Article(id=1320063045540364922, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320063036086407286, articleNumber=null, orderNo=null, doi=10.12377/1671-4393.25.04.10, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792657155641, onlineDateStr=2026-10-22, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792657155641, onlineIssueDateStr=2026-10-22, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792657155641, creator=13701087609, updateTime=1792657155641, updator=13701087609, issue=Issue{id=1320063036086407286, tenantId=1146029695717560320, journalId=1296801528146919473, year='2025', volume='', issue='4', pageStart='1', pageEnd='132', issueExtLink='null', onlineDate='null', pubDate='1745510400000', pubDateStr='2025-04-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1792657153388, creator='13701087609', updateTime=1792657302215, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320063660370800822, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320063036086407286, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320063660370800823, tenantId=1146029695717560320, journalId=1296801528146919473, issueId=1320063036086407286, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=55, endPage=58, ext={EN=ArticleExt(id=1320063045951406716, articleId=1320063045540364922, tenantId=1146029695717560320, journalId=1296801528146919473, language=EN, title=Research on Postpartum Metabolic Dynamics Characteristics and Health Regulation Strategies of Dairy Cows Based on NMR Metabolomics, columnId=null, journalTitle=China Dairy, columnName=null, runingTitle=null, highlight=null, articleAbstract=[Objective] This study aimed to analyze the dynamic changes in serum metabolites of dairy cows within 7 days postpartum,revealing their metabolic adaptation mechanisms and potential health risks,thereby providing a scientific basis for optimizing postpartum management. [Method] Serum samples were collected from 5 dairy cows at 1,4,and 7 days postpartum. Nuclear Magnetic Resonance（NMR） metabolomics technology combined with multivariate statistical analysis（PCA,OSC-PLS） was used to screen key differential metabolites,and their biological significance was integrated through metabolic pathways. [Result] The results showed that postpartum fat mobilization was enhanced,with significant increases in 3-hydroxybutyrate and acetone,indicating a risk of ketosis, glucose continued to decline,associated with increased demand for lactose synthesis, acetate and lactate increased,reflecting rumen fiber fermentation recovery and potential subacute acidosis risk,respectively, glycine and citrate initially increased and then decreased,participating in oxidative stress regulation and energy homeostasis transition,respectively. Further analysis revealed that postpartum metabolism in dairy cows exhibited a phased characteristic of fat mobilization-rumen recovery-milk component synthesis. [Conclusion] Based on these findings,it is recommended to implement strategies such as dietary optimization（increasing readily fermentable carbohydrates (35~40%) and balancing fiber）,ketosis monitoring（blood ketone testing）,and functional additives（e.g.,rumen-protected choline） to alleviate negative energy balance and ensure lactation performance. This study provided a metabolomics basis for precise nutritional interventions in postpartum dairy cows., authors=AI Juntao, ZHANG Fanjian, SUN Jian^*, authorsList=AI Juntao, ZHANG Fanjian, SUN Jian, authorCompany=Beijing Vocational College of Agriculture,Beijing 102442, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320063045884297851, articleId=1320063045540364922, tenantId=1146029695717560320, journalId=1296801528146919473, language=CN, title=基于NMR代谢组学的奶牛产后代谢动态特征及健康调控策略研究, columnId=1297134031582294810, journalTitle=中国乳业, columnName=饲养管理, runingTitle=null, highlight=null, articleAbstract=[目的]解析奶牛产后7 天内血清代谢物动态变化规律,揭示代谢适应机制及潜在健康风险,为优化产后管理提供依据。[方法]选取5 头健康经产奶牛,采集牛产后1 天、4 天和7 天血清样本,利用NMR代谢组学技术,结合多元统计分析（PCA、OSC-PLS）,筛选关键差异代谢物,并通过代谢通路整合其生物学意义。[结果]产后脂肪动员增强,3-羟基丁酸和丙酮显著升高,提示酮症风险;葡萄糖持续下降,与乳糖合成需求增加相关;乙酸盐和乳酸升高,分别反映瘤胃纤维发酵恢复与潜在亚急性酸中毒风险;甘氨酸和柠檬酸先升后降,分别参与氧化应激调控与能量稳态转换。进一步分析表明,奶牛产后代谢呈“脂肪动员-瘤胃恢复-乳成分合成”阶段性特征。[结论]建议通过日粮优化（提升易发酵碳水化合物比例至35%~40%、平衡纤维）、酮症监测（血酮检测）和功能性添加剂（如过瘤胃胆碱）等策略,缓解能量负平衡并保障泌乳性能。本研究为奶牛产后精准营养干预提供代谢组学依据。, authors=艾君涛, 张凡建, 孙健^*, authorsList=艾君涛, 张凡建, 孙健, authorCompany=北京农业职业学院,北京 102442, correspAuthors=^*孙 健（1980-）,男,山东济南人,博士,副教授,研究方向为临床兽医。, authorNote=艾君涛（1979-）,女,山东青岛人,硕士,副教授,研究方向为动物疾病防治;张凡建（1981-）,男,山东梁山人,博士,教授,研究方向为奶牛临床疾病防治。