (15/17) and 82.4% (14/17), respectively. Milk yield of all administration groups was higher than that of the control group. The levels of SA, ALT, AST and LDH in cow whey decreased significantly (P<0.05), whereas lactose content barely changed.

[Conclusion]

Chinese Medicine Compound Rulikang had prominent therapeutic effects on clinical bovine mastitis, which provided a safe and effective herbal preparation for the disease treatment.

, authors=Ziqi TAO1, Arsebek Jumamamat1, Yali LI2, Chao GONG1, Bo WANG1, Wanhe LUO3, Yakup Omar1, Zhihui HAO1, 4, Yan SUN5, Juncheng HAN1, *, Xiaohua DAI1, *, authorsList=Ziqi TAO, Arsebek Jumamamat, Yali LI, Chao GONG, Bo WANG, Wanhe LUO, Yakup Omar, Zhihui HAO, Yan SUN, Juncheng HAN, Xiaohua DAI, authorCompany=null, correspAuthors=Juncheng HAN, Xiaohua DAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1297139267499742079, articleId=1297139267000619901, tenantId=1146029695717560320, journalId=1296801528146919473, language=CN, title=中药复方乳立康对奶牛乳房炎的临床疗效研究, columnId=1297134043032736530, journalTitle=中国乳业, columnName=疾病防治, runingTitle=null, highlight=null, articleAbstract=
[目的]

验证中药复方乳立康对奶牛乳房炎致病菌的抑菌效果及临床疗效。

[方法]

本研究选用中药复方乳立康(由蒲公英、连翘、木通、王不留行和黄芪组成的中药复方)按照水煎浓缩法制成含生药1 g/mL的药液,选用临床型奶牛乳房炎源大肠杆菌、金黄色葡萄球菌和无乳链球菌,探究体外抑菌效果。将30头患有临床型乳房炎的奶牛分为低、中、高剂量组,10头健康奶牛为对照组,乳区灌注2次/d,连续7 d,观察中药复方乳立康对奶牛乳房炎的临床疗效和乳样蛋白的变化。

[结果]

中药复方乳立康对大肠杆菌、金黄色葡萄球菌和无乳链球菌具有较强的抑制作用,在实验7 d后,高剂量组有效率和治愈率分别达88.2%(15/17)、82.4%(14/17),低、中、高剂量组的产奶量均高于对照组;奶牛乳清中的SA、ALT、AST及LDH含量均显著降低(P<0.05),但对乳糖几乎无影响。

[结论]

中药复方乳立康对临床型奶牛乳房炎有显著的治疗效果,为治疗临床型奶牛乳房炎提供了安全有效的中药制剂。

, authors=陶子奇1, 阿尔斯别克·朱马买买提1, 李亚丽2, 弓超1, 王博1, 罗万和3, 吾买尔江·牙合甫1, 郝智慧1, 4, 孙岩5, 韩俊成1, *, 戴小华1, *, authorsList=陶子奇, 阿尔斯别克·朱马买买提, 李亚丽, 弓超, 王博, 罗万和, 吾买尔江·牙合甫, 郝智慧, 孙岩, 韩俊成, 戴小华, authorCompany=null, correspAuthors=韩俊成, 戴小华, authorNote=

陶子奇(2001-),男,江西九江人,硕士,研究方向为中兽药防治奶牛乳房炎

阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

李亚丽(1989-),女,河南周口人,博士,讲师,研究方向为兽医药理学与毒理学

弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

王博(2004-),男,河南信阳人,本科,研究方向为中兽药防治奶牛乳房炎

罗万和(1994-),男,河南南阳人,博士,讲师,研究方向为靶向纳米凝胶载药系统

吾买尔江·牙合甫(1988-),男,新疆哈密人,博士,讲师,研究方向为天然药物化学成分功能

郝智慧(1980-),女,内蒙古赤峰人,博士,教授,研究方向为新兽药

孙岩(1986-),男,河南社旗人,本科,研究方向为奶牛健康养殖。

, correspAuthorsNote=

*

韩俊成(1988-),男,河南周口人,博士,讲师,研究方向为新兽药
戴小华(1976-),女,广西陆川人,博士,副教授,研究方向为天然产物功能。
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陶子奇(2001-),男,江西九江人,硕士,研究方向为中兽药防治奶牛乳房炎

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陶子奇(2001-),男,江西九江人,硕士,研究方向为中兽药防治奶牛乳房炎

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阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

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阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

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李亚丽(1989-),女,河南周口人,博士,讲师,研究方向为兽医药理学与毒理学

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李亚丽(1989-),女,河南周口人,博士,讲师,研究方向为兽医药理学与毒理学

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弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

"}, bioImg=null, bioContent=

弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

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王博(2004-),男,河南信阳人,本科,研究方向为中兽药防治奶牛乳房炎

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王博(2004-),男,河南信阳人,本科,研究方向为中兽药防治奶牛乳房炎

