Article(id=1297134065447104581, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134051446514419, articleNumber=null, orderNo=null, doi=10.12377/1671-4393.26.01.09, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1787190460788, onlineDateStr=2026-08-20, pubDate=1769270400000, pubDateStr=2026-01-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1787190460788, onlineIssueDateStr=2026-08-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1787190460788, creator=13701087609, updateTime=1787190460788, updator=13701087609, issue=Issue{id=1297134051446514419, tenantId=1146029695717560320, journalId=1296801528146919473, year='2026', volume='', issue='1', pageStart='2', pageEnd='131', issueExtLink='null', onlineDate='null', pubDate='1769270400000', pubDateStr='2026-01-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1787190457450, creator='13701087609', updateTime=1787192303515, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1297141794467246419, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134051446514419, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1297141794467246420, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1297134051446514419, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=58, endPage=64, ext={EN=ArticleExt(id=1297134065698762822, articleId=1297134065447104581, tenantId=1146029695717560320, journalId=1296801528146919473, language=EN, title=Research on the Therapeutic Effect of Pulsatilla Saponin Injection on Clinical Bovine Mastitis, columnId=1297134042869158672, journalTitle=China Dairy, columnName=DISEASE PREVENTION, runingTitle=null, highlight=null, articleAbstract=
[Objective] This study aimed to investigate the therapeutic effect of Pulsatilla saponin injection on clinical bovine mastitis, thereby providing new drug options and technical support for its green prevention and control.
[Method] Eighty cows with clinical mastitis were selected and divided into four groups of 20 each based on the degree of mastitis lesions, milk traits, and somatic cell count (SCC). The control group (CON) was treated with a conventional antibiotic (ceftiofur sodium). Experimental groups Ⅰ, Ⅱ, and Ⅲ received intramuscular injections of Pulsatilla saponin injection (active ingredient content: 20 mg/mL) at doses of 5, 10, and 15 mL/cow, respectively, for 5 consecutive days, followed by a 7-day observation period after treatment cessation.
[Result] The cure rates in experimental groups Ⅱ and Ⅲ were 85.0% and 80.0%, respectively, significantly higher than the 70.0% in the CON group (P<0.05). The cure rate in experimental group Ⅰ was 55.0%, significantly lower than the other groups (P<0.05). After treatment, the SCC in milk decreased most significantly in experimental group Ⅱ, from (128.6±15.3) ×104 cells/mL before treatment to (22.5±3.1) ×104 cells/mL, which was significantly lower than the (35.8±4.2) ×104 cells/mL in the CON group (P< 0.05). The activities of lactate dehydrogenase (LDH) and alkaline phosphatase (AKP) in the milk of experimental groups Ⅱ and Ⅲ were significantly lower than those in the CON group (P<0.05), while the contents of milk protein and lactose were significantly higher (P<0.05). The serum levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in experimental group II were significantly lower than those in the CON group (P<0.05), whereas the immunoglobulin G (IgG) level was significantly higher (P<0.05).
[Conclusion] Under the experimental conditions, Pulsatilla saponin injection at a dose of 10 mL/cow demonstrated the optimal therapeutic effect on clinical bovine mastitis. It effectively improved milk traits, reduced SCC, regulated immune function, and presented a low risk of drug residues, making it an ideal green preparation for the prevention and control of clinical bovine mastitis.
, authors=Shengnan YANG
1, Yan LI
1, Yanqi ZHANG
1, Guohua LI
1, Rongzhao SUN
2, Xin LIU
3, Xiaoxiao DUAN
1, *, authorsList=Shengnan YANG, Yan LI, Yanqi ZHANG, Guohua LI, Rongzhao SUN, Xin LIU, Xiaoxiao DUAN, authorCompany=null, correspAuthors=Xiaoxiao DUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1297134065933643847, articleId=1297134065447104581, tenantId=1146029695717560320, journalId=1296801528146919473, language=CN, title=白头翁皂苷注射液对临床型奶牛乳房炎治疗效果的研究, columnId=1297134043032736530, journalTitle=中国乳业, columnName=疾病防治, runingTitle=null, highlight=null, articleAbstract=
［目的］ 探究白头翁皂苷注射液对临床型奶牛乳房炎的治疗效果，为临床型奶牛乳房炎的绿色防控提供新的药物选择与技术支撑。
［方法］ 选取临床型乳房炎奶牛80头，依据乳房炎病变程度、乳汁性状及体细胞数（SCC）分为4组，每组20头。对照组（CON组）采用常规抗生素（头孢噻呋钠）治疗，试验Ⅰ组、试验Ⅱ组、试验Ⅲ组分别肌内注射5、10、15 mL/头的白头翁皂苷注射液（有效成分含量20 mg/mL），连续治疗5 d，停药后观察7 d。
