首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1297134060829175834, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134028650468001, articleNumber=null, orderNo=null, doi=10.12377/1671-4393.26.03.09, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1787190459686, onlineDateStr=2026-08-20, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1787190459686, onlineIssueDateStr=2026-08-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1787190459686, creator=13701087609, updateTime=1787190459686, updator=13701087609, issue=Issue{id=1297134028650468001, tenantId=1146029695717560320, journalId=1296801528146919473, year='2026', volume='', issue='3', pageStart='2', pageEnd='157', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1787190452015, creator='13701087609', updateTime=1787192267815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1297141644734787890, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134028650468001, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1297141644734787891, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134028650468001, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=62, endPage=67, ext={EN=ArticleExt(id=1297134061022113819, articleId=1297134060829175834, tenantId=1146029695717560320, journalId=1296801528146919473, language=EN, title=The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity, columnId=1297134042869158672, journalTitle=China Dairy, columnName=DISEASE PREVENTION, runingTitle=null, highlight=null, articleAbstract=
[Objective]

To investigate the antibacterial activities of several antibiotics, hyaluronic acid (HA) alone, and HA combined with penicillin (PEN) against Staphylococcus aureus (S.aureus).

[Method]

The susceptibility of 1 standard strain and 9 clinical S.aureus strains isolated from dairy cattle to antimicrobial agents was evaluated using the double-dilution method and the micro-checkerboard method.

[Result]

The resistance rates of S.aureus to PEN, clindamycin and erythromycin were 90%, 80% and 40%, respectively. No methicillin-resistant strains were detected, and 40% of the strains showed inducible clindamycin resistance. The combination of HA and PEN exhibited either additive effect (FICI 0.5~1.0) or synergistic effect (FICI≤0.5) against all tested S.aureus strains.

[Conclusion]

The combination of HA and PEN can significantly reduce the effective minimal inhibitory concentration of both agents against S.aureus, which provides a new idea for the clinical treatment of drug-resistant S.aureus infections.

, authors=Qian WANG1, Fang JIA1, 2, Hongyu CUI3, Lixia ZHAO1, 2, *, authorsList=Qian WANG, Fang JIA, Hongyu CUI, Lixia ZHAO, authorCompany=null, correspAuthors=Lixia ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1297134061269577756, articleId=1297134060829175834, tenantId=1146029695717560320, journalId=1296801528146919473, language=CN, title=透明质酸联合青霉素抑制金黄色葡萄球菌活性的研究, columnId=1297134043032736530, journalTitle=中国乳业, columnName=疾病防治, runingTitle=null, highlight=null, articleAbstract=
［目的］

检测透明质酸（HA）单独及与青霉素（PEN）联合使用时，对金黄色葡萄球菌（金葡菌）的抗菌活性，并同步检测多种抗生素对该菌的药敏性。

［方法］

采用二倍稀释法和微量棋盘法，评估1株金葡菌标准株与9株奶牛源临床分离金葡菌对相关药物的敏感性。

［结果］

金葡菌对PEN、克林霉素、红霉素的耐药率分别为90%、80%和40%；未检测出耐甲氧西林菌株，诱导克林霉素耐药菌株占比40%；HA与PEN联合作用于金葡菌时，均表现出相加（部分抑菌浓度指数FICI 0.5~1.0）或协同（FICI≤0.5）效应。

［结论］

HA与PEN联用可显著降低2种药物对金葡菌的有效抑菌浓度，为临床应对金葡菌耐药问题提供新的用药思路。

, authors=王倩1, 贾芳1, 2, 崔红宇3, 赵丽霞1, 2, *, authorsList=王倩, 贾芳, 崔红宇, 赵丽霞, authorCompany=null, correspAuthors=赵丽霞, authorNote=