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=VSWTFTrI/8VAVt1/9gFDMw==, pdfFileSize=2609658, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=北京农业职业学院科技创新项目-奶牛产后低血钙症干预措施研究与示范推广（XY-XY-20-05）)}, authors=null, keywords=[Keyword(id=1320063046085624445, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=CN, orderNo=1, keyword=奶牛), Keyword(id=1320063046156927614, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=CN, orderNo=2, keyword=产后代谢), Keyword(id=1320063046232425087, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=CN, orderNo=3, keyword=代谢组学), Keyword(id=1320063046299533952, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=CN, orderNo=4, keyword=酮症), Keyword(id=1320063046366642817, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=CN, orderNo=5, keyword=能量负平衡), Keyword(id=1320063046463111810, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=EN, orderNo=1, keyword=dairy cow), Keyword(id=1320063046538609283, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=EN, orderNo=2, keyword=postpartum metabolism), Keyword(id=1320063046601523844, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=EN, orderNo=3, keyword=metabolomics), Keyword(id=1320063046668632709, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=EN, orderNo=4, keyword=ketosis), Keyword(id=1320063046727352966, tenantId=1146029695717560320, journalId=1296801528146919473, articleId=1320063045540364922, language=EN, orderNo=5, keyword=negative energy balance)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1296801172792901679, delFlag=0, nameCn=中国乳业, nameEn=China Dairy, nameHistory1=null, nameHistory2=null, issn=1671-4393, eissn=null, cn=11-4768/S, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=fy0U6rTUhrcBdKszdYVe3w==, journalPrice=null, startedYear=null, abbrevIsoEn=China Dairy, journalRemark=null, publicationField=null, createdTime=1787111092997, updatedTime=1788949480572, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Agriculture, subjectName=null, subjectCodeEn=Agriculture, subjectNameEn=null, picCn=fy0U6rTUhrcBdKszdYVe3w==, picEn=1lm7RNSd456gWkkoaDGdEQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511929255481461, language=CN, name=中国乳业, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480594, updatedTime=1788949480594, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511929301618806, language=EN, name=China Dairy, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949480605, updatedTime=1788949480605, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://zgryauthor.cast.org.cn/webm, submissionEditorUrl=https://zgryeditor.cast.org.cn/webm, submissionReviewUrl=https://zgryauthor.cast.org.cn/webm, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1296801528146919473, websiteList=[Website(id=1296802542923572121, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/CN, language=CN, createTime=1787111419659, createBy=18614031015, updateTime=1787111471367, updateBy=18614031015, name=中国乳业-中文, tplId=1146099689490845704, title=中国乳业, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802881777198042, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=articleTextType, value=kx, createTime=1787111500448, updateTime=1787111500448, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881747837911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=banner, value=null, createTime=1787111500441, updateTime=1787111500441, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881827529693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=grayFlag, value=0, createTime=1787111500460, updateTime=1787111500460, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881735254998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111500438, updateTime=1787111500438, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881844306911, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=minRunFlag, value=0, createTime=1787111500464, updateTime=1787111500464, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881768809433, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/CN/file/pic, createTime=1787111500446, updateTime=1787111500446, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881835918302, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=silenceFlag, value=0, createTime=1787111500462, updateTime=1787111500462, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881760420824, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1787111500444, updateTime=1787111500444, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