Article(id=1314917833625137747, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314917704910340427, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1737302400000, receivedDateStr=2025-01-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1791430441527, onlineDateStr=2026-10-08, pubDate=1755619200000, pubDateStr=2025-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791430441527, onlineIssueDateStr=2026-10-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791430441527, creator=13701087609, updateTime=1791430441527, updator=13701087609, issue=Issue{id=1314917704910340427, tenantId=1146029695717560320, journalId=1234093305789726721, year='2025', volume='45', issue='8', pageStart='4145', pageEnd='4736', issueExtLink='null', onlineDate='null', pubDate='1755619200000', pubDateStr='2025-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1791430410840, creator='13701087609', updateTime=1791431909627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1314923991341555972, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314917704910340427, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1314923991345750277, tenantId=1146029695717560320, journalId=1234093305789726721, issueId=1314917704910340427, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4638, endPage=4645, ext={EN=ArticleExt(id=1314917833830658644, articleId=1314917833625137747, tenantId=1146029695717560320, journalId=1234093305789726721, language=EN, title=Research progress on gut microbiota-mediated health damage induced by microplastic exposure in mice, columnId=1314917798002918356, journalTitle=China Environmental Science, columnName=Emerging Contaminants and Toxicology, runingTitle=null, highlight=null, articleAbstract=

To explore the mechanisms by which gut microbiota dysbiosis influences the health effects of microplastics (MPs), a systematic search was conducted across five English-language databases (PubMed, Embase, Scopus, Cochrane, and Web of Science) and three Chinese-language databases (CNKI, Wanfang Data, and China Biomedical Literature Database). Studies addressing gut microbiota-mediated health effects of MPs exposure in mice and rats were identified and reviewed. A total of 27 studies met the inclusion criteria. The animal models used were primarily C57BL/6 mice, aged between 4 and 12 weeks, mainly male. The MPs used were mainly polystyrene, with particle sizes ranging from 0.05~53μm. The primary exposure routes were oral gavage and free drinking water, with exposure durations ranging from 3 to 13 weeks. Microbial community analysis was primarily performed using 16S rRNA gene sequencing. The studies investigated gut microbiota on harm through the gut-organ axis (including the liver, brain, testes, bone marrow, and lungs) and the gut-function axis (encompassing immune and metabolic functions). Intestinal microflora mediates the damage of MPs to mice through various metabolic pathways (such as amino acids and lipids) and signaling pathways (including TLR 2-Myd 88-NF-κB and intestinal microflora -HIF 1α/PTBP 1). Further clinical studies are warranted to better elucidate the potential mechanisms by which gut microbiota modulates the health effects of MPs exposure in humans.

, authors=Ming-liang LIU¹, Chen LI², Yan-dan PAN¹, Hao-ran WANG¹, Cheng-yue FAN¹, Pin-ru YAN³, Lei HUANG^{1, 2, *}, authorsList=Ming-liang LIU, Chen LI, Yan-dan PAN, Hao-ran WANG, Cheng-yue FAN, Pin-ru YAN, Lei HUANG, authorCompany=null, correspAuthors=Lei HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1314917834199757397, articleId=1314917833625137747, tenantId=1146029695717560320, journalId=1234093305789726721, language=CN, title=肠道菌群介导微塑料致小鼠损伤的研究进展, columnId=1314917798195856342, journalTitle=中国环境科学, columnName=新污染物与毒理, runingTitle=null, highlight=null, articleAbstract=

为探讨肠道菌群紊乱在微塑料（Microplastics, MPs）健康的影响机制，检索了5个英文数据库（PubMed、Embase、Scopus、Cochrane和Web of Science）和3个中文数据库（中国知网、万方数据和中国生物医学文献数据库），收集了肠道菌群介导的微塑料对小鼠、大鼠损伤的相关文献资料．结果表明，最终符合标准的文献27篇，研究的动物品系主要为C57BL/6，鼠龄在4~12周之间，雄性为主．MPs的类型主要为聚苯乙烯，粒径在0.05~53μm，染毒途径主要为灌胃和自由饮水，造模周期在3~13周，微生物的组学检测方法主要为16S rRNA测序．研究涉及肠道菌群通过肠-器官轴（肝脏、脑、睾丸、骨髓、肺）以及肠-功能轴（免疫、代谢）对小鼠的损伤．肠道菌群通过如氨基酸、脂质等各种代谢途径或TLR2-Myd88-NF-κB、肠道菌群-HIF1a/PTBP1等信号通路介导微塑料对小鼠机体的损伤．未来需要更多的临床研究进一步验证微塑料暴露后肠道菌群对人体健康影响的潜在机制．

, authors=刘明亮¹, 李晨², 潘彦丹¹, 汪浩然¹, 范诚越¹, 闫品儒³, 黄蕾^{1, 2, *}, authorsList=刘明亮, 李晨, 潘彦丹, 汪浩然, 范诚越, 闫品儒, 黄蕾, authorCompany=null, correspAuthors=黄蕾, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=8eYmNWx8v7OoQcWzEHC4bw==, magXml=vaIn2+7/3+InmE0Z12xrQg==, pdfUrl=null, pdf=4bdTJ9MPUR4qfNLN6hXalw==, pdfFileSize=444922, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=pB28O/uacD8NukUWpbznJA==, mapNumber=null, fund=null)}, authors=[Author(id=1314917834648547936, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314917833625137747, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=lmingliang2023@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1314917834732434018, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314917833625137747, authorId=1314917834648547936, language=EN, stringName=Ming-liang LIU, firstName=Ming-liang, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1314917834971509347, tenantId=1146029695717560320, journalId=1234093305789726721, articleId=1314917833625137747, authorId=1314917834648547936, language=CN, stringName=刘明亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.南京大学环境学院，水污染控制与资源绿色循环全国重点实验室，江苏 南京 210023, bio={"content":"

刘明亮（1997-），男，四川绵阳人，南京大学博士研究生，主要从事环境健康方向研究．发表论文15篇．lmingliang2023@163.com.

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刘明亮（1997-），男，四川绵阳人，南京大学博士研究生，主要从事环境健康方向研究．发表论文15篇．lmingliang2023@163.com.

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