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

, correspAuthorsNote=

*

赵丽霞（1979-），女，内蒙古巴彦淖尔人，博士，研究员，研究方向为动物干细胞生物学。
, copyrightStatement=发表在《中国乳业》上的论文，视为将本论文的数字化复制权、发行权、汇编权及信息网络传播权许可给《中国乳业》使用。本刊已许可中国学术期刊（光盘版）电子杂志社、北京万方数据股份有限公司等多家单位在其相关数据库产品中以数字化方式复制、汇编、发行、信息网络传播本刊全文。作者向本刊提交文章发表的行为即视为同意我刊授权使用该文著作权。, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=gxgqzfYRO9amA8uHvxkiwA==, magXml=3aBG4k0MikdKEA33Uv0pbw==, pdfUrl=null, pdf=k0iYmwmGguLJVcxNFngCew==, pdfFileSize=966599, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=+aYhORloMwGHpTagx2B+CA==, mapNumber=null, fund=null)}, authors=[Author(id=1297134063140237351, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063467393065, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063140237351, language=EN, stringName=Qian WANG, firstName=Qian, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134063580639274, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063140237351, language=CN, stringName=王倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110, bio={"content":"

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

"}, bioImg=null, bioContent=

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)])]), Author(id=1297134063668719660, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063760994351, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063668719660, language=EN, stringName=Fang JIA, firstName=Fang, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134063828103216, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063668719660, language=CN, stringName=贾芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
2．国家乳业技术创新中心，内蒙古 呼和浩特 010080, bio={"content":"

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

"}, bioImg=null, bioContent=

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)]), AuthorCompany(id=1297134062951493664, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=2., ext=[AuthorCompanyExt(id=1297134062964076577, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080), AuthorCompanyExt(id=1297134062968270882, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2．国家乳业技术创新中心，内蒙古 呼和浩特 010080)])]), Author(id=1297134063895212082, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063979098164, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063895212082, language=EN, stringName=Hongyu CUI, firstName=Hongyu, middleName=null, lastName=CUI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134064037818421, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063895212082, language=CN, stringName=崔红宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110, bio={"content":"