881810752475, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeColor, value=null, createTime=1787111500456, updateTime=1787111500456, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802881819141084, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802542923572121, code=themeStyle, value=null, createTime=1787111500458, updateTime=1787111500458, creator=18614031015, updator=18614031015)]), Website(id=1296802543032624028, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1296801528146919473, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgry/EN, language=EN, createTime=1787111419685, createBy=18614031015, updateTime=1787111462939, updateBy=18614031015, name=中国乳业-英文, tplId=1146101810881728533, title=China Dairy, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1296802850798068681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=articleTextType, value=kx, createTime=1787111493062, updateTime=1787111493062, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850768708550, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=banner, value=null, createTime=1787111493055, updateTime=1787111493055, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850819040204, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=grayFlag, value=0, createTime=1787111493067, updateTime=1787111493067, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850760319941, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=logo, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic?fileId=qVbzVKBQlSo4CZ2uDrqTZw==, createTime=1787111493053, updateTime=1787111493053, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850831623118, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=minRunFlag, value=0, createTime=1787111493070, updateTime=1787111493070, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850789680072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgry/EN/file/pic, createTime=1787111493060, updateTime=1787111493060, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850823234509, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=silenceFlag, value=0, createTime=1787111493068, updateTime=1787111493068, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850781291463, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1787111493058, updateTime=1787111493058, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850802262986, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeColor, value=null, createTime=1787111493063, updateTime=1787111493063, creator=18614031015, updator=18614031015), WebsiteProps(id=1296802850810651595, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1296802543032624028, code=themeStyle, value=null, createTime=1787111493065, updateTime=1787111493065, creator=18614031015, updator=18614031015)])], journalTitle=中国乳业, weixinUrl=null, journalUrl=http://zhgry.aiijournal.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=China Dairy, journalPhotoCn=fy0U6rTUhrcBdKszdYVe3w==, journalPhotoEn=1lm7RNSd456gWkkoaDGdEQ==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/10.12377/1671-4393.25.04.10, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/10.12377/1671-4393.25.04.10, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgry/CN/PDF/10.12377/1671-4393.25.04.10, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgry/EN/PDF/10.12377/1671-4393.25.04.10, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1792657155641, fullTextJson=null, articleText=null, reference=[1] Van Saun R J,Sniffen C J. Transition cow nutrition and feeding management for disease prevention[J]. 2014,30(3):689-719.
[2] 张凡建,乔立东,孙健,等. 头胎与经产奶牛围产期生产性能和血清生化指标的比较[J]. 中国畜牧兽医,2017,44(8):2529-2532.
[3] Drackley J K.Biology of dairy cows during the transition period:The final frontier[J]. Journal of Dairy Science,1999,82(11):2259-2273.
[4] Beckonert O,Keun H C,Ebbels T M D,et al. Metabolic profiling,metabolomic and metabonomic procedures for NMR spectroscopy of urine,plasma,serum and tissue extracts[J]. Nature Protocols,2007,2(11):2692-2703.
[5] Allen M S.Effects of diet on short-term regulation of feed intake by lactating dairy cattle[J]. Journal of Dairy Science,2000,83(7):1598-1624.
[6] Oetzel G R.Monitoring and testing dairy herds for metabolic disease[J]. Veterinary Clinics of North America:Food Animal Practice,2004,20(3):651-674.
[7] McArt J A A,Nydam D V,Oetzel G R. Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance[J]. The Veterinary Journal,2012,198(3):560-570.
[8] 张雯晶,郭凯军.奶牛酸中毒相关行为模式的智慧识别[J].中国乳业,2024,(11):57-60.)