中国乳业

中药复方制剂对奶牛乳房炎主要病原菌的抑菌效果试验

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中国乳业 | 疾病防治 2026,(6): 106-110

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中国乳业 |疾病防治 2026 , (6) : 106 -110

中药复方制剂对奶牛乳房炎主要病原菌的抑菌效果试验

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高静（1981-），女，山东临沂莒南人，本科，高级兽医师，研究方向为畜牧兽医。

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高静（1981-），女，山东临沂莒南人，本科，高级兽医师，研究方向为畜牧兽医。

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高静

作者信息

山东省临沂市莒南县农业农村局十字路畜牧兽医站，山东临沂 276600

作者简介:

高静（1981-），女，山东临沂莒南人，本科，高级兽医师，研究方向为畜牧兽医。

Evaluation of in Vitro Bacteriostatic Activity and Therapeutic Effect of Traditional Chinese Medicine Compound Preparation on Major Pathogens of Dairy Cow Mastitis

Jing GAO

Affiliations

Cross Road Livestock and Veterinary Station, Junan County Agriculture and Rural Bureau, Linyi Shandong 276600

出版时间: 2026-06-25 doi: 10.12377/1671-4393.26.06.13

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摘要

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［目的］

探究自拟中药复方制剂对奶牛乳房炎的防控效果。

［方法］

本试验测定该复方对奶牛乳房炎主要病原菌的体外抑菌活性，并开展临床疗效评价。

［结果］

该中药复方对金黄色葡萄球菌、无乳链球菌的最低抑菌浓度（MIC）均为31.25 mg/mL，对大肠杆菌MIC为62.5 mg/mL，判定为中度敏感。不同药物干预结果表明，中药复方高剂量组临床有效率、治愈率最高，分别达100%、83.33%；其次为抗生素组，有效率83.33%、治愈率66.67%；中药复方中剂量组有效率为66.67%；中药复方低剂量组效果最差，有效率50%、治愈率16.67%。用药后，各组牛乳体细胞数（SCC）均显著下降（P<0.05）；其中中剂量组、高剂量组与抗生素组牛乳SCC均低于20万个/mL，依次为19.35±0.32、11.32±0.44、14.52±0.21万个/mL。相较于空白对照组，各用药组奶牛日均采食量显著提升（P<0.05）；中药复方中、高剂量组产奶量显著增加（P<0.05），奶料比呈上升趋势（P>0.05）。

［结论］

该中药复方可有效抑制金黄色葡萄球菌、无乳链球菌与大肠杆菌增殖，对奶牛乳房炎具备良好治疗作用，能够显著降低牛乳体细胞数；高剂量复方疗效优于常规抗生素，同时可提升患病奶牛采食量与产奶量，改善机体健康状态。

关键词

中药复方制剂 / 奶牛乳房炎 / 病原菌 / 体外抑菌活性 / 临床疗效

Abstract

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[Objective]

To investigate the preventive and therapeutic effects of a self-formulated traditional Chinese medicine compound on bovine mastitis.

[Method]

The in vitro antibacterial activity of this compound against the main pathogens causing bovine mastitis was determined, and its clinical efficacy was evaluated.

[Result]

The minimum inhibitory concentration (MIC) of the traditional Chinese medicine compound against Staphylococcus aureus and Streptococcus agalactiae was 31.25 mg/mL, and the MIC against Escherichia coli was 62.5 mg/mL, indicating moderate sensitivity. The results of different drug interventions showed that the high-dose group of the traditional Chinese medicine compound had the highest clinical efficacy and cure rate, reaching 100% and 83.33%, respectively; followed by the antibiotic group, with an efficacy rate of 83.33% and a cure rate of 66.67%; the medium-dose group of the traditional Chinese medicine compound had an efficacy rate of 66.67%; and the low-dose group of the traditional Chinese medicine compound had the worst effect, with an efficacy rate of 50% and a cure rate of 16.67%. After medication, the somatic cell count (SCC) of milk in all groups decreased significantly (P< 0.05) ; among them, the SCC of milk in the medium-dose group, high-dose group, and antibiotic group were all below 200000 cells/mL, namely 19.35±0.32, 11.32±0.44, and 14.52±0.21×104 cells/mL, respectively. Compared with the blank control group, the average daily feed intake of dairy cows in each medication group increased significantly (P<0.05) ; the milk yield of the medium and high dose groups of the traditional Chinese medicine compound increased significantly (P<0.05) , and the milk-to-feed ratio showed an upward trend (P>0.05) .

[Conclusion]

This traditional Chinese medicine compound can effectively inhibit the proliferation of Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coii, and has a good therapeutic effect on mastitis in dairy cows, which can significantly reduce the somatic cell count of milk; the high-dose compound is more effective than conventional antibiotics, and can also increase the feed intake and milk yield of sick dairy cows, and improve their health status.

Key words

traditional Chinese medicine compound preparation / dairy cow mastitis / pathogenic bacteria / in vitro bacteriostatic activity / therapeutic effect

引用本文

高静. 中药复方制剂对奶牛乳房炎主要病原菌的抑菌效果试验. 中国乳业, 2026 , (6) : 106 -110 . DOI: 10.12377/1671-4393.26.06.13

Jing GAO. Evaluation of in Vitro Bacteriostatic Activity and Therapeutic Effect of Traditional Chinese Medicine Compound Preparation on Major Pathogens of Dairy Cow Mastitis[J]. China Dairy, 2026 , (6) : 106 -110 . DOI: 10.12377/1671-4393.26.06.13

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2026年第卷第6期

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doi: 10.12377/1671-4393.26.06.13

首发时间：2026-08-20
出版时间：2026-06-25

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山东省临沂市莒南县农业农村局十字路畜牧兽医站，山东临沂 276600

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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