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

"}, bioImg=null, bioContent=

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134063043768355, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=3., ext=[AuthorCompanyExt(id=1297134063056351268, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134063064739877, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110)])]), Author(id=1297134064117510199, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1297134064201396282, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134064117510199, language=EN, stringName=Lixia ZHAO, firstName=Lixia, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, *, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134064264310843, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134064117510199, language=CN, stringName=赵丽霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, *, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
2．国家乳业技术创新中心，内蒙古 呼和浩特 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)]), AuthorCompany(id=1297134062951493664, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=2., ext=[AuthorCompanyExt(id=1297134062964076577, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080), AuthorCompanyExt(id=1297134062968270882, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2．国家乳业技术创新中心，内蒙古 呼和浩特 010080)])])], keywords=[Keyword(id=1297134064364974140, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=EN, orderNo=1, keyword=hyaluronic acid (HA)), Keyword(id=1297134064423694397, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=EN, orderNo=2, keyword=penicillin (PEN)), Keyword(id=1297134064478220350, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=EN, orderNo=3, keyword=Staphylococcus aureus (S.aureus)), Keyword(id=1297134064557912127, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=EN, orderNo=4, keyword=minimal inhibitory concentration (MIC)), Keyword(id=1297134064662769728, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=CN, orderNo=1, keyword=透明质酸（HA）), Keyword(id=1297134064742461505, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=CN, orderNo=2, keyword=青霉素（PEN）), Keyword(id=1297134064809570370, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=CN, orderNo=3, keyword=金黄色葡萄球菌（金葡菌）), Keyword(id=1297134064885067843, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, language=CN, orderNo=4, keyword=最小抑菌浓度（MIC）)], refs=null, funds=[Fund(id=1297134064981536836, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, awardId=2024-KFKT-036, language=CN, fundingSource=国家乳业技术创新中心开放课题(2024-KFKT-036), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)]), AuthorCompany(id=1297134062951493664, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=2., ext=[AuthorCompanyExt(id=1297134062964076577, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080), AuthorCompanyExt(id=1297134062968270882, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2．国家乳业技术创新中心，内蒙古 呼和浩特 010080)]), AuthorCompany(id=1297134063043768355, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=3., ext=[AuthorCompanyExt(id=1297134063056351268, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134063064739877, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110)])], figs=null, attaches=null, journal=Journal(id=1296801172792901679, delFlag=0, nameCn=中国乳业, nameEn=China Dairy, nameHistory1=null, nameHistory2=null, issn=1671-4393, eissn=null, cn=11-4768/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=fy0U6rTUhrcBdKszdYVe3w==, journalPrice=null, startedYear=null, abbrevIsoEn=China Dairy, journalRemark=null, publicationField=null, createdTime=1787111092997, updatedTime=1788949480572, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Agriculture, subjectName=null, subjectCodeEn=Agriculture, subjectNameEn=null, picCn=fy0U6rTUhrcBdKszdYVe3w==, picEn=1lm7RNSd456gWkkoaDGdEQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511929255481461, language=CN, name=中国乳业, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480594, updatedTime=1788949480594, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511929301618806, language=EN, name=China Dairy, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480605, updatedTime=1788949480605, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1296801528146919473, websiteList=[Website(id=1296802542923572121, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/CN, language=CN, createTime=1787111419659, createBy=18614031015, updateTime=1787111471367, updateBy=18614031015, name=中国乳业-中文, tplId=1146099689490845704, title=中国乳业, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802881777198042, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=articleTextType, value=kx, createTime=1787111500448, updateTime=1787111500448, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881747837911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=banner, value=null, createTime=1787111500441, updateTime=1787111500441, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881827529693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=grayFlag, value=0, createTime=1787111500460, updateTime=1787111500460, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881735254998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111500438, updateTime=1787111500438, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881844306911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=minRunFlag, value=0, createTime=1787111500464, updateTime=1787111500464, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881768809433, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic, createTime=1787111500446, updateTime=1787111500446, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881835918302, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=silenceFlag, value=0, createTime=1787111500462, updateTime=1787111500462, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881760420824, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1787111500444, updateTime=1787111500444, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881810752475, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeColor, value=null, createTime=1787111500456, updateTime=1787111500456, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881819141084, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeStyle, value=null, createTime=1787111500458, updateTime=1787111500458, creator=18614031015, updator=18614031015)]), Website(id=1296802543032624028, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/EN, language=EN, createTime=1787111419685, createBy=18614031015, updateTime=1787111462939, updateBy=18614031015, name=中国乳业-英文, tplId=1146101810881728533, title=China Dairy, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802850798068681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=articleTextType, value=kx, createTime=1787111493062, updateTime=1787111493062, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850768708550, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=banner, value=null, createTime=1787111493055, updateTime=1787111493055, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850819040204, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=grayFlag, value=0, createTime=1787111493067, updateTime=1787111493067, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850760319941, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111493053, updateTime=1787111493053, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850831623118, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=minRunFlag, value=0, createTime=1787111493070, updateTime=1787111493070, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850789680072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic, createTime=1787111493060, updateTime=1787111493060, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850823234509, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=silenceFlag, value=0, createTime=1787111493068, updateTime=1787111493068, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850781291463, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1787111493058, updateTime=1787111493058, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850802262986, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeColor, value=null, createTime=1787111493063, updateTime=1787111493063, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850810651595, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeStyle, value=null, createTime=1787111493065, updateTime=1787111493065, creator=18614031015, updator=18614031015)])], journalTitle=中国乳业, weixinUrl=null, journalUrl=http://zhgry.aiijournal.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=China Dairy, journalPhotoCn=fy0U6rTUhrcBdKszdYVe3w==, journalPhotoEn=1lm7RNSd456gWkkoaDGdEQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/10.12377/1671-4393.26.03.09, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/10.12377/1671-4393.26.03.09, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/PDF/10.12377/1671-4393.26.03.09, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/PDF/10.12377/1671-4393.26.03.09, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1774368000000, fullTextJson=null, articleText=null, reference=null)
收藏切换
透明质酸联合青霉素抑制金黄色葡萄球菌活性的研究
收藏切换
PDF下载
王倩 1 , 贾芳 1, 2 , 崔红宇 3 , 赵丽霞 1, 2, *
中国乳业 | 疾病防治 2026,(3): 62-67
收起
收藏切换
中国乳业 |疾病防治 2026 , (3) : 62 -67
透明质酸联合青霉素抑制金黄色葡萄球菌活性的研究
全屏
[Author(id=1297134063140237351, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063467393065, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063140237351, language=EN, stringName=Qian WANG, firstName=Qian, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134063580639274, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063140237351, language=CN, stringName=王倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110, bio={"content":"