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中药复方乳立康对奶牛乳房炎的临床疗效研究
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陶子奇 1 , 阿尔斯别克·朱马买买提 1 , 李亚丽 2 , 弓超 1 , 王博 1 , 罗万和 3 , 吾买尔江·牙合甫 1 , 郝智慧 1, 4 , 孙岩 5 , 韩俊成 1, * , 戴小华 1, *
中国乳业 | 疾病防治 2026,(5): 71-78
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中国乳业 |疾病防治 2026 , (5) : 71 -78
中药复方乳立康对奶牛乳房炎的临床疗效研究
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阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

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阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

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李亚丽(1989-),女,河南周口人,博士,讲师,研究方向为兽医药理学与毒理学

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弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

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弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

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王博(2004-),男,河南信阳人,本科,研究方向为中兽药防治奶牛乳房炎

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罗万和(1994-),男,河南南阳人,博士,讲师,研究方向为靶向纳米凝胶载药系统

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罗万和(1994-),男,河南南阳人,博士,讲师,研究方向为靶向纳米凝胶载药系统

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吾买尔江·牙合甫(1988-),男,新疆哈密人,博士,讲师,研究方向为天然药物化学成分功能

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郝智慧(1980-),女,内蒙古赤峰人,博士,教授,研究方向为新兽药

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郝智慧(1980-),女,内蒙古赤峰人,博士,教授,研究方向为新兽药

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孙岩(1986-),男,河南社旗人,本科,研究方向为奶牛健康养殖。

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陶子奇1, 阿尔斯别克·朱马买买提1, 李亚丽2, 弓超1, 王博1, 罗万和3, 吾买尔江·牙合甫1, 郝智慧1, 4, 孙岩5, 韩俊成1, *, 戴小华1, *
作者信息
  • 1.新疆农业大学动物医学学院新疆草食动物新药研究与创制重点实验室,新疆 乌鲁木齐 830052
  • 2.新疆农业职业大学动物科技学院,新疆 昌吉 831100
  • 3.塔里木大学动物科学与技术学院动物疫病诊断与防控工程实验室,新疆 阿拉尔 843300
  • 4.中国农业大学动物医学院,农业农村部中兽医生物学重点实验室,北京 100193
  • 5. 新疆农牧投集团豪子畜牧有限公司,新疆 昌吉 831100
通讯作者:

*

韩俊成(1988-),男,河南周口人,博士,讲师,研究方向为新兽药
戴小华(1976-),女,广西陆川人,博士,副教授,研究方向为天然产物功能。
作者简介:

陶子奇(2001-),男,江西九江人,硕士,研究方向为中兽药防治奶牛乳房炎

阿尔斯别克·朱马买买提(1998-),男,新疆克州人,本科,研究方向为中兽药防治奶牛乳房炎

李亚丽(1989-),女,河南周口人,博士,讲师,研究方向为兽医药理学与毒理学

弓超(1991-),男,河南三门峡人,博士,讲师,研究方向为人兽共患寄生虫病

王博(2004-),男,河南信阳人,本科,研究方向为中兽药防治奶牛乳房炎

罗万和(1994-),男,河南南阳人,博士,讲师,研究方向为靶向纳米凝胶载药系统

吾买尔江·牙合甫(1988-),男,新疆哈密人,博士,讲师,研究方向为天然药物化学成分功能

郝智慧(1980-),女,内蒙古赤峰人,博士,教授,研究方向为新兽药

孙岩(1986-),男,河南社旗人,本科,研究方向为奶牛健康养殖。

Clinical Efficacy of the Chinese Medicine Compound Rulikang in the Treatment of Bovine Mastitis
Ziqi TAO1, Arsebek Jumamamat1, Yali LI2, Chao GONG1, Bo WANG1, Wanhe LUO3, Yakup Omar1, Zhihui HAO1, 4, Yan SUN5, Juncheng HAN1, *, Xiaohua DAI1, *
Affiliations
  • 1.Xinjiang Key Laboratory of New Drug Research and Development for Herbivorous AnimaIs (XJ-LNDRDHA)), College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi Xinjiang 830052
  • 2.College of Animal Science and Technology, Xinjiang Agricultural Vocational and Technical University, Changji Xinjiang 831100
  • 3.College of Animal Science and Technology, Tarim University, Animal Disease Diagnosis, Prevention and Control Engineering Laboratory, Alar Xinjiang 843300
  • 4.College of Veterinary Medicine, China Agricultural University, Beijing 100193
  • 5.Xinjiang Nongmu Investment Group Haozi Animal Husbandry Co., Ltd., Changji Xinjiang 831100
出版时间: 2026-05-25 doi: 10.12377/1671-4393.26.05.11
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[目的]

验证中药复方乳立康对奶牛乳房炎致病菌的抑菌效果及临床疗效。

[方法]

本研究选用中药复方乳立康(由蒲公英、连翘、木通、王不留行和黄芪组成的中药复方)按照水煎浓缩法制成含生药1 g/mL的药液,选用临床型奶牛乳房炎源大肠杆菌、金黄色葡萄球菌和无乳链球菌,探究体外抑菌效果。将30头患有临床型乳房炎的奶牛分为低、中、高剂量组,10头健康奶牛为对照组,乳区灌注2次/d,连续7 d,观察中药复方乳立康对奶牛乳房炎的临床疗效和乳样蛋白的变化。

