Article(id=1314918541250363702, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314918450573701162, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747756800000, receivedDateStr=2025-05-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791430610239, onlineDateStr=2026-10-08, pubDate=1766160000000, pubDateStr=2025-12-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791430610239, onlineIssueDateStr=2026-10-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791430610239, creator=13701087609, updateTime=1791430610239, updator=13701087609, issue=Issue{id=1314918450573701162, tenantId=1146029695717560320, journalId=1234093305789726721, year='2025', volume='45', issue='12', pageStart='6513', pageEnd='7104', issueExtLink='null', onlineDate='null', pubDate='1766160000000', pubDateStr='2025-12-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791430588620, creator='13701087609', updateTime=1791431575400, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1314922589479333965, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314918450573701162, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1314922589479333966, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314918450573701162, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7008, endPage=7016, ext={EN=ArticleExt(id=1314918542869365048, articleId=1314918541250363702, tenantId=1146029695717560320, journalId=1234093305789726721, language=EN, title=Systematic transcriptomic analysis reveals differential toxicity of three typical perfluoroalkyl substances, columnId=1234106388687934088, journalTitle=China Environmental Science, columnName=Environmental Toxicology and Environmental Health, runingTitle=null, highlight=null, articleAbstract=

Publicly available transcriptomic datasets from zebrafish exposed to three representative per- and polyfluoroalkyl substances (PFAS)—PFHxS, PFOA, and PFOS—were systematically integrated with behavioral data to elucidate comparative toxic potencies and neurotoxic mechanisms. Transcriptomic point-of-departure (tPOD) modeling identified PFOS as the most potent compound (120-h tPOD = 0.3241μmol/L), followed by PFHxS (0.3735μmol/L) and PFOA (0.4506μmol/L). Developmental stage-dependent increases in PFAS tolerance were observed. Behavioral meta-analysis revealed a characteristic biphasic "stimulation-inhibition" response pattern across all three PFAS, with enhanced locomotor activity at low concentrations and suppression at higher doses. Behavior-anchored transcriptomic profiling demonstrated that PFAS exposure broadly perturbed metabolic homeostasis and neural signaling pathways, with PFOS eliciting more pronounced disruptions in signal transduction and immune regulatory networks. Single-cell transcriptomic analysis further indicated that PFOS substantially altered neuronal subtype composition, suggesting that augmented excitatory synaptic activity may underlie the observed behavioral phenotypes.

, authors=Hui-dong WANG^{1, 2}, Hao JIANG¹, Jia-qi CAI¹, Lu CHEN², Li-jian DING¹, An-yu NI³, Jin YAN⁴, Chun-ming DING¹, Sheng-nan JIN^{1, *}, authorsList=Hui-dong WANG, Hao JIANG, Jia-qi CAI, Lu CHEN, Li-jian DING, An-yu NI, Jin YAN, Chun-ming DING, Sheng-nan JIN, authorCompany=null, correspAuthors=Sheng-nan JIN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1314918543137800505, articleId=1314918541250363702, tenantId=1146029695717560320, journalId=1234093305789726721, language=CN, title=系统转录组分析揭示三种典型全氟化合物毒性差异, columnId=1234106394006311784, journalTitle=中国环境科学, columnName=环境毒理与健康, runingTitle=null, highlight=null, articleAbstract=

本研究整合分析了公开数据库中斑马鱼暴露于三种代表性PFAS（PFHxS、PFOA、PFOS）后的转录组测序数据，并结合行为学实验系统比较其综合毒性强度与神经毒性机制．转录组学起始点（tPOD）分析显示，PFOS 毒性最强（120h tPOD=0.3241μmol/L），其次为PFHxS（0.3735μmol/L）与PFOA（0.4506μmol/L），且斑马鱼对PFAS的耐受性随发育进程提升．行为学结果再分析显示，三种PFAS均可诱导“兴奋-抑制”型双相反应，即在低剂量下促进斑马鱼的游动行为，而在高剂量下表现出抑制效应．进一步通过行为驱动转录组分析发现，PFAS暴露普遍干扰代谢稳态与神经通路调控，其中PFOS在信号转导和免疫反应上展现更强扰动效应．单细胞转录组结果显示PFOS可显著影响神经元亚群组成，提示其可能通过增强兴奋性突触活动介导行为表型变化．

, authors=王慧东^{1, 2}, 姜浩¹, 蔡佳琪¹, 陈璐², 丁立健¹, 倪安煜³, 闫瑾⁴, 丁春明¹, 金胜男^{1, *}, authorsList=王慧东, 姜浩, 蔡佳琪, 陈璐, 丁立健, 倪安煜, 闫瑾, 丁春明, 金胜男, authorCompany=null, correspAuthors=金胜男, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=D++h1r/XVwpJYU6fLmzlsA==, magXml=1c9ITIbfE3rjG5kJZP/SPA==, pdfUrl=null, pdf=W2WN9bR5el43XEFDF5GEEQ==, pdfFileSize=3054817, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=GGDzpLrhqZSyc9uLs0PKmQ==, mapNumber=null, fund=null)}, authors=[Author(id=1314918543712420168, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314918541250363702, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1453165207@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1314918543829860683, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314918541250363702, authorId=1314918543712420168, language=EN, stringName=Hui-dong WANG, firstName=Hui-dong, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325000, China
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王慧东（1999-），男，江西萍乡人，温州医科大学硕士研究生，主要从事生物学与环境毒理学方面的研究．发表论文1篇．1453165207@qq.com.

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王慧东（1999-），男，江西萍乡人，温州医科大学硕士研究生，主要从事生物学与环境毒理学方面的研究．发表论文1篇．1453165207@qq.com.

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