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

"}, bioImg=null, bioContent=

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)])]), Author(id=1297134063668719660, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063760994351, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063668719660, language=EN, stringName=Fang JIA, firstName=Fang, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134063828103216, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063668719660, language=CN, stringName=贾芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
2．国家乳业技术创新中心，内蒙古 呼和浩特 010080, bio={"content":"

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

"}, bioImg=null, bioContent=

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)]), AuthorCompany(id=1297134062951493664, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=2., ext=[AuthorCompanyExt(id=1297134062964076577, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080), AuthorCompanyExt(id=1297134062968270882, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2．国家乳业技术创新中心，内蒙古 呼和浩特 010080)])]), Author(id=1297134063895212082, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134063979098164, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063895212082, language=EN, stringName=Hongyu CUI, firstName=Hongyu, middleName=null, lastName=CUI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134064037818421, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134063895212082, language=CN, stringName=崔红宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110, bio={"content":"

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

"}, bioImg=null, bioContent=

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134063043768355, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=3., ext=[AuthorCompanyExt(id=1297134063056351268, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134063064739877, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134063043768355, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110)])]), Author(id=1297134064117510199, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1297134064201396282, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134064117510199, language=EN, stringName=Lixia ZHAO, firstName=Lixia, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, *, address=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134064264310843, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, authorId=1297134064117510199, language=CN, stringName=赵丽霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, *, address=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
2．国家乳业技术创新中心，内蒙古 呼和浩特 010080, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1297134061458321437, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=1., ext=[AuthorCompanyExt(id=1297134061466710046, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110), AuthorCompanyExt(id=1297134061475098655, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134061458321437, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110)]), AuthorCompany(id=1297134062951493664, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, xref=2., ext=[AuthorCompanyExt(id=1297134062964076577, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080), AuthorCompanyExt(id=1297134062968270882, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134060829175834, companyId=1297134062951493664, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2．国家乳业技术创新中心，内蒙古 呼和浩特 010080)])])]
王倩1, 贾芳1, 2, 崔红宇3, 赵丽霞1, 2, *
作者信息
  • 1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
  • 2．国家乳业技术创新中心，内蒙古 呼和浩特 010080
  • 3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110
通讯作者:

*

赵丽霞（1979-），女，内蒙古巴彦淖尔人，博士，研究员，研究方向为动物干细胞生物学。
作者简介:

王倩（1999-），女，山东商河人，在读硕士，研究方向为干细胞分化

贾芳（1980-），女，内蒙古乌兰察布人，博士，副教授，研究方向为病原生物学

崔红宇（2000-），女，山西吕梁人，在读硕士，初级执业医师，研究方向为干细胞分化。

The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity
Qian WANG1, Fang JIA1, 2, Hongyu CUI3, Lixia ZHAO1, 2, *
Affiliations
  • 1.School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
  • 2.National Center of Technology Innovation for Dairy, Hohhot Inner Mongolia 010080
  • 3.The First Clinical Medical College, Inner Mongolia Medical University, Hohhot Inner Mongolia 010110
出版时间: 2026-03-25 doi: 10.12377/1671-4393.26.03.09
文章导航
收藏切换
摘要
收起
［目的］