[结果]

中药复方乳立康对大肠杆菌、金黄色葡萄球菌和无乳链球菌具有较强的抑制作用,在实验7 d后,高剂量组有效率和治愈率分别达88.2%(15/17)、82.4%(14/17),低、中、高剂量组的产奶量均高于对照组;奶牛乳清中的SA、ALT、AST及LDH含量均显著降低(P<0.05),但对乳糖几乎无影响。

[结论]

中药复方乳立康对临床型奶牛乳房炎有显著的治疗效果,为治疗临床型奶牛乳房炎提供了安全有效的中药制剂。

中药复方乳立康  /  奶牛乳房炎  /  体外抑菌  /  临床疗效
[Objective]

This study aimed to verify the antibacterial effect and clinical efficacy of Chinese Medicine Compound Rulikang against pathogenic bacteria of bovine mastitis.

[Method]

Chinese Medicine Compound Rulikang, consisting of Taraxacum mongolicum, Forsythia suspensa, Akebia quinata, Vaccaria segetalis and Astragalus membranaceus, was prepared into liquid with a crude drug concentration of 1 g/mL by water decoction and concentration. Escherichia coli, Staphylococcus aureus and Streptococcus agalactiae isolated from clinical bovine mastitis cases were used to assess its in vitro antibacterial activity. Thirty bovines suffering from clinical mastitis were assigned into low, medium and high dose groups, while 10 healthy bovines were set as the control group. Intramammary perfusion was performed twice a day for 7 consecutive days. The clinical efficacy and variations of milk protein indicators were observed.

[Result]

Chinese Medicine Compound Rulikang exhibited strong inhibitory effects on the three pathogenic strains. After 7 days of treatment, the effective rate and cure rate of the high dose group reached 88.2% (15/17) and 82.4% (14/17), respectively. Milk yield of all administration groups was higher than that of the control group. The levels of SA, ALT, AST and LDH in cow whey decreased significantly (P<0.05), whereas lactose content barely changed.

[Conclusion]

Chinese Medicine Compound Rulikang had prominent therapeutic effects on clinical bovine mastitis, which provided a safe and effective herbal preparation for the disease treatment.

Chinese Medicine Compound Rulikang  /  bovine mastitis  /  in vitro bacteriostasis  /  clinical efficacy
陶子奇, 阿尔斯别克·朱马买买提, 李亚丽, 弓超, 王博, 罗万和, 吾买尔江·牙合甫, 郝智慧, 孙岩, 韩俊成, 戴小华. 中药复方乳立康对奶牛乳房炎的临床疗效研究. 中国乳业, 2026 , (5) : 71 -78 . DOI: 10.12377/1671-4393.26.05.11
Ziqi TAO, Arsebek Jumamamat, Yali LI, Chao GONG, Bo WANG, Wanhe LUO, Yakup Omar, Zhihui HAO, Yan SUN, Juncheng HAN, Xiaohua DAI. Clinical Efficacy of the Chinese Medicine Compound Rulikang in the Treatment of Bovine Mastitis[J]. China Dairy, 2026 , (5) : 71 -78 . DOI: 10.12377/1671-4393.26.05.11
  • 2025年新疆农牧投集团科研项目(2025JTKY02-001)
  • 农业农村部中兽医生物学重点实验室开放基金资助项目(NYX2024006)
  • 2025年度“三区”科技人才支持计划资助项目(2225SQRC)
  • 新疆维吾尔自治区重大科技专项基金资助项目(2023A02007-2-11)
  • 新疆维吾尔自治区“三农”骨干人才培养项目(2024SNGGNT064)
  • 新疆农业大学大学生创新项目资助(dxscx2025127)
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doi: 10.12377/1671-4393.26.05.11
  • 首发时间:2026-08-20
  • 出版时间:2026-05-25
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作者
出版历史
基金
2025年新疆农牧投集团科研项目(2025JTKY02-001)
农业农村部中兽医生物学重点实验室开放基金资助项目(NYX2024006)
2025年度“三区”科技人才支持计划资助项目(2225SQRC)
新疆维吾尔自治区重大科技专项基金资助项目(2023A02007-2-11)
新疆维吾尔自治区“三农”骨干人才培养项目(2024SNGGNT064)
新疆农业大学大学生创新项目资助(dxscx2025127)
作者信息
    1.新疆农业大学动物医学学院新疆草食动物新药研究与创制重点实验室,新疆 乌鲁木齐 830052
    2.新疆农业职业大学动物科技学院,新疆 昌吉 831100
    3.塔里木大学动物科学与技术学院动物疫病诊断与防控工程实验室,新疆 阿拉尔 843300
    4.中国农业大学动物医学院,农业农村部中兽医生物学重点实验室,北京 100193
    5. 新疆农牧投集团豪子畜牧有限公司,新疆 昌吉 831100

通讯作者:

*

韩俊成(1988-),男,河南周口人,博士,讲师,研究方向为新兽药
戴小华(1976-),女,广西陆川人,博士,副教授,研究方向为天然产物功能。
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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