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HEK293-α-syn cells and primary cortical neurons of wild-type mice were used as experimental models to deeply explore the environmental neurotoxicity and mechanism of Maneb exposure at different concentrations (0, 0.1, 1.0, 5.0mg/L). The results showed that Maneb exposure inhibited the activity of HEK293-α-syn cells in a dose-dependent manner and induced primary neuronal damage. The higher the Maneb exposure concentration, the more significant its toxic effect. In the 0.1mg/L experimental group, the apoptosis rate of neurons was close to 60%. In addition, Maneb exposure induced the aggregation ofα-syn in HEK293-α-syn cells and primary neurons, stimulated its abnormal phosphorylation at the S129 site, and upregulated the level of insoluble phosphorylated α-syn, further forming Lewy body (LB)-like aggregates, indicating that Maneb induces Parkinson's (PD)-like neurotoxicity.

, authors=Zhi-bing ZHANG¹, Yan-yan FANG¹, Kun PENG¹, Xiang GAO¹, Ze-hua LIU², Fei LI¹, Chao-yang LIU^{1, 3, *}, authorsList=Zhi-bing ZHANG, Yan-yan FANG, Kun PENG, Xiang GAO, Ze-hua LIU, Fei LI, Chao-yang LIU, authorCompany=null, correspAuthors=Chao-yang LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1314922055984837318, articleId=1314922055561212612, tenantId=1146029695717560320, journalId=1234093305789726721, language=CN, title=代森锰暴露诱导神经毒性和α-突触核蛋白聚集的机制, columnId=1234106394006311784, journalTitle=中国环境科学, columnName=环境毒理与健康, runingTitle=null, highlight=null, articleAbstract=

以HEK293-α-syn细胞和野生型小鼠原代皮质神经元为实验模型，深入探讨了不同浓度（0，0.1，1.0，5.0mg/L）Maneb暴露的环境神经毒性及机制．结果表明，Maneb暴露浓度依赖性地抑制HEK293-α-syn细胞活性，诱导原代神经元损伤．Maneb暴露浓度越高，其毒性作用越显著，其中0.1mg/L实验组中神经元凋亡率接近60%．此外，Maneb暴露诱导HEK293-α-syn细胞和原代神经元内α-syn发生聚集，刺激其在S129位点发生异常磷酸化，不溶性磷酸化α-syn水平上调，进一步形成路易小体（LB）样聚集体，表明Maneb对帕金森（PD）样神经毒性的诱发作用．

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章智冰（2001-），女，江西上饶人，中南财经政法大学硕士研究生，主要研究方向为环境毒理与健康．发表论文3篇．zzbing@stu.zuel.edu.cn.

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章智冰（2001-），女，江西上饶人，中南财经政法大学硕士研究生，主要研究方向为环境毒理与健康．发表论文3篇．zzbing@stu.zuel.edu.cn.

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