［结果］ 试验Ⅱ组和试验Ⅲ组的治愈率分别达85.0%和80.0%，显著高于CON组的70.0%（P<0.05），试验Ⅰ组治愈率为55.0%，显著低于其他组（P<0.05）；治疗后，试验Ⅱ组乳汁体细胞数下降幅度最大，由治疗前的（128.6±15.3）×104个/mL降至（22.5±3.1）×104个/mL，显著低于CON组的（35.8±4.2）×104个/mL（P<0.05）；试验Ⅱ组和试验Ⅲ组乳汁中乳酸脱氢酶（LDH）、碱性磷酸酶（AKP）活性显著低于CON组（P<0.05），乳蛋白、乳糖含量显著高于CON组（P<0.05）；试验Ⅱ组奶牛血清中白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）含量显著低于CON组（P<0.05），免疫球蛋白G（IgG）含量显著高于CON组（P<0.05）。
［结论］ 在本试验条件下，10 mL/头剂量的白头翁皂苷注射液对临床型奶牛乳房炎的治疗效果最佳，可有效改善乳汁性状、降低体细胞数、调节机体免疫功能，且无药物残留风险，是临床型奶牛乳房炎防控的理想绿色制剂。
, authors=杨胜男
1, 李彦
1, 张严琦
1, 李国华
1, 孙荣钊
2, 刘欣
3, 段笑笑
1, *, authorsList=杨胜男, 李彦, 张严琦, 李国华, 孙荣钊, 刘欣, 段笑笑, authorCompany=null, correspAuthors=段笑笑, authorNote=
杨胜男（1987-），女，山东济南人，硕士，高级兽医师，研究方向为动物疫病防控
李彦（1967-），男，山东青岛人，博士，研究员，研究方向为兽医药理学、动物疫病防控
张严琦（1986-），女，山东青岛人，硕士，高级兽医师，研究方向为动物疫病监测
李国华（1995-），男，山东济南人，本科，助理兽医师，研究方向为动物疫病监测
孙荣钊（1987-），男，山东即墨人，博士，高级兽医师，研究方向为动物疫病防控与检测
刘欣（1976-），女，河北石家庄人，硕士，高级兽医师，研究方向为新兽药制剂开发。
, correspAuthorsNote=
*
段笑笑（1989-），女，河南济源人，硕士，高级兽医师，研究方向为疫病监测、流行病学调查等。
, copyrightStatement=
发表在《中国乳业》上的论文，视为将本论文的数字化复制权、发行权、汇编权及信息网络传播权许可给《中国乳业》使用。本刊已许可中国学术期刊（光盘版）电子杂志社、北京万方数据股份有限公司等多家单位在其相关数据库产品中以数字化方式复制、汇编、发行、信息网络传播本刊全文。作者向本刊提交文章发表的行为即视为同意我刊授权使用该文著作权。, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=6JV7HEvPK8gCmI8tGy48IA==, magXml=PwzTF4dlBju7WYPFpyR8aQ==, pdfUrl=null, pdf=xIgcFizrznDtxR6Grka/Ug==, pdfFileSize=820771, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=OcKEIk4+OZ/BSK5E3h57sg==, mapNumber=null, fund=null)}, authors=[Author(id=1297134069607854162, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1297134069691740244, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134069607854162, language=EN, stringName=Shengnan YANG, firstName=Shengnan, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.Qingdao Center For Animal Disease Control and Prevention, Shandong Province, Qingdao Shandong 266000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134069771432021, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134069607854162, language=CN, stringName=杨胜男, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．山东省青岛市动物疫病预防控制中心，山东 青岛 266000, bio={"content":"
杨胜男（1987-），女，山东济南人，硕士，高级兽医师，研究方向为动物疫病防控
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杨胜男（1987-），女，山东济南人，硕士，高级兽医师，研究方向为动物疫病防控
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1.Qingdao Center For Animal Disease Control and Prevention, Shandong Province, Qingdao Shandong 266000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134069993730138, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134069834346583, language=CN, stringName=李彦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．山东省青岛市动物疫病预防控制中心，山东 青岛 266000, bio={"content":"
李彦（1967-），男，山东青岛人，博士，研究员，研究方向为兽医药理学、动物疫病防控
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李彦（1967-），男，山东青岛人，博士，研究员，研究方向为兽医药理学、动物疫病防控
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1.Qingdao Center For Animal Disease Control and Prevention, Shandong Province, Qingdao Shandong 266000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134070274748511, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134070060839004, language=CN, stringName=张严琦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．山东省青岛市动物疫病预防控制中心，山东 青岛 266000, bio={"content":"
张严琦（1986-），女，山东青岛人，硕士，高级兽医师，研究方向为动物疫病监测
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张严琦（1986-），女，山东青岛人，硕士，高级兽医师，研究方向为动物疫病监测
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1.Qingdao Center For Animal Disease Control and Prevention, Shandong Province, Qingdao Shandong 266000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134072078299237, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134071923109986, language=CN, stringName=李国华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．山东省青岛市动物疫病预防控制中心，山东 青岛 266000, bio={"content":"
李国华（1995-），男，山东济南人，本科，助理兽医师，研究方向为动物疫病监测
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李国华（1995-），男，山东济南人，本科，助理兽医师，研究方向为动物疫病监测
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2, address=
2.Qingdao Lijian Biotechnology Co., Ltd., Qingdao Shandong 266041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1297134072447397994, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1297134065447104581, authorId=1297134072275431527, language=CN, stringName=孙荣钊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2．青岛立见生物科技有限公司，山东 青岛 266041, bio={"content":"
孙荣钊（1987-），男，山东即墨人，博士，高级兽医师，研究方向为动物疫病防控与检测
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孙荣钊（1987-），男，山东即墨人，博士，高级兽医师，研究方向为动物疫病防控与检测
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