检测透明质酸（HA）单独及与青霉素（PEN）联合使用时，对金黄色葡萄球菌（金葡菌）的抗菌活性，并同步检测多种抗生素对该菌的药敏性。

［方法］

采用二倍稀释法和微量棋盘法，评估1株金葡菌标准株与9株奶牛源临床分离金葡菌对相关药物的敏感性。

［结果］

金葡菌对PEN、克林霉素、红霉素的耐药率分别为90%、80%和40%；未检测出耐甲氧西林菌株，诱导克林霉素耐药菌株占比40%；HA与PEN联合作用于金葡菌时，均表现出相加（部分抑菌浓度指数FICI 0.5~1.0）或协同（FICI≤0.5）效应。

［结论］

HA与PEN联用可显著降低2种药物对金葡菌的有效抑菌浓度，为临床应对金葡菌耐药问题提供新的用药思路。

透明质酸（HA）  /  青霉素（PEN）  /  金黄色葡萄球菌（金葡菌）  /  最小抑菌浓度（MIC）
[Objective]

To investigate the antibacterial activities of several antibiotics, hyaluronic acid (HA) alone, and HA combined with penicillin (PEN) against Staphylococcus aureus (S.aureus).

[Method]

The susceptibility of 1 standard strain and 9 clinical S.aureus strains isolated from dairy cattle to antimicrobial agents was evaluated using the double-dilution method and the micro-checkerboard method.

[Result]

The resistance rates of S.aureus to PEN, clindamycin and erythromycin were 90%, 80% and 40%, respectively. No methicillin-resistant strains were detected, and 40% of the strains showed inducible clindamycin resistance. The combination of HA and PEN exhibited either additive effect (FICI 0.5~1.0) or synergistic effect (FICI≤0.5) against all tested S.aureus strains.

[Conclusion]

The combination of HA and PEN can significantly reduce the effective minimal inhibitory concentration of both agents against S.aureus, which provides a new idea for the clinical treatment of drug-resistant S.aureus infections.

hyaluronic acid (HA)  /  penicillin (PEN)  /  Staphylococcus aureus (S.aureus)  /  minimal inhibitory concentration (MIC)
王倩, 贾芳, 崔红宇, 赵丽霞. 透明质酸联合青霉素抑制金黄色葡萄球菌活性的研究. 中国乳业, 2026 , (3) : 62 -67 . DOI: 10.12377/1671-4393.26.03.09
Qian WANG, Fang JIA, Hongyu CUI, Lixia ZHAO. The Inhibitory Effects of Hyaluronic Acid Combined with Penicillin on Staphylococcus aureus Activity[J]. China Dairy, 2026 , (3) : 62 -67 . DOI: 10.12377/1671-4393.26.03.09
基金
收起
  • 国家乳业技术创新中心开放课题(2024-KFKT-036)
文献
收起
参考文献 引证文献
排序方式：
2026年第卷第3期
PDF下载
94
15
引用本文
BibTeX
文章信息
doi: 10.12377/1671-4393.26.03.09
  • 首发时间：2026-08-20
  • 出版时间：2026-03-25
补充材料
相关文章
文章信息
作者
出版历史
基金
国家乳业技术创新中心开放课题(2024-KFKT-036)
作者信息
    1．内蒙古医科大学基础医学院，内蒙古 呼和浩特 010110
    2．国家乳业技术创新中心，内蒙古 呼和浩特 010080
    3．内蒙古医科大学第一临床医学院，内蒙古 呼和浩特 010110

通讯作者:

*

赵丽霞（1979-），女，内蒙古巴彦淖尔人，博士，研究员，研究方向为动物干细胞生物学。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgry/CN/10.12377/1671-4393.26.03.09
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257（仅加盟咨询）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持