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The growth and death processes of microorganisms result in the release of pathogen-associated molecular patterns (PAMPs). Chronic exposure to PAMPs through the gastrointestinal, respiratory, and dermal routes poses a risk of inflammatory effects. The presence of large numbers of microorganisms in the air, water, and soil provides extremely favorable conditions for the release of PAMPs. This study summarizes the characteristics of endotoxins, peptidoglycan, teichoic acids, lipoproteins, and CpG DNA, which are pivotal substances in PAMPs. The occurrence and health risks of PAMPs in different environmental media, such as air, water, and soil, are introduced. The recognition mechanism of PAMPs and their ability to trigger disease are also discussed. The synergistic enhancement of inflammatory responses induced by combined exposure to PAMPs and environmental pollutants is analyzed. Based on current research of PAMPs in the environmental field, this study highlights the urgent need to accelerate research into standardized detection systems, exposure risk thresholds, and epidemiological studies of PAMPs, given the existing limitations. The aim of these efforts is to advance research progress on PAMPs in environmental science and to provide a reference for a comprehensive understanding and assessment of the health risks posed by PAMPs.

, authors=Can ZHANG¹, Ping GUI², Qian-xiu ZHAO³, Chuan-fu ZHANG³, Chao-hong TAN⁴, Xiao-mei CAO¹, Ying LI¹, Ming-lu ZHANG^{5, *}, Miao BAI^{3, 5, *}, authorsList=Can ZHANG, Ping GUI, Qian-xiu ZHAO, Chuan-fu ZHANG, Chao-hong TAN, Xiao-mei CAO, Ying LI, Ming-lu ZHANG, Miao BAI, authorCompany=null, correspAuthors=Ming-lu ZHANG, Miao BAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1314922020689764521, articleId=1314922019922206887, tenantId=1146029695717560320, journalId=1234093305789726721, language=CN, title=不同环境介质中微生物基本功能组分致炎效应研究进展, columnId=1240689596959346705, journalTitle=中国环境科学, columnName=环境微生物, runingTitle=null, highlight=null, articleAbstract=

微生物增殖及死亡过程释放病原相关分子模式（PAMPs），机体通过胃肠、呼吸和皮肤等途径长期暴露于PAMPs具有潜在致炎效应风险．空气、水和土壤等环境存在大量微生物，为PAMPs释放提供极为有利的天然条件．本研究归纳了PAMPs中重要物质内毒素、肽聚糖、磷壁酸、脂蛋白和CpG DNA特性；阐述不同环境介质如空气、水和土壤环境中PAMPs赋存特征与健康风险；介绍机体对PAMPs识别机制及其疾病诱发风险，并揭示PAMPs与环境污染物联合暴露后致炎能力呈现的协同增强效应；根据环境领域PAMPs研究现状，重点探讨现存不足之处，提出亟需加快PAMPs标准检测体系、暴露风险阈值和流行病学等方面研究，推动环境领域PAMPs研究进展，为全面理解和评估PAMPs健康风险提供参考依据．

, authors=张灿¹, 桂萍², 赵乾秀³, 张传福³, 谭朝洪⁴, 曹晓梅¹, 李颖¹, 张明露^{5, *}, 白淼^{3, 5, *}, authorsList=张灿, 桂萍, 赵乾秀, 张传福, 谭朝洪, 曹晓梅, 李颖, 张明露, 白淼, authorCompany=null, correspAuthors=张明露, 白淼, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=ZP+5OwMWGo/xKqUt14ZxEw==, magXml=JR9vAz2JCwaQuGe2MG629A==, pdfUrl=null, pdf=t2OyVuswYehez6NdPtfMtw==, pdfFileSize=931149, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=wyi1CODnnUp871SP7FMi6Q==, mapNumber=null, fund=null)}, authors=[Author(id=1314922023508336827, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314922019922206887, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhangcancqu@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1314922023822909629, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314922019922206887, authorId=1314922023508336827, language=EN, stringName=Can ZHANG, firstName=Can, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Chinese Academy of Quality and Inspection & Testing, Beijing 100176, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1314922023944544447, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314922019922206887, authorId=1314922023508336827, language=CN, stringName=张灿, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.中国质量检验检测科学研究院，北京 100176, bio={"content":"

张灿（1975-），女，山东泗水人，中国质量检验检测科学研究院研究员，主要从事环境微生物研究．发表论文80余篇．zhangcancqu@163.com.

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张灿（1975-），女，山东泗水人，中国质量检验检测科学研究院研究员，主要从事环境微生物研究．发表论文80余篇．zhangcancqu@163.com.

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